A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 46, 2009, Pages 19250-19255

  Koltes, James E ^a   Mishra, Bishnu P ^a,e   Kumar, Dinesh ^a,e   Kataria, Ranjit S ^a,e   Totir, Liviu R ^a   Fernando, Rohan L ^a   Cobbold, Rowland ^b   Steffen, David ^c   Coppieters, Wouter ^d   Georges, Michel ^d   Reecy, James M ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^d UNIVERSITY OF LIÈGE   (Belgium)

^e NATIONAL BUREAU OF ANIMAL GENETIC RESOURCES   (India)

Author keywords

Achondroplasic dwarfism; BTA6; cGKII; Recessive genetic disease

Indexed keywords

ARGININE; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE TYPE II; UNCLASSIFIED DRUG; CGMP DEPENDENT PROTEIN KINASE II; CGMP-DEPENDENT PROTEIN KINASE II; COLLAGEN TYPE 10; COLLAGEN TYPE 2; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; BOVINE DWARFISM; CARBOXY TERMINAL SEQUENCE; CATTLE DISEASE; COL10 GENE; COL2 GENE; DWARFISM; EXON; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENOTYPE; HUMAN; HUMAN CELL; LINKAGE ANALYSIS; MALE; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PEDIGREE; PRIORITY JOURNAL; PRKG2 GENE; PROTEIN DOMAIN; SEQUENCE ANALYSIS; STOP CODON; AMINO ACID SEQUENCE; ANIMAL; ANIMAL DISEASE; CATTLE; CELL CULTURE; GENETICS; GROWTH PLATE; METABOLISM; MOLECULAR GENETICS; RNA STABILITY;

BOS;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CELLS, CULTURED; CODON, NONSENSE; COLLAGEN TYPE II; COLLAGEN TYPE X; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DWARFISM; EXONS; GENE EXPRESSION REGULATION; GROWTH PLATE; MOLECULAR SEQUENCE DATA; RNA STABILITY; RNA, MESSENGER;

EID: 73349097595     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904513106     Document Type: Article

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