Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture

Journal of Pharmacological and Toxicological Methods

Volumn 73, Issue , 2015, Pages 63-71

  Oorts, Marlies ^a   Richert, Lysiane ^b,c   Annaert, Pieter ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b KaLy Cell   (France)

^c UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

Cryopreserved hepatocytes; Cyclosporin A; Drug induced cholestasis; Sandwich cultured rat hepatocytes; Troglitazone

Indexed keywords

BILE ACID; CYCLOSPORIN A; TROGLITAZONE; UREA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CHROMAN DERIVATIVE; CYCLOSPORIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL VIABILITY; CHOLESTASIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYOPRESERVATION; DRUG INDUCED DISEASE; FREEZE THAWING; IMAGE ANALYSIS; IN VITRO STUDY; LIVER CELL CULTURE; MALE; MICROSCOPY; NONHUMAN; RAT; SCANNING ELECTRON MICROSCOPY; UREA CYCLE; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; LIVER CELL; PATHOLOGY; PHYSIOLOGY; PROCEDURES; WISTAR RAT;

RATTUS;

ANIMALS; BILE ACIDS AND SALTS; CELL SURVIVAL; CELLS, CULTURED; CHOLESTASIS; CHROMANS; CRYOPRESERVATION; CYCLOSPORINE; HEPATOCYTES; MALE; RATS; RATS, WISTAR; THIAZOLIDINEDIONES;

EID: 84927645508     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2015.03.002     Document Type: Article

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