Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: Role of glycine conjugates

Toxicology in Vitro

Volumn 28, Issue 2, 2014, Pages 218-230

  Chatterjee, Sagnik ^a   Bijsmans, Ingrid T G W ^b   van Mil, Saskia W C ^b   Augustijns, Patrick ^a   Annaert, Pieter ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Bile acid conjugation; Bile acids; Chenodeoxycholic acid; Cholestasis; Hepatotoxicity; Sandwich cultured rat hepatocytes

Indexed keywords

BILE ACID; BILE ACID CONJUGATE; BILE ACID TAURINE CONJUGATE; GLYCINE; TAURINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BILE ACID METABOLISM; CELL CULTURE; CELL FUNCTION; CELL LEVEL; CELL LOSS; CELL METABOLISM; CELL TRANSPORT; CONCENTRATION RESPONSE; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; LIVER CELL; LIVER SINUSOID; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT;

RATTUS;

4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID; BAAT; BAS; BEI; BILE ACID COA: AMINO ACID N-ACYLTRANSFERASE; BILE ACID CONJUGATION; BILE ACIDS; BILE SALT EXPORT PUMP (HUMAN/RAT); BILIARY EXCRETION INDEX; BSEP/BSEP; CA; CDCA; CHENODEOXYCHOLIC ACID; CHOLESTASIS; CHOLIC ACID; DIMETHYL SULFOXIDE; DMSO; FBS; FETAL BOVINE SERUM GCDCA, GLYCOCHENODEOXYCHOLIC ACID; GDCA; GLYCODEOXYCHOLIC ACID; HANKS' BALANCED SALT SOLUTION; HBSS; HEPATOTOXICITY; HEPES; NO OBSERVED ADVERSE EFFECT LEVEL; NOAEL; NTCP/NTCP; PBS; PHOSPHATE BUFFERED SALINE; SANDWICH-CULTURED HEPATOCYTES; SANDWICH-CULTURED RAT HEPATOCYTES; SCH; SCRH; SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE (HUMAN/RAT); TAUROCHENODEOXYCHOLIC ACID; TAURODEOXYCHOLIC ACID; TCDCA; TDCA;

ALGORITHMS; ANIMALS; BILE; BILE ACIDS AND SALTS; CELL SEPARATION; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; GLYCINE; GLYCODEOXYCHOLIC ACID; HEPATOCYTES; MASS SPECTROMETRY; RATS; RNA, MESSENGER; TAURINE; TAUROCHENODEOXYCHOLIC ACID; TAURODEOXYCHOLIC ACID; UREA;

EID: 84889572681     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.10.020     Document Type: Article

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