The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions

Drug Metabolism and Disposition

Volumn 42, Issue 3, 2014, Pages 469-480

  Lundquist, Patrik ^a,b,c   Lööf, Johan ^a   Sohlenius Sternbeck, Anna Karin ^a   Floby, Eva ^a   Johansson, Jenny ^a   Bylund, Johan ^a   Hoogstraate, Janet ^a   Afzelius, Lovisa ^a   Andersson, Tommy B ^b,d  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; DRUG METABOLIZING ENZYME; FEXOFENADINE; IPRATROPIUM BROMIDE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTING POLYPEPTIDE; ORGANIC CATION TRANSPORTER; PROSTAGLANDIN E SYNTHASE 1 INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; ROSUVASTATIN; SODIUM BILE ACID COTRANSPORTER; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; UNCLASSIFIED DRUG; COTRANSPORTER; DRUG; PLASMA PROTEIN; SODIUM-BILE ACID COTRANSPORTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTERNALIZATION; INTRINSIC CLEARANCE; LIVER CELL; LIVER MICROSOME; MALE; METABOLIC CLEARANCE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; ANIMAL; BLOOD; CELL CULTURE; CRYOPRESERVATION; CULTURE TECHNIQUE; DRUG DETOXIFICATION; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; METABOLIC CLEARANCE RATE; METABOLISM; PREDICTIVE VALUE; PROTEIN BINDING; SPECIES DIFFERENCE; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CRYOPRESERVATION; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOCYTES; HUMANS; METABOLIC CLEARANCE RATE; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; MICROSOMES, LIVER; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; ORGANIC CATION TRANSPORT PROTEINS; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; RATS; SPECIES SPECIFICITY; SYMPORTERS;

EID: 84903177522     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.054676     Document Type: Article

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