Novel immunotherapy approaches to food allergy

Current Opinion in Allergy and Clinical Immunology

Volumn 14, Issue 6, 2014, Pages 549-556

  Hayen, Simone M ^a,b   Kostadinova, Atanaska I ^b,c   Garssen, Johan ^b,c   Otten, Henny G ^a   Willemsen, Linette E M ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c DANONE NUTRICIA RESEARCH   (Netherlands)

Author keywords

Adjunct therapy; Clinical tolerance; Desensitization; Food allergy; Immunotherapy

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; FRUCTOSE OLIGOSACCHARIDE; GALACTOSE OLIGOSACCHARIDE; IMMUNOGLOBULIN; MANNOSE OLIGOSACCHARIDE; OMALIZUMAB; POLYUNSATURATED FATTY ACID; SOMATOMEDIN B; VACCINE; VSL3; ALLERGEN; ANTIALLERGIC AGENT; IMMUNOLOGIC FACTOR;

BIFIDOBACTERIUM BREVE; DESENSITIZATION; DIET THERAPY; DRUG EFFICACY; FOOD ALLERGY; HUMAN; IMMUNOTHERAPY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; FOOD HYPERSENSITIVITY; IMMUNOLOGY; PROCEDURES; TH1 CELL;

ALLERGENS; ANTI-ALLERGIC AGENTS; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS; IMMUNOLOGIC FACTORS; TH1 CELLS;

EID: 84927609301     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0000000000000109     Document Type: Review

References (56)

1. Prescott SL. Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol 2013; 131:23-30.
2. Moran TP, Vickery BP, Burks AW. Oral and sublingual immunotherapy for food allergy: current progress and future directions. Curr Opin Immunol 2013; 25:781-787.
3. Kostadinova AI, Willemsen LE, Knippels LM, et al. Immunotherapy - risk/benefit in food allergy. Pediatr Allergy Immunol 2013; 24:633-644.
4. Oka T, Rios EJ, Tsai M, et al. Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells. J Allergy Clin Immunol 2013; 132:922.e1-932.e16.
5. Bartnikas LM, Gurish MF, Burton OT, et al. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol 2013; 131:451.e1-460.e6.
6. Syed A, Garcia MA, Lyu SC, et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol 2014; 133:500-510.
7. Yang G, Geng XR, Song JP, et al. Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol 2014; 133:1702.e5-1708.e5.
8. Nurmatov U, Devereux G, Worth A, et al. Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis. Br J Nutr 2014; 111:12-22.
9. Keet CA, Seopaul S, Knorr S, et al. Long-term follow-up of oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2013; 132:737.e6-739.e6.
10. Anagnostou K, Islam S, King Y, et al. Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. Lancet 2014; 383:1297-1304.
11. Blumchen K, Beder A, Beschorner J, et al. Modified oral food challenge used with sensitization biomarkers provides more real-life clinical thresholds for peanut allergy. J Allergy Clin Immunol 2014; 134:390-398.
12. Chin SJ, Vickery BP, Kulis MD, et al. Sublingual versus oral immunotherapy for peanut-allergic children: a retrospective comparison. J Allergy Clin Immunol 2013; 132:476.e2-478.e2.
13. Vickery BP, Lin J, Kulis M, et al. Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens. J Allergy Clin Immunol 2013; 131:128.e1-134.e3.
14. Vickery BP, Scurlock AM, Kulis M, et al. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol 2014; 133:468.e6-475.e6.
15. Meglio P, Giampietro PG, Carello R, et al. Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg. Pediatr Allergy Immunol 2013; 24:75-83.
16. Dello Iacono I, Tripodi S, Calvani M, et al. Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: a randomized controlled trial. Pediatr Allergy Immunol 2013; 24:66-74.
17. Badina L, Matarazzo L, Longo G, et al. Could slightly cooked egg be a suitable medium for oral immunotherapy in persistent hen's egg allergy? Allergol Immunopathol (Madr) 2013; 41:141-142.
18. Fleischer DM, Burks AW, Vickery BP, et al. Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial. J Allergy Clin Immunol 2013; 131:119.e1-127.e7.
19. Jones SM, Burks AW, Dupont C. State of the art on food allergen immunotherapy: oral, sublingual, and epicutaneous. J Allergy Clin Immunol 2014; 133:318-323.
20. Dioszeghy V, Mondoulet L, Dhelft V, et al. The regulatory T cells induction by epicutaneous immunotherapy is sustained and mediates long-term protection from eosinophilic disorders in peanut-sensitized mice. Clin Exp Allergy 2014; 44:867-881.
21. Feldman MF, Bird JA. Oral immunotherapy for food allergy, ready for prime time? Heated egg and milk. Curr Allergy Asthma Rep 2014; 14:436.
22. Turner PJ, Mehr S, Joshi P, et al. Safety of food challenges to extensively heated egg in egg-allergic children: a prospective cohort study. Pediatr Allergy Immunol 2013; 24:450-455.
23. Watanabe H, Toda M, Sekido H, et al. Heat treatment of egg white controls allergic symptoms and induces oral tolerance to ovalbumin in a murine model of food allergy. Mol Nutr Food Res 2014; 58:394-404.
24. Leonard SA, Martos G, Wang W, et al. Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa. J Allergy Clin Immunol 2012; 129:1579.e1-1587.e1.
25. Leonard SA, Sampson HA, Sicherer SH, et al. Dietary baked egg accelerates resolution of egg allergy in children. J Allergy Clin Immunol 2012; 130:473.e1-480.e1.
26. Gupta K, Kumar S, Das M, et al. Peptide based immunotherapy: a pivotal tool for allergy treatment. Int Immunopharmacol 2014; 19:391-398.
27. Rupa P, Mine Y. Oral immunotherapy with immunodominant T-cell epitope peptides alleviates allergic reactions in a Balb/c mouse model of egg allergy. Allergy 2012; 67:74-82.
28. Prickett SR, Voskamp AL, Dacumos-Hill A, et al. Ara h 2 peptides containing dominant CD4+ T-cell epitopes: candidates for a peanut allergy therapeutic. J Allergy Clin Immunol 2011; 127:608.e1-615.e5.
29. Prickett SR, Voskamp AL, Phan T, et al. Ara h 1 CD4+ T cell epitope-based peptides: candidates for a peanut allergy therapeutic. Clin Exp Allergy 2013; 43:684-697.
30. Bonnelykke K, Matheson MC, Pers TH, et al. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet 2013; 45:902-906.
31. Lanzavecchia A, Bove S. Specific B lymphocytes efficiently pick up, process and present antigen to T cells. Behring Inst Mitt 1985; 77:82-87.
32. Pascal M, Konstantinou GN, Masilamani M, et al. In silico prediction of Ara h 2 T cell epitopes in peanut-allergic children. Clin Exp Allergy 2013; 43:116-127.
33. Meulenbroek LA, van Esch BC, Hofman GA, et al. Oral treatment with beta-lactoglobulin peptides prevents clinical symptoms in a mouse model for cow's milk allergy. Pediatr Allergy Immunol 2013; 24:656-664.
34. Meulenbroek LA, den Hartog Jager CF, Lebens AF, et al. Characterization of T cell epitopes in bovine alpha-lactalbumin. Int Arch Allergy Immunol 2014; 163:292-296.
35. Wang J, Sampson HA. Treatments for food allergy: how close are we? Immunol Res 2012; 54:83-94.
36. Zhou Y, Kawasaki H, Hsu SC, et al. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nat Med 2010; 16:1128-1133.
37. Wood RA, Sicherer SH, Burks AW, et al. A phase 1 study of heat/phenol-killed, E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy. Allergy 2013; 68:803-808.
38. Ren C, Zhang Q, Wang G, et al. Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice. Appl Microbiol Biotechnol 2014; 98:6353-6364.
39. Eggel A, Baravalle G, Hobi G, et al. Accelerated dissociation of IgE-Fcepsi-lonRI complexes by disruptive inhibitors actively desensitizes allergic effector cells. J Allergy Clin Immunol 2014; 133:1709.e8-1719.e8.
40. Schneider LC, Rachid R, LeBovidge J, et al. A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol 2013; 132:1368-1374.
41. Zhu FG, Kandimalla ER, Yu D, et al. Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice. J Allergy Clin Immunol 2007; 120:631-637.
42. Kulis M, Gorentla B, Burks AW, et al. Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice. Mol Nutr Food Res 2013; 57:906-915.
43. Senti G, Johansen P, Haug S, et al. Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial. Clin Exp Allergy 2009; 39:562-570.
44. Beeh KM, Kanniess F, Wagner F, et al. The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma. J Allergy Clin Immunol 2013; 131:866-874.
45. Pali-Scholl I, Szollosi H, Starkl P, et al. Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice. Eur J Pharm Biopharm 2013; 85:656-664.
46. Massoud AH, Yona M, Xue D, et al. Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J Allergy Clin Immunol 2014; 133:853.e5-863.e5.
47. Cousens LP, Najafian N, Mingozzi F, et al. In vitro and in vivo studies of IgG-derived Treg epitopes (Tregitopes): a promising new tool for tolerance induction and treatment of autoimmunity. J Clin Immunol 2013; 33 (Suppl 1): S43-S49.
48. Kawakita A, Shirasaki H, Yasutomi M, et al. Immunotherapy with oligoman-nose-coated liposomes ameliorates allergic symptoms in a murine food allergy model. Allergy 2012; 67:371-379.
49. Kim HJ, Kim YJ, Lee SH, et al. Effects of Lactobacillus rhamnosus on asthma with an adoptive transfer of dendritic cells in mice. J Appl Microbiol 2013; 115:872-879.
50. Wang J. Treatment of food anaphylaxis with traditional Chinese herbal remedies: from mouse model to human clinical trials. Curr Opin Allergy Clin Immunol 2013; 13:386-391.
51. Barletta B, Rossi G, Schiavi E, et al. Probiotic VSL#3-induced TGF-beta ameliorates food allergy inflammation in a mouse model of peanut sensitization through the induction of regulatory T cells in the gut mucosa. Mol Nutr Food Res 2013; 57:2233-2244.
52. Moro G, Arslanoglu S, Stahl B, et al. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 2006; 91:814-819.
53. de Kivit S, Kraneveld AD, Knippels LM, et al. Intestinal epithelium-derived galectin-9 is involved in the immunomodulating effects of nondigestible oligosaccharides. J Innate Immun 2013; 5:625-638.
54. de Kivit S, Saeland E, Kraneveld AD, et al. Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans. Allergy 2012; 67:343-352.
55. van den Elsen LW, van Esch BC, Hofman GA, et al. Dietary long chain n-3 polyunsaturated fatty acids prevent allergic sensitization to cow's milk protein in mice. Clin Exp Allergy 2013; 43:798-810.
56. van den Elsen LW, Meulenbroek LA, van Esch BC, et al. CD25+ regulatory T cells transfer n-3 long chain polyunsaturated fatty acids-induced tolerance in mice allergic to cow's milk protein. Allergy 2013; 68:1562-1570.