State of the art on food allergen immunotherapy: Oral, sublingual, and epicutaneous

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 2, 2014, Pages 318-323

  Jones, Stacie M ^a   Burks, A Wesley ^b   Dupont, Christophe ^c  

^a ARKANSAS CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Food allergy; immunotherapy; investigational; treatment

Indexed keywords

ADRENALIN; FOOD ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G4; OMALIZUMAB;

ANGIONEUROTIC EDEMA; APPLICATION SITE ECZEMA; APPLICATION SITE ERYTHEMA; DESENSITIZATION; DIET RESTRICTION; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG WITHDRAWAL; EGG ALLERGY; EPICUTANEOUS IMMUNOTHERAPY; FOOD ALLERGY; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOTHERAPY; LARYNX EDEMA; MILK ALLERGY; NONHUMAN; ORAL IMMUNOTHERAPY; PEANUT ALLERGY; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REGULATORY T LYMPHOCYTE; RESPIRATORY DISTRESS; REVIEW; SKIN TOXICITY; SUBLINGUAL IMMUNOTHERAPY; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; URTICARIA; VOMITING; WHEEZING;

ADVERSE EVENT; AE; COFAR; CONSORTIUM OF FOOD ALLERGY RESEARCH; DBPC; DOUBLE-BLIND, PLACEBO-CONTROLLED; EPICUTANEOUS IMMUNOTHERAPY; EPIT; FOOD ALLERGY; IMMUNOTHERAPY; INVESTIGATIONAL; OFC; OIT; ORAL FOOD CHALLENGE; ORAL IMMUNOTHERAPY; REGULATORY T; SKIN PRICK TEST; SLIT; SPT; SUBLINGUAL IMMUNOTHERAPY; TREATMENT; TREG;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ADMINISTRATION, SUBLINGUAL; ANIMALS; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS;

EID: 84893373218     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.12.1040     Document Type: Article

References (58)

1. J.A. Boyce, A. Assa'ad, A.W. Burks, S.M. Jones, H.A. Sampson, and R.A. Wood et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel J Allergy Clin Immunol 126 Suppl 2010 S1 S58
2. B.P. Vickery, A.M. Scurlock, S.M. Jones, and A.W. Burks Mechanisms of immune tolerance relevant to food allergy J Allergy Clin Immunol 127 2011 576 586
3. B.P. Vickery, J. Lin, M. Kulis, Z. Fu, P.H. Steele, and S.M. Jones et al. Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens J Allergy Clin Immunol 131 2013 128 134 e1-3
4. A. Thyagarajan, S.M. Jones, A. Calatroni, L. Pons, M. Kulis, and C.S. Woo et al. Evidence of pathway-specific basophil anergy induced by peanut oral immunotherapy in peanut-allergic children Clin Exp Allergy 42 2012 1197 1205
5. A.W. Burks, S.M. Jones, R.A. Wood, D.M. Fleischer, S.H. Sicherer, and R.W. Lindblad et al. Oral immunotherapy for treatment of egg allergy in children N Engl J Med 367 2012 233 243
6. J.M. Skripak, S.D. Nash, H. Rowley, N.H. Brereton, S. Oh, and R.G. Hamilton et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy J Allergy Clin Immunol 122 2008 1154 1160
7. P. Varshney, S.M. Jones, A.M. Scurlock, T.T. Perry, A. Kemper, and P. Steele et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response J Allergy Clin Immunol 127 2011 654 660
8. G. Longo, E. Barbi, I. Berti, R. Meneghetti, A. Pittalis, and L. Ronfani et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions J Allergy Clin Immunol 121 2008 343 347
9. A. Martorell, B. De la Hoz, M.D. Ibanez, J. Bone, M.S. Terrados, and A. Michavila et al. Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy Clin Exp Allergy 41 2011 1297 1304
10. G.B. Pajno, L. Caminiti, P. Ruggeri, R. De Luca, D. Vita, and M. La Rosa et al. Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study Ann Allergy Asthma Immunol 105 2010 376 381
11. S. Salmivesi, M. Korppi, M.J. Makela, and M. Paassilta Milk oral immunotherapy is effective in school-aged children Acta Paediatr 102 2013 172 176
12. C.A. Keet, P.A. Frischmeyer-Guerrerio, A. Thyagarajan, J.T. Schroeder, R.G. Hamilton, and S. Boden et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy J Allergy Clin Immunol 129 2012 448 455 e1-5
13. B.P. Vickery, L. Pons, M. Kulis, P. Steele, S.M. Jones, and A.W. Burks Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance Ann Allergy Asthma Immunol 105 2010 444 450
14. B. Vickery, A.M. Scurlock, M. Kulis, P.H. Steele, J. Kamilaris, and J.P. Berglund et al. Sustained unresponsiveness in subjects completing peanut oral immunotherapy J Allergy Clin Immunol 133 2014 468 475
15. C.A. Keet, S. Seopaul, S. Knorr, S. Narisety, J. Skripak, and R.A. Wood Long-term follow-up of oral immunotherapy for cow's milk allergy J Allergy Clin Immunol 132 2013 737 739.e6
16. J.L. Brozek, L. Terracciano, J. Hsu, J. Kreis, E. Compalati, and N. Santesso et al. Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis Clin Exp Allergy 42 2012 363 374
17. H.R. Fisher, G. du Toit, and G. Lack Specific oral tolerance induction in food allergic children: is oral desensitisation more effective than allergen avoidance?: a meta-analysis of published RCTs Arch Dis Child 96 2011 259 264
18. U. Nurmatov, G. Devereux, A. Worth, L. Healy, and A. Sheikh Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis Br J Nutr 2013 1 11 [Epub ahead of print]
19. M. Vazquez-Ortiz, M. Alvaro-Lozano, L. Alsina, M.B. Garcia-Paba, M. Piquer-Gibert, and M.T. Giner-Munoz et al. Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test Clin Exp Allergy 43 2013 92 102
20. J.P. Yeung, L.A. Kloda, J. McDevitt, M. Ben-Shoshan, and R. Alizadehfar Oral immunotherapy for milk allergy Cochrane Database Syst Rev 2012 CD009542
21. K. Blumchen, H. Ulbricht, U. Staden, K. Dobberstein, J. Beschorner, and L.C. de Oliveira et al. Oral peanut immunotherapy in children with peanut anaphylaxis J Allergy Clin Immunol 126 2010 83 91.e1
22. A.M. Hofmann, A.M. Scurlock, S.M. Jones, K.P. Palmer, Y. Lokhnygina, and P.H. Steele et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy J Allergy Clin Immunol 124 2009 286 291 e1-6
23. B.P. Vickery, A.M. Scurlock, P. Steele, J. Kamilaris, A. Hiegel, and S. Carlisle et al. Early and persistent gastrointestinal side effects predict withdrawal from peanut oral immunotherapy (OIT) [abstract] J Allergy Clin Immunol 126 2011 AB87
24. S. Sanchez-Garcia, P. Rodriguez Del Rio, C. Escudero, M.J. Martinez-Gomez, and M.D. Ibanez Possible eosinophilic esophagitis induced by milk oral immunotherapy J Allergy Clin Immunol 129 2012 1155 1157
25. P. Varshney, P.H. Steele, B.P. Vickery, J.A. Bird, A. Thyagarajan, and A.M. Scurlock et al. Adverse reactions during peanut oral immunotherapy home dosing J Allergy Clin Immunol 124 2009 1351 1352
26. E. Barbi, G. Longo, I. Berti, E. Neri, A. Saccari, and L. Rubert et al. Adverse effects during specific oral tolerance induction: in-hospital "rush" phase Eur Ann Allergy Clin Immunol 44 2012 18 25
27. G.B. Pajno Oral desensitization for milk allergy in children: state of the art Curr Opin Allergy Clin Immunol 11 2011 560 564
28. K.C. Nadeau, L.C. Schneider, L. Hoyte, I. Borras, and D.T. Umetsu Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy J Allergy Clin Immunol 127 2011 1622 1624
29. L.C. Schneider, R. Rachid, J. Lebovidge, E. Blood, M. Mittal, and D.T. Umetsu A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients J Allergy Clin Immunol 132 2013 1368 1374
30. A. Nowak-Wegrzyn, K.A. Bloom, S.H. Sicherer, W.G. Shreffler, S. Noone, and N. Wanich et al. Tolerance to extensively heated milk in children with cow's milk allergy J Allergy Clin Immunol 122 2008 342 347 e1-2
31. H. Lemon-Mule, H.A. Sampson, S.H. Sicherer, W.G. Shreffler, S. Noone, and A. Nowak-Wegrzyn Immunologic changes in children with egg allergy ingesting extensively heated egg J Allergy Clin Immunol 122 2008 977 983.e1
32. J.S. Kim, A. Nowak-Wegrzyn, S.H. Sicherer, S. Noone, E.L. Moshier, and H.A. Sampson Dietary baked milk accelerates the resolution of cow's milk allergy in children J Allergy Clin Immunol 128 2011 125 131.e2
33. W.G. Shreffler, N. Wanich, M. Moloney, A. Nowak-Wegrzyn, and H.A. Sampson Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein J Allergy Clin Immunol 123 2009 43 52.e7
34. T. Mousallem, and A.W. Burks Immunology in the clinic review Series; focus on allergies: immunotherapy for food allergy Clin Exp Immunol 167 2012 26 31
35. N. Novak, E. Gros, T. Bieber, and J.P. Allam Human skin and oral mucosal dendritic cells as 'good guys' and 'bad guys' in allergic immune responses Clin Exp Immunol 161 2010 28 33
36. L.S. Cox, D. Larenas Linnemann, H. Nolte, D. Weldon, I. Finegold, and H.S. Nelson Sublingual immunotherapy: a comprehensive review J Allergy Clin Immunol 117 2006 1021 1035
37. N. Rodriguez-Perez, J. Ambriz-Moreno Mde, G.W. Canonica, and M. Penagos Frequency of acute systemic reactions in patients with allergic rhinitis and asthma treated with sublingual immunotherapy Ann Allergy Asthma Immunol 101 2008 304 310
38. D.R. Wilson, M.T. Lima, and S.R. Durham Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis Allergy 60 2005 4 12
39. M. Mempel, J. Rakoski, J. Ring, and M. Ollert Severe anaphylaxis to kiwi fruit: Immunologic changes related to successful sublingual allergen immunotherapy J Allergy Clin Immunol 111 2003 1406 1409
40. R. Kerzl, A. Simonowa, J. Ring, M. Ollert, and M. Mempel Life-threatening anaphylaxis to kiwi fruit: protective sublingual allergen immunotherapy effect persists even after discontinuation J Allergy Clin Immunol 119 2007 507 508
41. E. Enrique, F. Pineda, T. Malek, J. Bartra, M. Basagana, and R. Tella et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract J Allergy Clin Immunol 116 2005 1073 1079
42. M. Fernandez-Rivas, S. Garrido Fernandez, J.A. Nadal, M.D. Diaz de Durana, B.E. Garcia, and E. Gonzalez-Mancebo et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract Allergy 64 2009 876 883
43. D. de Boissieu, and C. Dupont Sublingual immunotherapy for cow's milk protein allergy: a preliminary report Allergy 61 2006 1238 1239
44. E.H. Kim, J.A. Bird, M. Kulis, S. Laubach, L. Pons, and W. Shreffler et al. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization J Allergy Clin Immunol 127 2011 640 646.e1
45. D.M. Fleischer, A.W. Burks, B.P. Vickery, A.M. Scurlock, R.A. Wood, and S.M. Jones et al. Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial J Allergy Clin Immunol 131 2013 119 127 e1-7
46. S.J. Chin, B.P. Vickery, M.D. Kulis, E.H. Kim, P. Varshney, and P. Steele et al. Sublingual versus oral immunotherapy for peanut-allergic children: a retrospective comparison J Allergy Clin Immunol 132 2013 476 478.e2
47. P.H. Benhamou, V. Dioszeghy, E. Puteaux, M. Ligouis, V. Dhelft, and C. Plaquet et al. Long-term protection against new sensitization after milk-EPIT in mice sensitized to milk is mediated by Tregs [abstract] J Allergy Clin Immunol 133 Suppl 2014 AB47
48. V. Dioszeghy, L. Mondoulet, V. Dhelft, M. Ligouis, E. Puteaux, and C. Plaquet et al. Epicutaneous immunotherapy-induced regulatory T cells could migrate to more various sites of allergen exposure compared to sublingual or subcutaneous immunotherapy in mice sensitized to peanut [abstract] J Allergy Clin Immunol 133 Suppl 2014 AB48
49. C. Dupont, N. Kalach, P. Soulaines, S. Legoue-Morillon, H. Piloquet, and P.H. Benhamou Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity J Allergy Clin Immunol 125 2010 1165 1167
50. W. Agbotounoi, L. Martin, D. Dupont, I. Pascal, C. Vauleon, and P.H. Benhamou Epicutaneous immunotherapy (EPIT) is safe for the treatment of peanut allergy in allergic patients [abstract] J Allergy Clin Immunol 131 2012 AB91
51. C. Dupont, T. Bourrier, F. deBlay, L. Guenard-Bibault, C. Sauvage, and M.-O. Cousin et al. Peanut epicutaneous immunotherapy (EPIT) in peanut-allergic children: 18 months treatment in the ARACHILD Study [abstract] J Allergy Clin Immunol 133 Suppl 2014 AB102
52. L. Mondoulet, V. Dioszeghy, M. Ligouis, V. Dhelft, C. Dupont, and P.H. Benhamou Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy Clin Exp Allergy 40 2010 659 667
53. L. Mondoulet, V. Dioszeghy, J.A. Vanoirbeek, B. Nemery, C. Dupont, and P.H. Benhamou Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts Int Arch Allergy Immunol 154 2011 299 309
54. V. Dioszeghy, L. Mondoulet, V. Dhelft, M. Ligouis, E. Puteaux, and P.H. Benhamou et al. Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice J Immunol 186 2011 5629 5637
55. L. Mondoulet, V. Dioszeghy, E. Puteaux, M. Ligouis, V. Dhelft, and F. Letourneur et al. Intact skin and not stripped skin is crucial for the safety and efficacy of peanut epicutaneous immunotherapy (EPIT) in mice Clin Transl Allergy 2 2012 22
56. V. Dioszeghy, L. Mondoulet, and V. Dhelft Protection from oral peanut-induced esophageal lesions in sensitized mice treated by epicutaneous immunotherapy is mediated by CD25+CD4+Tregs [abstract] J Allergy Clin Immunol 129 2012 AB114
57. V. Dioszeghy, L. Mondoulet, and V. Dhelft Long-term maintenance of regulatory T cells induced by specific epicutaneous vs sublingual immunotherapy in mice sensitized to peanut [abstract] J Allergy Clin Immunol 68 2013 S97
58. H.A. Sampson Peanut oral immunotherapy: is it ready for clinical practice? J Allergy Clin Immunol 1 2013 15 21