Oral immunotherapy for food allergy, ready for prime time? Heated egg and milk topical collection on anaphylaxis and drug allergy

Current Allergy and Asthma Reports

Volumn 14, Issue 5, 2014, Pages

  Feldman, Matthew F ^a   Bird, J Andrew ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Baked egg; Baked milk; Casein; Component testing; Egg allergy; Heated egg; Heated milk; Milk allergy; OFC; OIT; Oral immunotherapy; Ovomucoid; Recipe; Specific IgE; SPT

Indexed keywords

CASEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; OVOMUCOID;

ARTICLE; EGG; FOOD ALLERGY; HEATING; HUMAN; IMMUNOLOGICAL TOLERANCE; MILK; ORAL IMMUNOTHERAPY; PRICK TEST; ANIMAL; EGG ALLERGY; IMMUNOLOGY; IMMUNOTHERAPY; MILK ALLERGY; REVIEW; SKIN TEST;

ANIMALS; EGG HYPERSENSITIVITY; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN E; IMMUNOTHERAPY; MILK HYPERSENSITIVITY; SKIN TESTS;

EID: 84899058800     PISSN: 15297322     EISSN: 15346315     Source Type: Journal    
DOI: 10.1007/s11882-014-0436-6     Document Type: Article

References (36)

1. Eggesbø M, Botten G, Halvorsen R, Magnus P. The prevalence of allergy to egg: a population-based study in young children. Allergy. 2001;56(5):403-11.
2. Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009;124(6):1549-55.
3. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol. 2007;120(5):1172-7.
4. Werfel SJ, Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic to cow's milk. J Allergy Clin Immunol. 1997;99(3):293-300.
5. Kim JS, Nowak-Wegrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol. 2011;128(1):125-31. This article reports long-term immunologic and clinical results of incorporating heated milk into the diets of milk-allergic subjects.
6. Martos G, Lopez-Exposito I, Bencharitiwong R, Berin MC, Nowak-Wegrzyn A. Mechanisms underlying differential food allergy response to heated egg. J Allergy Clin Immunol. 2011;127(4):990-7. An excellent in vitro analysis of the mechanisms concerning how heating affects allergenicity including alterations in intestinal uptake.
7. Lemon-Mule H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol. 2008;122(5):977-83.
8. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol. 2008;122(2):342-7. e1-2.
9. Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol. 1997;99(6 pt 1):744-51.
10. Burks AW, Jones SM, Wood RA, Fleischer DM, Sicherer SH, Lindblad RW, et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med. 2012;367(3):233-43. This article is a landmark randomized double-blind placebo-controlled trial for egg (not heated) OIT for egg-allergic patients. Desensitization was achieved in a large number of subjects with evidence of sustained unresponsiveness in some, but 25 % of doses in the treatment group were associated with an adverse event.
11. Kamilaris JS, Steele PH, Kulis MD, Edie AH, Vickery BP, Burks AW. Participation in peanut oral immunotherapy improves quality of life. J Allergy Clin Immunol. 2012;129(2):AB29.
12. Bird A, Daly D, Burks W, Hourihane JOB, DunnGalvin A. Impact of oral food-specific immunotheraphy (OIT) on health related quality of life (HRQL) of children and parents during build up of tolerance. J Allergy Clin immunol. 2010; 125(2):Supplement 1.
13. Cooke SK, Sampson HA. Allergenic properties of ovomucoid in man. J Immunol. 1997;159:2026-32.
14. Nowak-Wegrzyn A, Fiocchi A. Rare, medium, or well done? The effect of heating and food matrix on food protein allergenicity. Curr Opin Allergy Clin Immunol. 2009;9(3):234-7.
15. Fiocchi A, Brozek J, Schunemann H, Bahna SL, von Berg A, Beyer K, et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. Pediatr Allergy Immunol. 2010;21 Suppl 21:1-125.
16. Chatchatee P, Jarvinen KM, Bardina L, Beyer K, Sampson HA. Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy. J Allergy Clin Immunol. 2001;107(2):379-83.
17. Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy. 2007;62(7):758-65.
18. Vickery BP, Scurlock AM, Jones SM, Burks AW. Mechanisms of immune tolerance relevant to food allergy. J Allergy Clin Immunol. 2011;127(3):576-84. This review is an excellent summary of known and hypothesized mechanisms of immune tolerance in relation to food.
19. Greer FR, Sicherer SH, Burks AW. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics. 2008;121(1):183-91.
20. Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009;123(4):789-94. e20.
21. University of Wisconsin Hospitals and Clinics Authority. Allergy: Food Challenge for Extensively Heated Milk (HMFC). [Internet]. Updated 8/14/2012. Accessed: 10/21/2013 http://www.uwhealth.org/healthfacts/B-EXTRANET-HEALTH- INFORMATION-FlexMember-Show-Public-HFFY-1126670436860.html.
22. Bartnikas LM, Sheehan WJ, Hoffman EB, Permaul P, Dioun AF, Friedlander J, et al. Predicting food challenge outcomes for baked milk: role of specific IgE and skin prick testing. Ann Allergy Asthma Immunol. 2012;109(5):309-13.
23. Lieberman JA, Huang FR, Sampson HA, Nowak-Wegrzyn A. Outcomes of 100 consecutive open, baked-egg oral food challanges in the allergy office. J Allergy Clin Immunol. 2012;129(6):1682. 4.e2.
24. Clark AT, Skypala I, Leech SC, Ewan PW, Dugue P, Brathwaite N, et al. British Society for Allergy and Clinical Immunology guidelines for the management of egg allergy. Clin Exp Allergy. 2010;40(8):1116-29.
25. Cortot CF, Sheehan WJ, Permaul P, Friedlander JL, Baxi SN, Gaffin JM, et al. Role of specific IgE and skin-prick testing in predicting food challenge results to baked egg. Allergy Asthma Proc. 2012;33(3):275-81.
26. Duke University Medical Center, Division of Pediatric Allergy & Immunology. Heated Egg Sponge Cake Recipe. [unpublished data].
27. Swamy N, Crain M, Bird JA. Identifying Characteristics in Egg-Allergic Patients to Predict Heated Egg Tolerance: A Retrospective Review. CA: ACAAI Oral Abstract Presentation Anaheim; 2012.
28. Leonard SA, Sampson HA, Sicherer SH, Noone S, Moshier EL, Godbold J, et al. Dietary baked egg accelerates resolution of egg allergy in children. J Allergy Clin immunol. 2012;130(2):473-80. e1. This article followed a large cohort of patients who incorporated heated egg into their diets and compared them to another cohort who followed a strict avoidance diet and showed a more rapid development of clinical tolerance to any form of egg.
29. Nowak-Wegrzyn A, Assa'ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS, et al. Work Group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123(6 Suppl):S365-83.
30. Ando H, Moverare R, Kondo Y, Tsuge I, Tanaka A, Borres MP, et al. Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy. J Allergy Clin Immunol. 2008;122(3):583-8.
31. Caubet JC, Bencharitiwong R, Moshier E, Godbold JH, Sampson HA, Nowak-Wegrzyn A. Significance of ovomucoid- and ovalbumin-specific IgE/IgG(4) ratios in egg allergy. J Allergy Clin immunol. 2012;129(3):739-47. These authors craft a new predictability model using clinical and immunologic data to help predict those who will tolerate and those who will not tolerate inclusion of heated egg into their diet.
32. Caubet JC, Nowak-Wegrzyn A, Moshier E, Godbold J, Wang J, Sampson HA. Utility of casein-specific IgE levels in predicting reactivity to baked milk. J Allergy Clin Immunol. 2013;131(1):222-4. e1-4. This article provides some of the most recent data supporting the use of casein-specific IgE levels to help predict reactivity to heated milk.
33. Faraj Z, Kim HL. Skin prick testing with extensively heated milk or egg products helps predict the outcome of an oral food challenge: a retrospective analysis. Allergy Asthma Clin Immunol. 2012;8(5).
34. Ford LS, Bloom KA, Nowak-Wegrzyn AH, Shreffler WG, Masilamani M, Sampson HA. Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance. J Allergy Clin Immunol. 2013;131(1):180-6. e1-3. This article adds to the mounting evidence that immunologic data may be able to distinguish between phenotypes of milk-allergic patients, namely those who tolerate and those who react to heated milk products.
35. Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol. 1997;100(4):444-51.
36. Leung J, Hundal NV, Katz AJ, Shreffler WG, Yuan Q, Butterworth CA, et al. Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis. J Allergy Clin immunol. 2013;132(5):1215-6.