Oral treatment with β-lactoglobulin peptides prevents clinical symptoms in a mouse model for cow's milk allergy

Pediatric Allergy and Immunology

Volumn 24, Issue 7, 2013, Pages 656-664

  Meulenbroek, Laura A P M ^a,b   van Esch, Betty C A M ^a,c   Hofman, Gerard A ^a   den Hartog Jager, Constance F ^b   Nauta, Alma J ^a,d   Willemsen, Linette E M ^a   Bruijnzeel Koomen, Carla A F M ^b   Garssen, Johan ^a,c   van Hoffen, Els ^b,e   Knippels, Léon M J ^a,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c DANONE RESEARCH   (Netherlands)

^d Danone Research Centre for Specialised Nutrition   (Singapore)

^e NIZO FOOD RESEARCH   (Netherlands)

Author keywords

lactoglobulin; Animal model; CD103+ dendritic cells; Cow's milk allergy; Non digestible oligosaccharides; Oral tolerance; Peptides; Prophylaxis; Regulatory T cells; T cell epitopes

Indexed keywords

BETA LACTOGLOBULIN; CD103 ANTIGEN; CD11B ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; PEPTIDE DERIVATIVE; TRANSCRIPTION FACTOR FOXP3;

ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; CD25+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; LYMPHOCYTE PROLIFERATION; MESENTERY LYMPH NODE; MILK ALLERGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMAL MODEL; CD103+ DENDRITIC CELLS; COW'S MILK ALLERGY; NON-DIGESTIBLE OLIGOSACCHARIDES; ORAL TOLERANCE; PEPTIDES; PROPHYLAXIS; REGULATORY T CELLS; T CELL EPITOPES; Β-LACTOGLOBULIN;

ADMINISTRATION, ORAL; ALLERGENS; AMINO ACID SEQUENCE; ANIMALS; CATTLE; CELL LINE; CELL PROLIFERATION; CHILD; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LACTOGLOBULINS; MICE; MICE, INBRED C3H; MILK HYPERSENSITIVITY; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; PEPTIDE FRAGMENTS; T-LYMPHOCYTES;

EID: 84885836953     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12120     Document Type: Article

References (38)

1. Venter C, Arshad SH. Epidemiology of food allergy. Pediatr Clin North Am 2011: 58: 327-49.
2. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 2007: 120: 638-46.
3. Saarinen KM, Pelkonen AS, Makela MJ, Savilahti E. Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status. J Allergy Clin Immunol 2005: 116: 869-75.
4. Vanto T, Helppila S, Juntunen-Backman K, et al. Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity. J Pediatr 2004: 144: 218-22.
5. Host A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol 2002: 13(Suppl. 15): 23-8.
6. Zeiger RS, Heller S, Mellon MH, et al. Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study. J Allergy Clin Immunol 1989: 84: 72-89.
7. Arshad SH, Matthews S, Gant C, Hide DW. Effect of allergen avoidance on development of allergic disorders in infancy. Lancet 1992: 339: 1493-7.
8. Du Toit G, Katz Y, Sasieni P, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol 2008: 122: 984-91.
9. Poole JA, Barriga K, Leung DY, et al. Timing of initial exposure to cereal grains and the risk of wheat allergy. Pediatrics 2006: 117: 2175-82.
10. Pecquet S, Bovetto L, Maynard F, Fritsche R. Peptides obtained by tryptic hydrolysis of bovine beta-lactoglobulin induce specific oral tolerance in mice. J Allergy Clin Immunol 2000: 105: 514-21.
11. van Esch BC, Schouten B, de Kivit S, et al. Oral tolerance induction by partially hydrolyzed whey protein in mice is associated with enhanced numbers of Foxp3 + regulatory T-cells in the mesenteric lymph nodes. Pediatr Allergy Immunol 2011: 22: 820-6.
12. Fritsche R, Pahud JJ, Pecquet S, Pfeifer A. Induction of systemic immunologic tolerance to beta-lactoglobulin by oral administration of a whey protein hydrolysate. J Allergy Clin Immunol 1997: 100: 266-73.
13. Agostoni C, Axelsson I, Goulet O, et al. Prebiotic oligosaccharides in dietetic products for infants: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2004: 39: 465-73.
14. Boehm G, Stahl B. Oligosaccharides from milk. J Nutr 2007: 137: 847S-9S.
15. Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 2006: 91: 814-9.
16. Gruber C, van Stuijvenberg M, Mosca F, et al. Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants. J Allergy Clin Immunol 2010: 126: 791-7.
17. Arslanoglu S, Moro GE, Schmitt J, Tandoi L, Rizzardi S, Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr 2008: 138: 1091-5.
18. Vos AP, van Esch BC, Stahl B, et al. Dietary supplementation with specific oligosaccharide mixtures decreases parameters of allergic asthma in mice. Int Immunopharmacol 2007: 7: 1582-7.
19. Schouten B, van Esch BC, Hofman GA, et al. Oligosaccharide-induced whey-specific CD25(+) regulatory T-cells are involved in the suppression of cow milk allergy in mice. J Nutr 2010: 140: 835-41.
20. Schade RP, Van Ieperen-Van Dijk AG, Van Reijsen FC, et al. Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow's milk allergy: relevance of TH2 cytokines. J Allergy Clin Immunol 2000: 106: 1155-62.
21. Flinterman AE, Pasmans SG, den Hartog Jager CF, et al. T cell responses to major peanut allergens in children with and without peanut allergy. Clin Exp Allergy 2010: 40: 590-7.
22. Ruiter B, Tregoat V, M'rabet L, et al. Characterization of T cell epitopes in alpha s1-casein in cow's milk allergic, atopic and non-atopic children. Clin Exp Allergy 2006: 36: 303-10.
23. Schulten V, Nagl B, Scala E, et al. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy 2011: 66: 1005-13.
24. Inoue R, Matsushita S, Kaneko H, et al. Identification of beta-lactoglobulin-derived peptides and class II HLA molecules recognized by T cells from patients with milk allergy. Clin Exp Allergy 2001: 31: 1126-34.
25. Tsuji NM, Kurisaki J, Mizumachi K, Kaminogawa S. Localization of T-cell determinants on bovine beta-lactoglobulin. Immunol Lett 1993: 37: 215-21.
26. Totsuka M, Ametani A, Kaminogawa S. Fine mapping of T-cell determinants of bovine beta-lactoglobulin. Cytotechnology 1997: 25: 101-13.
27. Hirahara K, Hisatsune T, Choi CY, Kaminogawa S. Profound immunological tolerance in the antibody response against bovine alpha s1-casein induced by intradermal administration of a dominant T cell determinant. Clin Immunol Immunopathol 1995: 76: 12-8.
28. Hoyne GF, Callow MG, Kuo MC, Thomas WR. Inhibition of T-cell responses by feeding peptides containing major and cryptic epitopes: studies with the Der p I allergen. Immunology 1994: 83: 190-5.
29. Daniel C, Weigmann B, Bronson R, von Boehmer H. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med 2011: 208: 1501-10.
30. Hoyne GF, Jarnicki AG, Thomas WR, Lamb JR. Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression. Int Immunol 1997: 9: 1165-73.
31. Campbell JD, Buckland KF, McMillan SJ, et al. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med 2009: 206: 1535-47.
32. Muller U, Akdis CA, Fricker M, et al. Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol 1998: 101: 747-54.
33. Worbs T, Bode U, Yan S, et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 2006: 203: 519-27.
34. Adel-Patient K, Wavrin S, Bernard H, Meziti N, Ah-Leung S, Wal JM. Oral tolerance and Treg cells are induced in BALB/c mice after gavage with bovine beta-lactoglobulin. Allergy 2011: 66: 1312-21.
35. Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, et al. A functionally specialized population of mucosal CD103 + DCs induces Foxp3 + regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007: 204: 1757-64.
36. Sun CM, Hall JA, Blank RB, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007: 204: 1775-85.
37. van't Land B, Schijf M, van Esch BC, et al. Regulatory T-cells have a prominent role in the immune modulated vaccine response by specific oligosaccharides. Vaccine 2010: 28: 5711-7.
38. Schijf MA, Kruijsen D, Bastiaans J, et al. Specific dietary oligosaccharides increase Th1 responses in a mouse respiratory syncytial virus infection model. J Virol 2012: 86: 11472-82.