Characterization of T cell epitopes in bovine α-lactalbumin

International Archives of Allergy and Immunology

Volumn 163, Issue 4, 2014, Pages 292-296

  Meulenbroek, Laura A P M ^a,b   Den Hartog Jager, Constance F ^a   Lebens, Ans F M ^a   Knulst, André C ^a   Bruijnzeel Koomen, Carla A F M ^a   Garssen, Johan ^b,c   Knippels, Léon M J ^b,c   Van Hoffen, Els ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c Nutricia Nederland   (Netherlands)

Author keywords

Cow's milk allergy; T cell epitopes; Lactalbumin

Indexed keywords

ALPHA LACTALBUMIN; EPITOPE; SYNTHETIC PEPTIDE; GAMMA INTERFERON; INTERLEUKIN 13;

ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; HUMAN; HUMAN CELL; IMMUNOGENICITY; MILK ALLERGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; T LYMPHOCYTE; BOVINAE; CELL PROLIFERATION; CELL SPECIFICITY; DRUG ACTIVATION; DRUG SPECIFICITY; MILK; NONHUMAN; PROTEIN ANALYSIS; SUPERNATANT;

ALLERGENS; AMINO ACID SEQUENCE; ANIMALS; CATTLE; CELLS, CULTURED; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNOGLOBULIN E; IMMUNOTHERAPY; LACTALBUMIN; MILK; MILK HYPERSENSITIVITY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; T-LYMPHOCYTES;

EID: 84899599493     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000360733     Document Type: Article

References (20)

1. Venter C, Arshad SH: Epidemiology of food allergy. Pediatr Clin North Am 2011; 58: 327-349.
2. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, Sigurdardottir ST, Lindner T, Goldhahn K, Dahlstrom J, Mc-Bride D, Madsen C: The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 2007; 120: 638-646.
3. Barbana C, Sanchez L, Perez MD: Bioactivity of alpha-lactalbumin related to its interaction with fatty acids: a review. Crit Rev Food Sci Nutr 2011; 51: 783-794.
4. Fiocchi A, Schunemann HJ, Brozek J, Restani P, Beyer K, Troncone R, Martelli A, Terracciano L, Bahna SL, Rance F, Ebisawa M, Heine RG, Assa'ad A, Sampson H, Verduci E, Bouygue GR, Baena-Cagnani C, Canonica W, Lockey RF: Diagnosis and Rationale for Action Against Cow's Milk Allergy (DRACMA): a summary report. J Allergy Clin Immunol 2010; 126: 1119-1128.
5. Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, Civaj V, Balic N, Nystrand M, Harlin A, Thalhamer J, Scheiblhofer S, Keller W, Pavkov T, Zafred D, Niggemann B, Quirce S, Mari A, Pauli G, Ebner C, Papadopoulos NG, Herz U, van Tol EA, Valenta R, Spitzauer S: Visualization of clustered IgE epitopes on alpha-lactalbumin. J Allergy Clin Immunol 2010; 125: 1279-1285.
6. Heine WE, Klein PD, Reeds PJ: The importance of alpha-lactalbumin in infant nutrition. J Nutr 1991; 121: 277-283.
7. Restani P, Ballabio C, Di Lorenzo C, Tripodi S, Fiocchi A: Molecular aspects of milk allergens and their role in clinical events. Anal Bioanal Chem 2009; 395: 47-56.
8. Shek LP, Bardina L, Castro R, Sampson HA, Beyer K: Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders. Allergy 2005; 60: 912-919.
9. Lam HY, van Hoffen E, Michelsen A, Guikers K, van der Tas CH, Bruijnzeel-Koomen CA, Knulst AC: Cow's milk allergy in adults is rare but severe: both casein and whey proteins are involved. Clin Exp Allergy 2008; 38: 995-1002.
10. Meulenbroek LA, Oliveira S, den Hartog Jager CF, Klemans RJ, Lebens AF, van Baalen T, Knulst AC, Bruijnzeel-Koomen CA, Garssen J, Knippels LM, van Hoffen E: The degree of whey hydrolysis does not uniformly affect in vitro basophil and T cell responses of cow's milk allergic patients. Clin Exp Allergy 2013, DOI: 10.1111/cea.12254.
11. Jarvinen KM, Chatchatee P, Bardina L, Beyer K, Sampson HA: IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy. Int Arch Allergy Immunol 2001; 126: 111-118.
12. Oldfield WL, Larche M, Kay AB: Effect of Tcell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial. Lancet 2002; 360: 47-53.
13. Inoue R, Matsushita S, Kaneko H, Shinoda S, Sakaguchi H, Nishimura Y, Kondo N: Identification of beta-lactoglobulin-derived peptides and class II HLA molecules recognized by T cells from patients with milk allergy. Clin Exp Allergy 2001; 31: 1126-1134.
14. Ruiter B, Tregoat V, M'rabet L, Garssen J, Bruijnzeel-Koomen CA, Knol EF, Hoffen E: Characterization of T cell epitopes in alphas1-casein in cow's milk allergic, atopic and nonatopic children. Clin Exp Allergy 2006; 36: 303-310.
15. Meulenbroek LA, van Esch BC, Hofman GA, den Hartog Jager CF, Nauta AJ, Willemsen LE, Bruijnzeel-Koomen CA, Garssen J, van Hoffen E, Knippels LM: Oral treatment with beta-lactoglobulin peptides prevents clinical symptoms in a mouse model for cow's milk allergy. Pediatr Allergy Immunol 2013; 24: 656-664.
16. Schade RP, Van Ieperen-Van Dijk AG, Van Reijsen FC, Versluis C, Kimpen JL, Knol EF, Bruijnzeel-Koomen CA, Van Hoffen E: Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow's milk allergy: relevance of TH2 cytokines. J Allergy Clin Immunol 2000; 106: 1155-1162.
17. Tiemessen MM, Van Ieperen-Van Dijk AG, Bruijnzeel-Koomen CA, Garssen J, Knol EF, Van Hoffen E: Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: key role for IL-10. J Allergy Clin Immunol 2004; 113: 932-939.
18. Flinterman AE, Pasmans SG, den Hartog Jager CF, Hoekstra MO, Bruijnzeel-Koomen CA, Knol EF, van Hoffen E: T cell responses to major peanut allergens in children with and without peanut allergy. Clin Exp Allergy 2010; 40: 590-597.
19. Campbell JD, Buckland KF, McMillan SJ, Kearley J, Oldfield WL, Stern LJ, Gronlund H, van Hage M, Reynolds CJ, Boyton RJ, Cobbold SP, Kay AB, Altmann DM, Lloyd CM, Larche M: Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med 2009; 206: 1535-1547.
20. Rupa P, Mine Y: Oral immunotherapy with immunodominant T-cell epitope peptides alleviates allergic reactions in a Balb/c mouse model of egg allergy. Allergy 2012; 67: 74-82.