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Volumn 24, Issue 5, 2015, Pages 659-672

Investigational drugs under development for the treatment of PTSD

Author keywords

Evidence based; Neurobiology; Posttraumatic stress disorder; Treatment

Indexed keywords

ANXIOLYTIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABINOID; CANNABINOID 1 RECEPTOR AGONIST; FATTY ACID AMIDASE INHIBITOR; GLUTAMIC ACID; OPIATE; OXYTOCIN; NEW DRUG;

EID: 84927603073     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2015.1020109     Document Type: Review
Times cited : (20)

References (165)
  • 1
    • 0028867185 scopus 로고
    • Posttraumatic stress disorder in the National Comorbidity Survey
    • Kessler RC, Sonnega A, Bromet E, et al. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 1995;52(12):1048-60
    • (1995) Arch Gen Psychiatry , vol.52 , Issue.12 , pp. 1048-1060
    • Kessler, R.C.1    Sonnega, A.2    Bromet, E.3
  • 2
    • 20344374645 scopus 로고    scopus 로고
    • Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    • Kessler RC, Chiu WT, Demler O, et al. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005;62(6):617-27
    • (2005) Arch Gen Psychiatry , vol.62 , Issue.6 , pp. 617-627
    • Kessler, R.C.1    Chiu, W.T.2    Demler, O.3
  • 3
    • 79952311583 scopus 로고    scopus 로고
    • Prevalence and axis i comorbidity of full and partial posttraumatic stress disorder in the United States: Results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions
    • Pietrzak RH, Goldstein RB, Southwick SM, et al. Prevalence and axis I comorbidity of full and partial posttraumatic stress disorder in the United States: results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. J Anxiety Disord 2011;25(3):456-65
    • (2011) J Anxiety Disord , vol.25 , Issue.3 , pp. 456-465
    • Pietrzak, R.H.1    Goldstein, R.B.2    Southwick, S.M.3
  • 4
    • 77953304470 scopus 로고    scopus 로고
    • Prevalence of mental health problems and functional impairment among active component and National Guard soldiers 3 and 12 months following combat in Iraq
    • Thomas JL, Wilk JE, Riviere LA, et al. Prevalence of mental health problems and functional impairment among active component and National Guard soldiers 3 and 12 months following combat in Iraq. Arch Gen Psychiatry 2010;67(6):614-23
    • (2010) Arch Gen Psychiatry , vol.67 , Issue.6 , pp. 614-623
    • Thomas, J.L.1    Wilk, J.E.2    Riviere, L.A.3
  • 5
    • 0037904353 scopus 로고    scopus 로고
    • Effect of cognitive behavioral therapy on heart rate variability during REM sleep in female rape victims with PTSD
    • Nishith P, Duntley SP, Domitrovich PP, et al. Effect of cognitive behavioral therapy on heart rate variability during REM sleep in female rape victims with PTSD. J Trauma Stress 2003;16(3):247-50
    • (2003) J Trauma Stress , vol.16 , Issue.3 , pp. 247-250
    • Nishith, P.1    Duntley, S.P.2    Domitrovich, P.P.3
  • 6
    • 0033743929 scopus 로고    scopus 로고
    • Meta-analysis of risk factors for posttraumatic stress disorder in traumaexposed adults
    • Brewin CR, Andrews B, Valentine JD. Meta-analysis of risk factors for posttraumatic stress disorder in traumaexposed adults. J Consult Clin Psychol 2000;68(5):748-66
    • (2000) J Consult Clin Psychol , vol.68 , Issue.5 , pp. 748-766
    • Brewin, C.R.1    Andrews, B.2    Valentine, J.D.3
  • 7
    • 84885987665 scopus 로고    scopus 로고
    • Evidence for proposed ICD-11 PTSD and complex PTSD: A latent profile analysis
    • Cloitre M, Garvert DW, Brewin CR, et al. Evidence for proposed ICD-11 PTSD and complex PTSD: a latent profile analysis. Eur J Psychotraumatol 2013;4
    • (2013) Eur J Psychotraumatol , pp. 4
    • Cloitre, M.1    Garvert, D.W.2    Brewin, C.R.3
  • 8
    • 8744282548 scopus 로고    scopus 로고
    • Partial PTSD versus full PTSD: An empirical examination of associated impairment
    • Breslau N, Lucia VC, Davis GC. Partial PTSD versus full PTSD: an empirical examination of associated impairment. Psychol Med 2004;34(7):1205-14
    • (2004) Psychol Med , vol.34 , Issue.7 , pp. 1205-1214
    • Breslau, N.1    Lucia, V.C.2    Davis, G.C.3
  • 9
    • 79952311304 scopus 로고    scopus 로고
    • Adolescent posttraumatic stress disorder: An examination of factor structure reliability in two national samples
    • Ayer LA, Cisler JM, Danielson CK, et al. Adolescent posttraumatic stress disorder: an examination of factor structure reliability in two national samples. J Anxiety Disord 2011;25(3):411-21
    • (2011) J Anxiety Disord , vol.25 , Issue.3 , pp. 411-421
    • Ayer, L.A.1    Cisler, J.M.2    Danielson, C.K.3
  • 10
    • 84873195290 scopus 로고    scopus 로고
    • Killing and latent classes of PTSD symptoms in Iraq and Afghanistan veterans
    • Maguen S, Madden E, Bosch J, et al. Killing and latent classes of PTSD symptoms in Iraq and Afghanistan veterans. J Affect Disord 2013;145(3):344-8
    • (2013) J Affect Disord , vol.145 , Issue.3 , pp. 344-348
    • Maguen, S.1    Madden, E.2    Bosch, J.3
  • 11
    • 63249116873 scopus 로고    scopus 로고
    • Structural equation modeling of associations among combat exposure, PTSD symptom factors, and Global Assessment of Functioning
    • Miller MW, Wolf EJ, Martin E, et al. Structural equation modeling of associations among combat exposure, PTSD symptom factors, and Global Assessment of Functioning. J Rehabil Res Dev 2008;45(3):359-69
    • (2008) J Rehabil Res Dev , vol.45 , Issue.3 , pp. 359-369
    • Miller, M.W.1    Wolf, E.J.2    Martin, E.3
  • 12
    • 0031979415 scopus 로고    scopus 로고
    • Duty-related and sexual stress in the etiology of PTSD among women veterans who seek treatment
    • Fontana A, Rosenheck R. Duty-related and sexual stress in the etiology of PTSD among women veterans who seek treatment. Psychiatr Serv 1998;49(5):658-62
    • (1998) Psychiatr Serv , vol.49 , Issue.5 , pp. 658-662
    • Fontana, A.1    Rosenheck, R.2
  • 13
    • 33847794614 scopus 로고    scopus 로고
    • Posttraumatic stress disorder in female veterans with military and civilian sexual trauma
    • Himmelfarb N, Yaeger D, Mintz J. Posttraumatic stress disorder in female veterans with military and civilian sexual trauma. J Trauma Stress 2006;19(6):837-46
    • (2006) J Trauma Stress , vol.19 , Issue.6 , pp. 837-846
    • Himmelfarb, N.1    Yaeger, D.2    Mintz, J.3
  • 15
    • 0036828717 scopus 로고    scopus 로고
    • Confirmatory factor analyses of posttraumatic stress symptoms in deployed and nondeployed veterans of the Gulf War
    • Simms LJ, Watson D, Doebbeling BN. Confirmatory factor analyses of posttraumatic stress symptoms in deployed and nondeployed veterans of the Gulf War. J Abnorm Psychol 2002;111(4):637-47
    • (2002) J Abnorm Psychol , vol.111 , Issue.4 , pp. 637-647
    • Simms, L.J.1    Watson, D.2    Doebbeling, B.N.3
  • 16
    • 0031866291 scopus 로고    scopus 로고
    • Confirmatory factor analysis of the Clinician-Administered PTSD Scale: Evidence for the dimensionality of posttraumatic stress disorder
    • King DW, Leskin GA, King LA, et al. Confirmatory factor analysis of the Clinician-Administered PTSD Scale: evidence for the dimensionality of posttraumatic stress disorder. Psychol Assess 1998;10(2):90-6
    • (1998) Psychol Assess , vol.10 , Issue.2 , pp. 90-96
    • King, D.W.1    Leskin, G.A.2    King, L.A.3
  • 17
    • 84865735963 scopus 로고    scopus 로고
    • Examining the relation between combatrelated concussion, a novel 5-factor model of posttraumatic stress symptoms, and health-related quality of life in Iraq and Afghanistan veterans
    • Tsai J, Whealin JM, Scott JC, et al. Examining the relation between combatrelated concussion, a novel 5-factor model of posttraumatic stress symptoms, and health-related quality of life in Iraq and Afghanistan veterans. J Clin Psychiatry 2012;73(8):1110-18
    • (2012) J Clin Psychiatry , vol.73 , Issue.8 , pp. 1110-1118
    • Tsai, J.1    Whealin, J.M.2    Scott, J.C.3
  • 18
    • 84857142714 scopus 로고    scopus 로고
    • Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/ Afghanistan veterans: A confirmatory factor analytic study
    • Pietrzak RH, Tsai J, Harpaz-Rotem I, et al. Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/ Afghanistan veterans: a confirmatory factor analytic study. J Psychiatr Res 2012;46(3):317-22
    • (2012) J Psychiatr Res , vol.46 , Issue.3 , pp. 317-322
    • Pietrzak, R.H.1    Tsai, J.2    Harpaz-Rotem, I.3
  • 19
    • 84891163334 scopus 로고    scopus 로고
    • The dimensional structure of posttraumatic stress symptomatology in 323,903 U.S. Veterans
    • Harpaz-Rotem I, Tsai J, Pietrzak RH, et al. The dimensional structure of posttraumatic stress symptomatology in 323,903 U.S. veterans. J Psychiatr Res 2014;49:31-6
    • (2014) J Psychiatr Res , vol.49 , pp. 31-36
    • Harpaz-Rotem, I.1    Tsai, J.2    Pietrzak, R.H.3
  • 20
    • 84871056056 scopus 로고    scopus 로고
    • Assessing the fit of the Dysphoric Arousal model across two nationally representative epidemiological surveys: The Australian NSMHWB and the United States NESARC
    • Armour C, Carragher N, Elhai JD. Assessing the fit of the Dysphoric Arousal model across two nationally representative epidemiological surveys: the Australian NSMHWB and the United States NESARC. J Anxiety Disord 2012;27(1):109-15
    • (2012) J Anxiety Disord , vol.27 , Issue.1 , pp. 109-115
    • Armour, C.1    Carragher, N.2    Elhai, J.D.3
  • 21
    • 79952310365 scopus 로고    scopus 로고
    • Evidence for a unique PTSD construct represented by PTSD's D1-D3 symptoms
    • Elhai JD, Biehn TL, Armour C, et al. Evidence for a unique PTSD construct represented by PTSD's D1-D3 symptoms. J Anxiety Disord 2011;25(3):340-5
    • (2011) J Anxiety Disord , vol.25 , Issue.3 , pp. 340-345
    • Elhai, J.D.1    Biehn, T.L.2    Armour, C.3
  • 22
    • 84892848774 scopus 로고    scopus 로고
    • DSM-5 PTSD's symptom dimensions and relations with major depression's symptom dimensions in a primary care sample
    • Contractor AA, Durham TA, Brennan JA, et al. DSM-5 PTSD's symptom dimensions and relations with major depression's symptom dimensions in a primary care sample. Psychiatry Res 2014;215(1):146-53
    • (2014) Psychiatry Res , vol.215 , Issue.1 , pp. 146-153
    • Contractor, A.A.1    Durham, T.A.2    Brennan, J.A.3
  • 23
    • 85007474194 scopus 로고    scopus 로고
    • Dimensional structure of DSM-5 posttraumatic stress symptoms: Results from the National Health and Resilience in Veterans Study
    • [Epub ahead of print]
    • Tsai J, Harpaz-Rotem I, Armour C, et al. Dimensional structure of DSM-5 posttraumatic stress symptoms: results from the National Health and Resilience in Veterans Study. J Clin Psychiatry 2014. [Epub ahead of print]
    • (2014) J Clin Psychiatry
    • Tsai, J.1    Harpaz-Rotem, I.2    Armour, C.3
  • 24
    • 77952102565 scopus 로고    scopus 로고
    • Comorbidity of posttraumatic stress disorder, anxiety and depression: A 20-year longitudinal study of war veterans
    • Ginzburg K, Ein-Dor T, Solomon Z. Comorbidity of posttraumatic stress disorder, anxiety and depression: a 20-year longitudinal study of war veterans. J Affect Disord 2010;123(1-3):249-57
    • (2010) J Affect Disord , vol.123 , Issue.1-3 , pp. 249-257
    • Ginzburg, K.1    Ein-Dor, T.2    Solomon, Z.3
  • 25
    • 0018425438 scopus 로고
    • A new depression scale designed to be sensitive to change
    • Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382-9
    • (1979) Br J Psychiatry , vol.134 , pp. 382-389
    • Montgomery, S.A.1    Asberg, M.2
  • 26
    • 51549099524 scopus 로고
    • The assessment of anxiety states by rating
    • Hamilton M. The assessment of anxiety states by rating. Br J Psychiatry 1959;32:50-5
    • (1959) Br J Psychiatry , vol.32 , pp. 50-55
    • Hamilton, M.1
  • 27
    • 35648934049 scopus 로고    scopus 로고
    • Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
    • Renthal W, Maze I, Krishnan V, et al. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 2007;56(3):517-29
    • (2007) Neuron , vol.56 , Issue.3 , pp. 517-529
    • Renthal, W.1    Maze, I.2    Krishnan, V.3
  • 28
    • 70350104892 scopus 로고    scopus 로고
    • The role of beta-endorphin in the pathophysiology of major depression
    • Hegadoren KM, O'Donnell T, Lanius R, et al. The role of beta-endorphin in the pathophysiology of major depression. Neuropeptides 2009;43(5):341-53
    • (2009) Neuropeptides , vol.43 , Issue.5 , pp. 341-353
    • Hegadoren, K.M.1    O'Donnell, T.2    Lanius, R.3
  • 29
    • 79958090007 scopus 로고    scopus 로고
    • An examination of the structure of posttraumatic stress disorder in relation to the anxiety and depressive disorders
    • Forbes D, Lockwood E, Elhai JD, et al. An examination of the structure of posttraumatic stress disorder in relation to the anxiety and depressive disorders. J Affect Disord 2011;132(1-2):165-72
    • (2011) J Affect Disord , vol.132 , Issue.1-2 , pp. 165-172
    • Forbes, D.1    Lockwood, E.2    Elhai, J.D.3
  • 30
    • 84888039502 scopus 로고    scopus 로고
    • Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus
    • Pietrzak RH, Gallezot JD, Ding YS, et al. Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus. JAMA Psychiatry 2013;70(11):1199-205
    • (2013) JAMA Psychiatry , vol.70 , Issue.11 , pp. 1199-1205
    • Pietrzak, R.H.1    Gallezot, J.D.2    Ding, Y.S.3
  • 31
    • 84884211317 scopus 로고    scopus 로고
    • Linking in vivo brain serotonin type 1B receptor density to phenotypic heterogeneity of posttraumatic stress symptomatology
    • Pietrzak RH, Henry S, Southwick SM, et al. Linking in vivo brain serotonin type 1B receptor density to phenotypic heterogeneity of posttraumatic stress symptomatology. Mol Psychiatry 2013;18(4):399-401
    • (2013) Mol Psychiatry , vol.18 , Issue.4 , pp. 399-401
    • Pietrzak, R.H.1    Henry, S.2    Southwick, S.M.3
  • 32
    • 84877626914 scopus 로고    scopus 로고
    • Toward the future of psychiatric diagnosis: The seven pillars of RDoC
    • Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med 2013;11:8
    • (2013) BMC Med , vol.11 , pp. 8
    • Cuthbert, B.N.1    Insel, T.R.2
  • 33
    • 0035499974 scopus 로고    scopus 로고
    • Modulation of transmitter release via presynaptic cannabinoid receptors
    • Schlicker E, Kathmann M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci 2001;22(11):565-72
    • (2001) Trends Pharmacol Sci , vol.22 , Issue.11 , pp. 565-572
    • Schlicker, E.1    Kathmann, M.2
  • 34
    • 84857208654 scopus 로고    scopus 로고
    • 78-dihydroxyflavone a TrkB receptor agonist blocks long-term spatial memory impairment caused by immobilization stress in rats
    • Andero R, Daviu N, Escorihuela RM, et al. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus 2012;22(3):399-408
    • (2012) Hippocampus , vol.22 , Issue.3 , pp. 399-408
    • Andero, R.1    Daviu, N.2    Escorihuela, R.M.3
  • 35
    • 48749103773 scopus 로고    scopus 로고
    • Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - A short review
    • Svizenska I, Dubovy P, Sulcova A. Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - a short review. Pharmacol Biochem Behav 2008;90(4):501-11
    • (2008) Pharmacol Biochem Behav , vol.90 , Issue.4 , pp. 501-511
    • Svizenska, I.1    Dubovy, P.2    Sulcova, A.3
  • 36
    • 84883158698 scopus 로고    scopus 로고
    • Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study
    • Neumeister A, Normandin MD, Pietrzak RH, et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry 2013;18(9):1034-40
    • (2013) Mol Psychiatry , vol.18 , Issue.9 , pp. 1034-1040
    • Neumeister, A.1    Normandin, M.D.2    Pietrzak, R.H.3
  • 37
    • 84888299927 scopus 로고    scopus 로고
    • Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks
    • Hill MN, Bierer LM, Makotkine I, et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks. Psychoneuroendocrinology 2013;38(12):2952-61
    • (2013) Psychoneuroendocrinology , vol.38 , Issue.12 , pp. 2952-2961
    • Hill, M.N.1    Bierer, L.M.2    Makotkine, I.3
  • 38
    • 84939881846 scopus 로고    scopus 로고
    • Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors
    • Pietrzak RH, Huang Y, Corsi-Travali S, et al. Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. Neuropsychopharmacology 2014;39(11):2519-28
    • (2014) Neuropsychopharmacology , vol.39 , Issue.11 , pp. 2519-2528
    • Pietrzak, R.H.1    Huang, Y.2    Corsi-Travali, S.3
  • 39
    • 84877957962 scopus 로고    scopus 로고
    • Sleep disturbances as the hallmark of PTSD: Where are we now?
    • Germain A. Sleep disturbances as the hallmark of PTSD: where are we now? Am J Psychiatry 2013;170(4):372-82
    • (2013) Am J Psychiatry , vol.170 , Issue.4 , pp. 372-382
    • Germain, A.1
  • 40
    • 7444253303 scopus 로고    scopus 로고
    • Review of the validity and significance of cannabis withdrawal syndrome
    • Budney AJ, Hughes JR, Moore BA, et al. Review of the validity and significance of cannabis withdrawal syndrome. Am J Psychiatry 2004;161(11):1967-77
    • (2004) Am J Psychiatry , vol.161 , Issue.11 , pp. 1967-1977
    • Budney, A.J.1    Hughes, J.R.2    Moore, B.A.3
  • 41
    • 60349127390 scopus 로고    scopus 로고
    • The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD).
    • Fraser GA. The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD). CNS Neurosci Ther 2009;15(1):84-8
    • (2009) CNS Neurosci Ther , vol.15 , Issue.1 , pp. 84-88
    • Fraser, G.A.1
  • 42
    • 84907423668 scopus 로고    scopus 로고
    • Use of a synthetic cannabinoid in a correctional population for posttraumatic stress disorder-related insomnia and nightmares, chronic pain, harm reduction, and other indications: A retrospective evaluation
    • Cameron C, Watson D, Robinson J. Use of a synthetic cannabinoid in a correctional population for posttraumatic stress disorder-related insomnia and nightmares, chronic pain, harm reduction, and other indications: a retrospective evaluation. J Clin Psychopharmacol 2014;34(5):559-64
    • (2014) J Clin Psychopharmacol , vol.34 , Issue.5 , pp. 559-564
    • Cameron, C.1    Watson, D.2    Robinson, J.3
  • 43
    • 84920602691 scopus 로고    scopus 로고
    • The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSDassociated nightmare: A preliminary tandomized, double-blind, placebocontrolled cross-over design study
    • Jetly R, Heber A, Fraser GA, et al. The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSDassociated nightmare: a preliminary tandomized, double-blind, placebocontrolled cross-over design study. Psychoneuroendocrinology 2015;51:585-8
    • (2015) Psychoneuroendocrinology , vol.51 , pp. 585-588
    • Jetly, R.1    Heber, A.2    Fraser, G.A.3
  • 44
    • 0032926695 scopus 로고    scopus 로고
    • The effects of cannabinoids on the brain
    • Ameri A. The effects of cannabinoids on the brain. Prog Neurobiol 1999;58(4):315-48
    • (1999) Prog Neurobiol , vol.58 , Issue.4 , pp. 315-348
    • Ameri, A.1
  • 45
    • 84893803414 scopus 로고    scopus 로고
    • Using cannabis to help you sleep: Heightened frequency of medical cannabis use among those with PTSD
    • Bonn-Miller MO, Babson KA, Vandrey R. Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Drug Alcohol Depend 2014;136:162-5
    • (2014) Drug Alcohol Depend , vol.136 , pp. 162-165
    • Bonn-Miller, M.O.1    Babson, K.A.2    Vandrey, R.3
  • 46
    • 84904573718 scopus 로고    scopus 로고
    • Preliminary open-label pilot study of add-on oral delta(9)-tetrahydrocannabinol in chronic post-traumatic stress disorder
    • Roitman P, Mechoulam R, Cooper-Kazaz R, et al. Preliminary, open-label, pilot study of add-on oral delta(9)-tetrahydrocannabinol in chronic post-traumatic stress disorder. Clin Drug Investig 2014;34(8):587-91
    • (2014) Clin Drug Investig , vol.34 , Issue.8 , pp. 587-591
    • Roitman, P.1    Mechoulam, R.2    Cooper-Kazaz, R.3
  • 47
    • 1342347749 scopus 로고    scopus 로고
    • Applying learning principles to the treatment of post-trauma reactions
    • King JA, Ferris CF, Lederhendler II, editors. New York Acad Sciences; New York:
    • Rothbaum BO, Davis M. Applying learning principles to the treatment of post-trauma reactions. In: King JA, Ferris CF, Lederhendler II, editors. Roots of mental illness in children. New York Acad Sciences; New York: 2003. p. 112-21
    • (2003) Roots of Mental Illness in Children , pp. 112-121
    • Rothbaum, B.O.1    Davis, M.2
  • 48
    • 0036213147 scopus 로고    scopus 로고
    • Exposure therapy for Posttraumatic stress disorder
    • Rothbaum BO, Schwartz AC. Exposure therapy for Posttraumatic stress disorder. Am J Psychother 2002;56(1):59-75
    • (2002) Am J Psychother , vol.56 , Issue.1 , pp. 59-75
    • Rothbaum, B.O.1    Schwartz, A.C.2
  • 49
    • 34147102736 scopus 로고    scopus 로고
    • Modulation of fear and anxiety by the endogenous cannabinoid system
    • Chhatwal JP, Ressler KJ. Modulation of fear and anxiety by the endogenous cannabinoid system. CNS Spectr 2007;12(3):211-20
    • (2007) CNS Spectr , vol.12 , Issue.3 , pp. 211-220
    • Chhatwal, J.P.1    Ressler, K.J.2
  • 50
    • 84902081383 scopus 로고    scopus 로고
    • Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans
    • Rabinak CA, Angstadt M, Lyons M, et al. Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans. Neurobiol Learn Mem 2014;113:125-34
    • (2014) Neurobiol Learn Mem , vol.113 , pp. 125-134
    • Rabinak, C.A.1    Angstadt, M.2    Lyons, M.3
  • 51
    • 84866361855 scopus 로고    scopus 로고
    • Cannabinoid facilitation of fear extinction memory recall in humans
    • Rabinak CA, Angstadt M, Sripada CS, et al. Cannabinoid facilitation of fear extinction memory recall in humans. Neuropharmacology 2013;64:396-402
    • (2013) Neuropharmacology , vol.64 , pp. 396-402
    • Rabinak, C.A.1    Angstadt, M.2    Sripada, C.S.3
  • 52
    • 74549185125 scopus 로고    scopus 로고
    • FAAH and MAGL inhibitors: Therapeutic opportunities from regulating endocannabinoid levels
    • Petrosino S, Di Marzo V. FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Curr Opin Investig Drugs 2010;11(1):51-62
    • (2010) Curr Opin Investig Drugs , vol.11 , Issue.1 , pp. 51-62
    • Petrosino, S.1    Di Marzo, V.2
  • 53
    • 84887406857 scopus 로고    scopus 로고
    • Amygdala FAAH and anandamide: Mediating protection and recovery from stress
    • Gunduz-Cinar O, Hill MN, McEwen BS, et al. Amygdala FAAH and anandamide: mediating protection and recovery from stress. Trends Pharmacol Sci 2013;34(11):637-44
    • (2013) Trends Pharmacol Sci , vol.34 , Issue.11 , pp. 637-644
    • Gunduz-Cinar, O.1    Hill, M.N.2    McEwen, B.S.3
  • 54
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of clonef cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, et al. Structure of a cannabinoid receptor and functional expression of clonef cDNA Nature. 1990;346(6284):561-4
    • (1990) Nature , vol.346 , Issue.6284 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3
  • 55
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abushaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993;365(6441):61-5
    • (1993) Nature , vol.365 , Issue.6441 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abushaar, M.3
  • 56
    • 84883158698 scopus 로고    scopus 로고
    • Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study
    • Neumeister A, Normandin MD, Pietrzak RH, et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry 2013;18(9):1034-40
    • (2013) Mol Psychiatry , vol.18 , Issue.9 , pp. 1034-1040
    • Neumeister, A.1    Normandin, M.D.2    Pietrzak, R.H.3
  • 57
    • 84879412059 scopus 로고    scopus 로고
    • Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction threat processing and stress-reactivity
    • Gunduz-Cinar O, MacPherson KP, Cinar R, et al. Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol Psychiatry 2013;18(7):813-23
    • (2013) Mol Psychiatry , vol.18 , Issue.7 , pp. 813-823
    • Gunduz-Cinar, O.1    Macpherson, K.P.2    Cinar, R.3
  • 58
    • 84890264813 scopus 로고    scopus 로고
    • Endocannabinoid signaling in hypothalamic-pituitary-adrenocortical axis recovery following stress: Effects of indirect agonists and comparison of male and female mice
    • Roberts CJ, Stuhr KL, Hutz MJ, et al. Endocannabinoid signaling in hypothalamic-pituitary-adrenocortical axis recovery following stress: effects of indirect agonists and comparison of male and female mice. Pharmacol Biochem Behav 2014;117:17-24
    • (2014) Pharmacol Biochem Behav , vol.117 , pp. 17-24
    • Roberts, C.J.1    Stuhr, K.L.2    Hutz, M.J.3
  • 60
    • 84872350576 scopus 로고    scopus 로고
    • Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: Relevance for their role in depression and in the actions of CB(1) receptor antagonists
    • Kirilly E, Hunyady L, Bagdy G. Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists. J Neural Transm 2013;120(1):177-86
    • (2013) J Neural Transm , vol.120 , Issue.1 , pp. 177-186
    • Kirilly, E.1    Hunyady, L.2    Bagdy, G.3
  • 61
    • 33845988787 scopus 로고    scopus 로고
    • Altered pain processing in veterans with posttraumatic stress disorder
    • Geuze E, Westenberg HG, Jochims A, et al. Altered pain processing in veterans with posttraumatic stress disorder. Arch Gen Psychiatry 2007;64(1):76-85
    • (2007) Arch Gen Psychiatry , vol.64 , Issue.1 , pp. 76-85
    • Geuze, E.1    Westenberg, H.G.2    Jochims, A.3
  • 62
    • 84908621921 scopus 로고    scopus 로고
    • Proinflammatory milieu in combatrelated PTSD is independent of depression and early life stress
    • Lindqvist D, Wolkowitz OM, Mellon S, et al. Proinflammatory milieu in combatrelated PTSD is independent of depression and early life stress. Brain Behav Immun 2014;42:81-8
    • (2014) Brain Behav Immun , vol.42 , pp. 81-88
    • Lindqvist, D.1    Wolkowitz, O.M.2    Mellon, S.3
  • 63
    • 67349112743 scopus 로고    scopus 로고
    • Differentiation of pain ratings in combat-related posttraumatic stress disorder
    • Kraus A, Geuze E, Schmahl C, et al. Differentiation of pain ratings in combat-related posttraumatic stress disorder. Pain 2009;143(3):179-85
    • (2009) Pain , vol.143 , Issue.3 , pp. 179-185
    • Kraus, A.1    Geuze, E.2    Schmahl, C.3
  • 64
    • 84898653003 scopus 로고    scopus 로고
    • Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk
    • Eraly SA, Nievergelt CM, Maihofer AX, et al. Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry 2014;71(4):423-31
    • (2014) JAMA Psychiatry , vol.71 , Issue.4 , pp. 423-431
    • Eraly, S.A.1    Nievergelt, C.M.2    Maihofer, A.X.3
  • 65
  • 66
    • 43949121784 scopus 로고    scopus 로고
    • Ligands that target cannabinoid receptors in the brain: From THC to anandamide and beyond
    • Pertwee RG. Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addict Biol 2008;13(2):147-59
    • (2008) Addict Biol , vol.13 , Issue.2 , pp. 147-159
    • Pertwee, R.G.1
  • 67
    • 29444460231 scopus 로고    scopus 로고
    • Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
    • Gobbi G, Bambico FR, Mangieri R, et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci USA 2005;102(51):18620-5
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.51 , pp. 18620-18625
    • Gobbi, G.1    Bambico, F.R.2    Mangieri, R.3
  • 68
    • 54349109924 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates
    • Justinova Z, Mangieri RA, Bortolato M, et al. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biol Psychiatry 2008;64(11):930-7
    • (2008) Biol Psychiatry , vol.64 , Issue.11 , pp. 930-937
    • Justinova, Z.1    Mangieri, R.A.2    Bortolato, M.3
  • 69
    • 84875230670 scopus 로고    scopus 로고
    • Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction
    • Panlilio LV, Justinova Z, Goldberg SR. Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction. Pharmacol Ther 2013;138(1):84-102
    • (2013) Pharmacol Ther , vol.138 , Issue.1 , pp. 84-102
    • Panlilio, L.V.1    Justinova, Z.2    Goldberg, S.R.3
  • 70
    • 78649349136 scopus 로고    scopus 로고
    • Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects
    • Godlewski G, Alapafuja SO, Batkai S, et al. Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chem Biol 2010;17(11):1256-66
    • (2010) Chem Biol , vol.17 , Issue.11 , pp. 1256-1266
    • Godlewski, G.1    Alapafuja, S.O.2    Batkai, S.3
  • 71
    • 0037234363 scopus 로고    scopus 로고
    • Modulation of anxiety through blockade of anandamide hydrolysis
    • Kathuria S, Gaetani S, Fegley D, et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 2003;9(1):76-81
    • (2003) Nat Med , vol.9 , Issue.1 , pp. 76-81
    • Kathuria, S.1    Gaetani, S.2    Fegley, D.3
  • 72
    • 0028589390 scopus 로고
    • Formation and Inactivation of Endogenous Cannabinoid Anandamide in Central Neurons
    • Di Marzo V, Fontana A, Cadas H, et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 1994;372(6507):686-91
    • (1994) Nature , vol.372 , Issue.6507 , pp. 686-691
    • Di Marzo, V.1    Fontana, A.2    Cadas, H.3
  • 73
    • 33847283286 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets
    • Zhang D, Saraf A, Kolasa T, et al. Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology 2007;52(4):1095-105
    • (2007) Neuropharmacology , vol.52 , Issue.4 , pp. 1095-1105
    • Zhang, D.1    Saraf, A.2    Kolasa, T.3
  • 74
    • 0029904838 scopus 로고    scopus 로고
    • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
    • Cravatt BF, Giang DK, Mayfield SP, et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 1996;384(6604):83-7
    • (1996) Nature , vol.384 , Issue.6604 , pp. 83-87
    • Cravatt, B.F.1    Giang, D.K.2    Mayfield, S.P.3
  • 75
    • 71749089107 scopus 로고    scopus 로고
    • Pain and beyond: Fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases
    • Pillarisetti S, Alexander CW, Khanna I. Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases. Drug Discov Today 2009;14(23-24):1098-111
    • (2009) Drug Discov Today , vol.14 , Issue.23-24 , pp. 1098-1111
    • Pillarisetti, S.1    Alexander, C.W.2    Khanna, I.3
  • 76
    • 5744223570 scopus 로고    scopus 로고
    • Recent advances in the cannabinoids
    • Hertzog DL. Recent advances in the cannabinoids. Expert Opin Ther Patents 2004;14(10):1435-52
    • (2004) Expert Opin Ther Patents , vol.14 , Issue.10 , pp. 1435-1452
    • Hertzog, D.L.1
  • 77
    • 12944277105 scopus 로고    scopus 로고
    • Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
    • Boger DL, Sato H, Lerner AE, et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proc Natl Acad Sci USA 2000;97(10):5044-9
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.10 , pp. 5044-5049
    • Boger, D.L.1    Sato, H.2    Lerner, A.E.3
  • 78
    • 79960901769 scopus 로고    scopus 로고
    • The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)
    • Otrubova K, Ezzili C, Boger DL. The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH). Bioorg Med Chem Lett 2011;21(16):4674-85
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.16 , pp. 4674-4685
    • Otrubova, K.1    Ezzili, C.2    Boger, D.L.3
  • 79
    • 33746474287 scopus 로고    scopus 로고
    • Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
    • Piomelli D, Tarzia G, Duranti A, et al. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev 2006;12(1):21-38
    • (2006) CNS Drug Rev , vol.12 , Issue.1 , pp. 21-38
    • Piomelli, D.1    Tarzia, G.2    Duranti, A.3
  • 80
    • 84879412059 scopus 로고    scopus 로고
    • Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction threat processing and stress-reactivity
    • Gunduz-Cinar O, MacPherson KP, Cinar R, et al. Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol Psychiatry 2013;18(7):813-23
    • (2013) Mol Psychiatry , vol.18 , Issue.7 , pp. 813-823
    • Gunduz-Cinar, O.1    Macpherson, K.P.2    Cinar, R.3
  • 81
    • 37149050777 scopus 로고    scopus 로고
    • Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoiddegrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
    • Moreira FA, Kaiser N, Monory K, et al. Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoiddegrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 2008;54(1):141-50
    • (2008) Neuropharmacology , vol.54 , Issue.1 , pp. 141-150
    • Moreira, F.A.1    Kaiser, N.2    Monory, K.3
  • 82
    • 34250786050 scopus 로고    scopus 로고
    • Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress
    • Bortolato M, Mangieri RA, Fu J, et al. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry 2007;62(10):1103-10
    • (2007) Biol Psychiatry , vol.62 , Issue.10 , pp. 1103-1110
    • Bortolato, M.1    Mangieri, R.A.2    Fu, J.3
  • 83
    • 34247403489 scopus 로고    scopus 로고
    • Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task
    • Varvel SA, Wise LE, Niyuhire F, et al. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology 2007;32(5):1032-41
    • (2007) Neuropsychopharmacology , vol.32 , Issue.5 , pp. 1032-1041
    • Varvel, S.A.1    Wise, L.E.2    Niyuhire, F.3
  • 84
    • 34247605930 scopus 로고    scopus 로고
    • Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality
    • Naidu PS, Varvel SA, Ahn K, et al. Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology (Berl) 2007;192(1):61-70
    • (2007) Psychopharmacology (Berl) , vol.192 , Issue.1 , pp. 61-70
    • Naidu, P.S.1    Varvel, S.A.2    Ahn, K.3
  • 85
    • 0026437728 scopus 로고
    • Molecular diversity of glutamate receptors and implications for brain function
    • Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 1992;258(5082):597-603
    • (1992) Science , vol.258 , Issue.5082 , pp. 597-603
    • Nakanishi, S.1
  • 86
    • 78649650201 scopus 로고    scopus 로고
    • Glutamate receptors in extinction and extinction-based therapies for psychiatric illness
    • Myers KM, Carlezon WA, Davis M. Glutamate receptors in extinction and extinction-based therapies for psychiatric illness. Neuropsychopharmacology 2011;36(1):274-93
    • (2011) Neuropsychopharmacology , vol.36 , Issue.1 , pp. 274-293
    • Myers, K.M.1    Carlezon, W.A.2    Davis, M.3
  • 87
    • 0037088911 scopus 로고    scopus 로고
    • Facilitation of conditioned fear extinction by systemic administration or intraamygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats
    • Walker DL, Ressler KJ, Lu KT, et al. Facilitation of conditioned fear extinction by systemic administration or intraamygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci 2002;22(6):2343-51
    • (2002) J Neurosci , vol.22 , Issue.6 , pp. 2343-2351
    • Walker, D.L.1    Ressler, K.J.2    Lu, K.T.3
  • 88
    • 84903759980 scopus 로고    scopus 로고
    • Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis
    • Rodrigues H, Figueira I, Lopes A, et al. Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis. PLoS One 2014;9(7):12
    • (2014) PLoS One , vol.9 , Issue.7 , pp. 12
    • Rodrigues, H.1    Figueira, I.2    Lopes, A.3
  • 89
    • 84911478299 scopus 로고    scopus 로고
    • D-cycloserine for treatment of numbing and avoidance in chronic post traumatic stress disorder: A randomized, double blind, clinical trial
    • Attari A, Rajabi F, Maracy MR. D-cycloserine for treatment of numbing and avoidance in chronic post traumatic stress disorder: a randomized, double blind, clinical trial. J Res Med Sci 2014;19(7):592-8
    • (2014) J Res Med Sci , vol.19 , Issue.7 , pp. 592-598
    • Attari, A.1    Rajabi, F.2    Maracy, M.R.3
  • 90
    • 0036903863 scopus 로고    scopus 로고
    • Pilot-controlled trial of D-cycloserine for the treatment of posttraumatic stress disorder
    • Heresco-Levy U, Kremer I, Javitt DC, et al. Pilot-controlled trial of D-cycloserine for the treatment of posttraumatic stress disorder. Int J Neuropsychopharmacol 2002;5(4):301-7
    • (2002) Int J Neuropsychopharmacol , vol.5 , Issue.4 , pp. 301-307
    • Heresco-Levy, U.1    Kremer, I.2    Javitt, D.C.3
  • 91
    • 84864395164 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of D-cycloserine and exposure therapy for posttraumatic stress disorder
    • Litz BT, Salters-Pedneault K, Steenkamp MM, et al. A randomized placebo-controlled trial of D-cycloserine and exposure therapy for posttraumatic stress disorder. J Psychiatr Res 2012;46(9):1184-90
    • (2012) J Psychiatr Res , vol.46 , Issue.9 , pp. 1184-1190
    • Litz, B.T.1    Salters-Pedneault, K.2    Steenkamp, M.M.3
  • 92
    • 84861096785 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder
    • de Kleine RA, Hendriks GJ, Kusters WJC, et al. A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol Psychiatry 2012;71(11):962-8
    • (2012) Biol Psychiatry , vol.71 , Issue.11 , pp. 962-968
    • De Kleine, R.A.1    Hendriks, G.J.2    Kusters, W.J.C.3
  • 93
    • 84901847975 scopus 로고    scopus 로고
    • A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in iraq and afghanistan war veterans
    • Rothbaum BO, Price M, Jovanovic T, et al. A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in iraq and afghanistan war veterans. Am J Psychiatry 2014;171(6):640-8
    • (2014) Am J Psychiatry , vol.171 , Issue.6 , pp. 640-648
    • Rothbaum, B.O.1    Price, M.2    Jovanovic, T.3
  • 94
    • 84896388390 scopus 로고    scopus 로고
    • D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: A pilot randomized clinical trial
    • Difede J, Cukor J, Wyka K, et al. D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial. Neuropsychopharmacology 2014;39(5):1052-8
    • (2014) Neuropsychopharmacology , vol.39 , Issue.5 , pp. 1052-1058
    • Difede, J.1    Cukor, J.2    Wyka, K.3
  • 95
    • 84876440651 scopus 로고    scopus 로고
    • Effects of ketamine on major depressive disorder in a patient with posttraumatic stress disorder
    • Womble AL. Effects of ketamine on major depressive disorder in a patient with posttraumatic stress disorder. AANA J 2013;81(2):118-19
    • (2013) AANA J , vol.81 , Issue.2 , pp. 118-119
    • Womble, A.L.1
  • 96
    • 84885434871 scopus 로고    scopus 로고
    • Transient resolution of treatmentresistant posttraumatic stress disorder following ketamine infusion
    • D'Andrea D, Andrew Sewell R. Transient resolution of treatmentresistant posttraumatic stress disorder following ketamine infusion. Biol Psychiatry 2013;74(9):e13-14
    • (2013) Biol Psychiatry , vol.74 , Issue.9 , pp. e13-14
    • D'Andrea, D.1    Andrew Sewell, R.2
  • 97
    • 84907314920 scopus 로고    scopus 로고
    • The intraoperative administration of ketamine to burned U.S. Service members does not increase the incidence of post-traumatic stress disorder
    • McGhee LL, Maani CV, Garza TH, et al. The intraoperative administration of ketamine to burned U.S. service members does not increase the incidence of post-traumatic stress disorder. Mil Med 2014;179(8 Suppl):41-6
    • (2014) Mil Med , vol.179 , Issue.8 , pp. 41-46
    • McGhee, L.L.1    Maani, C.V.2    Garza, T.H.3
  • 98
    • 84902132275 scopus 로고    scopus 로고
    • Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: A randomized clinical trial
    • Feder A, Parides MK, Murrough JW, et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 2014;71(6):681-8
    • (2014) JAMA Psychiatry , vol.71 , Issue.6 , pp. 681-688
    • Feder, A.1    Parides, M.K.2    Murrough, J.W.3
  • 99
    • 26844540069 scopus 로고    scopus 로고
    • Effects of peritraumatic ketamine medication on early and sustained posttraumatic stress symptoms in moderately injured accident victims
    • Schonenberg M, Reichwald U, Domes G, et al. Effects of peritraumatic ketamine medication on early and sustained posttraumatic stress symptoms in moderately injured accident victims. Psychopharmacology (Berl) 2005;182(3):420-5
    • (2005) Psychopharmacology (Berl) , vol.182 , Issue.3 , pp. 420-425
    • Schonenberg, M.1    Reichwald, U.2    Domes, G.3
  • 100
    • 0031020921 scopus 로고    scopus 로고
    • Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: Effects of pretreatment with saline or diazepam
    • Bagley J, Moghaddam B. Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam. Neuroscience 1997;77(1):65-73
    • (1997) Neuroscience , vol.77 , Issue.1 , pp. 65-73
    • Bagley, J.1    Moghaddam, B.2
  • 101
    • 0033210095 scopus 로고    scopus 로고
    • Glutamate and post-traumatic stress disorder: Toward a psychobiology of dissociation
    • Chambers RA, Bremner JD, Moghaddam B, et al. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Semin Clin Neuropsychiatry 1999;4(4):274-81
    • (1999) Semin Clin Neuropsychiatry , vol.4 , Issue.4 , pp. 274-281
    • Chambers, R.A.1    Bremner, J.D.2    Moghaddam, B.3
  • 102
    • 0030062255 scopus 로고    scopus 로고
    • Corticotropin-releasing factor modulates basal and stress-induced excitatory amino acid release in the locus coeruleus of conscious rats
    • Singewald N, Zhou GY, Chen F, et al. Corticotropin-releasing factor modulates basal and stress-induced excitatory amino acid release in the locus coeruleus of conscious rats. Neurosci Lett 1996;204(1-2):45-8
    • (1996) Neurosci Lett , vol.204 , Issue.1-2 , pp. 45-48
    • Singewald, N.1    Zhou, G.Y.2    Chen, F.3
  • 103
    • 0034742708 scopus 로고    scopus 로고
    • [3H] LY341495 binding to group II metabotropic glutamate receptors in rat brain
    • Wright RA, Arnold MB, Wheeler WJ, et al. [3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain. J Pharmacol Exp Ther 2001;298(2):453-60
    • (2001) J Pharmacol Exp Ther , vol.298 , Issue.2 , pp. 453-460
    • Wright, R.A.1    Arnold, M.B.2    Wheeler, W.J.3
  • 104
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn PJ, Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 1997;37:205-37
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 105
    • 0032834028 scopus 로고    scopus 로고
    • Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    • Schoepp DD, Jane DE, Monn JA. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 1999;38(10):1431-76
    • (1999) Neuropharmacology , vol.38 , Issue.10 , pp. 1431-1476
    • Schoepp, D.D.1    Jane, D.E.2    Monn, J.A.3
  • 106
    • 0032031663 scopus 로고    scopus 로고
    • Bidirectional synaptic plasticity in the rat basolateral amygdala: Characterization of an activity-dependent switch sensitive to the presynaptic metabotropic glutamate receptor antagonist 2S-alpha-ethylglutamic acid
    • Li H, Weiss SR, Chuang DM, et al. Bidirectional synaptic plasticity in the rat basolateral amygdala: characterization of an activity-dependent switch sensitive to the presynaptic metabotropic glutamate receptor antagonist 2S-alpha-ethylglutamic acid. J Neurosci 1998;18(5):1662-70
    • (1998) J Neurosci , vol.18 , Issue.5 , pp. 1662-1670
    • Li, H.1    Weiss, S.R.2    Chuang, D.M.3
  • 107
    • 33846222477 scopus 로고    scopus 로고
    • Unitary IPSPs enhance hilar mossy cell gain in the rat hippocampus
    • Kerr AM, Capogna M. Unitary IPSPs enhance hilar mossy cell gain in the rat hippocampus. J Physiol 2007;578(Pt 2):451-70
    • (2007) J Physiol , vol.578 , pp. 451-470
    • Kerr, A.M.1    Capogna, M.2
  • 108
    • 33751356156 scopus 로고    scopus 로고
    • Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor
    • Neale SA, Salt TE. Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor. J Physiol 2006;577(Pt 2):659-69
    • (2006) J Physiol , vol.577 , pp. 659-669
    • Neale, S.A.1    Salt, T.E.2
  • 109
    • 23644456344 scopus 로고    scopus 로고
    • Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare
    • Price CJ, Karayannis T, Pal BZ, et al. Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare. Neuropharmacology 2005;49(Suppl 1):45-56
    • (2005) Neuropharmacology , vol.49 , pp. 45-56
    • Price, C.J.1    Karayannis, T.2    Pal, B.Z.3
  • 110
    • 0242654923 scopus 로고    scopus 로고
    • Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro
    • Turner JP, Salt TE. Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro. Neuroscience 2003;122(2):459-69
    • (2003) Neuroscience , vol.122 , Issue.2 , pp. 459-469
    • Turner, J.P.1    Salt, T.E.2
  • 111
    • 0034193374 scopus 로고    scopus 로고
    • Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia nigra pars reticulata
    • Bradley SR, Marino MJ, Wittmann M, et al. Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia nigra pars reticulata. J Neurosci 2000;20(9):3085-94
    • (2000) J Neurosci , vol.20 , Issue.9 , pp. 3085-3094
    • Bradley, S.R.1    Marino, M.J.2    Wittmann, M.3
  • 112
    • 0031933951 scopus 로고    scopus 로고
    • Anxiolytic and side-effect profile of LY354740: A potent, highly selective, orally active agonist for group II metabotropic glutamate receptors
    • Helton DR, Tizzano JP, Monn JA, et al. Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J Pharmacol Exp Ther 1998;284(2):651-60
    • (1998) J Pharmacol Exp Ther , vol.284 , Issue.2 , pp. 651-660
    • Helton, D.R.1    Tizzano, J.P.2    Monn, J.A.3
  • 113
    • 0036895780 scopus 로고    scopus 로고
    • Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats
    • Walker DL, Rattiner LM, Davis M. Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats. Behav Neurosci 2002;116(6):1075-83
    • (2002) Behav Neurosci , vol.116 , Issue.6 , pp. 1075-1083
    • Walker, D.L.1    Rattiner, L.M.2    Davis, M.3
  • 114
    • 0036159862 scopus 로고    scopus 로고
    • The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction
    • Walker DL, Davis M. The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction. Pharmacol Biochem Behav 2002;71(3):379-92
    • (2002) Pharmacol Biochem Behav , vol.71 , Issue.3 , pp. 379-392
    • Walker, D.L.1    Davis, M.2
  • 115
    • 0035996365 scopus 로고    scopus 로고
    • The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam
    • Tizzano JP, Griffey KI, Schoepp DD. The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam. Pharmacol Biochem Behav 2002;73(2):367-74
    • (2002) Pharmacol Biochem Behav , vol.73 , Issue.2 , pp. 367-374
    • Tizzano, J.P.1    Griffey, K.I.2    Schoepp, D.D.3
  • 116
    • 0041488670 scopus 로고    scopus 로고
    • Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans
    • Grillon C, Cordova J, Levine LR, et al. Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans. Psychopharmacology (Berl) 2003;168(4):446-54
    • (2003) Psychopharmacology (Berl) , vol.168 , Issue.4 , pp. 446-454
    • Grillon, C.1    Cordova, J.2    Levine, L.R.3
  • 117
    • 0037169165 scopus 로고    scopus 로고
    • Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).
    • Spooren WP, Schoeffter P, Gasparini F, et al. Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608). Eur J Pharmacol 2002;435(2-3):161-70
    • (2002) Eur J Pharmacol , vol.435 , Issue.2-3 , pp. 161-170
    • Spooren, W.P.1    Schoeffter, P.2    Gasparini, F.3
  • 118
    • 15644369847 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo [3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties
    • Monn JA, Valli MJ, Massey SM, et al. Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo [3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J Med Chem 1997;40(4):528-37
    • (1997) J Med Chem , vol.40 , Issue.4 , pp. 528-537
    • Monn, J.A.1    Valli, M.J.2    Massey, S.M.3
  • 119
    • 0034937468 scopus 로고    scopus 로고
    • Interactions between LY354740, a group II metabotropic agonist and the GABA (A)-benzodiazepine receptor complex in the rat elevated plus-maze
    • Ferris P, Seward E, Dawson GR. Interactions between LY354740, a group II metabotropic agonist and the GABA (A)-benzodiazepine receptor complex in the rat elevated plus-maze. J Psychopharmacol 2001;15(2):76-82
    • (2001) J Psychopharmacol , vol.15 , Issue.2 , pp. 76-82
    • Ferris, P.1    Seward, E.2    Dawson, G.R.3
  • 120
    • 0141644133 scopus 로고    scopus 로고
    • LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress
    • Schoepp DD, Wright RA, Levine LR, et al. LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress. Stress 2003;6(3):189-97
    • (2003) Stress , vol.6 , Issue.3 , pp. 189-197
    • Schoepp, D.D.1    Wright, R.A.2    Levine, L.R.3
  • 121
    • 43649087034 scopus 로고    scopus 로고
    • Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder
    • Dunayevich E, Erickson J, Levine L, et al. Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder. Neuropsychopharmacology 2008;33(7):1603-10
    • (2008) Neuropsychopharmacology , vol.33 , Issue.7 , pp. 1603-1610
    • Dunayevich, E.1    Erickson, J.2    Levine, L.3
  • 122
    • 0021288895 scopus 로고
    • Endogenous opioids: Biology and function
    • Akil H, Watson SJ, Young E, et al. Endogenous opioids: biology and function. Annu Rev Neurosci 1984;7:223-55
    • (1984) Annu Rev Neurosci , vol.7 , pp. 223-255
    • Akil, H.1    Watson, S.J.2    Young, E.3
  • 123
    • 75149183092 scopus 로고    scopus 로고
    • The dynorphin/kappa opioid system as a modulator of stress-induced and proaddictive behaviors
    • Bruchas MR, Land BB, Chavkin C. The dynorphin/kappa opioid system as a modulator of stress-induced and proaddictive behaviors. Brain Res 2010;1314:44-55
    • (2010) Brain Res , vol.1314 , pp. 44-55
    • Bruchas, M.R.1    Land, B.B.2    Chavkin, C.3
  • 124
    • 38349031157 scopus 로고    scopus 로고
    • The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system
    • Land BB, Bruchas MR, Lemos JC, et al. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 2008;28(2):407-14
    • (2008) J Neurosci , vol.28 , Issue.2 , pp. 407-414
    • Land, B.B.1    Bruchas, M.R.2    Lemos, J.C.3
  • 125
    • 4444332549 scopus 로고    scopus 로고
    • Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects
    • Shirayama Y, Ishida H, Iwata M, et al. Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects. J Neurochem 2004;90(5):1258-68
    • (2004) J Neurochem , vol.90 , Issue.5 , pp. 1258-1268
    • Shirayama, Y.1    Ishida, H.2    Iwata, M.3
  • 126
    • 0028983787 scopus 로고
    • Kappa-Opioid receptor in humans: CDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system
    • Simonin F, Gaveriaux-Ruff C, Befort K, et al. kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc Natl Acad Sci USA 1995;92(15):7006-10
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.15 , pp. 7006-7010
    • Simonin, F.1    Gaveriaux-Ruff, C.2    Befort, K.3
  • 127
    • 84910081688 scopus 로고    scopus 로고
    • Association of in vivo k-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology
    • Pietrzak RH, Naganawa M, Huang YY, et al. Association of in vivo k-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology. JAMA Psychiatry 2014;71(11):1262-70
    • (2014) JAMA Psychiatry , vol.71 , Issue.11 , pp. 1262-1270
    • Pietrzak, R.H.1    Naganawa, M.2    Huang, Y.Y.3
  • 128
    • 33751185359 scopus 로고    scopus 로고
    • Ligands regulate cell surface level of the human kappa opioid receptor by activationinduced down-regulation and pharmacological chaperone-mediated enhancement: Differential effects of nonpeptide and peptide agonists
    • Chen Y, Chen C, Wang Y, et al. Ligands regulate cell surface level of the human kappa opioid receptor by activationinduced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists. J Pharmacol Exp Ther 2006;319(2):765-75
    • (2006) J Pharmacol Exp Ther , vol.319 , Issue.2 , pp. 765-775
    • Chen, Y.1    Chen, C.2    Wang, Y.3
  • 129
    • 68249140053 scopus 로고    scopus 로고
    • Peptide kappa opioid receptor ligands: Potential for drug development
    • Aldrich JV, McLaughlin JP. Peptide kappa opioid receptor ligands: potential for drug development. AAPS J 2009;11(2):312-22
    • (2009) AAPS J , vol.11 , Issue.2 , pp. 312-322
    • Aldrich, J.V.1    McLaughlin, J.P.2
  • 130
    • 73149124507 scopus 로고    scopus 로고
    • Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
    • Land BB, Bruchas MR, Schattauer S, et al. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc Natl Acad Sci USA 2009;106(45):19168-73
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.45 , pp. 19168-19173
    • Land, B.B.1    Bruchas, M.R.2    Schattauer, S.3
  • 131
    • 84861474525 scopus 로고    scopus 로고
    • Long-acting kappa opioid antagonists nor-BNI, GNTI and JDTic: Pharmacokinetics in mice and lipophilicity
    • Munro TA, Berry LM, Van't Veer A, et al. Long-acting kappa opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity. BMC Pharmacol 2012;12:5
    • (2012) BMC Pharmacol , vol.12 , pp. 5
    • Munro, T.A.1    Berry, L.M.2    Van'T Veer, A.3
  • 132
    • 0036390018 scopus 로고    scopus 로고
    • Kappa opioid antagonist effects of the novel kappa antagonist 5'- guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys
    • Negus SS, Mello NK, Linsenmayer DC, et al. Kappa opioid antagonist effects of the novel kappa antagonist 5'- guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys. Psychopharmacology (Berl) 2002;163(3-4):412-19
    • (2002) Psychopharmacology (Berl) , vol.163 , Issue.3-4 , pp. 412-419
    • Negus, S.S.1    Mello, N.K.2    Linsenmayer, D.C.3
  • 133
    • 84861170364 scopus 로고    scopus 로고
    • Kappa-Opioid receptors within the nucleus accumbens shell mediate pair bond maintenance
    • Resendez SL, Kuhnmuench M, Krzywosinski T, et al. kappa-Opioid receptors within the nucleus accumbens shell mediate pair bond maintenance. J Neurosci 2012;32(20):6771-84
    • (2012) J Neurosci , vol.32 , Issue.20 , pp. 6771-6784
    • Resendez, S.L.1    Kuhnmuench, M.2    Krzywosinski, T.3
  • 134
    • 70849130984 scopus 로고    scopus 로고
    • Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action
    • Aldrich JV, Patkar KA, McLaughlin JP. Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action. Proc Natl Acad Sci USA 2009;106(43):18396-401
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.43 , pp. 18396-18401
    • Aldrich, J.V.1    Patkar, K.A.2    McLaughlin, J.P.3
  • 135
    • 77953282058 scopus 로고    scopus 로고
    • Induction of fear extinction with hippocampal-infralimbic BDNF
    • Peters J, Dieppa-Perea LM, Melendez LM, et al. Induction of fear extinction with hippocampal-infralimbic BDNF. Science 2010;328(5983):1288-90
    • (2010) Science , vol.328 , Issue.5983 , pp. 1288-1290
    • Peters, J.1    Dieppa-Perea, L.M.2    Melendez, L.M.3
  • 136
    • 84926638866 scopus 로고    scopus 로고
    • The role of BDNF-TrkB signaling in the pathogenesis of PTSD
    • Neumeister A, Corsi-Travali S, Green CR. The role of BDNF-TrkB signaling in the pathogenesis of PTSD. J Depress Anxiety 2013;6(S4):1-6
    • (2013) J Depress Anxiety , vol.6 , Issue.S4 , pp. 1-6
    • Neumeister, A.1    Corsi-Travali, S.2    Green, C.R.3
  • 137
    • 77957938119 scopus 로고    scopus 로고
    • Acute stress and chronic stress change brainderived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus
    • Shi SS, Shao SH, Yuan BP, et al. Acute stress and chronic stress change brainderived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med J 2010;51(5):661-71
    • (2010) Yonsei Med J , vol.51 , Issue.5 , pp. 661-671
    • Shi, S.S.1    Shao, S.H.2    Yuan, B.P.3
  • 138
    • 34247856252 scopus 로고    scopus 로고
    • Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
    • Heldt SA, Stanek L, Chhatwal JP, et al. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 2007;12(7):656-70
    • (2007) Mol Psychiatry , vol.12 , Issue.7 , pp. 656-670
    • Heldt, S.A.1    Stanek, L.2    Chhatwal, J.P.3
  • 139
    • 84877352263 scopus 로고    scopus 로고
    • Impaired fear extinction learning in adult heterozygous BDNF knock-out mice
    • Psotta L, Lessmann V, Endres T. Impaired fear extinction learning in adult heterozygous BDNF knock-out mice. Neurobiol Learn Mem 2013;103:34-8
    • (2013) Neurobiol Learn Mem , vol.103 , pp. 34-38
    • Psotta, L.1    Lessmann, V.2    Endres, T.3
  • 140
    • 67649313501 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder
    • Dell'Osso L, Carmassi C, Del Debbio A, et al. Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(5):899-902
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , Issue.5 , pp. 899-902
    • Dell'Osso, L.1    Carmassi, C.2    Del Debbio, A.3
  • 141
    • 33749649795 scopus 로고    scopus 로고
    • Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    • Chen ZY, Jing DQ, Bath KG, et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 2006;314(5796):140-3
    • (2006) Science , vol.314 , Issue.5796 , pp. 140-143
    • Chen, Z.Y.1    Jing, D.Q.2    Bath, K.G.3
  • 142
    • 84877586206 scopus 로고    scopus 로고
    • The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder
    • Felmingham KL, Dobson-Stone C, Schofield PR, et al. The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder. Biol Psychiatry 2013;73(11):1059-63
    • (2013) Biol Psychiatry , vol.73 , Issue.11 , pp. 1059-1063
    • Felmingham, K.L.1    Dobson-Stone, C.2    Schofield, P.R.3
  • 143
    • 77249168715 scopus 로고    scopus 로고
    • A selective TrkB agonist with potent neurotrophic activities by 78- dihydroxyflavone
    • Jang SW, Liu X, Yepes M, et al. A selective TrkB agonist with potent neurotrophic activities by 7,8- dihydroxyflavone. Proc Natl Acad Sci USA 2010;107(6):2687-92
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.6 , pp. 2687-2692
    • Jang, S.W.1    Liu, X.2    Yepes, M.3
  • 144
    • 84877868707 scopus 로고    scopus 로고
    • Activation of BDNF signaling prevents the return of fear in female mice
    • Baker-Andresen D, Flavell CR, Li X, et al. Activation of BDNF signaling prevents the return of fear in female mice. Learn Mem 2013;20(5):237-40
    • (2013) Learn Mem , vol.20 , Issue.5 , pp. 237-240
    • Baker-Andresen, D.1    Flavell, C.R.2    Li, X.3
  • 145
    • 79952728977 scopus 로고    scopus 로고
    • Effect of 7,8-dihydroxyflavone, a smallmolecule TrkB agonist, on emotional learning
    • Andero R, Heldt SA, Ye KQ, et al. Effect of 7,8-dihydroxyflavone, a smallmolecule TrkB agonist, on emotional learning. Am J Psychiatry 2011;168(2):163-72
    • (2011) Am J Psychiatry , vol.168 , Issue.2 , pp. 163-172
    • Andero, R.1    Heldt, S.A.2    Ye, K.Q.3
  • 146
    • 0035069755 scopus 로고    scopus 로고
    • The oxytocin receptor system: Structure, function, and regulation
    • Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev 2001;81(2):629-83
    • (2001) Physiol Rev , vol.81 , Issue.2 , pp. 629-683
    • Gimpl, G.1    Fahrenholz, F.2
  • 147
    • 0347627798 scopus 로고    scopus 로고
    • Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
    • Heinrichs M, Baumgartner T, Kirschbaum C, et al. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 2003;54(12):1389-98
    • (2003) Biol Psychiatry , vol.54 , Issue.12 , pp. 1389-1398
    • Heinrichs, M.1    Baumgartner, T.2    Kirschbaum, C.3
  • 148
    • 84903691891 scopus 로고    scopus 로고
    • Oxytocin administration enhances controlled social cognition in patients with schizophrenia
    • Woolley JD, Chuang B, Lam O, et al. Oxytocin administration enhances controlled social cognition in patients with schizophrenia. Psychoneuroendocrinology 2014;47:116-25
    • (2014) Psychoneuroendocrinology , vol.47 , pp. 116-125
    • Woolley, J.D.1    Chuang, B.2    Lam, O.3
  • 149
    • 84897396537 scopus 로고    scopus 로고
    • Oxytocin and autism: A systematic review of randomized controlled trials
    • Preti A, Melis M, Siddi S, et al. Oxytocin and autism: a systematic review of randomized controlled trials. J Child Adolesc Psychopharmacol 2014;24(2):54-68
    • (2014) J Child Adolesc Psychopharmacol , vol.24 , Issue.2 , pp. 54-68
    • Preti, A.1    Melis, M.2    Siddi, S.3
  • 150
    • 84902595135 scopus 로고    scopus 로고
    • Affiliation buffers stress: Cumulative genetic risk in oxytocin-vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children
    • Feldman R, Vengrober A, Ebstein RP. Affiliation buffers stress: cumulative genetic risk in oxytocin-vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children. Transl Psychiatry 2014;4:e370
    • (2014) Transl Psychiatry , vol.4 , pp. e370
    • Feldman, R.1    Vengrober, A.2    Ebstein, R.P.3
  • 151
    • 77954730906 scopus 로고    scopus 로고
    • Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses
    • Cohen H, Kaplan Z, Kozlovsky N, et al. Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses. J Neuroendocrinol 2010;22(8):889-904
    • (2010) J Neuroendocrinol , vol.22 , Issue.8 , pp. 889-904
    • Cohen, H.1    Kaplan, Z.2    Kozlovsky, N.3
  • 152
    • 84866729264 scopus 로고    scopus 로고
    • Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner
    • Toth I, Neumann ID, Slattery DA. Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner. Psychopharmacology (Berl) 2012;223(2):149-58
    • (2012) Psychopharmacology (Berl) , vol.223 , Issue.2 , pp. 149-158
    • Toth, I.1    Neumann, I.D.2    Slattery, D.A.3
  • 153
    • 84893371207 scopus 로고    scopus 로고
    • Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salience processing and fear inhibition processes
    • Koch SB, van Zuiden M, Nawijn L, et al. Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes. Psychoneuroendocrinology 2014;40:242-56
    • (2014) Psychoneuroendocrinology , vol.40 , pp. 242-256
    • Koch, S.B.1    Van Zuiden, M.2    Nawijn, L.3
  • 154
    • 84881615635 scopus 로고    scopus 로고
    • The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample
    • Acheson D, Feifel D, de Wilde S, et al. The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample. Psychopharmacology (Berl) 2013;229(1):199-208
    • (2013) Psychopharmacology (Berl) , vol.229 , Issue.1 , pp. 199-208
    • Acheson, D.1    Feifel, D.2    De Wilde, S.3
  • 155
    • 84902013915 scopus 로고    scopus 로고
    • Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: Study protocol of a randomized controlled trial
    • Frijling JL, van Zuiden M, Koch SB, et al. Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial. BMC Psychiatry 2014;14:92
    • (2014) BMC Psychiatry , vol.14 , pp. 92
    • Frijling, J.L.1    Van Zuiden, M.2    Koch, S.B.3
  • 156
    • 84862116186 scopus 로고    scopus 로고
    • Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD).
    • Ipser JC, Stein DJ. Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD). Int J Neuropsychopharmacol 2012;15(6):825-40
    • (2012) Int J Neuropsychopharmacol , vol.15 , Issue.6 , pp. 825-840
    • Ipser, J.C.1    Stein, D.J.2
  • 159
    • 33748856240 scopus 로고    scopus 로고
    • The role of hyperarousal in the manifestation of posttraumatic psychological distress following injury
    • Marshall GN, Schell TL, Glynn SM, et al. The role of hyperarousal in the manifestation of posttraumatic psychological distress following injury. J Abnorm Psychol 2006;115(3):624-8
    • (2006) J Abnorm Psychol , vol.115 , Issue.3 , pp. 624-628
    • Marshall, G.N.1    Schell, T.L.2    Glynn, S.M.3
  • 160
    • 84899685801 scopus 로고    scopus 로고
    • Dimensional structure and course of post-traumatic stress symptomatology in World Trade Center responders
    • Pietrzak RH, Feder A, Schechter CB, et al. Dimensional structure and course of post-traumatic stress symptomatology in World Trade Center responders. Psychol Med 2013;44:2085-98. doi:10.1017/S0033291713002924
    • (2013) Psychol Med , vol.44 , pp. 2085-2098
    • Pietrzak, R.H.1    Feder, A.2    Schechter, C.B.3
  • 161
    • 2142809606 scopus 로고    scopus 로고
    • All symptoms are not created equal: The prominent role of hyperarousal in the natural course of posttraumatic psychological distress
    • Schell TL, Marshall GN, Jaycox LH. All symptoms are not created equal: the prominent role of hyperarousal in the natural course of posttraumatic psychological distress. J Abnorm Psychol 2004;113(2):189-97
    • (2004) J Abnorm Psychol , vol.113 , Issue.2 , pp. 189-197
    • Schell, T.L.1    Marshall, G.N.2    Jaycox, L.H.3
  • 162
    • 67649234204 scopus 로고    scopus 로고
    • The longitudinal course of posttraumatic stress disorder symptom clusters among war veterans
    • Solomon Z, Horesh D, Ein-Dor T. The longitudinal course of posttraumatic stress disorder symptom clusters among war veterans. J Clin Psychiatry 2009;70(6):837-43
    • (2009) J Clin Psychiatry , vol.70 , Issue.6 , pp. 837-843
    • Solomon, Z.1    Horesh, D.2    Ein-Dor, T.3
  • 163
    • 84922977692 scopus 로고    scopus 로고
    • Posttraumatic stress disorder and suicidal ideation: The role of specific symptoms within the framework of the interpersonal-psychological theory of suicide
    • Davis MT, Witte TK, Weathers FW. Posttraumatic stress disorder and suicidal ideation: the role of specific symptoms within the framework of the interpersonal-psychological theory of suicide. Psychol Trauma 2014;6(6):610-18
    • (2014) Psychol Trauma , vol.6 , Issue.6 , pp. 610-618
    • Davis, M.T.1    Witte, T.K.2    Weathers, F.W.3
  • 164
    • 84898000054 scopus 로고    scopus 로고
    • Risk for suicidal behaviors associated with PTSD, depression, and their comorbidity in the US Army
    • Ramsawh HJ, Fullerton CS, Mash HBH, et al. Risk for suicidal behaviors associated with PTSD, depression, and their comorbidity in the US Army. J Affect Disord 2014;161:116-22
    • (2014) J Affect Disord , vol.161 , pp. 116-122
    • Ramsawh, H.J.1    Fullerton, C.S.2    Mash, H.B.H.3
  • 165
    • 34247483139 scopus 로고    scopus 로고
    • Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample
    • Sareen J, Cox BJ, Stein MB, et al. Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosom Med 2007;69(3):242-8
    • (2007) Psychosom Med , vol.69 , Issue.3 , pp. 242-248
    • Sareen, J.1    Cox, B.J.2    Stein, M.B.3


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