SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas

Molecular Cancer

Volumn 14, Issue 1, 2015, Pages

  Sulaiman, Mahaboob K ^a   Chu, Zhengtao ^a,b   Blanco, Victor M ^a   Vallabhapurapu, Subrahmanya D ^a   Franco, Robert S ^a   Qi, Xiaoyang ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Bax polymerization; Dioleoylphosphatidylserine; Mitochondria mediated apoptosis; SapC DOPS; Saposin C; Smac Diablo

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; BONGKREKIC ACID; CASPASE 3; CYCLOPHILIN D; CYCLOSPORIN A; CYTOCHROME C; DIOLEOYLPHOSPHATIDYLSERINE; NANOPARTICLE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SAPOSIN C DIOLEOYLPHOSPHATIDYLSERINE NANOVESICLE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SHORT HAIRPIN RNA; SPHINGOLIPID ACTIVATOR PROTEIN; UNCLASSIFIED DRUG; 1,2-DIOLEOYLPHOSPHATIDYLSERINE; CYCLOPHILIN; CYCLOSPORIN; DIABLO PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; PHOSPHATIDYLSERINE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DNA FRAGMENTATION ASSAY; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROBLASTOMA; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN LIPID INTERACTION; PROTEIN POLYMERIZATION; TUMOR XENOGRAFT; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; MITOCHONDRION; NUDE MOUSE; TUMOR CELL LINE;

MUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; CYCLOPHILINS; CYCLOSPORINE; CYTOCHROMES C; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NANOPARTICLES; NEUROBLASTOMA; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES; SAPOSINS;

EID: 84927592890     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-015-0336-y     Document Type: Article

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