Saposin C coupled lipid nanovesicles enable cancer-selective optical and magnetic resonance imaging

Molecular Imaging and Biology

Volumn 13, Issue 5, 2011, Pages 886-897

  Vinod Kaimal, ^a,b   Chu, Zhengtao ^a   Mahller, Yonatan Y ^a   Papahadjopoulos Sternberg, Brigitte ^c   Cripe, Timothy P ^a   Holland, Scott K ^a   Qi, Xiaoyang ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Charles River Discovery and Imaging Services   (United States)

^c NanoAnalytical Laboratory   (United States)

Author keywords

Cancerselective detection; Fluorescence; Saposin C dioleylphosphatidylserine nanovesicles; USPIO

Indexed keywords

CYTOTOXIC AGENT; DEXTRAN; IRON OXIDE; SAPOSIN C PHOSPHOLIPID DIOLEYLPHOSPHATIDYLSERINE NANOVESICLE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC EMISSION SPECTROMETRY; BINDING AFFINITY; CANCER DIAGNOSIS; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG RESPONSE; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MATERIAL COATING; MOLECULAR IMAGING; MOLECULARLY TARGETED THERAPY; MOUSE; NANOENCAPSULATION; NEUROBLASTOMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; FLUORESCENT DYES; FREEZE FRACTURING; HUMANS; MAGNETIC RESONANCE IMAGING; MOLECULAR SEQUENCE DATA; PARTICLE SIZE; SAPOSINS; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 81855215668     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-010-0417-7     Document Type: Article

References (24)

1. Hoffman RM, Yang M (2006) Subcellular imaging in the live mouse. Nature Protoc 1:775-782
2. Marx V (2005) Molecular imaging: Companies set out to sharpen the in vivo perspective with new machines and novel contrast agents. Chem Eng News 83:25-34
3. Fernandes RS, Kirszberg C, Rumjanek VM et al (2006) On the molecular mechanisms for the highly procoagulant pattern of C6 glioma cells. J Thromb Haemost 4:1546-52
4. Ran S, Downes A, Thorpe PE (2002) Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res 62:6132-40 (Pubitemid 35244462)
5. Ran S, Thorpe PE (2002) Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy. Int J Radiat Oncol Biol Phys 54:1479-84 (Pubitemid 35380052)
6. Utsugi T, Schroit AJ, Connor J et al (1991) Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes. Cancer Res 51:3062-6
7. Qi X, Chu Z (2004) Fusogenic domain and lysines in saposin C. Arch Biochem Biophys 424:210-8 (Pubitemid 38401954)
8. Sandhoff K, Kolter T, Harzer K (2000) Sphingolipid activator proteins. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, 8th edn. McGraw-Hill, New York, pp 3371-3388
9. Nieh MP, Pencer J, Katsaras J et al (2006) Spontaneously forming ellipsoidal phospholipid unilamellar vesicles and their interactions with helical domains of saposin C. Langmuir 22:11028-33 (Pubitemid 46129639)
10. Wang Y, Grabowski GA, Qi X (2003) Phospholipid vesicle fusion induced by saposin C. Arch Biochem Biophys 415:43-53 (Pubitemid 36687915)
11. Qi X, Chu Z, Mahller YY et al (2009) Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein. Clin Cancer Res 15:5840-5851
12. Sachdeva MS (1998) Drug targeting systems for cancer chemotherapy. Expert Opin Investig Drugs 7:1849-64 (Pubitemid 28505092)
13. Stark DD, Weissleder R, Elizondo G et al (1998) Superparamagnetic iron oxide: Clinical application as a contrast agent for MR imaging of the liver. Radiology 168:297-301
14. Bulte JW, Kraitchman DL (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 17:484-499 (Pubitemid 39549426)
15. Mulder WJ, Strijkers GJ, van Tilborg GA et al (2006) Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging. NMR Biomed 19:142-164 (Pubitemid 43250800)
16. Dutton AH, Tokuyasu KT, Singer SJ (1979) Iron-dextran antibody conjugates: General method for simultaneous staining of two components in high-resolution immunoelectron microscopy. Proc Natl Acad Sci USA 76:3392-3396 (Pubitemid 9233967)
17. Renshaw PF, Owen CS, Evans AE et al (1986) Immunospecific NMR contrast agents. Magn Reson Imaging 4:351-357 (Pubitemid 17172216)
18. Bulte JW, Hoekstra Y, Kamman RL et al (1992) Specific MR imaging of human lymphocytes by monoclonal antibody-guided dextran-magnetite particles. Magn Reson Med 25:148-157
19. Tiefenauer LX, Tschirky A, Kuhne G et al (1996) In vivo evaluation of magnetite nanoparticles for use as a tumor contrast agent in MRI. Magn Reson Imaging 14:391-402 (Pubitemid 26195074)
20. Bogdanov AA Jr, Martin C, Weissleder R et al (1994) Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: Preparation of ferrosomes. Biochim Biophys Acta 1193:212-218 (Pubitemid 24234196)
21. Chu Z, Sun Y, Kuan CY et al (2005) Saposin C: Neuronal effect and CNS delivery by liposomes. Ann NY Acad Sci 1053:237-246 (Pubitemid 43031103)
22. Sternberg B (1993) Freeze-fracture electron microscopy of liposomes. In: Gregoriadis G (ed) Liposome Technology, Vol 1. CRC Press, Boca Raton, pp 363-374
23. Frank JA, Zywicke H, Jordan EK et al (2002) Magnetic intracellular labeling of mammalian cells by combining (FDA-approved) superparamagnetic iron oxide MR contrast agents and commonly used transfection agents. Acad Radiol 9(Suppl 2):S484-S487 (Pubitemid 34857762)
24. Shapiro EM, Skrtic S, Sharer K et al (2004) MRI detection of single particles for cellular imaging. Proc Natl Acad Sci USA 101:10901-10906 (Pubitemid 38989558)