Probing binding sites and mechanisms of action of an IKs activator by computations and experiments

Biophysical Journal

Volumn 108, Issue 1, 2015, Pages 62-75

  Xu, Yu ^a   Wang, Yuhong ^a   Zhang, Mei ^a   Jiang, Min ^a   Rosenhouse Dantsker, Avia ^b   Wassenaar, Tsjerk ^c   Tseng, Gea Ny ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAVIA;

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DELAYED RECTIFIER POTASSIUM CHANNEL; ION; POTASSIUM;

ANIMAL; BINDING SITE; CARDIAC MUSCLE CELL; CELL CULTURE; CHLOROCEBUS AETHIOPS; COS CELL LINE; DOG; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; GUINEA PIG; METABOLISM; MOLECULAR DYNAMICS; OOCYTE; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; VALIDATION STUDY;

ANIMALS; BINDING SITES; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DELAYED RECTIFIER POTASSIUM CHANNELS; DOGS; GUINEA PIGS; IONS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MYOCYTES, CARDIAC; NEUROTRANSMITTER AGENTS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM; PROTEIN STRUCTURE, SECONDARY; TRANSFECTION;

EID: 84921038746     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2014.10.059     Document Type: Article

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