Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1- tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K v7.1 (KCNQ1) potassium channel activator

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5936-5941

  Mattmann, Margrith E ^a,c   Yu, Haibo ^d,e   Lin, Zhihong ^d,e   Xu, Kaiping ^d,e   Huang, Xiaofang ^d,e   Long, Shunyou ^d,e   Wu, Meng ^d,e   McManus, Owen B ^d,e   Engers, Darren W ^a,c   Le, Uyen M ^a,c   Li, Min ^d,e   Lindsley, Craig W ^a,b,c   Hopkins, Corey R ^a,b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

KCNQ1 activator; ML277; MLPCN probe; Potassium channels; Voltage gated ion channels

Indexed keywords

ML 277; N [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 1 TOSYLPIPERIDINE 2 CARBOXAMIDE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KCNQ1 POTASSIUM CHANNEL; MOLECULAR STRUCTURE; PIPERIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZOLES; TOSYL COMPOUNDS;

EID: 84865483594     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.060     Document Type: Article

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