One-step derivation of cardiomyocytes and mesenchymal stem cells from human pluripotent stem cells

Stem Cell Research

Volumn 9, Issue 2, 2012, Pages 87-100

  Wei, Heming ^a   Tan, Grace ^a   Manasi, ^a   Qiu, Suhua ^a   Kong, Geraldine ^a   Yong, Pearly ^a   Koh, Caihong ^a   Ooi, Ting Huay ^a   Lim, Sze Yun ^a   Wong, Philip ^a,c   Gan, Shu Uin ^b   Shim, Winston ^a,c  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; BONE MARROW; CELL DIFFERENTIATION; CELL THERAPY; CHONDROGENESIS; CONTROLLED STUDY; FEMALE; FIBROBLAST; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MESODERM; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

ANIMALS; BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL MEMBRANE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; FEMALE; FLOW CYTOMETRY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KARYOTYPING; KINETICS; MESENCHYMAL STROMAL CELLS; MICE; MICE, SCID; MULTIPOTENT STEM CELLS; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; TELOMERASE; WOUND HEALING;

EID: 84861937125     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2012.04.003     Document Type: Article

References (36)

1. Amado L.C., Saliaris A.P., Schuleri K.H., St John M., Xie J.S., Cattaneo S., Durand D.J., Fitton T., Kuang J.Q., Stewart G., et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:11474-11479.
2. Briquet A., Dubois S., Bekaert S., Dolhet M., Beguin Y., Gothot A. Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages. Haematologica 2010, 95:47-56.
3. Chen S.L., Fang W.W., Ye F., Liu Y.H., Qian J., Shan S.J., Zhang J.J., Chunhua R.Z., Liao L.M., Lin S., et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am. J. Cardiol. 2004, 94:92-95.
4. Covas D.T., Panepucci R.A., Fontes A.M., Silva W.A., Orellana M.D., Freitas M.C., Neder L., Santos A.R., Peres L.C., Jamur M.C., et al. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Exp. Hematol. 2008, 36:642-654.
5. Crisan M., Yap S., Casteilla L., Chen C.W., Corselli M., Park T.S., Andriolo G., Sun B., Zheng B., Zhang L., et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008, 3:301-313.
6. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F., Krause D., Deans R., Keating A., Prockop D., Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8:315-317.
7. Fan M., Chen W., Liu W., Du G.Q., Jiang S.L., Tian W.C., Sun L., Li R.K., Tian H. The effect of age on the efficacy of human mesenchymal stem cell transplantation after a myocardial infarction. Rejuvenation Res. 2010, 13:429-438.
8. Freund C., Ward-van Oostwaard D., Monshouwer-Kloots J., van den Brink S., van Rooijen M., Xu X., Zweigerdt R., Mummery C., Passier R. Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells. Stem Cells 2008, 26:724-733.
9. Graichen R., Xu X., Braam S.R., Balakrishnan T., Norfiza S., Sieh S., Soo S.Y., Tham S.C., Mummery C., Colman A., et al. Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation 2008, 76:357-370.
10. Heeschen C., Lehmann R., Honold J., Assmus B., Aicher A., Walter D.H., Martin H., Zeiher A.M., Dimmeler S. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation 2004, 109:1615-1622.
11. Hwang N.S., Varghese S., Lee H.J., Zhang Z., Ye Z., Bae J., Cheng L., Elisseeff J. In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:20641-20646.
12. Kasper G., Mao L., Geissler S., Draycheva A., Trippens J., Kuhnisch J., Tschirschmann M., Kaspar K., Perka C., Duda G.N., et al. Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton. Stem Cells 2009, 27:1288-1297.
13. Kehat I., Kenyagin-Karsenti D., Snir M., Segev H., Amit M., Gepstein A., Livne E., Binah O., Itskovitz-Eldor J., Gepstein L. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest. 2001, 108:407-414.
14. Kim N.W., Piatyszek M.A., Prowse K.R., Harley C.B., West M.D., Ho P.L., Coviello G.M., Wright W.E., Weinrich S.L., Shay J.W. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266:2011-2015.
15. Kinnaird T., Stabile E., Burnett M.S., Lee C.W., Barr S., Fuchs S., Epstein S.E. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ. Res. 2004, 94:678-685.
16. Kinnaird T., Stabile E., Burnett M.S., Shou M., Lee C.W., Barr S., Fuchs S., Epstein S.E. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 2004, 109:1543-1549.
17. Kreutziger K.L., Muskheli V., Johnson P., Braun K., Wight T.N., Murry C.E. Developing vasculature and stroma in engineered human myocardium. Tissue Eng. Part A 2011, 17:1219-1228.
18. Li W.Y., Choi Y.J., Lee P.H., Huh K., Kang Y.M., Kim H.S., Ahn Y.H., Lee G., Bang O.Y. Mesenchymal stem cells for ischemic stroke: changes in effects after ex vivo culturing. Cell Transplant. 2008, 17:1045-1059.
19. Lian Q., Lye E., Suan Yeo K., Khia Way Tan E., Salto-Tellez M., Liu T.M., Palanisamy N., El Oakley R.M., Lee E.H., Lim B., et al. Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells 2007, 25:425-436.
20. Lian Q., Zhang Y., Zhang J., Zhang H.K., Wu X., Lam F.F., Kang S., Xia J.C., Lai W.H., Au K.W., et al. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation 2010, 121:1113-1123.
21. Macmillan M.L., Blazar B.R., DeFor T.E., Wagner J.E. Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I-II clinical trial. Bone Marrow Transplant. 2009, 43:447-454.
22. Maltsev V.A., Wobus A.M., Rohwedel J., Bader M., Hescheler J. Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ. Res. 1994, 75:233-244.
23. Mehta A., Chung Y.Y., Ng A., Iskandar F., Atan S., Wei H., Dusting G., Sun W., Wong P., Shim W. Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells. Cardiovasc. Res. 2011, 91:577-586.
24. Nie Y., Lau C., Lie A., Chan G., Mok M. Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2010, 19:850-859.
25. Park I.H., Arora N., Huo H., Maherali N., Ahfeldt T., Shimamura A., Lensch M.W., Cowan C., Hochedlinger K., Daley G.Q. Disease-specific induced pluripotent stem cells. Cell 2008, 134:877-886.
26. Schugar R.C., Chirieleison S.M., Wescoe K.E., Schmidt B.T., Askew Y., Nance J.J., Evron J.M., Peault B., Deasy B.M. High harvest yield, high expansion, and phenotype stability of CD146 mesenchymal stromal cells from whole primitive human umbilical cord tissue. J. Biomed. Biotechnol. 2009, 2009:789526.
27. Schuleri K.H., Feigenbaum G.S., Centola M., Weiss E.S., Zimmet J.M., Turney J., Kellner J., Zviman M.M., Hatzistergos K.E., Detrick B., et al. Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy. Eur. Heart J. 2009, 30:2722-2732.
28. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
29. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
30. Walter M.N., Wright K.T., Fuller H.R., MacNeil S., Johnson W.E. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp. Cell Res. 2010, 316:1271-1281.
31. Wu Y., Chen L., Scott P.G., Tredget E.E. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007, 25:2648-2659.
32. Xu C., Police S., Rao N., Carpenter M.K. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ. Res. 2002, 91:501-508.
33. Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., Nie J., Jonsdottir G.A., Ruotti V., Stewart R., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920.
34. Yu J.M., Wu X., Gimble J.M., Guan X., Freitas M.A., Bunnell B.A. Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow. Aging Cell 2011, 10:66-79.
35. Zhang J., Wilson G.F., Soerens A.G., Koonce C.H., Yu J., Palecek S.P., Thomson J.A., Kamp T.J. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ. Res. 2009, 104:e30-e41.
36. Zweigerdt R., Burg M., Willbold E., Abts H., Ruediger M. Generation of confluent cardiomyocyte monolayers derived from embryonic stem cells in suspension: a cell source for new therapies and screening strategies. Cytotherapy 2003, 5:399-413.