Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: The importance of genetic background and gender

DMM Disease Models and Mechanisms

Volumn 8, Issue 4, 2015, Pages 351-361

  Kovács, Attila D ^a   Pearce, David A ^a,b  

^a SANFORD RESEARCH   (United States)

^b UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

129S6 SvEv; Batten disease; C57BL 6J; CLN3; Cln3 mouse model; Cln3 ex7 8 knock in mouse model; Juvenile neuronal ceroid lipofuscinosis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLN3 GENE; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FEMALE; GENE; GENE MUTATION; MALE; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ROTAROD TEST; AGING; ANIMAL; BODY WEIGHT; C57BL MOUSE; DEFICIENCY; DEPRESSION; DISEASE MODEL; GENE TARGETING; GENETIC BACKGROUND; GENETICS; IMMOBILIZATION; METABOLISM; MOTOR ACTIVITY; NEURONAL CEROID-LIPOFUSCINOSES; PATHOLOGY; SEXUAL DEVELOPMENT; TIME FACTOR;

MUS;

CHAPERONE; CLN3 PROTEIN, MOUSE; MEMBRANE PROTEIN;

AGING; ANIMALS; BODY WEIGHT; DEPRESSION; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FEMALE; GENE KNOCK-IN TECHNIQUES; GENETIC BACKGROUND; IMMOBILIZATION; MALE; MEMBRANE GLYCOPROTEINS; MICE, INBRED C57BL; MOLECULAR CHAPERONES; MOTOR ACTIVITY; NEURONAL CEROID-LIPOFUSCINOSES; PHENOTYPE; ROTAROD PERFORMANCE TEST; SEX CHARACTERISTICS; TIME FACTORS;

EID: 84927521103     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.018804     Document Type: Article

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