Factors in the genetic background suppress the Engrailed-1 cerebellar phenotype

Journal of Neuroscience

Volumn 23, Issue 12, 2003, Pages 5105-5112

  Bilovocky, Natalie A ^a   Romito DiGiacomo, Rita R ^a   Murcia, Crystal L ^a   Maricich, Stephen M ^a   Herrup, Karl ^a,b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Cerebellar development; Engrailed 1; Engrailed 2; Genetic background; Midbrain hindbrain; Purkinje cells

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEIN ENGRAILED 1; PROTEIN ENGRAILED 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; EMBRYO; GENETIC ANALYSIS; IN SITU HYBRIDIZATION; MESENCEPHALON; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PURKINJE CELL; RHOMBENCEPHALON;

EID: 0038790309     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-12-05105.2003     Document Type: Article

References (22)

1. Bonyadi M, Rusholme SA, Cousins FM, Su HC, Biron CA, Farrall M, Akhurst RJ (1997) Mapping of a major genetic modifier of embryonic lethality in TGF β1 knockout mice. Nat Genet 15:207-211.
2. Davis C, Joyner A (1988) Expression patterns of the homeobox- containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev 2:1736-1744.
3. Davis C, Noble-Topham S, Rossant J, Joyner A (1988) Expression of the homeobox-containing gene En-2 delineates a specific region of the developing mouse brain. Genes Dev 2:361-371.
4. Gerlai R, Millen KJ, Herrup K, Fabien K, Joyner AL, Roder J (1996) Impaired motor learning performance in cerebellar En-2 mutant mice. Behav Neurosci 110:126-133.
5. Greferath U, Bennie A, Kourakis A, Bartlett PF, Murphy M, Barrett GL (2000) Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice. Eur J Neurosci 12:885-893.
6. Hanks M, Wurst W, Anson-Cartwright L, Auerbach A, Joyner A (1995) Rescue of the En-1 mutant phenotype by replacement of En-1 with. En-2. Science 269:679-682.
7. Hanks MC, Loomis CA, Harris E, Tong CX, Anson-Cartwright L, Auerbach A, Joyner A (1998) Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development. Development 125:4521-4530.
8. Herrup K, Sunter K (1987) Numerical matching during cerebellar development: quantitative analysis of granule cell death in staggerer mouse chimeras. J Neurosci 7:829-836.
9. Herrup K, Shojaeian-Zanjani H, Panzini L, Sunter K, Mariani J (1996) The numerical matching of source and target populations in the CNS: the inferior olive to Purkinje cell projection. Brain Res Dev Brain Res 96:28-35.
10. Ikeda S, Hawes NL, Chang B, Avery CS, Smith RS, Nishina PM (1999) Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice. Invest Ophthalmol Vis Sci 40:1874-1878.
11. Inouye N, Oda S (1980) Strain-specific variations in the folial pattern of the mouse cerebellum. J Comp Neurol 190:357-362.
12. Joyner A, Auerbach B, Davis C, Herrup K, Rossant J (1991) Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 259:1239-1243.
13. Joyner AL, Skarnes WC, Rossant J (1989) Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature 338:153-156.
14. Kuemerle B, Zanjani H, Joyner A, Herrup K (1997) Pattern deformities and cell loss in Engrailed-2 mutant mice suggest two separate patterning events during cerebellar development. J Neurosci 17:7881-7889.
15. Liu A, Joyner AL (2001) Early anterior/posterior patterning of the midbrain and cerebellum. Annu Rev Neurosci 24:869-896.
16. Loomis CA, Harris E, Michaud J, Wurst W, Hanks M, Joyner AL (1996) The mouse Engrailed-1 gene and ventral limb patterning. Nature 382:360-363.
17. McMahon A, Joyner A, Bradley A, McMahon J (1992) The midbrain-hindbrain phenotype of Wnt-1 - /Wnt-1 - mice results from stepwise deletion of engrailed-expressing cells by 9.5 days post coitum. Cell 69:581-595.
18. Millen KJ, Wurst W, Herrup K, Joyner AL (1994) Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development 120:695-706.
19. Schwarz M, Alvarez-Bolado G, Urbanek P, Busslinger M, Gruss P (1997) Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations. Proc Natl Acad Sci USA 94:14518-14523.
20. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Magnuson T (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230-234.
21. Vogel MW, Sunter K, Herrup K (1989) Numerical matching between granule and Purkinje cells in lurcher chimeric mice: a hypothesis for the trophic rescue of granule cells from target-related cell death. J Neurosci 9:3454-3462.
22. Wurst W, Auerbach AB, Joyner AL (1994) Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120:2065-2075.