Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Staropoli, John F ^a   Haliw, Larissa ^a   Biswas, Sunita ^a   Garrett, Lillian ^b   Hölter, Sabine M ^b   Becker, Lore ^b,c   Skosyrski, Sergej ^d   da Silva Buttkus, Patricia ^b   Calzada Wack, Julia ^b   Neff, Frauke ^b   Rathkolb, Birgit ^b,e   Rozman, Jan ^b,f   Schrewe, Anja ^b   Adler, Thure ^b,g   Puk, Oliver ^b   Sun, Minxuan ^b   Favor, Jack ^b   Racz, Ildikó ^h   Bekeredjian, Raffi ⁱ   Busch, Dirk H ^g   Graw, Jochen ^b   Klingenspor, Martin ^f   Klopstock, Thomas ^c   Wolf, Eckhard ^e   Wurst, Wolfgang ^b,f,j,k   Zimmer, Andreas ^h   Lopez, Edith ^a   Harati, Hayat ^a,l   Hill, Eric ^a   Krause, Daniela S ^a   Guide, Jolene ^a   Dragileva, Ella ^a   Gale, Evan ^a   Wheeler, Vanessa C ^a   Boustany, Rose Mary ^l   Brown, Diane E ^a   Breton, Sylvie ^a   Ruether, Klaus ^m   Gailus Durner, Valérie ^b   Fuchs, Helmut ^b   de Angelis, Martin Hrabě ^b,f   Cotman, Susan L ^a   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^h UNIVERSITY OF BONN   (Germany)

ⁱ UNIVERSITY OF HEIDELBERG   (Germany)

^j MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^k GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^l AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^m Sankt Gertrauden Krankenhaus   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; CHAPERONE; CLN3 PROTEIN, MOUSE; MEMBRANE PROTEIN;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EPIDIDYMIS; FEMALE; FERRITIN BLOOD LEVEL; GENETIC MODEL; HEART WEIGHT; HEMATOPOIESIS; HETEROZYGOTE; HOMOZYGOTE; MALE; MEAN CORPUSCULAR VOLUME; MOUSE; NEURONAL CEROID LIPOFUSCINOSIS; NEWBORN; NONHUMAN; OXYGEN CONSUMPTION; PERIPHERAL LYMPHOCYTE; PHENOTYPE; RECTUM TEMPERATURE; RETICULOCYTE COUNT; RETINA CONE; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; BODY TEMPERATURE; BRAIN; C57BL MOUSE; DISEASE MODEL; EXPLORATORY BEHAVIOR; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; HEART; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; METABOLISM; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; RETINA DEGENERATION; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANALYSIS OF VARIANCE; ANIMALS; BODY TEMPERATURE; BRAIN; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EXPLORATORY BEHAVIOR; FEMALE; FERRITINS; GENOTYPE; HEART; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR CHAPERONES; NEURONAL CEROID-LIPOFUSCINOSES; ORGAN SIZE; OXYGEN CONSUMPTION; PHENOTYPE; RETINAL DEGENERATION;

EID: 84862007259     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038310     Document Type: Article

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