Inhibitory effect of ethanol extract of Piper longum L. on rabbit platelet aggregation through antagonizing thromboxane A2 receptor

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 7, 2007, Pages 1221-1225

  Iwashita, Masaya ^a   Saito, Masaki ^a   Yamaguchi, Yasunaga ^b   Takagaki, Ryoji ^b   Nakahata, Norimichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Maruzen Pharmaceuticals Co   (Japan)

Author keywords

Piper longum L.; Platelet aggregation; Thromboxane A2 receptor

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ALCOHOL; BUTANOL; PHOSPHATIDYLINOSITIDE; THROMBIN; THROMBOXANE A2 RECEPTOR; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; THROMBOXANE A2 RECEPTOR STIMULATING AGENT; TRITIUM;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG HYDROLYSIS; MALE; NONHUMAN; PIPER LONGUM; PIPERACEAE; RABBIT; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE FUNCTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ALKALOIDS; ANIMALS; BENZODIOXOLES; DIOXOLANES; HYDRAZINES; MALE; PHOSPHATIDYLINOSITOLS; PIPER; PIPERIDINES; PLANT EXTRACTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; POLYUNSATURATED ALKAMIDES; RABBITS; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2;

EID: 34447133473     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.1221     Document Type: Article

References (23)

1. Aronow W. S., J. Gerontol., 59, 172-177 (2004).
2. McNicol A., Israels S. J., J. Pharmacol. Sci., 93, 381-396 (2003).
3. Stoyioglou A., Jaff M. R., J. Vasc. Interv. Radiol., 15, 1197-1207 (2004).
4. Ohkubo S., Nakahata N., Ohizumi Y., Br. J. Pharmacol., 117, 1095-1104 (1996).
5. Shenker A., Goldsmith P., Unson C. G., Spiegel A. M., Trans. Assoc. Am. Physicians, 104, 11-20 (1991).
6. Offermanns S., Laugwitz K. L., Spicher K., Schultz G., Proc. Natl. Acad. Sci. U.S.A., 91, 504-508 (1994).
7. Djellas Y., Manganello J. M., Antonakis K., Le Breton G. C., J. Biol. Chem., 274, 14325-14330 (1999).
8. Ushikubi F., Nakamura K., Narumiya S., Mol. Pharmacol., 46, 808-816 (1994).
9. Klages B., Brandt U., Simon M. I., Schultz G., Offermanns S., J. Cell Biol., 144, 745-754 (1999).
10. Nakahata N., Miyamoto A., Ohkubo S., Ishimoto H., Sakai K., Nakanishi H., Ohshika H., Ohizumi Y., Res. Commun. Mol. Pathol. Pharmacol., 87, 243-251 (1995).
11. Offermanns S., Toombs C. F., Hu Y. H., Simon M. I., Nature (London), 389, 183-186 (1997).
12. Nakahata N., Matsuoka I., Ono T., Nakanishi H., Eur. J. Pharmacol., 162, 407-417 (1989).
13. Buchanan G. R., Martin V., Levine P. H., Scoon K., Handin R. I., Am. J. Clin. Pathol., 68, 355-359 (1977).
14. Hiraku S., Taniguchi K., Wakitani K., Omawari N., Kira H., Miyamoto T., Okegawa T., Kawasaki A., Ujiie A., Jpn. J. Pharmacol., 41, 393-401 (1986).
15. Nagatome Y., Hirayama Y., Ito T., Ebihara S., Watanabe Y., J. Pharmacol. Sci., 97 (Suppl.), 115 (2005).
16. Sugama J., Ohkubo S., Atsumi M., Nakahata N., Mol. Pharmacol., 68, 1466-1474 (2005).
17. Sakai K., Nakahata N., Ono H., Yamamoto T., Ohizumi Y., J. Pharmacol. Exp. Ther., 276, 829-836 (1996).
18. Yacoub D., Theoret J. F., Villeneuve L., Abou-Saleh H., Mourad W., Allen B. G., Merhi Y., J. Biol. Chem., 281, 30024-30035 (2006).
19. Dorsam R. T., Kim S., Murugappan S., Rachoor S., Shankar H., Jin J., Kunapuli S. P., Blood, 105, 2749-2756 (2005).
20. Mitsuhashi M., Tanaka A., Fujisawa C., Kawamoto K., Itakura A., Takaku M., Hironaka T., Sawada S., Matsuda H., J. Immunol., 166, 617-623 (2001).
21. Jin Y. R., Cho M. R., Ryu C. K., Chung J. H., Yuk D. Y., Hong J. T., Lee K. S., Lee J. J., Lee M. Y., Lim Y., Yun Y. P., J. Pharmacol. Exp. Ther., 312, 214-219 (2005).
22. Huang J. S., Ramamurthy S. K., Lin X., Le Breton G. C., Cell Signal., 16, 521-533 (2004).
23. Imura Y., Terashita Z., Shibouta Y., Inada Y., Nishikawa K., Jpn. J. Pharmacol., 52, 35-43 (1990).