Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-Δ12,14-prostaglandin J2

Molecular Pharmacology

Volumn 63, Issue 3, 2003, Pages 607-616

  Jung, Kyung Mi ^b   Park, Ki Sook ^b   Oh, Jae Ho ^b   Jung, Soo Youn ^b   Yang, Ki Hwa ^b   Song, Youn Sook ^a   Son, Dong Ju ^c   Park, Young Hyun ^c   Yun, Yeo Pyo ^a   Lee, Myung Koo ^a   Oh, Ki Wan ^a   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

^c Soonchunhyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NERVE GROWTH FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROTEIN INHIBITOR; SYNAPSIN I; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ANIMAL CELL; ARTICLE; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MACROPHAGE; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NEURITE; NEUROBLASTOMA; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL RESPONSE MODIFIERS; ENZYME ACTIVATION; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTORS; NEURITES; NEUROFILAMENT PROTEINS; NEUROPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PROSTAGLANDIN D2; PYRIDINES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0345701304     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.3.607     Document Type: Article

References (32)

1. 2 expression in rat gastric epithelial cells. J Biol Chem 276:21854-21862.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Chan GK, Deckelbaum RA, Bolivar I, Goltzman D, and Karaplis AC (2001) PTHrP inhibits adipocyte differentiation by down-regulating PPAR gamma activity via a MAPK-dependent pathway. Endocrinology 142:4900-4909.
4. Cheung WM, Hui WS, Chu PW, Chiu SW, and Ip NY (2000) Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett 486:291-296.
5. Crumpton T, Atkins DS, Zawia NH, and Barone S Jr (2001) Lead exposure in pheochromocytoma (PC12) cells alters neural differentiation and Spl DNA-binding. Neurotoxicology 22:49-62.
6. DeGeorge JJ, Walenga R, and Carbonetto S (1988) Nerve growth factor rapidly stimulates arachidonate metabolism in PC12 cells: potential involvement in nerve fiber growth. J Neurosci Res 21:323-332.
7. 2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83:803-812.
8. Feng Z and Porter AG (1999) NF-κB/Rel proteins are required for neuronal differentiation of SH-SY5Y neuroblastoma cells. J Biol Chem 274:30341-30344.
9. Furukawa K, Guo Q, Schellenberg GD, and Mattson MP (1998) Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis and transcription factor (AP-1) activation in PC12 cells. J Neurosci Res 52:618-624.
10. 2 and related compounds: an update. Prostaglandins Leukot Essent Fatty Acids. 47:1-12.
11. Harris SG, Smith RS, and Phipps RP (2002) 15-Deoxy-Delta12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. J Immunol 168:1372-1379.
12. Hong JT and Glauert HP (1998) Stimulation of the DNA binding activity of AP-1 by the peroxisome proliferator ciprofibrate and eicosanoids in cultured rat hepatocytes. Toxicology 131:99-107.
13. Hong JT, Park KL, Han SY, Park KS, Kim HS, Oh SD, Lee RD, and Jang SJ (2000) Effects of ochratoxin A on cytotoxicity and cell differentiation in cultured rat embryonic cells. J Toxicol Environ Health A 61:609-621.
14. Hsi LC, Wilson L, Nixon J, and Eling TE (2001) 15-Lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway. J Biol Chem 276:34545-34552.
15. Iwasaki S, Iguchi M, Watanabe K, Hoshino R, Tsujimoto M, and Kohno M (1999) Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction ofneurite outgrowth in PC12 cells by bone morphogenetic protein-2. J Biol Chem 274:26503-26510.
16. 2 induces synthesis of interleakin-8 by endothelial cells in a PPAR-gamma-independent manner. Prostaglandins Other Lipid Mediat 66:165-177.
17. Kamata H, Tanaka C, Yagisawa H, Matsuda S, Gotoh Y, Nishida E, and Hirata H (1996) Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-Acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade. J Biol Chem 271:33018-33025.
18. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, and Lehmann JMA (1995) Prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-819.
19. 2 and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor γ-independent mechanisms involving reactive oxygenated species. J Biol Chem 277:29681-29685.
20. Leppa S, Saffrich R, Ansorge W, and Bohmann D (1998) Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO (Eur Mol Biol Organ) J 17:4404-4413.
21. 2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J Biol Chem 276:38152-38158.
22. Morooka T and Nishida E (1998) Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J Biol Chem 273:24285-24288.
23. Nagy L, Tontonoz P, Alvarez JG, Chen H, and Evans RM (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93:229-240.
24. Ricote M, Li AC, Willson TM, Kelly CJ, and Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature (Lond) 391:79-82.
25. Rosen ED, Sarra P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, and Mortensen RM (1999) PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 4:611-617.
26. Satoh T, Furuta K, Suzuki M, and Watanabe Y (1999) Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells. Biochem Biophys Res Commun 258:50-53.
27. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, and Evans RM (1998) PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93:241-252.
28. Vaidya S, Somers EP, Wright SD, Detmers PA and Bansal VS (1999) 15-Deoxy-Deltal2, 14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation. J Immunol 163:6187-6192.
29. Vernochet C, Milstone DS, Lehle C, Belmonte N, Phillips B, Wdziekonski B, Villageois P, Amri EZ, O'Donnell PE, Mortensen RM, et al. (2002) PPARgamma-dependent and PPARgamma-independent effects on the development of adipose cells from embryonic stem cells. FEBS Lett 510:94-98.
30. 2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. J Immunol 168:6232-6243.
31. Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R and Serhan CN Spiegelman BM (2000) A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation. J Biol Chem 275: 1873-1877.
32. Yao R, Yoshihara M, and Osada H (1997) Specific activation of a c-Jun NH2-terminal kinase isoform and induction ofneurite outgrowth in PC-12 cells by staurosporine. J Biol Chem 272:18261-18266.