Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model

Acta Pharmacologica Sinica

Volumn 33, Issue 4, 2012, Pages 523-530

  Lai, Li Hua ^a   Fu, Qi Hong ^b   Liu, Yang ^a   Jiang, Kai ^a   Guo, Qing Ming ^a   Chen, Qing Yun ^a   Yan, Bin ^c   Wang, Qing Qing ^a   Shen, Jian Gen ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HANGZHOU NORMAL UNIVERSITY   (China)

^c NINGBO FIRST HOSPITAL   (China)

Author keywords

4T1 breast cancer; anticancer drug; apoptosis; cell cycle; metastasis; MMP 13; MMP 9; piperine

Indexed keywords

CASPASE 3; COLLAGENASE 3; CYCLIN B1; GELATINASE B; PIPERINE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CANCER INHIBITION; CANCER MODEL; CELL ASSAY; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IC 50; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZODIOXOLES; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; MAMMARY NEOPLASMS, EXPERIMENTAL; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; PIPER; PIPERIDINES; POLYUNSATURATED ALKAMIDES;

EID: 84859606303     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.209     Document Type: Article

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