Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages

Food and Chemical Toxicology

Volumn 50, Issue 7, 2012, Pages 2342-2348

  Kim, Hyung Gyun ^a   Han, Eun Hee ^a   Jang, Woo Seok ^a   Choi, Jae Ho ^a   Khanal, Tilak ^a   Park, Bong Hwan ^a   Tran, Thu Phuong ^a   Chung, Young Chul ^b   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Korea International University   (South Korea)

Author keywords

AP 1; C EBP; COX 2; NF B; Piperine

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PIPERINE; PROSTAGLANDIN E2; PROTEIN C JUN; PROTEIN KINASE B; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CYCLOOXYGENASE 2 GENE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION REGULATION; MACROPHAGE; MOLECULAR MODEL; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION;

ALKALOIDS; ANIMALS; BENZODIOXOLES; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; MACROPHAGES; MICE; NF-KAPPA B; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

CAPSICUM; MURINAE; PIPER LONGUM; PIPER NIGRUM;

EID: 84861433857     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.04.024     Document Type: Article

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