Piperine, a dietary phytochemical, inhibits angiogenesis

Journal of Nutritional Biochemistry

Volumn 24, Issue 1, 2013, Pages 231-239

  Doucette, Carolyn D ^a   Hilchie, Ashley L ^a   Liwski, Robert ^a   Hoskin, David W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Akt; Angiogenesis; Endothelial cell; Piperine

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PIPERINE; PROTEIN KINASE B; VANILLOID RECEPTOR 1;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; AORTA; ARTICLE; BREAST CANCER; CELL DEATH; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; DRUG BINDING; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RAT; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ALKALOIDS; ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; BENZODIOXOLES; BREAST NEOPLASMS; CELL MOVEMENT; CELL PROLIFERATION; CHICK EMBRYO; CHROMONES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MORPHOLINES; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-AKT; RATS, WISTAR; S PHASE; SERINE; THREONINE; TRPV CATION CHANNELS;

PIPER NIGRUM; RATTUS;

EID: 84870469261     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.05.009     Document Type: Article

References (48)

1. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003, 9:653-660.
2. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 1990, 82:4-6.
3. Bridges E.M., Harris A.L. The angiogenic process as a therapeutic target in cancer. Biochem Pharmacol 2011, 81:1183-1191.
4. Duda D.G., Jain R.K., Willett C.G. Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol 2007, 25:4033-4042.
5. Deorukhkar A., Krishnan S., Sethi G., Aggarwal B.B. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs 2007, 16:1753-1773.
6. Szallasi A. Piperine: researchers discover new flavor in an ancient spice. Trends Pharmacol Sci 2005, 26:437-439.
7. Kim S.H., Lee Y.C. Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model. J Pharm Pharmacol 2009, 61:353-359.
8. Kumar S., Singhal V., Roshan R., Sharma A., Rembhotkar G.W., Ghosh B. Piperine inhibits TNF-α induced adhesion of neutrophils to endothelial monolayer through suppression of NF-κB and IκB kinase activation. Eur J Pharmacol 2007, 575:177-186.
9. Chonpathompikunlert P., Wattanathorn J., Muchimapura S. Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease. Food Chem Toxicol 2010, 48:798-802.
10. Taqvi S.I., Shah A.J., Gilani A.H. Blood pressure lowering and vasomodulator effects of piperine. J Cardiovasc Pharmacol 2008, 52:452-458.
11. Khajuria A., Thusu N., Zutshi U. Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics. Phytomedicine 2002, 9:224-231.
12. Bhardwaj R.K., Glaeser H., Becquemont L., Klotz U., Gupta S.K., Fromm M.F. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002, 302:645-650.
13. Pradeep C.R., Kuttan G. Effect of piperine on the inhibition of lung metastasis induced B16F-10 melanoma cells in mice. Clin Exp Metastasis 2002, 19:703-708.
14. Sunila E.S., Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J Ethnopharmacol 2004, 90:339-346.
15. Hwang Y.P., Yun H.J., Kim H.G., Han E.H., Choi J.H., Chung Y.C., et al. Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression. Toxicol Lett 2011, 203:9-19.
16. McNamara F.N., Randall A., Gunthorpe M.J. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 2005, 144:781-790.
17. Somanath P.R., Razorenova O.V., Chen J., Byzova T.V. Akt1 in endothelial cell and angiogenesis. Cell Cycle 2006, 5:512-518.
18. Liang C.C., Park A.Y., Guan J.L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007, 2:329-333.
19. Kayashima T., Mori M., Yoshida H., Mizushina Y., Matsubara K. 1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis. Cancer Lett 2009, 278:34-40.
20. Seki N., Shirasaki H., Kikuchi M., Sakamoto T., Watanabe N., Himi T. Expression and localization of TRPV1 in human nasal mucosa. Rhinology 2006, 44:128-134.
21. Lewis J.D., Destito G., Zijlstra A., Gonzalez M.J., Quigley J.P., Manchester M., et al. Viral nanoparticles as tools for intravital vascular imaging. Nat Med 2006, 12:354-360.
22. Montiel M., Urso L., de la Blanca E.R., Marsigliante S., Jiménez E. Cisplatin reduces endothelial cell migration via regulation of type 2-matrix metalloproteinase activity. Cell Physiol Biochem 2009, 23:441-448.
23. Koch S., Tugues S., Li X., Gualandi L., Claesson-Welsh C. Signal transduction by vascular endothelial growth factor receptors. Biochem J 2011, 437:169-183.
24. Shibata A., Nagaya T., Imai T., Funahashi H., Nakao A., Seo H. Inhibition of NF-κB activity decreases the VEGF mRNA expression in MDA-MB-231 breast cancer cells. Breast Cancer Res Treat 2002, 73:237-243.
25. Long D.J., Devantier H.R., Brennan F.X., Bryant R.W., Salemme F.R., Palmer R.K. Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay. J Pharmacol Exp Ther 2010, 332:525-530.
26. Golech S.A., McCarron R.M., Chen Y., Bembry J., Lenz F., Mechoulam R., et al. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Brain Res Mol Brain Res 2004, 132:87-92.
27. + entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 2003, 285:L1233-L1245.
28. Luo D., Zhang Y.W., Peng W.J., Peng J., Chen Q.Q., Li D., et al. Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide. Regul Pept 2008, 150:66-72.
29. Yao X., Garland C.J. Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 2005, 97:853-863.
30. Pradeep C.R., Kuttan G. Piperine is a potent inhibitor of nuclear factor-κB (NF-κB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. Int Immunopharmacol 2004, 4:1795-1803.
31. Kakarala M., Brenner D.E., Korkaya H., Cheng C., Tazi K., Ginestier C., et al. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat 2010, 122:777-785.
32. Bae G.S., Kim M.S., Jung W.S., Seo S.W., Yun S.W., Kim S.G., et al. Inhibition of lipopolysaccharide-induced inflammatory responses by piperine. Eur J Pharmacol 2010, 642:154-162.
33. Liang J., Slingerland J.M. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003, 2:339-345.
34. Shiojima I., Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 2002, 90:1243-1250.
35. Edwards E., Geng L., Tan J., Onishko H., Donnelly E., Hallahan D.E. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res 2002, 62:4671-4677.
36. Toyoshima H., Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994, 78:67-74.
37. Muise-Helmericks R.C., Grimes H.L., Bellacosa A., Malstrom S.E., Tsichlis P.N., Rosen N. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 1998, 273:29864-29872.
38. Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M., et al. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000, 60:1541-1545.
39. Cascio S., Ferla R., D'Andrea A., Gerbino A., Bazan V., Surmacz E., et al. Expression of angiogenic regulators, VEGF and leptin, is regulated by EGF/PI3K/STAT3 pathway in colorectal cancer cells. J Cell Physiol 2009, 221:189-194.
40. Shinkai A., Ito M., Anazawa H., Yamaguchi S., Shitara K., Shibuya M. Mapping of the sites involved in ligand association and dissociation at the extracellular domaine of the kinase insert domain-containing receptor for vascular endothelial growth factor. J Biol Chem 1998, 273:31283-31288.
41. Gille H., Kowalski J., Li B., LeCouter J., Moffat B., Zioncheck T.F., et al. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J Biol Chem 2001, 276:3222-3230.
42. Tosetti F., Ferrari N., De Flora S., Albini A. "Angioprevention": angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J 2002, 16:2-14.
43. Schetter A.J., Heegaard N.H., Harris C.C. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 2010, 31:37-49.
44. Kumar S., Arya P., Mukherjee C., Singh B.K., Singh N., Parmar V.S., et al. Novel aromatic ester from Piper longum and its analogues inhibit expression of cell adhesion molecules on endothelial cells. Biochemistry 2005, 44:15944-15952.
45. Pradeep C.R., Kuttan G. Effect of piperine on the inhibition of nitric oxide (NO) and TNF-alpha production. Immunopharmacol Immunotoxicol 2003, 25:337-346.
46. Khajuria A., Thusu N., Zutshi U., Bedi K.L. Piperine modulation of carcinogen induced oxidative stress in intestinal mucosa. Mol Cell Biochem 1998, 189:113-118.
47. Selvendiran K., Banu S.M., Sakthisekaran D. Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis. Mol Cell Biochem 2005, 268:141-147.
48. Vijayakumar R.S., Surya D., Nalini N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep 2004, 9:105-110.