Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 6, 2013, Pages

  Xu, Fengguo ^a   Tavintharan, Subramaniam ^b   Sum, Chee Fang ^b   Woon, Kaing ^b   Lim, Su Chi ^b   Ong, Choon Nam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b KHOO TECK PUAT HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BRANCHED CHAIN AMINO ACID; GLUCOSE; GLYCEROPHOSPHOLIPID; GLYCOSYLATED HEMOGLOBIN; ISOLEUCINE; LEUCINE; MYRISTIC ACID; PALMITIC ACID; PHENYLALANINE; PROLINE; PYROGLUTAMIC ACID; SPHINGOMYELIN; STEARIC ACID; THREONINE; VALINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID COMPOSITION; AMINO ACID METABOLISM; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMAN; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLIC DISORDER; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; MASS SPECTROMETRY; METABOLOMICS; MIDDLE AGED;

EID: 84878494552     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-4132     Document Type: Article

References (20)

1. Tuomilehto J, Lindström J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344:1343-1350. (Pubitemid 32378388)
2. Xu F, Zou L, Ong CN. Multiorigination of chromatographic peaks in derivatized GC/MS metabolomics: a confounder that influences metabolic pathway interpretation. J Proteome Res. 2009;8:5657-5665.
3. Tai ES, Tan ML, Stevens RD, et al. Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia. 2010;53:757-767.
4. Redman LM, Huffman KM, Landerman LR, et al. Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. J Clin Endocrinol Metab. 2011;96:E312-321.
5. Mitsutake S, Zama K, Yokota H, et al. Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes. J Biol Chem. 2011;286:28544-28555.
6. Shui G, Stebbins JW, Lam BD, et al. Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys? PLoS One. 2011;6:e19731.
7. Ho WE, Xu YJ, Xu F, et al. Metabolomics reveals altered metabolic pathways in experimental asthma. Am J Respir Cell Mol Biol. 2013;48:204-211.
8. Ng DP, Salim A, Liu Y, et al. A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus. Diabetologia. 2012;55:499-508.
9. Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17:448-453.
10. Samuel VT. Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends Endocrinol Metab. 2011;22:60-65.
11. She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJ. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol-Endocrinol Metab. 2007;293:E1552-E1563. (Pubitemid 350255104)
12. Drummond MJ, Bell JA, Fujita S, et al. Amino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle. Clin Nutr. 2008;27:447-456.
13. Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012;15:606-614.
14. Menge BA, Schrader H, Ritter PR, et al. Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes. Regul Pept. 2010;160:75-80.
15. Gall WE, Beebe K, Lawton KA, et al. α-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One. 2010;5:e10883.
16. Zeng MM, Che ZH, Liang YZ, et al. GC-MS based plasma metabolic profiling of type 2 diabetes mellitus. Chromatographia. 2009;69:941-948.
17. Yoshinari O, Igarashi K. Anti-diabetic effect of pyroglutamic acid in type 2 diabetic Goto-Kakizaki rats and KK-Ay mice. Br J Nutr. 2011;106:995-1004.
18. Charles MA, Eschwège E, Thibult N, et al. The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia. 1997;40:1101-1106. (Pubitemid 27381974)
19. Yano M, Watanabe K, Yamamoto T, et al. Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice. J Biol Chem. 2011;286:3992-4002.
20. Park J-W, Park W-J, Kuperman Y, Boura-Halfon S, Pewzner-Jung Y, Futerman AH. Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes. Hepatology. 2013;57:525-532.