메뉴 건너뛰기




Volumn 27, Issue 1, 2014, Pages 80-89

High-resolution NMR spectroscopy of human body fluids and tissues in relation to prostate cancer

Author keywords

Body fluid; Choline; Citrate; in vitro; Metabolomics; NMR spectroscopy; Prostate cancer; Spermine; Tissue extract

Indexed keywords

CHOLINE; CITRATE; IN-VITRO; METABOLOMICS; PROSTATE CANCERS; SPERMINE; TISSUE EXTRACTS;

EID: 84890865912     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.2979     Document Type: Article
Times cited : (48)

References (81)
  • 1
    • 0036065012 scopus 로고    scopus 로고
    • Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons
    • Quinn M, Babb P. Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons. BJU Int. 2002; 90: 162-173.
    • (2002) BJU Int. , vol.90 , pp. 162-173
    • Quinn, M.1    Babb, P.2
  • 3
    • 0033991685 scopus 로고    scopus 로고
    • International trends and patterns of prostate cancer incidence and mortality
    • Hsing AW, Tsao L, Devesa SS. International trends and patterns of prostate cancer incidence and mortality. Int. J. Cancer, 2000; 85: 60-67.
    • (2000) Int. J. Cancer , vol.85 , pp. 60-67
    • Hsing, A.W.1    Tsao, L.2    Devesa, S.S.3
  • 4
    • 84873250208 scopus 로고    scopus 로고
    • Defining prostate cancer risk before prostate biopsy
    • PMID: 22795499. Epub ahead of print
    • Pal RP, Maitra NU, Mellon JK, Khan MA. Defining prostate cancer risk before prostate biopsy. Urol. Oncol. 2012: PMID: 22795499. Epub ahead of print.
    • (2012) Urol. Oncol.
    • Pal, R.P.1    Maitra, N.U.2    Mellon, J.K.3    Khan, M.A.4
  • 14
    • 0034044699 scopus 로고    scopus 로고
    • Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer
    • van der Graaf M, Schipper RG, Oosterhof GO, Schalken JA, Verhofstad AA, Heerschap A. Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer. MAGMA 2000; 10: 153-159.
    • (2000) MAGMA , vol.10 , pp. 153-159
    • van der Graaf, M.1    Schipper, R.G.2    Oosterhof, G.O.3    Schalken, J.A.4    Verhofstad, A.A.5    Heerschap, A.6
  • 16
    • 57449094419 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy of the central, transition and peripheral zones of the prostate: assignments and correlation with histopathology
    • Swindle P, Ramadan S, Stanwell P, McCredie S, Russell P, Mountford C. Proton magnetic resonance spectroscopy of the central, transition and peripheral zones of the prostate: assignments and correlation with histopathology. MAGMA 2008; 21: 423-434.
    • (2008) MAGMA , vol.21 , pp. 423-434
    • Swindle, P.1    Ramadan, S.2    Stanwell, P.3    McCredie, S.4    Russell, P.5    Mountford, C.6
  • 17
    • 12544249171 scopus 로고    scopus 로고
    • 1H nuclear magnetic resonance spectroscopically determined citrate in human seminal fluid accompanies the development of prostate adenocarcinoma
    • 1H nuclear magnetic resonance spectroscopically determined citrate in human seminal fluid accompanies the development of prostate adenocarcinoma. J. Urol. 2005; 173: 433-438.
    • (2005) J. Urol. , vol.173 , pp. 433-438
    • Averna, T.A.1    Kline, E.E.2    Smith, A.Y.3    Sillerud, L.O.4
  • 19
    • 42949103970 scopus 로고    scopus 로고
    • The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions
    • Serkova NJ, Gamito EJ, Jones RH, O'Donnell C, Brown JL, Green S, Sullivan H, Hedlund T, Crawford ED. The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions. Prostate 2008; 68: 620-628.
    • (2008) Prostate , vol.68 , pp. 620-628
    • Serkova, N.J.1    Gamito, E.J.2    Jones, R.H.3    O'Donnell, C.4    Brown, J.L.5    Green, S.6    Sullivan, H.7    Hedlund, T.8    Crawford, E.D.9
  • 20
    • 0030952929 scopus 로고    scopus 로고
    • Proton MRS of human prostatic fluid: correlations between citrate, spermine, and myo-inositol levels and changes with disease
    • Lynch MJ, Nicholson JK. Proton MRS of human prostatic fluid: correlations between citrate, spermine, and myo-inositol levels and changes with disease. Prostate 1997; 30: 248-255.
    • (1997) Prostate , vol.30 , pp. 248-255
    • Lynch, M.J.1    Nicholson, J.K.2
  • 21
    • 0026093087 scopus 로고
    • Concepts of citrate production and secretion by prostate. 1. Metabolic relationships
    • Costello LC, Franklin RB. Concepts of citrate production and secretion by prostate. 1. Metabolic relationships. Prostate 1991; 18: 25-46.
    • (1991) Prostate , vol.18 , pp. 25-46
    • Costello, L.C.1    Franklin, R.B.2
  • 22
    • 0002562777 scopus 로고    scopus 로고
    • Intermediary energy metabolism of normal and malignant prostate epithelial cells
    • Naz RK (ed.). CRC Press: New York
    • Franklin RB, Costello LC. Intermediary energy metabolism of normal and malignant prostate epithelial cells. In: Naz RK (ed.). Prostate: Basic and Clinical Aspects. CRC Press: New York; 1997, pp. 115-150.
    • (1997) Prostate: Basic and Clinical Aspects , pp. 115-150
    • Franklin, R.B.1    Costello, L.C.2
  • 23
    • 0033668356 scopus 로고    scopus 로고
    • The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy
    • Costello LC, Franklin RB. The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy. Oncology 2000; 59: 269-282.
    • (2000) Oncology , vol.59 , pp. 269-282
    • Costello, L.C.1    Franklin, R.B.2
  • 24
    • 20444484872 scopus 로고    scopus 로고
    • Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer
    • Costello LC, Franklin RB, Feng P. Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer. Mitochondrion 2005; 5: 143-153.
    • (2005) Mitochondrion , vol.5 , pp. 143-153
    • Costello, L.C.1    Franklin, R.B.2    Feng, P.3
  • 25
    • 0001221487 scopus 로고
    • Citric acid in human prostatic secretion and metastasizing cancer of prostate gland
    • Marberger H, Marberger E, Mann T, Lutwak-Mann C. Citric acid in human prostatic secretion and metastasizing cancer of prostate gland. Br. Med. J. 1962; 1: 835-836.
    • (1962) Br. Med. J. , vol.1 , pp. 835-836
    • Marberger, H.1    Marberger, E.2    Mann, T.3    Lutwak-Mann, C.4
  • 26
    • 84870656636 scopus 로고    scopus 로고
    • The role of choline in prostate cancer
    • Awwad HM, Geisel J, Obeid R. The role of choline in prostate cancer. Clin. Biochem. 2012; 45: 1548-1553.
    • (2012) Clin. Biochem. , vol.45 , pp. 1548-1553
    • Awwad, H.M.1    Geisel, J.2    Obeid, R.3
  • 27
    • 57449084210 scopus 로고    scopus 로고
    • Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective
    • Erratum in: MAGMA, 2008; 21: 2409
    • Jagannathan NR, Kumar V, Kumar R, Thulkar S. Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective. MAGMA 2008; 21: 393-407. Erratum in: MAGMA, 2008; 21: 2409.
    • (2008) MAGMA , vol.21 , pp. 393-407
    • Jagannathan, N.R.1    Kumar, V.2    Kumar, R.3    Thulkar, S.4
  • 29
    • 12844274447 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI
    • Noworolski SM, Henry RG, Vigneron DB, Kurhanewicz J. Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI. Magn. Reson. Med. 2005; 53: 249-255.
    • (2005) Magn. Reson. Med. , vol.53 , pp. 249-255
    • Noworolski, S.M.1    Henry, R.G.2    Vigneron, D.B.3    Kurhanewicz, J.4
  • 30
    • 11844287000 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a useful modality for the precise detection and staging of early prostate cancer
    • Hara N, Okuizumi M, Koike H, Kawaguchi M, Bilim V. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a useful modality for the precise detection and staging of early prostate cancer. Prostate 2005; 62: 140-147.
    • (2005) Prostate , vol.62 , pp. 140-147
    • Hara, N.1    Okuizumi, M.2    Koike, H.3    Kawaguchi, M.4    Bilim, V.5
  • 34
  • 35
    • 84863417598 scopus 로고    scopus 로고
    • Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer
    • Kumar V, Jagannathan NR, Thulkar S, Kumar R. Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer. Int. J. Urol. 2012; 19: 602-613.
    • (2012) Int. J. Urol. , vol.19 , pp. 602-613
    • Kumar, V.1    Jagannathan, N.R.2    Thulkar, S.3    Kumar, R.4
  • 37
    • 79959836532 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic imaging of benign prostatic tissue: findings at 3.0T compared to 1.5T - initial experience
    • Chitkara M, Westphalen A, Kurhanewicz J, Qayyum A, Poder L, Reed G, Coakley FV. Magnetic resonance spectroscopic imaging of benign prostatic tissue: findings at 3.0T compared to 1.5T - initial experience. Clin. Imaging 2011; 35: 288-293.
    • (2011) Clin. Imaging , vol.35 , pp. 288-293
    • Chitkara, M.1    Westphalen, A.2    Kurhanewicz, J.3    Qayyum, A.4    Poder, L.5    Reed, G.6    Coakley, F.V.7
  • 39
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat. Protoc. 2007; 2: 2692-2703.
    • (2007) Nat. Protoc. , vol.2 , pp. 2692-2703
    • Beckonert, O.1    Keun, H.C.2    Ebbels, T.M.3    Bundy, J.4    Holmes, E.5    Lindon, J.C.6    Nicholson, J.K.7
  • 40
    • 0028060589 scopus 로고
    • Proton magnetic resonance spectroscopy of brain tumors: an in vitro study
    • discussion 604-613
    • Kinoshita Y, Kajiwara H, Yokota A, Koga Y. Proton magnetic resonance spectroscopy of brain tumors: an in vitro study. Neurosurgery 1994; 35: 606-613; discussion 604-613.
    • (1994) Neurosurgery , vol.35 , pp. 606-613
    • Kinoshita, Y.1    Kajiwara, H.2    Yokota, A.3    Koga, Y.4
  • 41
    • 0028447439 scopus 로고
    • 1H NMR spectroscopic characterization of perchloric acid extracts from breast carcinomas and non-involved breast tissue
    • 1H NMR spectroscopic characterization of perchloric acid extracts from breast carcinomas and non-involved breast tissue. NMR Biomed. 1994; 7: 181-194.
    • (1994) NMR Biomed. , vol.7 , pp. 181-194
    • Gribbestad, I.S.1    Petersen, S.B.2    Fjosne, H.E.3    Kvinnsland, S.4    Krane, J.5
  • 43
    • 0033371680 scopus 로고    scopus 로고
    • Tumour phospholipid metabolism
    • Podo F. Tumour phospholipid metabolism. NMR Biomed. 1999; 12: 413-439.
    • (1999) NMR Biomed. , vol.12 , pp. 413-439
    • Podo, F.1
  • 44
    • 0024946615 scopus 로고
    • High resolution proton magnetic resonance spectroscopy of biological fluids
    • Nicholson JK, Wilson ID. High resolution proton magnetic resonance spectroscopy of biological fluids. Prog. Nucl. Magn. Reson. Spectrosc. 1989; 21: 449-501.
    • (1989) Prog. Nucl. Magn. Reson. Spectrosc. , vol.21 , pp. 449-501
    • Nicholson, J.K.1    Wilson, I.D.2
  • 45
    • 0036384102 scopus 로고    scopus 로고
    • NMR-based metabolomics
    • Reo NV. NMR-based metabolomics. Drug Chem. Toxicol. 2002; 25: 375-382.
    • (2002) Drug Chem. Toxicol. , vol.25 , pp. 375-382
    • Reo, N.V.1
  • 50
    • 0030062465 scopus 로고    scopus 로고
    • Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy
    • Tyagi RK, Azrad A, Degani H, Salomon Y. Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magn. Reson. Med. 1996; 35: 194-200.
    • (1996) Magn. Reson. Med. , vol.35 , pp. 194-200
    • Tyagi, R.K.1    Azrad, A.2    Degani, H.3    Salomon, Y.4
  • 51
    • 0025874665 scopus 로고
    • In vitro proton spectroscopy of normal and abnormal prostate
    • Yacoe ME, Sommer G, Peehl D. In vitro proton spectroscopy of normal and abnormal prostate. Magn. Reson. Med. 1991; 19: 429-438.
    • (1991) Magn. Reson. Med. , vol.19 , pp. 429-438
    • Yacoe, M.E.1    Sommer, G.2    Peehl, D.3
  • 52
    • 0026612115 scopus 로고
    • 1H NMR spectroscopy studies of extracts of human cerebral neoplasms
    • 1H NMR spectroscopy studies of extracts of human cerebral neoplasms. Magn. Reson. Med. 1992; 24: 123-136.
    • (1992) Magn. Reson. Med. , vol.24 , pp. 123-136
    • Peeling, J.1    Sutherland, G.2
  • 54
    • 0020367858 scopus 로고
    • P-31 nuclear magnetic resonance analysis of brain: the perchloric acid extract spectrum
    • Glonek T, Kopp SJ, Kot E, Pettegrew JW, Harrison WH, Cohen MM. P-31 nuclear magnetic resonance analysis of brain: the perchloric acid extract spectrum. J. Neurochem. 1982; 39: 1210-1219.
    • (1982) J. Neurochem. , vol.39 , pp. 1210-1219
    • Glonek, T.1    Kopp, S.J.2    Kot, E.3    Pettegrew, J.W.4    Harrison, W.H.5    Cohen, M.M.6
  • 55
    • 33947427846 scopus 로고    scopus 로고
    • Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics
    • Lin CY, Wu H, Tjeerdema RS, Viant MR. Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics 2007; 3: 55-67.
    • (2007) Metabolomics , vol.3 , pp. 55-67
    • Lin, C.Y.1    Wu, H.2    Tjeerdema, R.S.3    Viant, M.R.4
  • 61
    • 0018079655 scopus 로고
    • Basic principles of ROC analysis
    • Metz CE. Basic principles of ROC analysis. Semin. Nucl. Med. 1978; 8: 283-298.
    • (1978) Semin. Nucl. Med. , vol.8 , pp. 283-298
    • Metz, C.E.1
  • 62
    • 0034732869 scopus 로고    scopus 로고
    • Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests
    • Greiner M, Pfeiffer D, Smith RD. Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Prev. Vet. Med. 2000; 45: 23-41.
    • (2000) Prev. Vet. Med. , vol.45 , pp. 23-41
    • Greiner, M.1    Pfeiffer, D.2    Smith, R.D.3
  • 63
    • 4043165350 scopus 로고
    • Removal of dipolar broadening of nuclear magnetic resonance spectra of solids by specimen rotation
    • Andrew E, Bradbury A, Eades R. Removal of dipolar broadening of nuclear magnetic resonance spectra of solids by specimen rotation. Nature 1959; 183: 1802-1803.
    • (1959) Nature , vol.183 , pp. 1802-1803
    • Andrew, E.1    Bradbury, A.2    Eades, R.3
  • 64
    • 11144326895 scopus 로고    scopus 로고
    • Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics
    • Burns MA, He W, Wu CL, Cheng LL. Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics. Technol. Cancer Res. Treat. 2004; 3: 591-598.
    • (2004) Technol. Cancer Res. Treat. , vol.3 , pp. 591-598
    • Burns, M.A.1    He, W.2    Wu, C.L.3    Cheng, L.L.4
  • 66
    • 78650283281 scopus 로고    scopus 로고
    • Semi-parametric time-domain quantification of HR-MAS data from prostate tissue
    • Ratiney H, Albers MJ, Rabeson H, Kurhanewicz J. Semi-parametric time-domain quantification of HR-MAS data from prostate tissue. NMR Biomed. 2010; 23: 1146-1157.
    • (2010) NMR Biomed. , vol.23 , pp. 1146-1157
    • Ratiney, H.1    Albers, M.J.2    Rabeson, H.3    Kurhanewicz, J.4
  • 67
    • 70449411175 scopus 로고    scopus 로고
    • Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate
    • Levin YS, Albers MJ, Butler TN, Spielman D, Peehl DM, Kurhanewicz J. Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate. Magn. Reson. Med. 2009; 62: 1091-1098.
    • (2009) Magn. Reson. Med. , vol.62 , pp. 1091-1098
    • Levin, Y.S.1    Albers, M.J.2    Butler, T.N.3    Spielman, D.4    Peehl, D.M.5    Kurhanewicz, J.6
  • 68
    • 17144387912 scopus 로고    scopus 로고
    • Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy
    • Cheng LL, Burns MA, Taylor JL, He W, Halpern EF, McDougal WS, Wu CL. Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy. Cancer Res. 2005; 65: 3030-3034.
    • (2005) Cancer Res. , vol.65 , pp. 3030-3034
    • Cheng, L.L.1    Burns, M.A.2    Taylor, J.L.3    He, W.4    Halpern, E.F.5    McDougal, W.S.6    Wu, C.L.7
  • 69
    • 0042839755 scopus 로고    scopus 로고
    • High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates
    • Taylor JL, Wu CL, Cory D, Gonzalez RG, Bielecki A, Cheng LL. High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates. Magn. Reson. Med. 2003; 50: 627-632.
    • (2003) Magn. Reson. Med. , vol.50 , pp. 627-632
    • Taylor, J.L.1    Wu, C.L.2    Cory, D.3    Gonzalez, R.G.4    Bielecki, A.5    Cheng, L.L.6
  • 70
    • 12344332587 scopus 로고    scopus 로고
    • Improved signal to noise in high-resolution magic angle spinning total correlation spectroscopy studies of prostate tissues using rotor-synchronized adiabatic pulses
    • Zektzer AS, Swanson MG, Jarso S, Nelson SJ, Vigneron DB, Kurhanewicz J. Improved signal to noise in high-resolution magic angle spinning total correlation spectroscopy studies of prostate tissues using rotor-synchronized adiabatic pulses. Magn. Reson. Med. 2005; 53: 41-48.
    • (2005) Magn. Reson. Med. , vol.53 , pp. 41-48
    • Zektzer, A.S.1    Swanson, M.G.2    Jarso, S.3    Nelson, S.J.4    Vigneron, D.B.5    Kurhanewicz, J.6
  • 72
    • 21244497298 scopus 로고    scopus 로고
    • Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning
    • Burns MA, Taylor JL, Wu CL, Zepeda AG, Bielecki A, Cory D, Cheng LL. Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning. Magn. Reson. Med. 2005; 54: 34-42.
    • (2005) Magn. Reson. Med. , vol.54 , pp. 34-42
    • Burns, M.A.1    Taylor, J.L.2    Wu, C.L.3    Zepeda, A.G.4    Bielecki, A.5    Cory, D.6    Cheng, L.L.7
  • 75
    • 79958118842 scopus 로고    scopus 로고
    • Sarcosine as a marker in prostate cancer progression: a rapid and simple method for its quantification in human urine by solid-phase microextraction-gas chromatography-triple quadrupole mass spectrometry
    • Cavaliere B, Macchione B, Monteleone M, Naccarato A, Sindona G, Tagarelli A. Sarcosine as a marker in prostate cancer progression: a rapid and simple method for its quantification in human urine by solid-phase microextraction-gas chromatography-triple quadrupole mass spectrometry. Anal. Bioanal. Chem. 2011; 400: 2903-2912.
    • (2011) Anal. Bioanal. Chem. , vol.400 , pp. 2903-2912
    • Cavaliere, B.1    Macchione, B.2    Monteleone, M.3    Naccarato, A.4    Sindona, G.5    Tagarelli, A.6
  • 76
    • 78049523638 scopus 로고    scopus 로고
    • Quantitative determination of sarcosine and related compounds in urinary samples by liquid chromatography with tandem mass spectrometry
    • Jiang Y, Cheng X, Wang C, Ma Y. Quantitative determination of sarcosine and related compounds in urinary samples by liquid chromatography with tandem mass spectrometry. Anal. Chem. 2010; 82: 9022-9027.
    • (2010) Anal. Chem. , vol.82 , pp. 9022-9027
    • Jiang, Y.1    Cheng, X.2    Wang, C.3    Ma, Y.4
  • 78
    • 76649086671 scopus 로고    scopus 로고
    • Detection of polyunsaturated omega-6 fatty acid in human malignant prostate tissue by 1D and 2D high-resolution magic angle spinning NMR spectroscopy
    • Stenman K, Hauksson JB, Grobner G, Stattin P, Bergh A, Riklund K. Detection of polyunsaturated omega-6 fatty acid in human malignant prostate tissue by 1D and 2D high-resolution magic angle spinning NMR spectroscopy. MAGMA 2009; 22: 327-331.
    • (2009) MAGMA , vol.22 , pp. 327-331
    • Stenman, K.1    Hauksson, J.B.2    Grobner, G.3    Stattin, P.4    Bergh, A.5    Riklund, K.6
  • 80
    • 79952502199 scopus 로고    scopus 로고
    • Metabolomics: a novel approach to early and noninvasive prostate cancer detection
    • Roberts MJ, Schirra HJ, Lavin MF, Gardiner RA. Metabolomics: a novel approach to early and noninvasive prostate cancer detection. Korean J. Urol. 2011; 52: 79-89.
    • (2011) Korean J. Urol. , vol.52 , pp. 79-89
    • Roberts, M.J.1    Schirra, H.J.2    Lavin, M.F.3    Gardiner, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.