1H NMR-based spectroscopy detects metabolic alterations in serum of patients with early-stage ulcerative colitis

Biochemical and Biophysical Research Communications

Volumn 433, Issue 4, 2013, Pages 547-551

  Zhang, Ying ^a   Lin, Lianjie ^a   Xu, Yanbin ^b   Lin, Yan ^a   Jin, Yu ^a   Zheng, Changqing ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Wanlei Life Sciences (Shenyang) Co Ltd   (China)

Author keywords

Metabolomics; NMR; Serum; Ulcerative colitis

Indexed keywords

3 HYDROXYBUTYRIC ACID; BATROXOBIN; CHINESE DRUG; DEXAMETHASONE; GENTAMICIN; GLUCOSE; KANGFUXING; MESALAZINE; METHYLPREDNISOLONE; PHENYLALANINE; UNCLASSIFIED DRUG; XILEI SAN; BIOLOGICAL MARKER; LIPID;

ADULT; ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC PROCEDURE; DISEASE COURSE; FEMALE; HUMAN; MALE; METABOLIC DISORDER; METABOLOMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SERUM; ULCERATIVE COLITIS; BLOOD; CASE CONTROL STUDY; GLUCOSE BLOOD LEVEL; METABOLISM; METABOLOME; METHODOLOGY; MIDDLE AGED; MULTIVARIATE ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRINCIPAL COMPONENT ANALYSIS; PROGNOSIS; SEVERITY OF ILLNESS INDEX;

3-HYDROXYBUTYRIC ACID; ADULT; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; FEMALE; HUMANS; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; METABOLOMICS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHENYLALANINE; PRINCIPAL COMPONENT ANALYSIS; PROGNOSIS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

MLCS; MLOWN;

EID: 84876477982     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.012     Document Type: Article

References (27)

1. Frank D.N., St Amand A.L., Feldman R.A., Boedeker E.C., Harpaz N., Pace N.R. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl. Acad. Sci. USA 2007, 104:13780-13785.
2. Vilela E.G., Torres H.O., Martins F.P., Ferrari Mde L., Andrade M.M., Cunha A.S. Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis. World J. Gastroenterol. 2012, 18:872-881.
3. Wang Y., Ouyang Q. Ulcerative colitis in China: retrospective analysis of 3100 hospitalized patients. J. Gastroenterol. Hepatol. 2007, 22:1450-1455.
4. Wang Y.F., Zhang H., Ouyang Q. Clinical manifestations of inflammatory bowel disease: east and west differences. J. Dig. Dis. 2007, 8:121-127.
5. Wang Y.F., Ouyang Q., Hu R.W. Progression of inflammatory bowel disease in China. J. Dig. Dis. 2010, 11:76-82.
6. Hanauer S.B. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm. Bowel Dis. 2006, 12(Suppl 1):S3-9.
7. Strober W., Fuss I., Mannon P. The fundamental basis of inflammatory bowel disease. J. Clin. Invest. 2007, 117:514-521.
8. Colombel J.F., Watson A.J., Neurath M.F. The 10 remaining mysteries of inflammatory bowel disease. Gut 2008, 57:429-433.
9. Marchesi J.R., Holmes E., Khan F., Kochhar S., Scanlan P., Shanahan F., Wilson I.D., Wang Y. Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J. Proteome Res. 2007, 6:546-551.
10. Panteris V., Haringsma J., Kuipers E.J. Colonoscopy perforation rate, mechanisms and outcome: from diagnostic to therapeutic colonoscopy. Endoscopy 2009, 41:941-951.
11. 1H NMR metabonomics of serum explored by use of a microflow NMR probe. J. Proteome Res. 2011, 10:1765-1771.
12. 1H NMR spectroscopy: the road to biomarker discovery in gastroenterology and hepatology. Expert Rev. Gastroenterol. Hepatol. 2012, 6:239-251.
13. 1H NMR-based metabolomics. Neoplasia 2009, 11:269-276. 264p following 269.
14. Williams H.R., Cox I.J., Walker D.G., North B.V., Patel V.M., Marshall S.E., Jewell D.P., Ghosh S., Thomas H.J., Teare J.P., Jakobovits S., Zeki S., Welsh K.I., Taylor-Robinson S.D., Orchard T.R. Characterization of inflammatory bowel disease with urinary metabolic profiling. Am. J. Gastroenterol. 2009, 104:1435-1444.
15. Stephens N.S., Siffledeen J., Su X., Murdoch T.B., Fedorak R.N., Slupsky C.M. Urinary NMR metabolomic profiles discriminate inflammatory bowel disease from healthy. J. Crohns Colitis 2012, 7:e42-e48.
16. Le Gall G., Noor S.O., Ridgway K., Scovell L., Jamieson C., Johnson I.T., Colquhoun I.J., Kemsley E.K., Narbad A. Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J. Proteome Res. 2011, 10:4208-4218.
17. 1H NMR spectroscopy. J. Proteome Res. 2010, 9:6265-6273.
18. Ooi M., Nishiumi S., Yoshie T., Shiomi Y., Kohashi M., Fukunaga K., Nakamura S., Matsumoto T., Hatano N., Shinohara M., Irino Y., Takenawa T., Azuma T., Yoshida M. GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis. Inflamm. Res. 2011, 60:831-840.
19. 1H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals. J. Proteome Res. 2012, 11:3344-3357.
20. Bjerrum J.T., Nielsen O.H., Hao F., Tang H., Nicholson J.K., Wang Y., Olsen J. Metabonomics in ulcerative colitis: diagnostics, biomarker identification, and insight into the pathophysiology. J. Proteome Res. 2010, 9:954-962.
21. Lin H.M., Helsby N.A., Rowan D.D., Ferguson L.R. Using metabolomic analysis to understand inflammatory bowel diseases. Inflamm. Bowel Dis. 2011, 17:1021-1029.
22. Lin H.M., Edmunds S.I., Helsby N.A., Ferguson L.R., Rowan D.D. Nontargeted urinary metabolite profiling of a mouse model of Crohn's disease. J. Proteome Res. 2009, 8:2045-2057.
23. Owen O.E., Morgan A.P., Kemp H.G., Sullivan J.M., Herrera M.G., Cahill G.F. Brain metabolism during fasting. J. Clin. Invest. 1967, 46:1589-1595.
24. 1H) MR spectroscopy study. Magn. Reson. Imaging 2010, 28:1022-1029.
25. Edwards F.C., Truelove S.C. The course and prognosis of ulcerative colitis. Gut 1963, 4:299-315.
26. Shiomi Y., Nishiumi S., Ooi M., Hatano N., Shinohara M., Yoshie T., Kondo Y., Furumatsu K., Shiomi H., Kutsumi H., Azuma T., Yoshida M. GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium. Inflamm. Bowel Dis. 2011, 17:2261-2274.
27. Edidin M. Lipids on the frontier: a century of cell-membrane bilayers. Nat. Rev. Mol. Cell Biol. 2003, 4:414-418.