Proteomic and metabolomic profiles in atherothrombotic vascular disease

Current Atherosclerosis Reports

Volumn 12, Issue 3, 2010, Pages 202-208

  Martinez Pinna, Roxana ^a   Barbas, Coral ^b   Blanco Colio, Luis Miguel ^a   Tunon, Jose ^a   Ramos Mozo, Priscila ^a   Lopez, Juan Antonio ^c   Meilhac, Olivier ^d   Michel, Jean Baptiste ^d   Egido, Jesus ^a   Martin Ventura, José Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

^c CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^d INSERM   (France)

Author keywords

Abdominal aortic aneurysm; Atherosclerosis; Biomarkers; Metabolomics; Proteomics

Indexed keywords

ATHEROTHROMBOSIS; CORONARY ARTERY THROMBOSIS; ERYTHROCYTE; HUMAN; METABOLOMICS; MORBIDITY; MORTALITY; NONHUMAN; POLYMORPHONUCLEAR CELL; PROTEIN BLOOD LEVEL; PROTEOMICS; REVIEW; THROMBOCYTE; THROMBOGENESIS; ATHEROSCLEROSIS; BLOOD; CHEMISTRY; COMPLICATION; METABOLISM; THROMBOSIS; VASCULAR ENDOTHELIUM;

ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BLOOD PROTEINS; ENDOTHELIUM, VASCULAR; HUMANS; METABOLOMICS; PROTEINS; PROTEOMICS; THROMBOSIS;

BIOLOGICAL MARKER; PLASMA PROTEIN; PROTEIN;

EID: 77953540503     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-010-0102-y     Document Type: Review

References (48)

1. Bhatt DL, Steg PG, Ohman EM, et al.: International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006, 295:180-189.
2. Baumgartner I, Hirsch AT, Abola MT, et al.: Cardiovascular risk profile and outcome of patients with abdominal aortic aneurysm in out-patients with atherothrombosis: data from the Reduction of Atherothrombosis for Continued Health (REACH) Registry. J Vasc Surg 2008, 48:808-814.
3. Cacoub PP, Abola MT, Baumgartner I, et al.: Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry. Atherosclerosis 2009, 204:e86-e92.
4. Kolodgie FD, Gold HK, Burke AP, et al.: Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 2003, 349:2316-2325.
5. Takaya N, Yuan C, Chu B, et al.: Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study, Circulation 2005, 111:2768-2775.
6. Virmani R, Kolodgie FD, Burke AP, et al.: Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage, Arterioscler Thromb Vasc Biol 2005, 25:2054-2061.
7. Levy AP, Moreno PR: Intraplaque hemorrhage. Curr Mol Med 2006, 6:479-488.
8. Sluimer JC, Kolodgie FD, Bijnens AP, et al.: Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J Am Coll Cardiol 2009, 53:1517-1527.
9. Coutard M, Touat Z, Houard X, et al.: Thrombus versus wall biological activities in experimental aortic aneurysms. J Vasc Res 2009, 47:355-366.
10. Swedenborg J, Eriksson P: The intraluminal thrombus as a source of proteolytic activity. Ann N Y Acad Sci 2006, 1085:133-138.
11. Wei Y, Czuchlewski D, Peerschke EI: Development of proteomic signatures of platelet activation using Surface-Enhaced Laser Desrption/Ionization technology in a clinical setting. Am J Clin Pathol 2008, 129:862-869.
12. Hernandez-Ruiz L, Valverde F, Jimenez-Nuñez MD, et al.: Organellar proteomics of human platelet dense granules reveals that 14-3-3zeta is a granule protein related to atherosclerosis. J Proteome Res 2007, 6:4449-4457.
13. Thandavarayan RA, Watanabe K, Ma M, et al.: 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. Biochem Pharacol 2008, 75:1797-1806.
14. Tucker KL, Kaiser WJ, Bergeron AL, et al.: Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics 2009, 9:4340-4354.
15. Garcia A, Senis YA, Antrobus R, et al.: A global proteomics approach identifies novel phosphorylated signalling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics 2006, 6:5332-5343.
16. Kaiser WJ, Holbrook LM, Tucker KL, et al.: A functional proteomics method for the enrichment of Peripherals membrane proteins reveals the collagen binding protein Hsp47 is exposed on the surface of activated human platelets. J Proteome Res 2009, 8:2903-2914.
17. Roux-Dalvai F, Gonzalez de Peredo A, Simó C, et al.: Extensive analysis of the cytoplasmic proteome of human erythrocytes using the peptide ligand library technology and advanced mass spectrometry. Mol Cell Proteomics 2008, 7:2254-2269.
18. Ringrose JH, van Solinge WW, Mohammed S, et al.: Highly efficient depletion strategy for the two most abundant erythrocyte soluble proteins improves proteome coverage dramatically. J Proteome Res 2008, 7:3060-3063.
19. Baetta R, Corsini A: Role of polymorphonuclear neutrophils in atherosclerosis: current state and future perspectives. Atherosclerosis 2009 (in press).
20. Naruko T, Ueda M, Haze K, et al.: Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation 2002, 3:2894-2900.
21. Leclercq A, Houard X, Philippe M, et al.: Involvement of intraplaque hemorrhage in atherothrombosis evolution via neutrophil protease enrichment. J Leukoc Biol 2007, 82:1420-1429.
22. Lominadze G, Powell DW, Luerman GC, et al.: Proteomic analysis of human neutrophil granules. Mol Cell Proteomics 2005, 4:1503-1521.
23. Karadag B, KucurM, Isman FK, et al.: Serum chitotriosidase activity in patients with coronary artery disease. Circ J 2008, 72:71-75.
24. Xu P, Crawford M, Way M, et al.: Subproteome analysis of the neutrophil cytoskeleton. Proteomics 2009, 9:2037-2049.
25. Dittrich M, Birschmann I, Mietner S, et al.: Platelet protein interactions. Maps signaling components and phosphorylation groundstate. Arterioscler Thromb Vasc Biol 2008, 28:1326-1331.
26. Lewandrowski U, Wortelkamp S, Lohrig K, et al.: Platelet membrane proteomics: a novel repository for functional research. Blood 2009, 114:e10-19.
27. Goodman SR, Kurdia A, Ammann L, et al.: The human red blood cell proteome and interactome. Exp Biol Med (Maywood) 2007, 232:1391-1408.
28. Lepedda AJ, Cigliano A, Cherchi GM, et al.: A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries. Atherosclerosis 2009, 203:112-118.
29. de Kleijn DP, Moll FL, Hellings WE, et al.: Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events. Arterioscler Thromb Vasc Biol 2010(in press). This is the first study in which proteomics applied to human atherosclerotic plaques identified a biomarker with predictive value for the occurrence of adverse cardiovascular events.
30. Urbonavicius S, Lindholt JS, Vorum H, et al.: Proteomic identification of differentially expressed proteins in aortic wall of patients with ruptured and nonruptured abdominal aortic aneurysms. J Vasc Surg 2009, 49:455-463. The is the first study in which proteomics were applied to human walls from patients with ruptured AAA.
31. Martin-Ventura JL, Duran MC, Blanco-Colio LM, et al.: Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis. Circulation 2004, 110:2216-2219.
32. Blanco-Colio LM, Martín-Ventura JL, Muñóz- García B, et al.: Identification of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) as a possible biomarker of subclinical atherosclerosis. Arterioscler Thromb Vasc Biol 2007, 27:916-922.
33. Dejouvencel T, Féron D, Rossignol P, et al.: Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 2010, 30:269-275. The is the first study in which proteomics were applied to human thrombus from patients with AAA.
34. Pernemalm M, Orre LM, Lengqvist J, et al.: Evaluation of three principally different intact protein prefractionation methods for plasma biomarker discovery. J Proteome Res 2008, 7:2712-2722.
35. Wilson AM, Kimura E, Harada RK, et al.: Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies. Circulation 2007, 116:1396-1403.
36. Distelmaier K, Adlbrecht C, Jakowitsch J, et al.: Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction. Thromb Haemost 2009, 102:564-572.
37. Bossi F, Rizzi L, Bulla R, et al.: C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. Blood 2009, 113:3640-3648.
38. Pagano MB, Zhou HF, Ennis TL, et al.: Complement-dependent neutrophil recruitment is critical for the development of elastaseinduced abdominal aortic aneurysm. Circulation 2009, 119:1805-1813.
39. Sabatine MS, Liu E, Morrow DA, et al.: Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation 2005, 112:3868-3875.
40. Brindle JT, Antti H, Holmes E, et al.: Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 2002, 8:1439-1444.
41. Brindle JT, Nicholson JK, Schofield PM, et al.: Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension. Analyst 2003, 128:32-36.
42. Kirschenlohr HL, Griffin JL, Clarke SC, et al.: Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nat Med 2006, 12:705-710.
43. Vallejo A, Usobiaga A, Martinez-Arkarazo I, et al.: Ultrasonicassisted derivatization of estrogenic compounds in a cup horn booster and determination by GC-MS. J Sep Sci 2009, 33:104-111.
44. Teul J, Rupérez FJ, Garcia A, et al.: Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC-MS and 1H NMR fingerprints. J Proteome Res 2009, 8:5580-5589.
45. Mayr M, Chung YL, Mayr U, et al.: Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler Thromb Vasc Biol 2005, 25:2135-2142.
46. He W, Miao FJ, Lin DC, et al.: Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature 2004, 429:188-193.
47. Lewis GD, Asnani A, Gerszten RE: Application of metabolomics to cardiovascular biomarker and pathway discovery. J Am Coll Cardiol 2008, 52:117-123.
48. Wheelock CE, Wheelock AM, Kawashima S, et al.: Systems biology approaches and pathway tools for investigating cardiovascular disease. Mol Biosyst 2009, 5:588-602.