NMR and pattern recognition can distinguish neuroinflammation and peripheral inflammation

Journal of Proteome Research

Volumn 10, Issue 10, 2011, Pages 4428-4438

  Smolinska, Agnieszka ^a   Attali, Amos ^b   Blanchet, Lionel ^a   Ampt, Kirsten ^a   Tuinstra, Tinka ^b   Van Aken, Hans ^b   Suidgeest, Ernst ^b   Van Gool, Alain J ^c   Luider, Theo ^d   Wijmenga, Sybren S ^a   Buydens, Lutgarde M C ^a,e  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b Chemical Design and Synthesis Unit   (Netherlands)

^c MSD   (Singapore)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

1H NMR spectroscopy; ANOVA PCA; cerebrospinal fluid; EAE model; pattern recognition; PLS DA

Indexed keywords

ARGININE; CREATININE; LYSINE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE MARKER; MALE; METABOLISM; MOLECULAR DIAGNOSIS; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROINFLAMMATION; NONHUMAN; PATTERN RECOGNITION; PERIPHERAL INFLAMMATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; CITRATES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GLUTAMINE; HUMANS; INFLAMMATION; LACTATES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, STATISTICAL; MULTIPLE SCLEROSIS; MYCOBACTERIUM TUBERCULOSIS; PATTERN RECOGNITION, AUTOMATED; PENTANOIC ACIDS; RATS; RATS, INBRED LEW; REPRODUCIBILITY OF RESULTS;

ANIMALIA; RATTUS;

EID: 80053901173     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200203v     Document Type: Article

References (51)

1. Pilz, G.; Wipfler, P.; Ladurner, G.; Kraus, J. Modern multiple sclerosis treatment-what is approved, what is on the horizon Drug Discovery Today 2008, 13 (23-24) 1013-1025
2. Sobocki, P.; Pugliatti, M.; Lauer, K.; Kobelt, G. Estimation of the cost of MS in Europe: extrapolations from a multinational cost study Mult. Scler. 2007, 13 (8) 1054-1064 (Pubitemid 351541442)
3. Kantarci, O.; Wingerchuk, D. Epidemiology and natural history of multiple sclerosis: new insights Curr. Opin. Neurol. 2006, 19 (3) 248-254 (Pubitemid 43804678)
4. Rivers, T. M.; Sprunt, D. H.; Berry, G. P. Observations on Attempts to Produce Acute Disseminated Encephalomyelitis in Monkeys J. Exp. Med. 1933, 58 (1) 39-53
5. Schwentker, F. F.; Rivers, T. M. The Antibody Response of Rabbits to Injections of Emulsions and Extracts of Homologous Brain J. Exp. Med. 1934, 60 (5) 559-574
6. Kabat, E. A.; Wolf, A.; Bezer, A. E. Rapid Production of Acute Disseminated Encephalomyelitis in Rhesus Monkeys by Injection of Brain Tissue With Adjuvants Science 1946, 104 (2703) 362-363
7. Morgan, I. M. Allergic Encephalomyelitis in Monkeys in Response to Injection of Normal Monkey Nervous Tissue J. Exp. Med. 1947, 85 (1) 131-140
8. Steinman, L.; Zamvil, S. S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis Ann. Neurol. 2006, 60 (1) 12-21
9. Baxter, A. G. The origin and application of experimental autoimmune encephalomyelitis Nat. Rev. Immunol. 2007, 7 (11) 904-912 (Pubitemid 350006239)
10. Bradl, M.; Linington, C. Animal models of demyelination Brain Pathol. 1996, 6 (3) 303-311 (Pubitemid 26246385)
11. Lublin, F. D. Relapsing experimental allergic encephalomyelitis. An autoimmune model of multiple sclerosis Springer Semin. Immunopathol. 1985, 8 (3) 197-208 (Pubitemid 15225653)
12. Wolf, A.; Kabat, E. A.; Bezer, A. E. The Pathology of Acute Disseminated Encephalomyelitis Produced Experimentally in the Rhesus Monkey and Its Resemblance to Human Demyelinating Disease J. Neuropathol. Exp. Neurol. 1947, 6 (4) 333-357
13. Teitelbaum, D.; Meshorer, A.; Arnon, R.; Sela, M. Suppresion of experimental allergic encephalomyelitis by a synthetic polypeptide Eur. J. Immunol. 1971, 1, 242-248
14. Yednock, T. A.; Cannon, C.; Fritz, L. C.; Sanchezmadrid, F.; Steinman, L.; Karin, N. Prevention of Experimental Autoimmune Encephalomyelitis by Antibodies against Alpha-4-Beta-1 Integrin Nature 1992, 356 (6364) 63-66
15. Ridge, S. C.; Sloboda, A. E.; Mcreynolds, R. A.; Levine, S.; Oronsky, A. L.; Kerwar, S. S. Suppression of Experimental Allergic Encephalomyelitis by Mitoxantrone Clin. Immunol. Immunopathol. 1985, 35 (1) 35-42 (Pubitemid 15115469)
16. Tintore, M. Early MS treatment Int. MS J. 2007, 14, 5-10 (Pubitemid 46917293)
17. Hendricks, J. J. A.; Alblas, J.; van der Pol, S. M. A.; van Tol, E. A. F.; Dijkstra, C. D.; de Vries, H. E. Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis J. Exp. Med. 2004, 200 (12) 1667-1672 (Pubitemid 40094190)
18. Piotto, M.; Saudek, V.; Sklena, V. Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions J. Biomol. NMR 1992, 2 (6) 661-665
19. ACD/1D HNMR Manager; Advanced Chemistry Development, Inc: Toronto Ontario, 2003; www.acdlabs.com.
20. Eilers, P. H. C. A perfect smoother Anal. Chem. 2003, 75 (14) 3631-3636 (Pubitemid 36871257)
21. Bloemberg, T. G.; Gerretzen, J.; Wouters, H. J. P.; Gloerich, J.; van Dael, M.; Wessels, H. J. C. T.; van den Heuvel, L. P.; Eilers, P. H. C.; Buydens, L. M. C.; Wehrens, R. Improved parametric time warping for proteomics Chemom. Intell. Lab. Syst. 2010, 104, 65-74
22. de Meyer, T.; Sinnaeve, D.; Van Gasse, B.; Tsiporkova, E.; Rietzschel, E. R.; De Buyzere, M. L.; Gillebert, T. C.; Bekaert, S.; Martins, J. C.; Van Criekinge, W. NMR-based characterization of metabolic alterations in hypertension using an adaptive, intelligent binning algorithm Anal. Chem. 2008, 80 (10) 3783-3790 (Pubitemid 351705882)
23. Keun, H. C.; Ebbels, T. M. D.; Antt, H.; Bollard, M. E.; Beckonert, O.; Holmes, E.; Lindon, J. C.; Nicholson, J. K. Improved analysis of multivariate data by variable stability scaling:aplication to NMR-based metabolic profiling Anal. Chim. ACTA 2003, 490 (1-2) 265-276 (Pubitemid 37281308)
24. Weljie, A. M.; Newton, J.; Mercier, P.; Carlson, E.; Slupsky, C. M. Targeted profiling: Quantitative analysis of H-1 NMR metabolomics data Anal. Chem. 2006, 78 (13) 4430-4442
25. Trygg, J.; Holmes, E.; Lundstedt, T. Chemometrics in metabonomics J. Proteome Res. 2007, 6 (2) 469-479 (Pubitemid 46340151)
26. Giskeodegard, G. F.; Grinde, M. T.; Sitter, B.; Axelson, D. E.; Lundgren, S.; Fjosne, H. E.; Dahl, S.; Gribbestad, I. S.; Bathen, T. F. Multivariate Modeling and Prediction of Breast Cancer Prognostic Factors Using MR Metabolomics J. Proteome Res. 2010, 9 (2) 972-979
27. de Haan, J. R.; Wehrens, R.; Bauerschmidt, S.; Piek, E.; van Schaik, R. C.; Buydens, L. M. C. Interpretation of ANOVA models for microarray data using PCA Bioinformatics 2007, 23 (2) 184-190 (Pubitemid 46189608)
28. Westerhuis, J. A.; Hoefsloot, H. C. J.; Smit, S.; Vis, D. J.; Smilde, A. K.; van Velzen, E. J. J.; van Duijnhoven, J. P. M.; van Dorsten, F. A. Assessment of PLSDA cross validation Metabolomics 2008, 4 (1) 81-89 (Pubitemid 351217591)
29. Snee, R. D. Validation of regression models: Methods and examples Technometrics 1977, 19 (4) 415-428
30. Anderssen, E.; Dyrstad, K.; Westad, F.; Martens, H. Reducing over-optimism in variable selection by cross-model validation Chemom. Intell. Lab. Syst. 2006, 84 (1-2) 69-74 (Pubitemid 44708396)
31. Gidskehaug, L.; Anderssen, E.; Alsberg, B. K. Cross model validation and optimization of bilinear regression models Chemom. Intell. Lab. Syst. 2008, 93 (1) 1-10
32. t'Hart, B. A.; Vogels, J. T.; Spijksma, G.; Brok, H. P.; Polman, C.; van der Greef, J. 1H-NMR spectroscopy combined with pattern recognition analysis reveals characteristic chemical pattern in urines of MS patients and non-human primates with MS-like disease J. Neurol. Sci. 2003, 212 (1-2) 21-30 (Pubitemid 36693962)
33. Hattingen, E.; Magerkurth, J.; Pilatus, U.; Hubers, A.; Wahl, M.; Ziemann, U. Combined (1)H and (31)P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis NMR Biomed. 2010, 24, 536-546
34. Qian, J.; Herrera, J. J.; Narayana, P. A. Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology J. Neurotrauma 2010, 27 (3) 599-610
35. Sajja, B. R.; Wolinsky, J. S.; Narayana, P. A. Proton magnetic resonance spectroscopy in multiple sclerosis Neuroimaging Clin. N. Am. 2009, 19 (1) 45-58
36. Sarchielli, P.; Presciutti, O.; Tarducci, R.; Gobbi, G.; Alberti, A.; Pelliccioli, G. P.; Chiarini, P.; Gallai, V. Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis J. Neurol. 2002, 249 (7) 902-910 (Pubitemid 34763777)
37. Sinclair, A. J.; Viant, M. R.; Ball, A. K.; Burdon, M. A.; Walker, E. A.; Stewart, P. M.; Rauz, S.; Young, S. P. NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases - a diagnostic tool? NMR Biomed. 2010, 23 (2) 123-132
38. Noga, M. J.; Dane, A.; Shi, S.; Attali, A.; van Aken, H.; Suidgeest, E.; Tuinstra, T.; Muilwijk, B.; Coulier, L.; Luider, T. M.; Reijmers, T. H.; Vreeken, R. J.; Hankemeier, T. Metabolomics of cerebrospinal fluid reveals changes in central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics 2011; DOI: 10.1007/s11306-011-0306-3.
39. Danilov, A. I.; Andersson, M.; Bavand, N.; Wiklund, N. P.; Olsson, T.; Brundin, L. Nitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosis J. Neuroimmunol. 2003, 136 (1-2) 112-118 (Pubitemid 36300799)
40. Ding, M. Z.; Zhang, M.; Wong, J. L.; Rogers, N. E.; Ignarro, L. J.; Voskuhl, R. R. Cutting edge: Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice J. Immunol. 1998, 160 (6) 2560-2564 (Pubitemid 28136703)
41. Zielasek, J.; Jung, S.; Gold, R.; Liew, F. Y.; Toyka, K. V.; Hartung, H. P. Administration of Nitric-Oxide Synthase Inhibitors in Experimental Autoimmune Neuritis and Experimental Autoimmune Encephalomyelitis J. Neuroimmunol. 1995, 58 (1) 81-88
42. Qureshi, G. A.; Baig, S. M. Role of Neurotransmitter Amino-Acids in Multiple-Sclerosis in Exacerbation, Remission and Chronic Progressive Course Biog. Amines 1993, 10 (1) 39-48 (Pubitemid 24003286)
43. Smith, M. E.; Rauch, H. C. Metabolic-Activity of Cns Proteins in Rats and Monkeys with Experimental Allergic Encephalomyelitis (Eae) J. Neurochem. 1974, 23 (4) 775-783
44. Ghauri, F. Y. K.; Nicholson, J. K.; Sweatman, B. C.; Wood, J.; Beddell, C. R.; Lindon, J. C.; Cairns, N. J. Nmr-Spectroscopy of Human Postmortem Cerebrospinal-Fluid-Distinction of Alzheimers-Disease from Control Using Pattern-Recognition and Statistics NMR Biomed. 1993, 6 (2) 163-167
45. Wilmore, D. W.; Shabert, J. K. Role of glutamine in immunologic responses Nutrition 1998, 14 (7-8) 618-626 (Pubitemid 28345461)
46. Watson, M. A.; Scott, M. G. Clinical utility of biochemical analysis of cerebrospinal fluid Clin. Chem. 1995, 41 (3) 343-360
47. Lutz, N. W.; A., V.; Malikova, I.; Confort-Gouny, S.; Ranjeva, J. P.; Cozzone, P. J. A branched-chain organic acid linked to multiple sclerosis:First identification by NMR spectroscopy of CSF Biochem. Biophys. Res. Commun. 2007, 354 (1) 160-164 (Pubitemid 46123214)
48. Kunz, J.; Krause, D.; Gehrmann, J.; Dermietzel, R. Changes in the Expression Pattern of Blood-Brain Barrier-Associated Pericytic Aminopeptidase-N (Pap-N) in the Course of Acute Experimental Autoimmune Encephalomyelitis J. Neuroimmunol. 1995, 59 (1-2) 41-55
49. Pan, W.; Banks, W. A.; Kennedy, M. K.; Gutierrez, E. G.; Kastin, A. J. Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha Am. J. Physiol. 1996, 271 (4 Pt 1) E636-642
50. Pan, W.; Banks, W. A.; Kennedy, M. K.; Gutierrez, E. G.; Kastin, A. J. Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis Brain Res. Bull. 1999, 832 (1-2) 84-96
51. Linington, C.; Bradl, M.; Lassmann, H.; Brunner, C.; Vass, K. Augmentation of Demyelination in Rat Acute Allergic Encephalomyelitis by Circulating Mouse Monoclonal-Antibodies Directed against a Myelin Oligodendrocyte Glycoprotein Am. J. Pathol. 1988, 130 (3) 443-454 (Pubitemid 18091372)