OCT4B modulates OCT4A expression as ceRNA in tumor cells

Oncology Reports

Volumn 33, Issue 5, 2015, Pages 2622-2630

  Li, Dong ^a   Yang, Zheng Kai ^a   Bu, Jing Yi ^a   Xu, Chun Yan ^a   Sun, Hui ^a   Tang, Jie Bing ^a   Lin, Ping ^a   Cheng, Wen ^a   Huang, Ning ^a   Cui, Rong Jun ^a   Yu, Xiao Guang ^a   Zheng, Xiu Lan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

CeRNA; MiRNA; OCT4; Tumor

Indexed keywords

CERNA; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ISOPROTEIN; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; POU5F1 PROTEIN, HUMAN; UNTRANSLATED RNA;

AMINO ACID SEQUENCE; ARTICLE; BREAST CANCER; CANCER THERAPY; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN RNA BINDING; PROTEIN TARGETING; RNA METHYLATION; RNA PROCESSING; RNA SPLICING; TUMOR CELL LINE; ALTERNATIVE RNA SPLICING; GENETICS; HCT116 CELL LINE;

ALTERNATIVE SPLICING; CELL LINE, TUMOR; HCT116 CELLS; HUMANS; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN ISOFORMS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; RNA, UNTRANSLATED; TRANSCRIPTION FACTORS;

EID: 84927145743     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3862     Document Type: Article

References (52)

1. Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe. Nebenius D, Chambers I, Scholer H and Smith A: Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379-391, 1998.
2. Niwa H, Miyazaki J and Smith AG: Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376, 2000.
3. Boyer LA, Lee TI, Cole MF, et al: Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947-956, 2005.
4. Hay DC, Sutherland L, Clark J and Burdon T: Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells 22:225-235, 2004.
5. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K and Yamanaka S: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872, 2007.
6. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW and Daley GQ: Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451:141-146, 2008.
7. Kumar SM, Liu S, Lu H, Zhang H, Zhang PJ, Gimotty PA, Guerra M, Guo W and Xu X: Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. Oncogene 31:4898-4911, 2012.
8. Reers S, Pfannerstill AC, Maushagen R, Pries R and Wollenberg B: Stem cell profiling in head and neck cancer reveals an Oct-4 expressing subpopulation with properties of chemoresistance. Oral Oncol 50:155-162, 2014.
9. Chiou SH, Yu CC, Huang CY, Lin SC, Liu CJ, Tsai TH, Chou SH, Chien CS, Ku HH and Lo JF: Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res 14:4085-4095, 2008.
10. Chen YC, Hsu HS, Chen YW, et al: Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133.positive cells. PLoS One 3:e2637, 2008.
11. Atlasi Y, Mowla SJ, Ziaee SA and Bahrami AR: OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer. Int J Cancer 120:1598-1602, 2007.
12. Linn DE, Yang X, Sun F, Xie Y, Chen H, Jiang R, Chen H, Chumsri S, Burger AM and Qiu Y: A role for OCT4 in tumor initiation of drug-resistant prostate cancer cells. Genes Cancer 1:908-916, 2010.
13. De Resende MF, Chinen LT, Vieira S, Jampietro J, Da Fonseca FP, Vassallo J, Campos LC, Guimaraes GC, Soares FA and Rocha RM: Prognostication of OCT4 isoform expression in prostate cancer. Tumour Biol 34:2665-2673, 2013.
14. Wen K, Fu Z, Wu X, Feng J, Chen W and Qian J: Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: Effects associated with STAT3/Survivin. Cancer Lett 333:56-65, 2013.
15. Takeda J, Seino S and Bell GI: Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res 20:4613-4620, 1992.
16. Asadi MH, Mowla SJ, Fathi F, Aleyasin A, Asadzadeh J and Atlasi Y: OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor. Int J Cancer 128:2645-2652, 2011.
17. Wang X, Zhao Y, Xiao Z, et al: Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response. Stem Cells 27:1265-1275, 2009.
18. Atlasi Y, Mowla SJ, Ziaee SA, Gokhale PJ and Andrews PW: OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. Stem Cells 26:3068-3074, 2008.
19. Cauffman G, Liebaers I, Van Steirteghem A and Van De Velde H: POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos. Stem Cells 24:2685-2691, 2006.
20. Cauffman G, Van De Velde H, Liebaers I and Van Steirteghem A: Oct-4 mRNA and protein expression during human preimplantation development. Mol Hum Reprod 11:173-181, 2005.
21. Gao Y, Wei J, Han J, Wang X, Su G, Zhao Y, Chen B, Xiao Z, Cao J and Dai J: The novel function of OCT4B isoform-265 in genotoxic stress. Stem Cells 30:665-672, 2012.
22. Cantz T, Key G, Bleidissel M, Gentile L, Han DW, Brenne A and Scholer H: Absence of OCT4 expression in somatic tumor cell lines. Stem Cells 26:692-697, 2008.
23. Zhao S, Yuan Q, Hao H, et al: Expression of OCT4 pseudogenes in human tumours: Lessons from glioma and breast carcinoma. J Pathol 223:672-682, 2011.
24. Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell 136:215-233, 2009.
25. Mendell JT and Olson EN: MicroRNAs in stress signaling and human disease. Cell 148:1172-1187, 2012.
26. Ebert MS and Sharp PA: Roles for microRNAs in conferring robustness to biological processes. Cell 149:515-524, 2012.
27. Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature 505:344-352, 2014.
28. Tay Y, Kats L, Salmena L, et al: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147:344-357, 2011.
29. Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell 146:353-358, 2011.
30. Karreth FA, Tay Y, Perna D, et al: In vivo identification of tumorsuppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147:382-395, 2011.
31. Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B and Rigoutsos I: A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 126:1203-1217, 2006.
32. Fang L, Du WW, Yang X, et al: Versican 3'-untranslated region (3'-UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity. FASEB J 27:907-919, 2013.
33. Wang L, Guo ZY, Zhang R, et al: Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma. Carcinogenesis 34:1773-1781, 2013.
34. Yoshino H, Enokida H, Itesako T, Kojima S, Kinoshita T, Tatarano S, Chiyomaru T, Nakagawa M and Seki N: Tumorsuppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma. Cancer Sci 104:1567-1574, 2013.
35. Iio A, Takagi T, Miki K, Naoe T, Nakayama A and Akao Y: DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells. Biochim Biophys Acta 1829:1102-1110, 2013.
36. Kojima S, Enokida H, Yoshino H, et al: The tumor-suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOLM1 in prostate cancer. J Hum Genet 59:78-87, 2014.
37. Lin F, Lin P, Zhao D, et al: Sox2 targets cyclinE, p27 and survivin to regulate androgen-independent human prostate cancer cell proliferation and apoptosis. Cell Prolif 45:207-216, 2012.
38. Xu N, Papagiannakopoulos T, Pan G, Thomson JA and Kosik KS: MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137:647-658, 2009.
39. Cortes-Dericks L, Yazd EF, Mowla SJ, Schmid RA and Karoubi G: Suppression of OCT4B enhances sensitivity of lung adenocarcinoma A549 cells to cisplatin via increased apoptosis. Anticancer Res 33:5365-5373, 2013.
40. Lin H, Sun LH, Han W, et al: Knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of the AKT pathway. Mol Med Rep 10:1335-1342, 2014.
41. Gao Y, Wang X, Han J, Xiao Z, Chen B, Su G and Dai J: The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B. J Genet Genomics 37:461-465, 2010.
42. Smith JE, Alvarez-Dominguez JR, Kline N, Huynh NJ, Geisler S, Hu W, Coller J and Baker KE: Translation of small open reading frames within unannotated RNA transcripts in Saccharomyces cerevisiae. Cell Rep 7:1858-1866, 2014.
43. Li J, Zhang Y, Wang Y, Zhang C, Wang Q, Shi X, Li C, Zhang R and Li X: Functional combination strategy for prioritization of human miRNA target. Gene 533:132-141, 2014.
44. Denzler R, Agarwal V, Stefano J, Bartel DP and Stoffel M: Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol Cell 54:766-776, 2014.
45. Ramsahoye BH, Davies CS and Mills KI: DNA methylation: Biology and significance. Blood Rev 10:249-261, 1996.
46. Leonhardt H, Rahn HP and Cardoso MC: Functional links between nuclear structure, gene expression, DNA replication, and methylation. Crit Rev Eukaryot Gene Expr 9:345-351, 1999.
47. Ruvinsky A: Basics of gametic imprinting. J Anim Sci 77(Suppl 2):S228-S237, 1999.
48. Amente S, Lania L and Majello B: The histone LSD1 demethylase in stemness and cancer transcription programs. Biochim Biophys Acta 1829:981-986, 2013.
49. Chase A and Cross NC: Aberrations of EZH2 in cancer. Clin Cancer Res 17:2613-2618, 2011.
50. Kellner S and Kikyo N: Transcriptional regulation of the Oct4 gene, a master gene for pluripotency. Histol Histopathol 25:405-412, 2010.
51. Lee YH and Wu Q: Chromatin regulation landscape of embryonic stem cell identity. Biosci Rep 31:77-86, 2011.
52. Das S and Levasseur D: Transcriptional regulatory mechanisms that govern embryonic stem cell fate. Methods Mol Biol 1029:191-203, 2013.