Functional links between nuclear structure, gene expression, DNA replication, and methylation

Critical Reviews in Eukaryotic Gene Expression

Volumn 9, Issue 3-4, 1999, Pages 345-351

  Leonhardt, Heinrich ^a,b   Rahn, Hans Peter ^a   Cardoso, M Cristina ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b FRANZ VOLHARD CLINIC   (Germany)

Author keywords

Chromatin structure; DNA ligase I; DNA methyltransferase; Functional organization of the nucleus; PCNA; Targeting sequence

Indexed keywords

DNA METHYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

CELL NUCLEUS; CHROMATIN STRUCTURE; DNA METHYLATION; DNA REPLICATION; GENE EXPRESSION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVIEW; RNA METABOLISM;

EID: 0033369325     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.190     Document Type: Review

References (29)

1. Becker PB, Ruppert S, Schutz G (1987): Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell 51:435-443.
2. Berezney R, Mortillaro MJ, Ma H, Wei X, Samarabandu J (1995): The nuclear matrix: a structural milieu for genomic function. Int Rev Cytol:1-65.
3. Bravo R, Macdonald-Bravo H (1987): Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 105:1549-1554.
4. Cardoso MC, Joseph C, Rahn HP, Reusch R, Nadal-Ginard B, Leonhardt H (1997): Mapping and use of a sequence that targets DNA ligase I to sites of DNA replication in vivo. J Cell Biol 139:579-587.
5. Cardoso MC, Leonhardt H (1998): Protein targeting to sub-nuclear higher order structures: a new level of regulation and coordination of nuclear processes. J Cell Biochem 70:222-230.
6. Cardoso MC, Leonhardt H (1999): DNA methyltransferase is actively retained in the cytoplasm during early development. J Cell Biol (in press).
7. Cardoso MC, Leonhardt H, Nadal-Ginard B (1993): Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell 74:979-992.
8. Carlson LL, Page AW, Bestor TH (1992): Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting. Genes Dev 6:2536-2541.
9. Chuang LS, Ian HI, Koh TW, Ng HH, Xu G, Li BF (1997): Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277:1996-2000.
10. Cook PR (1999): The organization of replication and transcription. Science 284:1790-1795.
11. Engel FB, Hauck L, Cardoso MC, Leonhardt H, Dietz R, von Harsdorf R (1999): A mammalian myocardial cell-free system to study cell cycle reentry in terminally differentiated cardiomyocytes. Circ Res 85:294-301.
12. Hozak P, Hassan AB, Jackson DA, Cook PR (1993): Visualization of replication factories attached to nucleo-skeleton. Cell 73:361-373.
13. Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP (1998): Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19:187-191.
14. Krude T (1995): Chromatin assembly factor 1 (CAF-1) colocalizes with replication foci in HeLa cell nuclei. Exp Cell Res 220:304-311.
15. Krude T, Jackman M, Pines J, Laskey RA (1997): Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system. Cell 88:109-119.
16. Laskey RA (1986): Prospects for reassembling the cell nucleus. J Cell Sci (Suppl) 4:1-9.
17. Leonhardt H, Page AW, Weier HU, Bestor TH (1992): A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71:865-873.
18. Leonhardt H, Rahn HP, Cardoso MC (1998): Intranuclear targeting of DNA replication factors. J Cell Biochem (Suppl) 31:243-249.
19. Liu Y, Oakeley EJ, Sun L, Jost JP (1998): Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci. Nucleic Acids Res 26:1038-1045.
20. Montecucco A, Rossi R, Levin DS, Gary R, Park MS, Motycka TA, Ciarrocchi G, Villa A, Biamonti G, Tomkinson AE (1998): DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. EMBO J 17:3786-3795.
21. Montecucco A, Savini E, Weighardt F, Rossi R, Ciarrocchi G, Villa A, Biamonti G (1995): The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication. EMBO J 14:5379-5386.
22. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A (1998): Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389.
23. Ng HH, Bird A (1999): DNA methylation and chromatin modification. Curr Opin Genet Dev 9:158-163.
24. Noguchi H, Prem veer Reddy G, Pardee AB (1983): Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei. Cell 32:443-451.
25. Schmitz ML, Henkel T, Baeuerle PA (1991): Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal. Trends Cell Biol 1:130-137.
26. Shibahara K, Stillman B (1999): Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. Cell 96:575-585.
27. Sobczak-Thepot J, Harper F, Florentin Y, Zindy F, Brechot C, Puvion E ( 1993): Localization of cyclin A at the sites of cellular DNA replication. Exp Cell Res 206:43-48.
28. Stoeber K, Mills AD, Kubota Y, Krude T, Romanowski P, Marheineke K, Laskey RA, Williams GH (1998): Cdc6 protein causes premature entry into S phase in a mammalian cell-free system. EMBO J 17:7219-7229.
29. Tom TD, Malkas LH, Hickey RJ (1996): Identification of multiprotein complexes containing DNA replication factors by native immunoblotting of HeLa cell protein preparations with T-antigen-dependent SV40 DNA replication activity. J Cell Biochem 63:259-267.