The tumor-suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOLM1 in prostate cancer

Journal of Human Genetics

Volumn 59, Issue 2, 2014, Pages 78-87

  Kojima, Satoko ^a   Enokida, Hideki ^b   Yoshino, Hirofumi ^b   Itesako, Toshihiko ^b   Chiyomaru, Takeshi ^b   Kinoshita, Takashi ^c   Fuse, Miki ^c   Nishikawa, Rika ^c   Goto, Yusuke ^c   Naya, Yukio ^a   Nakagawa, Masayuki ^b   Seki, Naohiko ^c  

^a TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

GOLM1; microRNA; miR 143; miR 145; Prostate cancer; Tumor suppressor

Indexed keywords

GOLGI MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; MICRORNA 143; MICRORNA 145; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER TISSUE; CELL INVASION; CELL MIGRATION; COMPUTER MODEL; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE TARGETING; GOLGI COMPLEX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUCIFERASE ASSAY; PROSTATE CANCER; UPREGULATION;

AGED; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION; HUMANS; MALE; MEMBRANE PROTEINS; MICRORNAS; MIDDLE AGED; MULTIGENE FAMILY; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; RNA, NEOPLASM;

EID: 84896878421     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2013.121     Document Type: Article

References (32)

1. Siegel, R., Naishadham, D. & Jemal, A. Cancer statistics, 2013. CA Cancer J. Clin. 63, 11-30 (2013).
2. Bott, S. R., Birtle, A. J., Taylor, C. J. & Kirby, R. S. Prostate cancer management: 2. An update on locally advanced and metastatic disease. Postgrad. Med. J. 79, 643-645 (2003).
3. Timsit, M. O., Lebret, T. & Mejean, A. Chemotherapy of hormonorefractory and hormonoresistant metastatic prostate cancer. Prog. Urol. 18(Suppl 7), S365-S375 (2008).
4. Carthew, R. W. & Sontheimer, E. J. Origins and mechanisms of miRNAs and siRNAs. Cell 136, 642-655 (2009).
5. Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9, 102-114 (2008).
6. Friedman, R. C., Farh, K. K., Burge, C. B. & Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 10, 92-105 (2009).
7. Hobert, O. Gene regulation by transcription factors and microRNAs. Science 319, 1785-1786 (2008).
8. Iorio, M. V. & Croce, C. M. MicroRNAs in cancer: small molecules with a huge impact. J. Clin. Oncol. 27, 5848-5856 (2009).
9. Fuse, M., Kojima, S., Enokida, H., Chiyomaru, T., Yoshino, H., Nohata, N. et al. Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer. J. Hum. Genet. 57, 691-699 (2012).
10. Kano, M., Seki, N., Kikkawa, N., Fujimura, L., Hoshino, I., Akutsu, Y. et al. miR-145, miR-133a and miR-133b: tumor suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. Int. J. Cancer 127, 2804-2814 (2010).
11. Fuse, M., Nohata, N., Kojima, S., Sakamoto, S., Chiyomaru, T., Kawakami, K. et al. Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1. Int. J. Oncol. 38, 1093-1101 (2011).
12. Huang, S., Guo, W., Tang, Y., Ren, D., Zou, X. & Peng, X. miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells. Oncol. Rep. 28, 1831-1837 (2012).
13. Guo, W., Ren, D., Chen, X., Tu, X., Huang, S., Wang, M. et al. HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145. J. Cell Biochem. 114, 1606-1615 (2013).
14. Kim, H. J., Lv, D., Zhang, Y., Peng, T. & Ma, X. Golgi phosphoprotein 2 in physiology and in diseases. Cell Biosci. 2, 31 (2012).
15. Varambally, S., Laxman, B., Mehra, R., Cao, Q., Dhanasekaran, S. M., Tomlins, S. A. et al. Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer. Neoplasia 10, 1285-1294 (2008).
16. Kristiansen, G., Fritzsche, F. R., Wassermann, K., Jager, C., Tolls, A., Lein, M. et al. GOLPH2 protein expression as a novel tissue biomarker for prostate cancer: implications for tissue-based diagnostics. Br. J. Cancer 99, 939-948 (2008).
17. Li, W., Wang, X., Li, B., Lu, J. & Chen, G. Diagnostic significance of overexpression of Golgi membrane protein 1 in prostate cancer. Urology 80, 952 e1-7 (2012).
18. Yoshino, H., Chiyomaru, T., Enokida, H., Kawakami, K., Tatarano, S., Nishiyama, K. et al. The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. Br. J. Cancer 104, 808-818 (2011).
19. Nohata, N., Hanazawa, T., Kikkawa, N., Sakurai, D., Fujimura, L., Chiyomaru, T. et al. Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. Br. J. Cancer 105, 833-841 (2011).
20. Brase, J. C., Johannes, M., Mannsperger, H., Falth, M., Metzger, J., Kacprzyk, L. A. et al. TMPRSS-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-b signaling. BMC Cancer 11, 507 (2011).
21. Kojima, S., Chiyomaru, T., Kawakami, K., Yoshino, H., Enokida, H., Nohata, N. et al. Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. Br. J. Cancer 106, 405-413 (2012).
22. Jain, A. K., Allton, K., Iacovino, M., Mahen, E., Milczarek, R. J., Zwaka, T. P. et al. p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol. 10, e1001268 (2012).
23. Sachdeva, M., Zhu, S., Wu, F., Wu, H., Walia, V., Kumar, S. et al. p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc. Natl Acad. Sci. USA 106, 3207-3212 (2009).
24. Kent, O. A., Chivukula, R. R., Mullendore, M., Wentzel, E. A., Feldmann, G., Lee, K. H. et al. Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. Genes Dev. 24, 2754-2759 (2010).
25. Sachdeva, M. & Mo, Y. Y. miR-145-mediated suppression of cell growth, invasion and metastasis. Am. J. Transl. Res. 2, 170-180 (2010).
26. Yoshino, H., Seki, N., Itesako, T., Chiyomaru, T., Nakagawa, M. & Enokida, H. Abberant expression of microRNAs in bladder cancer. Nat. Rev. Urol. 10, 396-404 (2013).
27. Yoshino, H., Enokida, H., Itesako, T., Kojima, S., Kinoshita, T., Tatarano, S. et al. The tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma. Cancer Sci. doi:10.1111/cas.12282 (2013).
28. Zhang, F., Gu, Y., Li, X., Wang, W., He, J. & Peng, T. Up-regulated Golgi phosphoprotein 2 (GOLPH2) expression in lung adenocarcinoma tissue. Clin. Biochem. 43, 983-991 (2010).
29. Bachert, C., Fimmel, C. & Linstedt, A.D. Endosomal trafficking and proprotein convertase cleavage of cis Golgi protein GP73 produces marker for hepatocellular carcinoma. Traffic 8, 1415-1423 (2007).
30. Kladney, R. D., Bulla, G. A., Guo, L., Mason, A. L., Tollefson, A. E., Simon, D. J. et al. GP73, a novel Golgi-localized protein upregulated by viral infection. Gene 249, 53-65 (2000).
31. Migita, T. & Inoue, S. Implications of the Golgi apparatus in prostate cancer. Int. J. Biochem. Cell Biol. 44, 1872-1876 (2012).
32. Millarte, V. & Farhan, H. The Golgi in cell migration: regulation by signal transduction and its implications for cancer cell metastasis. ScientificWorldJournal 2012, 498278 (2012).