Wistar-Zagreb 5HT rats: A rodent model with constitutional upregulation/downregulation of serotonin transporter

Experimental Models in Serotonin Transporter Research

Volumn , Issue , 2010, Pages 214-243

  Cicin Sain, Lipa ^a   Jernej, Branimir ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84927093120     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511729935.008     Document Type: Chapter

References (114)

1. Lesch K P, Mossner R (2006). Inactivation of 5HT transport in mice: modelling altered 5HT homeostasis implicated in emotional dysfunction, affective disorders and somatic syndromes. Handb Exp Pharmacol 175: 417-56.
2. Murphy D L, Lesch K P (2008). Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 9: 85-96.
3. Fox M A, Andrews A M, Wendland J R, Lesch K P, Holmes A, Murphy D L (2007a). A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology 195: 147-66.
4. Berger M, Tecott L H (2006). Serotonin system gene knockouts. In Roth B L, editor. The serotonin receptors: from molecular pharmacology to human therapeutics. Totowa: Humana Press, pp. 537-75.
5. Bechtholt A, Lucki I (2006). Effects of serotonin-related gene deletion on measures of anxiety, depression and neurotransmission. In Roth B L, editor. The serotonin receptors: from molecular pharmacology to human therapeutics. Totowa: Humana Press, pp. 577-606.
6. Shih J C (2004). Cloning, after cloning, knock-out mice and physiological functions of MAO A and B. Neurotoxicology 25: 21-30.
7. Fernandez F, Sarre S, Launay J M, et al. (2003). Rat strain differences in peripheral and central serotonin transporter protein expression and function. Eur J Neurosci 17: 494-506.
8. Calcagno E, Cannetta A, Guzzetti S, Cervo L, Ivernizzi R W (2007). Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity. J Neurochem 103: 1111-20.
9. Van der Staay F J (2006). Animal models of behavioural dysfunctions: basic concepts and classifications, and an evaluation strategy. Brain Res Rev 52: 131-59.
10. Singewald N (2007). Altered brain activity processing in high-anxiety rodents revealed by challenge paradigms in functional mapping. Neurosci Biobehav Rev 31: 18-40.
11. Nestler E J, Gould E, Manji H, et al. (2002). Preclinical models: status of basic research in depression. Biol Psychiatry 52: 503-28.
12. Crabbe J C (2002). Alcohol and genetics: new models. Am J Med Genet 114: 969-74.
13. Pletscher A (1968). Metabolism, transfer and storage of 5HT in blood platelets. Br J Pharmacol 32: 1-16.
14. Stahl S M, Meltzer H Y (1978). A kinetic and pharmacologic analysis of 5-hydroxytryptamine transport by human platelets and platelet storage granules: comparison with central serotonergic neurons. J Pharmacol Exp Ther 205: 118-32.
15. Chen K, Wu H F, Shih J C (1993). The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical. J Neurochem 61: 187-90.
16. Cook E H, Fletcher K E, Wainwright M, Marks N, Yan S Y, Leventhal B L (1994). Primary structure of the human platelet serotonin 5HT2A receptor: identity with the frontal cortex serotonin 5HT2A receptor. J Neurochem 63: 465-9.
17. Lesch K P, Wolozin B L, Murphy D L, Riederer P (1993). Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 60: 2319-21.
18. Pletscher A (1988). Platelets as models: use and limitations. Experientia 44: 152-5.
19. Hrdina P D (1994). Platelet serotonergic markers in psychiatric disorders: use, abuse and limitations. J Psychiatry Neurosci 19: 87-90.
20. Jernej B (1995). Platelet versus neuron: a glimpse from serotonergic perspective. Period Biol 97: 183-90.
21. Camacho A, Dimsdale J E (2000). Platelets and psychiatry: lessons learned from old and new studies. Psychosom Med 62: 326-36.
22. Jernej B, Cicin-Sain L, Iskric S (1988). A simple and reliable method for monitoring platelet serotonin levels in rats. Life Sci 43: 1663-70.
23. Jernej B, Froebe A, Hranilovic D, Cicin-Sain L (1999a). Platelet serotonin transporter: ex vivo monitoring of kinetic parameters in the individual rat. Neurosci Res Comm 24: 163-72.
24. Jernej B, Cicin-Sain L, Kveder S (1989). Physiological characteristics of platelet serotonin in rats. Life Sci 45: 485-92.
25. Cicin-Sain L, Jernej B, Magnus V (1989). Platelet serotonin levels and gonadal hormones in rats. Life Sci 45: 1885-92.
26. Cicin-Sain L, Froebe A, Jernej B (1998). Physiological characteristics of serotonin transporter on rat platelets. Comp Biochem Phys A 120: 723-9.
27. Jernej B, Cicin-Sain L (1990). Platelet serotonin level in rats is under genetic control. Psychiat Res 32: 167-74.
28. Cicin-Sain L, Perovic S, Iskric S, Jernej B (1995). Development of sublines of Wistar-derived rats with high or low platelet serotonin level. Period Biol 97: 211-16.
29. Cicin-Sain L, Froebe A, Bordukalo-Niksic T, Jernej B (2005). Serotonin transporter kinetics in rats selected for extreme values of platelet serotonin level. Life Sci 77: 452-61.
30. Hranilovic D, Herak-Kramberger C, Cicin-Sain L, Sabolic I, Jernej B (2001). Serotonin transporter in rat platelets: level of protein expression underlies inherited differences in uptake kinetics. Life Sci 69: 59-65.
31. Bordukalo-Niksic T, Cicin-Sain L, Jernej B (2004). Expression of brain and platelet serotonin transporters in sublines of rats with constitutionally altered serotonin homeostasis. Neurosci Lett 369: 44-9.
32. Jernej B, Hranilovic D, Cicin-Sain L (1999b). Serotonin transporter on rat platelets: level of mRNA underlie inherited differences in uptake kinetics. Neurochem Int 33: 519-23.
33. Anderson G M, Stevenson J M, Cohen D J (1987). Steady-state model for plasma-free and platelet serotonin in man. Life Sci 41: 1777-85.
34. Fozard J R (1989). The peripheral actions of 5-hydroxytryptamine. New York: Oxford University Press.
35. Dube F, Amireault P (2007). Local serotonergic signaling in mammalian follicles, oocytes and early embrios. Life Sci 81: 1627-37.
36. Hull E M, Muschamp J W, Sato S (2004). Dopamine and serotonin: influences on male sexual behavior. Physiol Behav 83: 291-307.
37. Gershon M D, Tack J (2007). The serotonin signalling system: from basic understanding to drug development for functional GI disorders. Gastroenten- terology 132: 397-414.
38. Watts S W (2005). 5-HT in systemic hypertension: foe, friend or fantasy? Clin Sci (Lond.) 108: 399-412.
39. Blakely R D (2001). Physiological genomics of antidepressant targets: keeping periphery in mind. J Neurosci 21: 8319-23.
40. Murphy D L, Lerner A, Rudnick G, Lesch K P (2004). Serotonin transporter: gene, genetic disorders and pharmacogenetics. Mol Interv 4: 109-23.
41. Cicin-Sain L, Oreskovic D, Perovic S, Jernej B, Iskric S (1990). Determination of serotonin in peripheral rat tissues by ion-exchange chromatography-fluoro- metry. Validation by high performance liquid chromatography with electrochemical detection. Biogen Amines 7: 641-50.
42. Ortiz J, Artigas F (1992). Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine. Br J Pharmacol 105: 941-6.
43. Mekontso-Dessap A, Brouri F, Pascal O, et al. (2006). Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulo- pathy in mice. Circulation 113: 81-9.
44. Guignabert C, Izikki M, Tu L I, et al. (2006). Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Circ Res 98: 1323-30.
45. Janusonis S, Anderson G M, Shifrovich I, Rakic P (2006). Ontogeny of brain and blood serotonin levels in 5-HT1A receptor knockout mice: potential relevance to the neurobiology of autism. J Neurochem 99: 1019-31.
46. Cicin-Sain L, Froebe A, Jernej B (1996). The effect of antidepressants on platelet serotonin level and serotonin uptake in rats genetically selected for these traits. Eur Neuropsychopharm 6 (Suppl. 4): 76-7.
47. Binder E B, Holsboer F (2006). Pharmacogenomics and antidepressant drugs. Ann Med 38: 82-94.
48. Serretti A, Benedetti F, Zanardi R, Smeraldi E (2005). The influence of serotonin transporter promoter polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Prog Neuropsychopharmacol Biol Psychiatry 29: 1074-84.
49. Lesch K P, Gutknecht L (2005). Pharmacogenetics of the serotonin transporter. Prog Neuropsychopharmacol Biol Psychiatry 29: 1062-73.
50. Lesch K P, Mossner R (1998). Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental and neurodegenerative disorders. Biol Psychiatry 44: 179-92.
51. Jernej B, Cicin-Sain L, Banovic M (1994). Platelet aggregation in rats genetically selected for high or low platelet serotonin levels. Can J Physiol Pharmacol 72 (Suppl. 1): 10.
52. De Clerck F, de Chaffoy, de Courcelles D (1990). Serotonergic amplification in platelet function: mechanisms and in vivo relevance. In Progress in pharmacology and clinical pharmacology 7/4. Stuttgart: Gustav Fischer Verlag, pp. 51-9.
53. Froebe A, Cicin-Sain L, Jernej B (1997). Intracellular calcium in platelets of rats with genetically altered serotonin system. Period Biol 99 (Suppl. 1): 85.
54. Froebe A (2006). Serotonin-2A receptor and its signaling: studies in rats with altered serotonergic homeostasis. PhD Thesis, University of Zagreb, pp. 1-83.
55. Vanhoutte P M (1985). Serotonin and the cardiovascular system. New York: Raven Press.
56. Vorchheimer D A, Becker R (2006). Platelets in atherothrombosis. Mayo Clin Proc 81: 59-68.
57. Hegedis K (2001). Serotonin transporter: kinetic studies in rat cerebral cortex. MSc Thesis, University of Zagreb, pp. 1-61.
58. Perez X A, Bianco L E, Andrews A M (2006). Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: comparison with chrono- amperometry in SERT knockout mice. J Neurosci Methods 154: 245-55.
59. Bengel D, Murphy D L, Andrews A, et al. (1998). Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylendioxymethamphetamine (“ecstasy”) in serotonin transporter-deficient mice. Mol Pharmacol 53: 649-55.
60. Perez X A, Andrews A M (2005). Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Anal Chem 77: 818-26.
61. Homberg J R, Olivier J D A, Smits B M G, et al. (2007). Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience 146: 1662-76.
62. Romero L, Jernej B, Bel N, Cicin-Sain L, Cortes R, Artigas F (1998). Basal and stimulated extracellular serotonin concentration in the brain of rats with altered serotonin uptake. Synapse 28: 313-21.
63. Jayanthi L D, Ramamoorthy S (2005). Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. Am Ass Pharmaceut Sci J 7: E728-38.
64. Zahniser N R, Doolen S (2001). Chronic and acute regulation of Na+/Cl-- dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. Pharmacol Ther 92: 21-55.
65. Bokulic Z, Cicin-Sain L, Jernej B (2003). Wistar-Zagreb 5HT rats: study of serotonergic activity in brain regions. Neurol Croat 52 (Suppl.): 91.
66. Kim D K, Tolliver T J, Huang S J, et al. (2005). Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 49: 798-810.
67. Zhao S, Edwards J, Carroll J, et al. (2006). Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion- related behaviors in mice. Neuroscience 140: 321-34.
68. Stefulj J (2005). Tryptophan hydroxylase: polymorphism and expression of the gene in altered serotonergic homeostasis. PhD Thesis, University of Zagreb, pp. 1-76.
69. Montanez S, Owens W A, Gould G G, Murphy D L, Daws L C (2003). Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J Neurochem 86: 210-9.
70. Mathews T A, Fedele D E, Coppelli F M, Avila A M, Murphy D L, Andrews A M (2004). Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods 140: 169-81.
71. Fabre V, Beaufour C, Evrard A, et al. (2000). Altered expression and function of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5HT transporter. Eur J Neurosci 12: 2299-310.
72. Jennings KA, Loder M K, Sheward WJ, et al. (2006). Increased expression of the 5HT transporter confers a low-anxiety phenotype linked to decreased 5HT transmission. J Neurosci 26: 8955-64.
73. Wagstaff AJ, Ormrod D, Spencer C M (2001). Tianeptine: a review of its use in depressive disorders. CNS Drugs 15: 231-59.
74. Hariri A R, Holmes A (2006). Genetics of emotional regulation: the role of the serotonin transporter in neuronal function. Trends Cogn Sci 10: 182-91.
75. Li Q, Wichems C H, Ma L, Van de Kar L D, Garcia F, Murphy D L (2003). Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice. J Neurochem 84: 1256-65.
76. Rioux A, Fabre V, Lesch K P, et al. (1999). Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter. Neurosci Lett 262: 113-6.
77. Bordukalo-Niksic T, Mokrovic G, Jernej B, Cicin-Sain L (2007). Expression of 5HT-1A and 5HT-1B receptor genes in brains of Wistar-Zagreb 5HT rats. Coll Antropol 31: 37-41.
78. Bordukalo-Niksic T (2003). Gene expression of 5HT-synaptic elements in brain of rats with altered serotonin homeostasis. MSc Thesis, University of Zagreb, pp. 1-73.
79. Froebe A, Cicin-Sain L, Bordukalo-Niksic T, Jernej B (2007). Serotonin-2A receptors and its signal transduction in brains and platelets of Wistar-Zagreb 5HT rats. Neurol Croat 56 (Suppl. 2): 7.
80. Isbister G K, Buckley N A (2005). The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment. Clin Neuro- pharmacol 28: 205-14.
81. Kalueff A V, LaPorte J, Murphy D L (2007b). Perspectives on genetic animal models of serotonin toxicity. Neurochem Int 52: 649-58.
82. Fox M A, Jensen C L, Gallagher P S, Murphy D L (2007b). Receptor mediation of exaggerated response to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice. Neuropharmacology 53: 643-56.
83. Van Oekelen D, Megens A, Meert T, Luyten W H, Leysen J E (2002). Role of 5HT2 receptors in the tryptamine-induced 5HT syndrome in rats. Behav Pharmacol 13: 313-8.
84. Nisijima K, Yoshino T, Yui K, Katoh S (2001). Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain Res 890: 23-31.
85. Briley M, Chopin P (1991). Serotonin in anxiety: evidence from animal models. In Sandler M, Coppen A, Harnett S, editors. 5-Hydroxytryptamine in psychiatry: a spectrum of ideas. New York: Oxford University Press, pp. 177-97.
86. Lesch K P, Zeng Y, Reif A, Gutknecht L (2003). Anxiety-related traits in mice with modified genes of the serotonergic pathway. Eur J Phamacol 480: 185-204.
87. Holmes A, Li Q, Murphy D L, Gold E, Crawley J N (2003). Abnormal anxiety related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav 2: 365-80.
88. Hranilovic D, Cicin-Sain L, Bordukalo-Niksic T, Jernej B (2005). Rats with constitutionally upregulated/downregulated platelet 5HT transporter: differences in anxiety-related behavior. Behav Brain Res 165: 271-7.
89. Quevedo G, Moscoso O, Prado-Moreno A, Cicin-Sain L, Jernej B, Delgado- Garcia J M (2002). Behavioral and molecular studies in rats over-expressing and under-expressing serotonin transporter. COST B10: Brain Damage Repair, 11th Committee Meeting, Dublin, Abstract book, p. 15.
90. Ansorge M S, Zhou M, Lira A, Hen R, Gingrich J A (2004). Early-life blockade of the 5HT transporter alters emotional behavior in adult mice. Science 306: 879-81.
91. Kalueff A V, Fox M A, Gallagher P S, Murphy D L (2007a). Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. Gen Brain Behav 6: 389-400.
92. Mann J (1999). Role of serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 21: 99S-105S.
93. Ordway G A, Klimek V, Mann J J (2002). Neurocircuitry of mood disorders. In Davis K L, Charney D, Coyle J T, Nemeroff C, editors. Neuropsychopharmacology - the fifth generation of progress. Philadelphia: Lippincott, Williams and Wilkins, pp. 1051-64.
94. Blier P, de Montigny C (1994). Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15: 220-6.
95. Ressler K J, Nemeroff C B (2000). Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12: 2-19.
96. Kalueff A V, Tuohimaa P (2004). Experimental modelling of anxiety and depression. Acta Neurobiol Exp 64: 439-48.
97. Cryan J F, Markou A, Lucki I (2002). Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23: 238-45.
98. Detke M J, Rickels M, Lucki I (1995). Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 121: 66-72.
99. Reneric J P, Bouvard M, Stinus L (2002). In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments, may produce greater effects than selective drugs. Behav Brain Res 136: 521-32.
100. Lira A, Zhou M, Castanon N, et al. (2003). Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter deficient mice. Biol Psychiatry 54: 960-71.
101. Holmes A, Yang R J, Murphy D L, Crawley J N (2002). Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology 27: 914-23.
102. Kalueff A V, Gallagher P S, Murphy D L (2006). Are serotonin transporter knockout mice depressed? Hypoactivity but no anhedonia. Neuroreport 17: 1347-51.
103. Olivier J D A, Van der Hart M G C, Van Swelm R P L, et al. (2008). A study in male and female 5HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience 152: 573-84.
104. LeMarquand D, Phil R O, Benkelfat C (1994b). Serotonin and alcohol intake, abuse and dependence: findings of animal studies. Biol Psychiatry 36: 395-421.
105. LeMarquand D, Phil R O, Benkelfat C (1994a). Serotonin and alcohol intake, abuse and dependence: clinical evidence. Biol Psychiatry 36: 326-37.
106. Lesch K P (2005). Alcohol dependence and gene x environment interaction in emotion regulation: is serotonin the link? Eur J Pharmacol 526: 113-24.
107. Cicin-Sain L, Bordukalo-Niksic T, Jernej B (2004). Wistar-Zagreb 5HT rats: a new animal model of alcoholism. Alcoholism 40 (Suppl. 3): 92-3.
108. McBride W J, Li T K (1998). Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol 12: 339-69.
109. Mokrovic G, Cicin-Sain L (2006). Chronic ethanol intake and brain monoamine oxidase A and B in rats with constitutionally altered serotonin homeostasis. 5th Forum of European Neuroscience, Vienna, book of abstracts, A165.19.
110. Kelai S, Aissi F, Lesch K P, Cohen-Salmon C, Hamon M, Lanfumey L (2003). Alcohol intake after serotonin transporter inactivation in mice. Alcohol Alcohol 38: 386-9.
111. Boyce-Rustay J M, Wiedholz L M, Millstein R A, et al. (2006). Ethanol-related behaviors in serotonin transporter knockout mice. Alcohol Clin Exp Res 30: 1957-65.
112. Gabrilovac J, Cicin-Sain L, Osmak M, Jernej B (1992). Alteration of NK- and ADCC-activities in rats genetically selected for low or high platelet serotonin level. J Neuroimmunol 37: 213-22.
113. Poljak-Blazi M, Jernej B, Cicin-Sain L, Boranic M (1990). Immunological response of rats selected for high or low platelet serotonin content. Period Biol 92: 189-90.
114. Djurkovic M, Tvrdeic A, Cicin-Sain L, Jernej B, Birus I (2004). Pain sensitivity in Wistar and Wistar-Zagreb 5HT rats: the effect of habituation to experimental conditions. Fourth Croatian Congress of Pharmacology, Split, book of abstracts, p. 78.