Tumor-induced CD11b+ Gr-1+ myeloid-derived suppressor cells exacerbate immune-mediated hepatitis in mice in a CD40-dependent manner

European Journal of Immunology

Volumn 45, Issue 4, 2015, Pages 1148-1158

  Kapanadze, Tamar ^a,b   Medina Echeverz, José ^a   Gamrekelashvili, Jaba ^a,b   Weiss, Jonathan M ^a   Wiltrout, Robert H ^a   Kapoor, Veena ^c   Hawk, Nga ^c   Terabe, Masaki ^a   Berzofsky, Jay A ^a   Manns, Michael P ^b   Wang, Ena ^c,d   Marincola, Francesco M ^c,d   Korangy, Firouzeh ^a   Greten, Tim F ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

Author keywords

CD40; Concanavalin A; Immune mediated hepatitis; Myeloid derived suppressor cells; Reactive oxygen species; Galactosylceramide

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA GALACTOSYLCERAMIDE; ARGINASE; ASPARTATE AMINOTRANSFERASE; B7 ANTIGEN; CD1D ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CONCANAVALIN A; FLUOROURACIL; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; ALPHA-GALACTOSYLCERAMIDE; CD11B ANTIGEN; CD1D ANTIGEN, MOUSE; CD86 PROTEIN, MOUSE; CHEMOKINE RECEPTOR; GALACTOSYLCERAMIDE; GR-1 PROTEIN, MOUSE; MITOGENIC AGENT;

ADOPTIVE TRANSFER; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BONE MARROW CELL; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HEPATITIS; IMMUNE MEDIATED HEPATITIS; IMMUNOPATHOLOGY; IN VITRO STUDY; LIVER INJURY; LIVER TOXICITY; LIVER TUMOR; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPPRESSOR CELL; TUMOR GROWTH; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CELL LINE; CYTOLOGY; GENETICS; IMMUNOLOGY; INJURIES; KNOCKOUT MOUSE; LIVER; LIVER CELL; METABOLISM; PATHOLOGY; TRANSPLANTATION;

ADOPTIVE TRANSFER; ALANINE TRANSAMINASE; ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD1D; ANTIGENS, CD40; ANTIGENS, CD80; ANTIGENS, CD86; ARGINASE; ASPARTATE AMINOTRANSFERASES; CELL LINE; CONCANAVALIN A; FEMALE; GALACTOSYLCERAMIDES; HEPATITIS; HEPATOCYTES; LIVER; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGENS; MYELOID CELLS; REACTIVE OXYGEN SPECIES; RECEPTORS, CHEMOKINE;

EID: 84927066226     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445093     Document Type: Article

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