Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice

Journal of Leukocyte Biology

Volumn 92, Issue 6, 2012, Pages 1199-1206

  Ma, Chi ^a   Kapanadze, Tamar ^a,b   Gamrekelashvili, Jaba ^a,b   Manns, Michael P ^b   Korangy, Firouzeh ^a   Greten, Tim F ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Inflammatory neutrophils; Liver; MDSC; RB6 8C5; Tolerance

Indexed keywords

CD11B ANTIGEN; IMMUNOSUPPRESSIVE AGENT; LIPOCORTIN 5; RB6 8C5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; BONE MARROW CELL; CELL DEATH; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLON TUMOR; CONTROLLED STUDY; DRUG ELIMINATION; FEMALE; FLOW CYTOMETRY; LIVER CELL; MELANOMA; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SUPPRESSOR CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL DEATH; CELL LINE; CELL MOVEMENT; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSION; LEUKOCYTE REDUCTION PROCEDURES; LIVER; MICE; MYELOID CELLS; NEOPLASMS; PROTEIN BINDING; RECEPTORS, CHEMOKINE; SPLEEN;

MUS;

EID: 84870429906     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0212059     Document Type: Article

References (37)

1. Gabrilovich, D. I., Nagaraj, S. (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174.
2. Chen, S., Akbar, S. M., Abe, M., Hiasa, Y., Onji, M. (2011) Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus. Clin. Exp. Immunol. 166, 134-142.
3. Hegde, V. L., Nagarkatti, P. S., Nagarkatti, M. (2011) Role of myeloidderived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol. PLoS One 6, e18281.
4. Haile, L. A., von Wasielewski, R., Gamrekelashvili, J., Kruger, C., Bachmann, O., Westendorf, A. M., Buer, J., Liblau, R., Manns, M. P., Korangy, F., Greten, T. F. (2008) Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology 135, 871-881, 881.e1-881.e5.
5. Haile, L. A., Gamrekelashvili, J., Manns, M. P., Korangy, F., Greten, T. F. (2010) CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice. J. Immunol. 185, 203-10.
6. Greten, T. F., Manns, M. P., Korangy, F. (2011) Myeloid derived suppressor cells in human diseases. Int. Immunopharmacol. 11, 802-807.
7. Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., Gabrilovich, D. I. (2001) Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J. Immunol. 166, 678-689.
8. Pak, A. S., Wright, M. A., Matthews, J. P., Collins, S. L., Petruzzelli, G. J., Young, M. R. (1995) Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor. Clin. Cancer Res. 1, 95-103.
9. Young, M. R., Newby, M., Wepsic, H. T. (1987) Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors. Cancer Res. 47, 100-105.
10. Bronte, V., Mocellin, S. (2009) Suppressive influences in the immune response to cancer. J. Immunother. 32, 1-11.
11. Hoechst, B., Voigtlaender, T., Ormandy, L., Gamrekelashvili, J., Zhao, F., Wedemeyer, H., Lehner, F., Manns, M. P., Greten, T. F., Korangy, F. (2009) Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor. Hepatology 50, 799-807.
12. Hoechst, B., Ormandy, L. A., Ballmaier, M., Lehner, F., Kruger, C., Manns, M. P., Greten, T. F., Korangy, F. (2008) A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells. Gastroenterology 135, 234-243.
13. Sinha, P., Clements, V. K., Bunt, S. K., Albelda, S. M., Ostrand-Rosenberg, S. (2007) Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J. Immunol. 179, 977-983.
14. Ugel, S., Delpozzo, F., Desantis, G., Papalini, F., Simonato, F., Sonda, N., Zilio, S., Bronte, V. (2009) Therapeutic targeting of myeloid-derived suppressor cells. Curr. Opin. Pharmacol. 9, 470-481.
15. Hu, C. E., Gan, J., Zhang, R. D., Cheng, Y. R., Huang, G. J. (2011) Upregulated myeloid-derived suppressor cell contributes to hepatocellular carcinoma development by impairing dendritic cell function. Scand. J. Gastroenterol. 46, 156-164.
16. Li, H., Han, Y., Guo, Q., Zhang, M., Cao, X. (2009) Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-β 1. J. Immunol. 182, 240-249.
17. Younos, I., Donkor, M., Hoke, T., Dafferner, A., Samson, H., Westphal, S., Talmadge, J. (2011) Tumor- and organ-dependent infiltration by myeloid- derived suppressor cells. Int. Immunopharmacol. 11, 816-826.
18. Ilkovitch, D., Lopez, D. M. (2009) The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression. Cancer Res. 69, 5514-5521.
19. Connolly, M. K., Mallen-St Clair, J., Bedrosian, A. S., Malhotra, A., Vera, V., Ibrahim, J., Henning, J., Pachter, H. L., Bar-Sagi, D., Frey, A. B., Miller, G. (2010) Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra- abdominal tumor. J. Leukoc. Biol. 87, 713-725.
20. Cheng, L., Wang, J., Li, X., Xing, Q., Du, P., Su, L., Wang, S. (2011) Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cell-mediated liver injury in mice. PLoS One 6, e17631.
21. Lee, J. M., Seo, J. H., Kim, Y. J., Kim, Y. S., Ko, H. J., Kang, C. Y. (2010) Agonistic anti-CD137 monoclonal antibody treatment induces CD11bGr-1 myeloid-derived suppressor cells. Immune Netw. 10, 104-108.
22. Bonder, C. S., Ajuebor, M. N., Zbytnuik, L. D., Kubes, P., Swain, M. G. (2004) Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J. Immunol. 172, 45-53.
23. Hatada, S., Ohta, T., Shiratsuchi, Y., Hatano, M., Kobayashi, Y. (2005) A novel accessory role of neutrophils in concanavalin A-induced hepatitis. Cell. Immunol. 233, 23-29.
24. Malchow, S., Thaiss, W., Janner, N., Waetzig, G. H., Gewiese-Rabsch, J., Garbers, C., Yamamoto, K., Rose-John, S., Scheller, J. (2011) Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling. Biochim. Biophys. Acta 1812, 290-301.
25. Suzuki, E., Kapoor, V., Jassar, A. S., Kaiser, L. R., Albelda, S. M. (2005) Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin. Cancer Res. 11, 6713-6721.
26. Vincent, J., Mignot, G., Chalmin, F., Ladoire, S., Bruchard, M., Chevriaux, A., Martin, F., Apetoh, L., Rebe, C., Ghiringhelli, F. (2010) 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. 70, 3052-3061.
27. Ko, J. S., Zea, A. H., Rini, B. I., Ireland, J. L., Elson, P., Cohen, P., Golshayan, A., Rayman, P. A., Wood, L., Garcia, J., Dreicer, R., Bukowski, R., Finke, J. H. (2009) Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 15, 2148-2157.
28. Liu, Z. X., Han, D., Gunawan, B., Kaplowitz, N. (2006) Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology 43, 1220-1230.
29. Xia, S., Sha, H., Yang, L., Ji, Y., Ostrand-Rosenberg, S., Qi, L. (2011) Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity. J. Biol. Chem. 286, 23591-23599.
30. Nausch, N., Galani, I. E., Schlecker, E., Cerwenka, A. (2008) Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells. Blood 112, 4080-4089.
31. Apetoh, L., Vegran, F., Ladoire, S., Ghiringhelli, F. (2011) Restoration of antitumor immunity through selective inhibition of myeloid derived suppressor cells by anticancer therapies. Curr. Mol. Med. 11, 365-372.
32. Dugast, A. S., Haudebourg, T., Coulon, F., Heslan, M., Haspot, F., Poirier, N., Vuillefroy de Silly, R., Usal, C., Smit, H., Martinet, B., Thebault, P., Renaudin, K., Vanhove, B. (2008) Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion. J. Immunol. 180, 7898-7906.
33. Ochoa, A. C., Zea, A. H., Hernandez, C., Rodriguez, P. C. (2007) Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. Clin. Cancer Res. 13, 721s-726s.
34. Huang, B., Lei, Z., Zhao, J., Gong, W., Liu, J., Chen, Z., Liu, Y., Li, D., Yuan, Y., Zhang, G. M., Feng, Z. H. (2007) CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett. 252, 86-92.
35. Obstfeld, A. E., Sugaru, E., Thearle, M., Francisco, A. M., Gayet, C., Ginsberg, H. N., Ables, E. V., Ferrante A. W., Jr., (2010) C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 59, 916-925.
36. Sander, L. E., Sackett, S. D., Dierssen, U., Beraza, N., Linke, R. P., Muller, M., Blander, J. M., Tacke, F., Trautwein, C. (2010) Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J. Exp. Med. 207, 1453-1464.
37. Ribechini, E., Leenen, P. J., Lutz, M. B. (2009) Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid- derived suppressor cell activity in BM cells. Eur. J. Immunol. 39, 3538-3551.