Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 46, 2009, Pages 19455-19460

  Weiss, Jonathan M ^a   Back, Timothy C ^a   Scarzello, Anthony J ^a   Subleski, Jeff J ^a   Hall, Veronica L ^a   Stauffer, Jimmy K ^a   Chen, Xin ^a   Micic, Dejan ^a   Alderson, Kory ^b   Murphy, William J ^b   Wiltrout, Robert H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CD40; Chemokines; Tumor immunotherapy

Indexed keywords

CD4 ANTIGEN; CD40 ANTIBODY; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; GAMMA INTERFERON; INTERLEUKIN 2; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 15; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; ANTIBODY; ARGINASE; BETA CHEMOKINE; CCL9 PROTEIN, MOUSE; CCR2 PROTEIN, MOUSE; CD40 ANTIGEN; CXCL9 CHEMOKINE; CXCL9 PROTEIN, MOUSE; CYTOKINE RECEPTOR; IP10 MIG RECEPTOR; IP10-MIG RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN; RANTES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENTIATION; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN; TUMOR ASSOCIATED LEUKOCYTE; TUMOR REGRESSION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; GENETICS; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; METHODOLOGY; NEOPLASM;

MUS;

ANIMALS; ANTIBODIES; ANTIGENS, CD40; ARGINASE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL5; CHEMOKINE CXCL9; CHEMOKINES; CHEMOKINES, CC; DRUG SYNERGISM; IMMUNOSUPPRESSION; INTERLEUKIN-2; LYMPHOCYTES, TUMOR-INFILTRATING; MACROPHAGE INFLAMMATORY PROTEINS; MICE; MICE, INBRED BALB C; NEOPLASMS; RECEPTORS, CCR2; RECEPTORS, CYTOKINE;

EID: 73349133743     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909474106     Document Type: Article

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