Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma

Immunology

Volumn 128, Issue 1, 2009, Pages 141-149

  Zhao, Fei ^a   Obermann, Sonja ^a   Von Wasielewski, Reinhard ^b   Haile, Lydia ^a   Manns, Michael P ^a   Korangy, Firouzeh ^a   Greten, Tim F ^a  

^a INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^b Gynäkologie Humangenetik und Pathologie ^*  (Germany)

Author keywords

Immune suppressor mechanisms; Immunotherapy; Myeloid derived suppressor cell; T cell; Tumour immunology

Indexed keywords

ARGINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; LYMPH NODE; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PANCREAS; PANCREAS CARCINOMA; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE;

ADENOCARCINOMA; ANIMALS; ANTIGENS, CD11B; ARGINASE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELOID CELLS; NEOPLASM TRANSPLANTATION; PANCREAS; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS; SPLEEN;

EID: 68249113734     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03105.x     Document Type: Article

References (22)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer Statistics, 2008. CA Cancer J Clin 2008 58 : 71 96.
2. Laheru D, Jaffee EM. Immunotherapy for pancreatic cancer - science driving clinical progress. Nat Rev 2005 5 : 459 67.
3. Garbe AI, Vermeer B, Gamrekelashvili J et al. Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses. Cancer Res 2006 66 : 508 16.
4. Wagner M, Greten FR, Weber CK et al. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev 2001 15 : 286 93.
5. Wagner M, Luhrs H, Kloppel G, Adler G, Schmid RM. Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice. Gastroenterology 1998 115 : 1254 62.
6. Hruban RH, Adsay NV, Albores-Saavedra J et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 2006 66 : 95 106.
7. Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007 117 : 1137 46.
8. Marigo I, Dolcetti L, Serafini P, Zanovello P, Bronte V. Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol Rev 2008 222 : 162 79.
9. Serafini P, Borrello I, Bronte V. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 2006 16 : 53 65.
10. Sinha P, Clements VK, Ostrand-Rosenberg S. Reduction of myeloid-derived suppressor cells and induction of m1 macrophages facilitate the rejection of established metastatic disease. J Immunol 2005 174 : 636 45.
11. Movahedi K, Guilliams M, Van den Bossche J, Van den Bergh R, Gysemans C, Beschin A, De Baetselier P, Van Ginderachter JA. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T-cell suppressive activity. Blood 2008 111 : 4233 44.
12. Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 2008 181 : 5791 802.
13. Gallina G, Dolcetti L, Serafini P et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 2006 116 : 2777 90.
14. Ostrand-Rosenberg S. Animal models of tumor immunity, immunotherapy and cancer vaccines. Curr Opin Immunol 2004 16 : 143 50.
15. Rabinovich GA, Gabrilovich D, Sotomayor EM. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 2007 25 : 267 96.
16. Lyman MA, Aung S, Biggs JA, Sherman LA. A spontaneously arising pancreatic tumor does not promote the differentiation of naive CD8+ T lymphocytes into effector CTL. J Immunol 2004 172 : 6558 67.
17. Melani C, Chiodoni C, Forni G, Colombo MP. Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB\c mice suppresses immune reactivity. Blood 2003 102 : 2138 45.
18. Clark CE, Hingorani SR, Mick R, Combs C, Tuveson DA, Vonderheide RH. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res 2007 67 : 9518 27.
19. Tinder TL, Subramani DB, Basu GD, Bradley JM, Schettini J, Million A, Skaar T, Mukherjee P. MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma. J Immunol 2008 181 : 3116 25.
20. Mukherjee P, Basu GD, Tinder TL, Subramani DB, Bradley JM, Arefayene M, Skaar T, De Petris G. Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition. J Immunol 2009 182 : 216 24.
21. Cheng P, Corzo CA, Luetteke N et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008 205 : 2235 49.
22. Greten FR, Weber CK, Greten TF, Schneider G, Wagner M, Adler G, Schmid RM. Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology 2002 123 : 2052 63.