Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria

PLoS Pathogens

Volumn 11, Issue 3, 2015, Pages 1-24

  Pérez Mazliah, Damián ^a   Ng, Dorothy Hui Lin ^a   Freitas do Rosário, Ana Paula ^a   McLaughlin, Sarah ^a   Mastelic Gavillet, Béatris ^a   Sodenkamp, Jan ^a   Kushinga, Garikai ^a   Langhorne, Jean ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; CHLOROQUINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; PROTEIN BCL 6; PYRIMETHAMINE; INTERLEUKIN DERIVATIVE;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SECRETING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL INTERACTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; GENE; HELPER CELL; HUMORAL IMMUNITY; IL21 GENE; MALARIA; MEMORY CELL; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM CHABAUDI INFECTION; PLASMODIUM YOELII INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLENOMEGALY; T CELL B CELL INTERACTION; ANIMAL; B LYMPHOCYTE; C57BL MOUSE; CELL COMMUNICATION; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; PLASMODIUM CHABAUDI; PLASMODIUM YOELII; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

MUS; PLASMODIUM CHABAUDI;

ANIMALS; B-LYMPHOCYTES; CELL COMMUNICATION; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNITY, HUMORAL; INTERLEUKINS; MALARIA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLASMODIUM CHABAUDI; PLASMODIUM YOELII; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84926483977     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004715     Document Type: Article

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