Critical role for IL-21 in both primary and memory anti-viral CD8 + T-cell responses

European Journal of Immunology

Volumn 40, Issue 11, 2010, Pages 3085-3096

  Barker, Brianne R ^a   Gladstone, Michael N ^a   Gillard, Geoffrey O ^a   Panas, Michael W ^a   Letvin, Norman L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anti viral immunity; CD8 +T cells; IL 21; Memory cells; T cell help

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 21; INTERLEUKIN DERIVATIVE; TNFSF10 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS INFECTION; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MOUSE MUTANT; VACCINIA VIRUS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; IMMUNOLOGIC MEMORY; INTERLEUKINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; TNF-RELATED APOPTOSIS-INDUCING LIGAND; VACCINIA VIRUS;

EID: 79952113870     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939939     Document Type: Article

References (34)

1. Sun, J. C., Williams, M. A. and Bevan, M. J., CD4+T cells are required for the maintenance, not programming, of memory CD81T cells after acute infection. Nat. Immunol. 2004. 5: 927-933.
2. Janssen, E. M., Droin, N. M., Lemmens, E. E., Pinkoski, M. J. and Bensinger, S. J., CD4+T-cell help controls CD8+T-cell memory via TRAIL-mediated activation-induced cell death. Nature 2005. 434: 88.
3. Bevan, M. J., Helping the CD8(+) T-cell response. Nat. Rev. Immunol. 2004. 4: 595-602.
4. Williams, M. A., Tyznik, A. J. and Bevan, M. J., Interleukin-2 signals during priming are required for secondary expansion of CD8+memory T cells. Nature 2006, 441, 890-893.
5. Livingstone, A. M., Wilson, E. B., Ontiveros, F. and Wang, J. C., Unravelling the mechanisms of help for CD8+T cell responses. Immunol. Res. 2009. 45: 209-217.
6. Harty, J. T. and Badovinac, V. P., Shaping and reshaping CD8+T-cell memory. Nat. Rev. Immunol. 2008. 8: 107-119.
7. Shin, H. and Wherry, E. J., CD8 T cell dysfunction during chronic viral infection. Curr. Opin. Immunol. 2007. 19: 408-415.
8. Schluns, K. S., Kieper, W. C., Jameson, S. C. and Lefrancois, L., Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 2000. 1: 426-432.
9. Becker, T. C., Wherry, E. J., Boone, D., Murali-Krishna, K., Antia, R., Ma, A. and Ahmed, R., Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J. Exp. Med. 2002. 195: 1541-1548.
10. Parrish-Novak, J., Dillon, S. R., Nelson, A., Hammond, A., Sprecher, C., Gross, J. A., Johnston, J. et al., Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000. 408: 57-63.
11. Spolski, R. and Leonard, W. J., Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 2008. 26: 57-79.
12. Zhou, L., Ivanov, I. I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D. E. et al., IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 2007. 8: 967-974.
13. Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K. et al., Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007. 448: 480-483.
14. Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jager, A., Strom, T. B., Oukka, M. and Kuchroo, V. K., IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007. 448: 484-487.
15. Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y. H. et al., Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008. 29: 138-149.
16. Vogelzang, A., McGuire, H. M., Yu, D., Sprent, J., Mackay, C. R. and King, C., A Fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008. 29: 127-137.
17. Elsaesser, H., Sauer, K. and Brooks, D. G., IL-21 is required to control chronic viral infection. Science 2009. 324: 1569-1572.
18. Yi, J. S., Du, M. and Zajac, A. J., A vital role for interleukin-21 in the control of a chronic viral infection. Science 2009. 324: 1572-1576.
19. Frohlich, A., Kisielow, J., Schmitz, I., Freigang, S., Shamshiev, A.T., Weber, J., Marsland, B. J. et al., IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 2009. 324: 1576-1580.
20. Bolesta, E., Kowalczyk, A., Wierzbicki, A., Eppolito, C., Kaneko, Y., Takiguchi, M., Stamatatos, L. et al., Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery. J. Immunol. 2006. 177: 177-191.
21. Alves, N. L., Arosa, F. A. and van Lier, R. A., IL-21 sustains CD28 expression on IL-15-activated human naive CD8+T cells. J. Immunol. 2005. 175: 755-762.
22. Zeng, R., Spolski, R., Finkelstein, S. E., Oh, S. and Kovanen, P. E., Synergy of IL-21 and IL-15 in regulating CD8+T cell expansion and function. J. Exp. Med. 2005. 201: 139.
23. Barker, B. R., Parvani, J. G., Meyer, D., Hey, A. S., Skak, K. and Letvin, N. L., IL-21 induces apoptosis of antigen-specific CD8+T lymphocytes. J. Immunol. 2007. 179: 3596-3603.
24. Zeng, R., Spolski, R., Casas, E., Zhu, W., Levy, D. E. and Leonard, W. J., The molecular basis of IL-21-mediated proliferation. Blood 2007. 109: 4135-4142.
25. Kasaian, M. T., Whitters, M. J., Carter, L. L., Lowe, L. D. and Jussif, J. M., IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 2002. 16: 559.
26. Allard, E. L., Hardy, M. P., Leignadier, J., Marquis, M., Rooney, J., Lehoux, D. and Labrecque, N., Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation. Eur. J. Immunol. 2007. 37: 3069-3077.
27. Jackson, S. S., Schmitz, J. E., Kuroda, M. J., McKay, P. F., Sumida, S. M., Martin, K. L., Yu, F. et al., Evaluation of CD62L expression as a marker for vaccine-elicited memory cytotoxic T lymphocytes. Immunology 2005. 116: 443-453.
28. Sarkar, S., Kalia, V., Haining, W. N., Konieczny, B. T., Subramaniam, S. and Ahmed, R., Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J. Exp. Med. 2008. 205: 625-640.
29. Badovinac, V. P. and Harty, J. T., Programming, demarcating, and manipulating CD8+T-cell memory. Immunol. Rev. 2006. 211: 67-80.
30. Hovav, A. H., Panas, M. W., Osuna, C. E., Cayabyab, M. J., Autissier, P. and Letvin, N. L., The impact of a boosting immunogen on the differentiation of secondary memory CD8+T cells. J. Virol. 2007. 81: 12793-12802.
31. van Faassen, H., Saldanha, M., Gilbertson, D., Dudani, R., Krishnan, L. and Sad, S., Reducing the stimulation of CD8+T cells during infection with intracellular bacteria promotes differentiation primarily into a central (CD62LhighCD44high) subset. J. Immunol. 2005. 174: 5341-5350.
32. Badovinac, V. P., Porter, B. B. and Harty, J. T., CD8+T cell contraction is controlled by early inflammation. Nat. Immunol. 2004. 5: 809-817.
33. King, C., Ilic, A., Koelsch, K. and Sarvetnick, N., Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004. 117: 265-277.
34. Staats, H. F., Bradney, C. P., Gwinn, W. M., Jackson, S. S., Sempowski, G. D., Liao, H. X., Letvin, N. L. and Haynes, B. F., Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization. J. Immunol. 2001. 167: 5386-5394.