Gefitinib-mediated reactive oxygen specie (ROS) instigates mitochondrial dysfunction and drug resistance in lung cancer cells

Journal of Biological Chemistry

Volumn 290, Issue 14, 2015, Pages 9101-9110

  Okon, Imoh S ^a   Coughlan, Kathleen A ^a   Zhang, Miao ^a   Wang, Qiongxin ^a   Zou, Ming Hui ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL ORGANS; CELL CULTURE; CLONE CELLS; CLONING; CYTOLOGY; DISEASES; DRUG PRODUCTS; DRUG THERAPY; GENE EXPRESSION; MOBILE SECURITY; OXYGEN; TRANSMISSION ELECTRON MICROSCOPY;

CELLULAR REACTIVE OXYGEN SPECIES; EPIDERMAL GROWTH FACTOR RECEPTORS; EPITHELIAL-MESENCHYMAL TRANSITION; MEDIATED RESISTANCES; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MORPHOLOGY; REACTIVE OXYGEN SPECIES; TYROSINE KINASE INHIBITOR;

CELLS;

EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; REACTIVE OXYGEN METABOLITE; UVOMORULIN; VIMENTIN; ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE;

ARTICLE; CANCER RESISTANCE; CELL DEATH; CHRONIC DRUG ADMINISTRATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EGFR GENE; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; GENE; GENE DELETION; GENE EXPRESSION; LUNG CANCER CELL LINE; MICROARRAY ANALYSIS; MITOCHONDRIAL RESPIRATION; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING; DRUG EFFECTS; DRUG RESISTANCE; HUMAN; METABOLISM; MITOCHONDRION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; MITOCHONDRIA; QUINAZOLINES; REACTIVE OXYGEN SPECIES;

EID: 84926432179     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.631580     Document Type: Article

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