Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection

PLoS Pathogens

Volumn 11, Issue 3, 2015, Pages 1-22

  Hewitson, James P ^a   Filbey, Kara J ^a   Esser von Bieren, Julia ^b   Camberis, Mali ^c   Schwartz, Christian ^d   Murray, Janice ^a   Reynolds, Lisa A ^a   Blair, Natalie ^a   Robertson, Elaine ^a   Harcus, Yvonne ^a   Boon, Louis ^e   Huang, Stanley Ching Cheng ^f   Yang, Lihua ^g   Tu, Yizheng ^g   Miller, Mark J ^g   Voehringer, David ^d   Le Gros, Graham ^c   Harris, Nicola ^b   Maizels, Rick M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b EPFL   (Switzerland)

^c MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e BIOCEROS   (Netherlands)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD23 ANTIGEN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN G1; INTERLEUKIN 17; INTERLEUKIN 25; INTERLEUKIN 4; SECRETED ANTIGEN; UNCLASSIFIED DRUG; D17WSU104E PROTEIN, MOUSE; HELMINTH ANTIBODY; IMMUNOGLOBULIN G; INTERLEUKIN DERIVATIVE; PARASITE ANTIGEN;

ADULT; ANIMAL EXPERIMENT; ANIMAL IMAGING SYSTEM; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOPHIL; CELL INFILTRATION; CONTROLLED STUDY; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; EXTRAVASATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; HELIGMOSOMOIDES POLYGYRUS; HELMINTH; IMMUNITY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INFECTION; INTRACELLULAR SIGNALING; LARVA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MAST CELL; MONOCYTE; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION; VACCINATION; WESTERN BLOTTING; ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; STRONGYLIDA INFECTIONS;

HELIGMOSOMOIDES POLYGYRUS; MUS; VERMES;

ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-4; INTERLEUKINS; LARVA; MICE; MICE, KNOCKOUT; NEMATOSPIROIDES DUBIUS; STRONGYLIDA INFECTIONS; VACCINATION;

EID: 84926431249     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004676     Document Type: Article

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