Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 1, 2012, Pages

  Diemert, David J ^a,b,c   Pinto, Antonio G ^c   Freire, Janaina ^c   Jariwala, Amar ^a   Santiago, Helton ^b,c   Hamilton, Robert G ^d   Periago, Maria Victoria ^c   Loukas, Alex ^e   Tribolet, Leon ^e   Mulvenna, Jason ^e,f   Correa Oliveira, Rodrigo ^c   Hotez, Peter J ^a,g   Bethony, Jeffrey M ^b,c  

^a Albert B Sabin Vaccine Institute   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JAMES COOK UNIVERSITY   (Australia)

^f QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^g BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Brazil; Hookworm; IgE; Na ASP 2; Necator americanus; urticaria; vaccine

Indexed keywords

ALUMINUM HYDROXIDE; EPITOPE; HEPATITIS B VACCINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN ASP 2; UNCLASSIFIED DRUG; VACCINE;

ADOLESCENT; ADULT; AGED; ARTHRALGIA; ARTICLE; CHILD; CONTROLLED STUDY; DRUG SAFETY; DRUG TOLERABILITY; ENDEMIC DISEASE; EPITOPE MAPPING; FEVER; HEADACHE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOGENICITY; INFANT; INJECTION SITE ERYTHEMA; INJECTION SITE REACTION; INJECTION SITE SWELLING; MALAISE; MYALGIA; NAUSEA; NECATOR AMERICANUS; NECATORIASIS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEROEPIDEMIOLOGY; SEROLOGY; SKIN TEST; URTICARIA; VACCINATION;

EID: 84862856774     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.04.027     Document Type: Article

References (39)

1. J. Bethony, A. Loukas, M. Smout, S. Brooker, S. Mendez, and J. Plieskatt Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals FASEB J 19 2005 1743 1745 (Pubitemid 41429549)
2. G.N. Goud, M.E. Bottazzi, B. Zhan, S. Mendez, V. Deumic, and J. Plieskatt Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials Vaccine 23 2005 4754 4764 (Pubitemid 41557326)
3. P.J. Hotez, J. Bethony, M.E. Bottazzi, S. Brooker, and P. Buss Hookworm: "the great infection of mankind." PLoS Med 2 2005 e67
4. J. Bethony, S. Brooker, M. Albonico, S.M. Geiger, A. Loukas, and D. Diemert Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm Lancet 367 2006 1521 1532
5. D.J. Diemert, J.M. Bethony, and P.J. Hotez Hookworm vaccines Clin Infect Dis 46 2008 282 288 (Pubitemid 351269171)
6. A. Loukas, J. Bethony, S. Brooker, and P. Hotez Hookworm vaccines: past, present, and future Lancet Infect Dis 6 2006 733 741 (Pubitemid 44601993)
7. J.M. Hawdon, B.F. Jones, D.R. Hoffman, and P.J. Hotez Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae J Biol Chem 271 1996 6672 6678
8. J.M. Hawdon, S. Narasimhan, and P.J. Hotez Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum Mol Biochem Parasitol 99 1999 149 165 (Pubitemid 29182679)
9. O.A. Asojo, G. Goud, K. Dhar, A. Loukas, B. Zhan, and V. Deumic X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infection J Mol Biol 346 2005 801 814 (Pubitemid 40247719)
10. J. Parkinson, M. Mitreva, C. Whitton, M. Thomson, J. Daub, and J. Martin A transcriptomic analysis of the phylum Nematoda Nat Genet 36 2004 1259 1267 (Pubitemid 39577933)
11. J.M. Bethony, G. Simon, D.J. Diemert, D. Parenti, A. Desrosiers, and S. Schuck Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults Vaccine 26 2008 2408 2417
12. F.M. Fleming, S. Brooker, S.M. Geiger, I.R. Caldas, R. Correa-Oliveira, and P.J. Hotez Synergistic associations between hookworm and other helminth species in a rural community in Brazil Trop Med Int Health 11 2006 56 64 (Pubitemid 43381362)
13. A. Jardim-Botelho, S. Brooker, S.M. Geiger, F. Fleming, A.C. Souza Lopes, and D.J. Diemert Age patterns in undernutrition and helminth infection in a rural area of Brazil: associations with ascariasis and hookworm Trop Med Int Health 13 2008 458 467 (Pubitemid 351533595)
14. A. Jardim-Botelho, S. Raff, A. Rodrigues Rde, H.J. Hoffman, D.J. Diemert, and R. Correa-Oliveira Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren Trop Med Int Health 13 2008 994 1004
15. R.L. Pullan, J.M. Bethony, S.M. Geiger, B. Cundill, R. Correa-Oliveira, and R.J. Quinnell Human helminth co-infection: analysis of spatial patterns and risk factors in a Brazilian community PLoS Negl Trop Dis 2 2008 e352
16. S. Brooker, A. Jardim-Botelho, R.J. Quinnell, S.M. Geiger, I.R. Caldas, and F. Fleming Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil Trans R Soc Trop Med Hyg 101 2007 146 154 (Pubitemid 44835344)
17. N. Katz, A. Chaves, and J. Pellegrino A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni Rev Inst Med Trop Sao Paulo 14 1972 397 400
18. W. Humphrey, A. Dalke, and K. Schulten VMD: visual molecular dynamics J Mol Graph 14 1996 33 38 27-8 (Pubitemid 26152973)
19. R.M. Maizels, A. Balic, N. Gomez-Escobar, M. Nair, M.D. Taylor, and J.E. Allen Helminth parasites - masters of regulation Immunol Rev 201 2004 89 116 (Pubitemid 39318446)
20. R.M. Maizels, and M. Yazdanbakhsh Immune regulation by helminth parasites: cellular and molecular mechanisms Nat Rev Immunol 3 2003 733 744 (Pubitemid 41070814)
21. P. Hagan, U.J. Blumenthal, D. Dunn, A.J. Simpson, and H.A. Wilkins Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium Nature 349 1991 243 245 (Pubitemid 21912056)
22. M. Webster, A.J. Fulford, G. Braun, J.H. Ouma, H.C. Kariuki, and J.C. Havercroft Human immunoglobulin E responses to a recombinant 22.6-kilodalton antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment Infect Immun 64 1996 4042 4046 (Pubitemid 26318120)
23. H. Faulkner, J. Turner, J. Kamgno, S.D. Pion, M. Boussinesq, and J.E. Bradley Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE J Infect Dis 185 2002 665 672 (Pubitemid 34171472)
24. J.D. Turner, H. Faulkner, J. Kamgno, M.W. Kennedy, J. Behnke, and M. Boussinesq Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection Microbes Infect 7 2005 990 996 (Pubitemid 40982666)
25. M. Moreno, U. Benavidez, H. Carol, C. Rosenkranz, M. Welle, and C. Carmona Local and systemic immune responses to Echinococcus granulosus in experimentally infected dogs Vet Parasitol 119 2004 37 50 (Pubitemid 38223831)
26. F.N. Kooyman, H.D. Schallig, M.A. Van Leeuwen, A. MacKellar, J.F. Huntley, and A.W. Cornelissen Protection in lambs vaccinated with Haemonchus contortus antigens is age related, and correlates with IgE rather than IgG1 antibody Parasite Immunol 22 2000 13 20
27. D. Abraham, O. Leon, S. Schnyder-Candrian, C.C. Wang, A.M. Galioto, and L.A. Kerepesi Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae Infect Immun 72 2004 810 817 (Pubitemid 38166659)
28. R.T. Fujiwara, A. Loukas, S. Mendez, A.L. Williamson, L.L. Bueno, and Y. Wang Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs Vaccine 24 2006 501 509 (Pubitemid 41832554)
29. M. Yazdanbakhsh, P.G. Kremsner, and R. van Ree Allergy, parasites, and the hygiene hypothesis Science 296 2002 490 494
30. K.J. Erb Helminths, allergic disorders and IgE-mediated immune responses: where do we stand? Eur J Immunol 37 2007 1170 1173 (Pubitemid 46925301)
31. J. Leonardi-Bee, D. Pritchard, and J. Britton Asthma and current intestinal parasite infection: systematic review and meta-analysis Am J Respir Crit Care Med 174 2006 514 523 (Pubitemid 44330543)
32. M.D. Chapman, A. Pomes, H. Breiteneder, and F. Ferreira Nomenclature and structural biology of allergens J Allergy Clin Immunol 119 2007 414 420
33. C. Traidl-Hoffmann, T. Jakob, and H. Behrendt Determinants of allergenicity J Allergy Clin Immunol 123 2009 558 566
34. C.M. Fitzsimmons, and D.W. Dunne Survival of the fittest: allergology or parasitology? Trends Parasitol 25 2009 447 451
35. K. Bohlke, R.L. Davis, S.M. Marcy, M.M. Braun, F. DeStefano, and S.B. Black Risk of anaphylaxis after vaccination of children and adolescents Pediatrics 112 2003 815 820 (Pubitemid 37248689)
36. A. Madaan, and D.E. Maddox Vaccine allergy: diagnosis and management Immunol Allergy Clin North Am 23 2003 555 588 (Pubitemid 38030159)
37. R. Edelman, S.S. Wasserman, J.G. Kublin, S.A. Bodison, E.H. Nardin, and G.A. Oliveira Immediate-type hypersensitivity and other clinical reactions in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum sporozoites Vaccine 21 2002 269 280 (Pubitemid 35350854)
38. M.S. Pearson, J.M. Bethony, D.A. Pickering, L.M. de Oliveira, A. Jariwala, and H. Santiago An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection FASEB J 23 2009 3007 3019
39. J.L. Deen, and J.D. Clemens Issues in the design and implementation of vaccine trials in less developed countries Nat Rev Drug Discov 5 2006 932 940 (Pubitemid 44660606)