메뉴 건너뛰기




Volumn 111, Issue 48, 2014, Pages E5169-E5177

Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion

Author keywords

Basophils; Helminths; IgE; IL 4; Protective immunity

Indexed keywords

HELIGMOSOMOIDES POLYGYRUS; IXODIDA; MUS; NIPPOSTRONGYLUS BRASILIENSIS; VERMES;

EID: 84914127563     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412663111     Document Type: Article
Times cited : (78)

References (51)
  • 1
    • 33646180655 scopus 로고    scopus 로고
    • Soil-transmitted helminth infections: Ascariasis, trichuriasis, and hookworm
    • Bethony J, et al. (2006) Soil-transmitted helminth infections: Ascariasis, trichuriasis, and hookworm. Lancet 367(9521):1521-1532.
    • (2006) Lancet , vol.367 , Issue.9521 , pp. 1521-1532
    • Bethony, J.1
  • 2
    • 65249149535 scopus 로고    scopus 로고
    • Geohelminth infection and reinfection after chemotherapy among slum-dwelling children in Durban, South Africa
    • Appleton CC, Mosala TI, Levin J, Olsen A (2009) Geohelminth infection and reinfection after chemotherapy among slum-dwelling children in Durban, South Africa. Ann Trop Med Parasitol 103(3):249-261.
    • (2009) Ann Trop Med Parasitol , vol.103 , Issue.3 , pp. 249-261
    • Appleton, C.C.1    Mosala, T.I.2    Levin, J.3    Olsen, A.4
  • 3
    • 44649133452 scopus 로고    scopus 로고
    • Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus
    • Unit 19.12.2-19.12.27
    • Camberis M, Le Gros G, Urban J, Jr (2003) Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr Protoc Immunol Chapter 19:Unit 19.12.2-19.12.27.
    • (2003) Curr Protoc Immunol Chapter , vol.19
    • Camberis, M.1    Le Gros, G.2    Urban, J.3
  • 4
    • 84971149822 scopus 로고
    • Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): Dose-dependent expulsion of adult worms
    • Robinson M, Wahid F, Behnke JM, Gilbert FS (1989) Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): Dose-dependent expulsion of adult worms. Parasitology 98(Pt 1):115-124.
    • (1989) Parasitology , vol.98 , Issue.1 , pp. 115-124
    • Robinson, M.1    Wahid, F.2    Behnke, J.M.3    Gilbert, F.S.4
  • 5
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill DR, et al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464(7293):1367-1370.
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1367-1370
    • Neill, D.R.1
  • 6
    • 84860211299 scopus 로고    scopus 로고
    • Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines
    • Hepworth MR, et al. (2012) Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines. Proc Natl Acad Sci USA 109(17):6644-6649.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.17 , pp. 6644-6649
    • Hepworth, M.R.1
  • 7
    • 84901658227 scopus 로고    scopus 로고
    • Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection
    • Filbey KJ, et al. (2014) Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunol Cell Biol 92(5):436-448.
    • (2014) Immunol Cell Biol , vol.92 , Issue.5 , pp. 436-448
    • Filbey, K.J.1
  • 8
    • 84866172350 scopus 로고    scopus 로고
    • Fcγ receptors inhibit mouse and human basophil activation
    • Cassard L, Jönsson F, Arnaud S, Daëron M (2012) Fcγ receptors inhibit mouse and human basophil activation. J Immunol 189(6):2995-3006.
    • (2012) J Immunol , vol.189 , Issue.6 , pp. 2995-3006
    • Cassard, L.1    Jönsson, F.2    Arnaud, S.3    Daëron, M.4
  • 9
    • 4344647601 scopus 로고    scopus 로고
    • Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    • Min B, et al. (2004) Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med 200(4):507-517.
    • (2004) J Exp Med , vol.200 , Issue.4 , pp. 507-517
    • Min, B.1
  • 10
    • 0025753325 scopus 로고
    • Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils
    • Seder RA, et al. (1991) Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci USA 88(7):2835-2839.
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.7 , pp. 2835-2839
    • Seder, R.A.1
  • 11
    • 11844280961 scopus 로고    scopus 로고
    • Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production
    • Gessner A, Mohrs K, Mohrs M (2005) Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J Immunol 174(2):1063-1072.
    • (2005) J Immunol , vol.174 , Issue.2 , pp. 1063-1072
    • Gessner, A.1    Mohrs, K.2    Mohrs, M.3
  • 12
    • 79956158089 scopus 로고    scopus 로고
    • Genetic analysis of basophil function in vivo
    • Sullivan BM, et al. (2011) Genetic analysis of basophil function in vivo. Nat Immunol 12(6):527-535.
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 527-535
    • Sullivan, B.M.1
  • 13
    • 77957020655 scopus 로고    scopus 로고
    • Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths
    • Ohnmacht C, et al. (2010) Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 33(3):364-374.
    • (2010) Immunity , vol.33 , Issue.3 , pp. 364-374
    • Ohnmacht, C.1
  • 14
    • 77955291570 scopus 로고    scopus 로고
    • Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
    • Wada T, et al. (2010) Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120(8):2867-2875.
    • (2010) J Clin Invest , vol.120 , Issue.8 , pp. 2867-2875
    • Wada, T.1
  • 15
    • 77953812779 scopus 로고    scopus 로고
    • The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    • Tang H, et al. (2010) The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 11(7):608-617.
    • (2010) Nat Immunol , vol.11 , Issue.7 , pp. 608-617
    • Tang, H.1
  • 16
    • 84875508135 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited to allergic skin acquire an antiinflammatory M2 phenotype via basophil-derived interleukin-4
    • EgawaM, et al. (2013) Inflammatory monocytes recruited to allergic skin acquire an antiinflammatory M2 phenotype via basophil-derived interleukin-4. Immunity 38(3):570-580.
    • (2013) Immunity , vol.38 , Issue.3 , pp. 570-580
    • Egawa, M.1
  • 17
    • 84887448189 scopus 로고    scopus 로고
    • The skin is an important bulwark of acquired immunity against intestinal helminths
    • Obata-Ninomiya K, et al. (2013) The skin is an important bulwark of acquired immunity against intestinal helminths. J Exp Med 210(12):2583-2595.
    • (2013) J Exp Med , vol.210 , Issue.12 , pp. 2583-2595
    • Obata-Ninomiya, K.1
  • 18
    • 84866274943 scopus 로고    scopus 로고
    • Antibodies and IL-3 support helminth-induced basophil expansion
    • Herbst T, et al. (2012) Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci USA 109(37):14954-14959.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.37 , pp. 14954-14959
    • Herbst, T.1
  • 19
    • 67649229687 scopus 로고    scopus 로고
    • MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity
    • Perrigoue JG, et al. (2009) MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol 10(7):697-705.
    • (2009) Nat Immunol , vol.10 , Issue.7 , pp. 697-705
    • Perrigoue, J.G.1
  • 20
    • 0030935344 scopus 로고    scopus 로고
    • Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models
    • Finkelman FD, et al. (1997) Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models. Annu Rev Immunol 15:505-533.
    • (1997) Annu Rev Immunol , vol.15 , pp. 505-533
    • Finkelman, F.D.1
  • 21
    • 0026246291 scopus 로고
    • Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice
    • Urban JF, Jr, Katona IM, Finkelman FD (1991) Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice. Exp Parasitol 73(4):500-511.
    • (1991) Exp Parasitol , vol.73 , Issue.4 , pp. 500-511
    • Urban, J.F.1    Katona, I.M.2    Finkelman, F.D.3
  • 22
    • 0026043865 scopus 로고
    • Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice
    • Urban JF, Jr, Katona IM, Paul WE, Finkelman FD (1991) Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci USA 88(13):5513-5517.
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.13 , pp. 5513-5517
    • Urban, J.F.1    Katona, I.M.2    Paul, W.E.3    Finkelman, F.D.4
  • 23
    • 33746806604 scopus 로고    scopus 로고
    • Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
    • Anthony RM, et al. (2006) Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med 12(8):955-960.
    • (2006) Nat Med , vol.12 , Issue.8 , pp. 955-960
    • Anthony, R.M.1
  • 24
    • 53349139166 scopus 로고    scopus 로고
    • Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    • McCoy KD, et al. (2008) Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection. Cell Host Microbe 4(4):362-373.
    • (2008) Cell Host Microbe , vol.4 , Issue.4 , pp. 362-373
    • McCoy, K.D.1
  • 25
    • 78650646562 scopus 로고    scopus 로고
    • A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection
    • King IL, Mohrs K, Mohrs M (2010) A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection. J Immunol 185(10):6138-6145.
    • (2010) J Immunol , vol.185 , Issue.10 , pp. 6138-6145
    • King, I.L.1    Mohrs, K.2    Mohrs, M.3
  • 26
    • 61949121872 scopus 로고    scopus 로고
    • Cytokine-producing effector B cells regulate type 2 immunity to H. Polygyrus
    • Wojciechowski W, et al. (2009) Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30(3):421-433.
    • (2009) Immunity , vol.30 , Issue.3 , pp. 421-433
    • Wojciechowski, W.1
  • 27
    • 0017341950 scopus 로고
    • Immune mechanisms to Ascaris suum in inbred guinea-pigs. I. Passive transfer of immunity by cells or serum
    • Khoury PB, Stromberg BE, Soulsby EJ (1977) Immune mechanisms to Ascaris suum in inbred guinea-pigs. I. Passive transfer of immunity by cells or serum. Immunology 32(4):405-411.
    • (1977) Immunology , vol.32 , Issue.4 , pp. 405-411
    • Khoury, P.B.1    Stromberg, B.E.2    Soulsby, E.J.3
  • 28
    • 0018627707 scopus 로고
    • Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum
    • Behnke JM, Parish HA (1979) Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum. Parasite Immunol 1(1):13-26.
    • (1979) Parasite Immunol , vol.1 , Issue.1 , pp. 13-26
    • Behnke, J.M.1    Parish, H.A.2
  • 29
    • 0020956956 scopus 로고
    • Specificity of passive serum protection against Nippostrongylus brasiliensis and Nematospiroides dubius in mice
    • Brindley PJ, Dobson C (1983) Specificity of passive serum protection against Nippostrongylus brasiliensis and Nematospiroides dubius in mice. Aust J Exp Biol Med Sci 61(Pt 1):37-45.
    • (1983) Aust J Exp Biol Med Sci , vol.61 , Issue.1 , pp. 37-45
    • Brindley, P.J.1    Dobson, C.2
  • 30
    • 63849092743 scopus 로고    scopus 로고
    • Basophil effector function and homeostasis during helminth infection
    • Ohnmacht C, Voehringer D (2009) Basophil effector function and homeostasis during helminth infection. Blood 113(12):2816-2825.
    • (2009) Blood , vol.113 , Issue.12 , pp. 2816-2825
    • Ohnmacht, C.1    Voehringer, D.2
  • 31
    • 0034877815 scopus 로고    scopus 로고
    • Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
    • Mohrs M, Shinkai K, Mohrs K, Locksley RM (2001) Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15(2):303-311.
    • (2001) Immunity , vol.15 , Issue.2 , pp. 303-311
    • Mohrs, M.1    Shinkai, K.2    Mohrs, K.3    Locksley, R.M.4
  • 32
    • 5444254615 scopus 로고    scopus 로고
    • Basophils initiate IL-4 production during a memory T-dependent response
    • Khodoun MV, Orekhova T, Potter C, Morris S, Finkelman FD (2004) Basophils initiate IL-4 production during a memory T-dependent response. J Exp Med 200(7):857-870.
    • (2004) J Exp Med , vol.200 , Issue.7 , pp. 857-870
    • Khodoun, M.V.1    Orekhova, T.2    Potter, C.3    Morris, S.4    Finkelman, F.D.5
  • 33
    • 45549087159 scopus 로고    scopus 로고
    • Basophils enhance immunological memory responses
    • Denzel A, et al. (2008) Basophils enhance immunological memory responses. Nat Immunol 9(7):733-742.
    • (2008) Nat Immunol , vol.9 , Issue.7 , pp. 733-742
    • Denzel, A.1
  • 34
    • 78650647718 scopus 로고    scopus 로고
    • Basophils support the survival of plasma cells in mice
    • Rodriguez Gomez M, et al. (2010) Basophils support the survival of plasma cells in mice. J Immunol 185(12):7180-7185.
    • (2010) J Immunol , vol.185 , Issue.12 , pp. 7180-7185
    • Rodriguez Gomez, M.1
  • 35
    • 73949086150 scopus 로고    scopus 로고
    • Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
    • Herbert DR, et al. (2009) Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med 206(13):2947-2957.
    • (2009) J Exp Med , vol.206 , Issue.13 , pp. 2947-2957
    • Herbert, D.R.1
  • 36
    • 84876825969 scopus 로고    scopus 로고
    • IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis
    • Lübben W, et al. (2013) IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis. Eur J Immunol 43(5):1231-1242.
    • (2013) Eur J Immunol , vol.43 , Issue.5 , pp. 1231-1242
    • Lübben, W.1
  • 37
    • 79751527363 scopus 로고    scopus 로고
    • To B or not to B: B cells and the Th2-type immune response to helminths
    • Harris N, Gause WC (2011) To B or not to B: B cells and the Th2-type immune response to helminths. Trends Immunol 32(2):80-88.
    • (2011) Trends Immunol , vol.32 , Issue.2 , pp. 80-88
    • Harris, N.1    Gause, W.C.2
  • 38
    • 0032913166 scopus 로고    scopus 로고
    • Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children
    • McSharry C, Xia Y, Holland CV, Kennedy MW (1999) Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children. Infect Immun 67(2):484-489.
    • (1999) Infect Immun , vol.67 , Issue.2 , pp. 484-489
    • McSharry, C.1    Xia, Y.2    Holland, C.V.3    Kennedy, M.W.4
  • 39
    • 0036499271 scopus 로고    scopus 로고
    • Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: The importance of IgE
    • Faulkner H, et al. (2002) Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: The importance of IgE. J Infect Dis 185(5):665-672.
    • (2002) J Infect Dis , vol.185 , Issue.5 , pp. 665-672
    • Faulkner, H.1
  • 40
    • 0026563362 scopus 로고
    • Immunity after treatment of human schistosomiasis: Association between IgE antibodies to adult worm antigens and resistance to reinfection
    • Dunne DW, et al. (1992) Immunity after treatment of human schistosomiasis: Association between IgE antibodies to adult worm antigens and resistance to reinfection. Eur J Immunol 22(6):1483-1494.
    • (1992) Eur J Immunol , vol.22 , Issue.6 , pp. 1483-1494
    • Dunne, D.W.1
  • 41
    • 33846866735 scopus 로고    scopus 로고
    • When is a mouse basophil not a basophil?
    • Lee JJ, McGarry MP (2007) When is a mouse basophil not a basophil? Blood 109(3): 859-861.
    • (2007) Blood , vol.109 , Issue.3 , pp. 859-861
    • Lee, J.J.1    McGarry, M.P.2
  • 42
    • 73949111782 scopus 로고    scopus 로고
    • Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells
    • Ohnmacht C, Voehringer D (2010) Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells. J Immunol 184(1):344-350.
    • (2010) J Immunol , vol.184 , Issue.1 , pp. 344-350
    • Ohnmacht, C.1    Voehringer, D.2
  • 43
    • 79952741741 scopus 로고    scopus 로고
    • Basophils are the major producers of IL-4 during primary helminth infection
    • van Panhuys N, et al. (2011) Basophils are the major producers of IL-4 during primary helminth infection. J Immunol 186(5):2719-2728.
    • (2011) J Immunol , vol.186 , Issue.5 , pp. 2719-2728
    • Van Panhuys, N.1
  • 44
    • 34548047670 scopus 로고    scopus 로고
    • Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis
    • Knott ML, et al. (2007) Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis. Int J Parasitol 37(12): 1367-1378.
    • (2007) Int J Parasitol , vol.37 , Issue.12 , pp. 1367-1378
    • Knott, M.L.1
  • 45
    • 0032830632 scopus 로고    scopus 로고
    • Trapping and immobilization of Nippostrongylus brasiliensis larvae at the site of inoculation in primary infections of in-terleukin-5 transgenic mice
    • Daly CM, Mayrhofer G, Dent LA (1999) Trapping and immobilization of Nippostrongylus brasiliensis larvae at the site of inoculation in primary infections of in-terleukin-5 transgenic mice. Infect Immun 67(10):5315-5323.
    • (1999) Infect Immun , vol.67 , Issue.10 , pp. 5315-5323
    • Daly, C.M.1    Mayrhofer, G.2    Dent, L.A.3
  • 46
    • 77956641353 scopus 로고    scopus 로고
    • The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites
    • Harvie M, et al. (2010) The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites. Infect Immun 78(9): 3753-3762.
    • (2010) Infect Immun , vol.78 , Issue.9 , pp. 3753-3762
    • Harvie, M.1
  • 47
    • 33646026384 scopus 로고    scopus 로고
    • IgE memory: Persistence of antigen-specific IgE responses years after treatment of human filarial infections
    • Mitre E, Nutman TB (2006) IgE memory: Persistence of antigen-specific IgE responses years after treatment of human filarial infections. J Allergy Clin Immunol 117(4): 939-945.
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.4 , pp. 939-945
    • Mitre, E.1    Nutman, T.B.2
  • 48
    • 0033577811 scopus 로고    scopus 로고
    • Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
    • McKenzie GJ, Fallon PG, Emson CL, Grencis RK, McKenzie AN (1999) Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med 189(10):1565-1572.
    • (1999) J Exp Med , vol.189 , Issue.10 , pp. 1565-1572
    • McKenzie, G.J.1    Fallon, P.G.2    Emson, C.L.3    Grencis, R.K.4    McKenzie, A.N.5
  • 49
    • 0028071646 scopus 로고
    • Active anaphylaxis in IgE-deficient mice
    • Oettgen HC, et al. (1994) Active anaphylaxis in IgE-deficient mice. Nature 370(6488): 367-370.
    • (1994) Nature , vol.370 , Issue.6488 , pp. 367-370
    • Oettgen, H.C.1
  • 50
    • 0028042424 scopus 로고
    • FcR gamma chain deletion results in pleiotrophic effector cell defects
    • Takai T, Li M, Sylvestre D, Clynes R, Ravetch JV (1994) FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 76(3):519-529.
    • (1994) Cell , vol.76 , Issue.3 , pp. 519-529
    • Takai, T.1    Li, M.2    Sylvestre, D.3    Clynes, R.4    Ravetch, J.V.5
  • 51
    • 0033695963 scopus 로고    scopus 로고
    • Spontaneous autoimmune disease in Fc(gamma)RIIBdeficient mice results from strain-specific epistasis
    • Bolland S, Ravetch JV (2000) Spontaneous autoimmune disease in Fc(gamma)RIIBdeficient mice results from strain-specific epistasis. Immunity 13(2):277-285.
    • (2000) Immunity , vol.13 , Issue.2 , pp. 277-285
    • Bolland, S.1    Ravetch, J.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.