Quantitative targeted absolute proteomics for 28 human transporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and 4 weeks

Drug Metabolism and Pharmacokinetics

Volumn 30, Issue 2, 2015, Pages 205-208

  Uchida, Yasuo ^a   Ohtsuki, Sumio ^b   Kamiie, Junichi ^c   Ohmine, Ken ^a   Iwase, Ryo ^a   Terasaki, Tetsuya ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c AZABU UNIVERSITY   (Japan)

Author keywords

BCRP; Caco 2; Different culture period; LC MS MS; MDR1; OST ; PEPT1; Protein expression level; QTAP; SRM MRM analysis

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE; BREAST CANCER RESISTANCE PROTEIN; CELL MEMBRANE PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER B; ORGANIC ANION TRANSPORTER D; ORGANIC ANION TRANSPORTER E; OST APHA PROTEIN; OST BETA PROTEIN; PEPTIDE TRANSPORTER 1; SODIUM CHANNEL; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; TRANSCRIPTION FACTOR OSTERIX; TRYPSIN; UNCLASSIFIED DRUG; CARRIER PROTEIN;

ARTICLE; CACO 2 CELL LINE; CELL MEMBRANE; FILTERS AND MEMBRANES; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; LIQUID CHROMATOGRAPHY; MEMBRANE MARKER; MONOLAYER CULTURE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN TARGETING; PROTEOMICS; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; COMPARATIVE STUDY; EPITHELIUM CELL; INTESTINE MUCOSA; METABOLISM; PERMEABILITY; PROCEDURES; TIME FACTOR;

CACO-2 CELLS; CHROMATOGRAPHY, LIQUID; EPITHELIAL CELLS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MEMBRANE TRANSPORT PROTEINS; PERMEABILITY; PROTEOMICS; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 84926395449     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.1016/j.dmpk.2014.11.002     Document Type: Article

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