-
1
-
-
0142126681
-
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections
-
De Clercq E. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clin Microbiol Rev 16 (2003) 569-596
-
(2003)
Clin Microbiol Rev
, vol.16
, pp. 569-596
-
-
De Clercq, E.1
-
2
-
-
0028792567
-
Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients
-
Cundy K.C., Barditch-Crovo P., Walker R.E., Collier A.C., Ebeling D., Toole J., et al. Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother 39 (1995) 2401-2405
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 2401-2405
-
-
Cundy, K.C.1
Barditch-Crovo, P.2
Walker, R.E.3
Collier, A.C.4
Ebeling, D.5
Toole, J.6
-
3
-
-
0030842430
-
Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients
-
Barditch-Crovo P., Toole J., Hendrix C.W., Cundy K.C., Ebeling D., Jaffe H.S., et al. Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. J Infect Dis 176 (1997) 406-413
-
(1997)
J Infect Dis
, vol.176
, pp. 406-413
-
-
Barditch-Crovo, P.1
Toole, J.2
Hendrix, C.W.3
Cundy, K.C.4
Ebeling, D.5
Jaffe, H.S.6
-
4
-
-
0032887069
-
Adefovir dipivoxil
-
discussion 88-9
-
Noble S., and Goa K.L. Adefovir dipivoxil. Drugs 58 (1999) 479-487 discussion 88-9
-
(1999)
Drugs
, vol.58
, pp. 479-487
-
-
Noble, S.1
Goa, K.L.2
-
5
-
-
0033812631
-
In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil
-
Annaert P., Tukker J.J., van Gelder J., Naesens L., de Clercq E., van Den Mooter G., et al. In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil. J Pharm Sci 89 (2000) 1054-1062
-
(2000)
J Pharm Sci
, vol.89
, pp. 1054-1062
-
-
Annaert, P.1
Tukker, J.J.2
van Gelder, J.3
Naesens, L.4
de Clercq, E.5
van Den Mooter, G.6
-
6
-
-
0031022120
-
Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium
-
Gan L.S.L., and Thakker D.R. Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium. Adv Drug Deliv Rev 23 (1997) 77-98
-
(1997)
Adv Drug Deliv Rev
, vol.23
, pp. 77-98
-
-
Gan, L.S.L.1
Thakker, D.R.2
-
7
-
-
0030974779
-
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)
-
Annaert P., Kinget R., Naesens L., de Clercq E., and Augustijns P. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2). Pharm Res 14 (1997) 492-496
-
(1997)
Pharm Res
, vol.14
, pp. 492-496
-
-
Annaert, P.1
Kinget, R.2
Naesens, L.3
de Clercq, E.4
Augustijns, P.5
-
8
-
-
0031666188
-
Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers
-
Annaert P., Van Gelder J., Naesens L., De Clercq E., Van den Mooter G., Kinget R., et al. Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers. Pharm Res 15 (1998) 1168-1173
-
(1998)
Pharm Res
, vol.15
, pp. 1168-1173
-
-
Annaert, P.1
Van Gelder, J.2
Naesens, L.3
De Clercq, E.4
Van den Mooter, G.5
Kinget, R.6
-
9
-
-
33947430596
-
Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice
-
Kruh G.D., Belinsky M.G., Gallo J.M., and Lee K. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice. Cancer Metastasis Rev 26 (2007) 5-14
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 5-14
-
-
Kruh, G.D.1
Belinsky, M.G.2
Gallo, J.M.3
Lee, K.4
-
10
-
-
0030841332
-
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
-
Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., et al. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57 (1997) 3537-3547
-
(1997)
Cancer Res
, vol.57
, pp. 3537-3547
-
-
Kool, M.1
de Haas, M.2
Scheffer, G.L.3
Scheper, R.J.4
van Eijk, M.J.5
Juijn, J.A.6
-
11
-
-
0032879904
-
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
-
Schuetz J.D., Connelly M.C., Sun D., Paibir S.G., Flynn P.M., Srinivas R.V., et al. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5 (1999) 1048-1051
-
(1999)
Nat Med
, vol.5
, pp. 1048-1051
-
-
Schuetz, J.D.1
Connelly, M.C.2
Sun, D.3
Paibir, S.G.4
Flynn, P.M.5
Srinivas, R.V.6
-
12
-
-
0036186107
-
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP
-
van Aubel R.A., Smeets P.H., Peters J.G., Bindels R.J., and Russel F.G. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol 13 (2002) 595-603
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 595-603
-
-
van Aubel, R.A.1
Smeets, P.H.2
Peters, J.G.3
Bindels, R.J.4
Russel, F.G.5
-
13
-
-
0037693882
-
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)
-
Zelcer N., Reid G., Wielinga P., Kuil A., van der Heijden I., Schuetz J.D., et al. Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J 371 (2003) 361-367
-
(2003)
Biochem J
, vol.371
, pp. 361-367
-
-
Zelcer, N.1
Reid, G.2
Wielinga, P.3
Kuil, A.4
van der Heijden, I.5
Schuetz, J.D.6
-
14
-
-
12144257103
-
Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
-
van Aubel R.A., Smeets P.H., van den Heuvel J.J., and Russel F.G. Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol 288 (2005) F327-F333
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
van Aubel, R.A.1
Smeets, P.H.2
van den Heuvel, J.J.3
Russel, F.G.4
-
15
-
-
34547169521
-
Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
-
Hilgendorf C., Ahlin G., Seithel A., Artursson P., Ungell A.L., and Karlsson J. Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos 35 (2007) 1333-1340
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1333-1340
-
-
Hilgendorf, C.1
Ahlin, G.2
Seithel, A.3
Artursson, P.4
Ungell, A.L.5
Karlsson, J.6
-
16
-
-
0032997095
-
Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir
-
Cundy K.C. Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir. Clin Pharmacokinet 36 (1999) 127-143
-
(1999)
Clin Pharmacokinet
, vol.36
, pp. 127-143
-
-
Cundy, K.C.1
-
17
-
-
0032856603
-
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
-
Cihlar T., Lin D.C., Pritchard J.B., Fuller M.D., Mendel D.B., and Sweet D.H. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 56 (1999) 570-580
-
(1999)
Mol Pharmacol
, vol.56
, pp. 570-580
-
-
Cihlar, T.1
Lin, D.C.2
Pritchard, J.B.3
Fuller, M.D.4
Mendel, D.B.5
Sweet, D.H.6
-
18
-
-
33846420624
-
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir
-
Imaoka T., Kusuhara H., Adachi M., Schuetz J.D., Takeuchi K., and Sugiyama Y. Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol 71 (2007) 619-627
-
(2007)
Mol Pharmacol
, vol.71
, pp. 619-627
-
-
Imaoka, T.1
Kusuhara, H.2
Adachi, M.3
Schuetz, J.D.4
Takeuchi, K.5
Sugiyama, Y.6
-
19
-
-
0034811602
-
Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
-
Taipalensuu J., Tornblom H., Lindberg G., Einarsson C., Sjoqvist F., Melhus H., et al. Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J Pharmacol Exp Ther 299 (2001) 164-170
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 164-170
-
-
Taipalensuu, J.1
Tornblom, H.2
Lindberg, G.3
Einarsson, C.4
Sjoqvist, F.5
Melhus, H.6
-
20
-
-
33846441251
-
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage
-
Belinsky M.G., Guo P., Lee K., Zhou F., Kotova E., Grinberg A., et al. Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res 67 (2007) 262-268
-
(2007)
Cancer Res
, vol.67
, pp. 262-268
-
-
Belinsky, M.G.1
Guo, P.2
Lee, K.3
Zhou, F.4
Kotova, E.5
Grinberg, A.6
-
21
-
-
0043132421
-
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
-
Reid G., Wielinga P., Zelcer N., van der Heijden I., Kuil A., de Haas M., et al. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci USA 100 (2003) 9244-9249
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9244-9249
-
-
Reid, G.1
Wielinga, P.2
Zelcer, N.3
van der Heijden, I.4
Kuil, A.5
de Haas, M.6
-
22
-
-
40049110714
-
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
-
Dobson P.D., and Kell D.B. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?. Nat Rev Drug Discov 7 (2008) 205-220
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 205-220
-
-
Dobson, P.D.1
Kell, D.B.2
-
23
-
-
34347379290
-
+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
-
+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol 92 (2007) 603-619
-
(2007)
Exp Physiol
, vol.92
, pp. 603-619
-
-
Thwaites, D.T.1
Anderson, C.M.2
-
24
-
-
1442302325
-
Intestinal drug transporters: in vivo function and clinical importance
-
Kunta J.R., and Sinko P.J. Intestinal drug transporters: in vivo function and clinical importance. Curr Drug Metab 5 (2004) 109-124
-
(2004)
Curr Drug Metab
, vol.5
, pp. 109-124
-
-
Kunta, J.R.1
Sinko, P.J.2
-
25
-
-
11944257758
-
Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2
-
Irie M., Terada T., Okuda M., and Inui K. Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2. Pflugers Arch 449 (2004) 186-194
-
(2004)
Pflugers Arch
, vol.449
, pp. 186-194
-
-
Irie, M.1
Terada, T.2
Okuda, M.3
Inui, K.4
-
26
-
-
2442696471
-
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia
-
Dallas S., Schlichter L., and Bendayan R. Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia. J Pharmacol Exp Ther 309 (2004) 1221-1229
-
(2004)
J Pharmacol Exp Ther
, vol.309
, pp. 1221-1229
-
-
Dallas, S.1
Schlichter, L.2
Bendayan, R.3
-
27
-
-
6344242987
-
Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells
-
Prime-Chapman H.M., Fearn R.A., Cooper A.E., Moore V., and Hirst B.H. Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells. J Pharmacol Exp Ther 311 (2004) 476-484
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 476-484
-
-
Prime-Chapman, H.M.1
Fearn, R.A.2
Cooper, A.E.3
Moore, V.4
Hirst, B.H.5
-
28
-
-
50549083191
-
Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells
-
Lemos C., Kathmann I., Giovannetti E., Dekker H., Scheffer G.L., Calhau C., et al. Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells. Int J Cancer 123 (2008) 1712-1720
-
(2008)
Int J Cancer
, vol.123
, pp. 1712-1720
-
-
Lemos, C.1
Kathmann, I.2
Giovannetti, E.3
Dekker, H.4
Scheffer, G.L.5
Calhau, C.6
-
29
-
-
0034119967
-
Expression and localization of multidrug resistant protein mrp2 in rat small intestine
-
Mottino A.D., Hoffman T., Jennes L., and Vore M. Expression and localization of multidrug resistant protein mrp2 in rat small intestine. J Pharmacol Exp Ther 293 (2000) 717-723
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 717-723
-
-
Mottino, A.D.1
Hoffman, T.2
Jennes, L.3
Vore, M.4
-
30
-
-
33846708489
-
ABCC10, ABCC11, and ABCC12
-
Kruh G.D., Guo Y., Hopper-Borge E., Belinsky M.G., and Chen Z.S. ABCC10, ABCC11, and ABCC12. Pflugers Arch 453 (2007) 675-684
-
(2007)
Pflugers Arch
, vol.453
, pp. 675-684
-
-
Kruh, G.D.1
Guo, Y.2
Hopper-Borge, E.3
Belinsky, M.G.4
Chen, Z.S.5
-
31
-
-
34547114499
-
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution
-
Takenaka K., Morgan J.A., Scheffer G.L., Adachi M., Stewart C.F., Sun D., et al. Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Res 67 (2007) 6965-6972
-
(2007)
Cancer Res
, vol.67
, pp. 6965-6972
-
-
Takenaka, K.1
Morgan, J.A.2
Scheffer, G.L.3
Adachi, M.4
Stewart, C.F.5
Sun, D.6
-
32
-
-
0346958512
-
Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist
-
Beaumont K., Webster R., Gardner I., and Dack K. Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist. Curr Drug Metab 4 (2003) 461-485
-
(2003)
Curr Drug Metab
, vol.4
, pp. 461-485
-
-
Beaumont, K.1
Webster, R.2
Gardner, I.3
Dack, K.4
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