Functional diversity of fibroblast growth factors in bone formation

International Journal of Endocrinology

Volumn 2015, Issue , 2015, Pages

  Takei, Yuichiro ^a   Minamizaki, Tomoko ^a   Yoshiko, Yuji ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLECALCIFEROL; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR RECEPTOR; PHOSPHATE;

BONE DEFECT; BONE MINERALIZATION; CARBOXY TERMINAL SEQUENCE; FEEDBACK SYSTEM; HUMAN; KIDNEY TUBULE ABSORPTION; MOLECULAR PATHOLOGY; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; PHOSPHATE BLOOD LEVEL; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84926384834     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2015/729352     Document Type: Review

References (98)

1. X. Feng and J. M. McDonald, "Disorders of bone remodeling", Annual Review of Pathology, vol. 6, pp. 121-145, 2011.
2. M. Ferron, M. D. McKee, R. L. Levine, P. Ducy, and G. Karsenty, "Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice", Bone, vol. 50, no. 2, pp. 568-575, 2012.
3. L. M. Calvi, G. B. Adams, K. W. Weibrecht et al., "Osteoblastic cells regulate the haematopoietic stem cell niche", Nature, vol. 425, no. 6960, pp. 841-846, 2003.
4. J. Zhang, C. Niu, L. Ye et al., "Identification of the haematopoietic stem cell niche and control of the niche size", Nature, vol. 425, no. 6960, pp. 836-841, 2003.
5. H. Iwasaki and T. Suda, "Cancer stem cells and their niche", Cancer Science, vol. 100, no. 7, pp. 1166-1172, 2009.
6. S. Takeda, F. Eleferiou, R. Levasseur et al., "Leptin regulates bone formation via the sympathetic nervous system", Cell, vol. 111, no. 3, pp. 305-317, 2002.
7. 2B receptor controls bone mass via osteoblast recruitment and proliferation", The FASEB Journal, vol. 22, no. 2, pp. 418-427, 2008.
8. M. Kuro-O, "Endocrine FGFs and Klothos: emerging concepts", Trends in Endocrinology & Metabolism, vol. 19, no. 7, pp. 239-245, 2008.
9. H. Wang, Y. Yoshiko, R. Yamamoto et al., "Overexpression of fbroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro", Journal of Bone and Mineral Research, vol. 23, no. 6, pp. 939-948, 2008.
10. R. T. Böttcher and C. Niehrs, "Fibroblast growth factor signaling during early vertebrate development", Endocrine Reviews, vol. 26, no. 1, pp. 63-77, 2005.
11. B. Thisse and C. Thisse, "Functions and regulations of fibroblast growth factor signaling during embryonic development", Developmental Biology, vol. 287, no. 2, pp. 390-402, 2005.
12. H. Kurosu and M. Kuro-O, "Endocrine fibroblast growth factors as regulators of metabolic homeostasis", BioFactors, vol. 35, no. 1, pp. 52-60, 2009.
13. M. Mohammadi, S. K. Olsen, and O. A. Ibrahimi, "Structural basis for fibroblast growth factor receptor activation", Cytokine and Growth Factor Reviews, vol. 16, no. 2, pp. 107-137, 2005.
14. L. Dailey, D. Ambrosetti, A. Mansukhani, and C. Basilico, "Mechanisms underlying differential responses to FGF signaling", Cytokine and Growth Factor Reviews, vol. 16, no. 2, pp. 233-247, 2005.
15. N. Hacohen, S. Kramer, D. Sutherland, Y. Hiromi, and M. A. Krasnow, "Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways", Cell, vol. 92, no. 2, pp. 253-263, 1998.
16. M. Fürthauer, F. Reifers, M. Brand, B. Thisse, and C. Thisse, "Sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish", Development, vol. 128, no. 12, pp. 2175-2186, 2001.
17. M. Fürthauer, W. Lin, S.-L. Ang, B. Thisse, and C. Thisse, "Sef is a feedback-induced antagonist of RAs/MAPK-mediated FGF signalling", Nature Cell Biology, vol. 4, no. 2, pp. 170-174, 2002.
18. Y. Hirate and H. Okamoto, "Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafsh", Current Biology, vol. 16, no. 4, pp. 421-427, 2006.
19. T. Matsui, S. Titamadee, T. Murata et al., "Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupfer's vesicle organogenesis", Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 24, pp. 9881-9886, 2011.
20. F. Debiais, M. Hott, A. M. Graulet, and P. J. Marie, "The effects of fibroblast growth factor-2 on human neonatal calvaria osteoblastic cells are differentiation stage specific", Journal of Bone and Mineral Research, vol. 13, no. 4, pp. 645-654, 1998.
21. H. Okazaki, T. Kurokawa, K. Nakamura, T. Matsushita, K. Mamada, and H. Kawaguchi, "Stimulation of bone formation by recombinant fibroblast growth factor-2 in callotasis bone lengthening of rabbits", Calcifed Thissue International, vol. 64, no. 6, pp. 542-546, 1999.
22. M. Kitamura, M. Akamatsu, M. MacHigashira et al., "FGF-2 stimulates periodontal regeneration: results of a multi-center randomized clinical trial", Journal of Dental Research, vol. 90, no. 1, pp. 35-40, 2011.
23. H. Nagai, R. Tsukuda, and H. Mayahara, "Effects of basic fibroblast growth factor (bFGF) on bone formation in growing rats", Bone, vol. 16, no. 3, pp. 367-373, 1995.
24. C. R. Dunstan, R. Boyce, B. F. Boyce et al., "Systemic administration of acidic fibroblast growth factor (FGF-1) prevents bone loss and increases new bone formation in ovariectomized rats", Journal of Bone and Mineral Research, vol. 14, no. 6, pp. 953-959, 1999.
25. J. I. Aguirre, M. E. Leal, M. F. Rivera, S. M. Vanegas, M. Jorgensen, and T. J. Wronski, "Effects of basic fibroblast growth factor and a prostaglandin E2 receptor subtype 4 agonist on osteoblastogenesis and adipogenesis in aged ovariectomized rats", Journal of Bone and Mineral Research, vol. 22, no. 6, pp. 877-888, 2007.
26. A. Montero, Y. Okada, M. Tomita et al., "Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation", Journal of Clinical Investigation, vol. 105, no. 8, pp. 1085-1093, 2000.
27. T. Naganawa, L. Xiao, J. D. Coffin et al., "Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice", Journal of Cellular Biochemistry, vol. 103, no. 6, pp. 1975-1988, 2008.
28. L. Xiao, T. Sobue, A. Esliger et al., "Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells", Bone, vol. 47, no. 2, pp. 360-370, 2010.
29. L. Xiao, P. Liu, X. Li et al., "Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice", Journal of Biological Chemistry, vol. 284, no. 5, pp. 3170-3182, 2009.
30. K. T. Tang, C. Capparelli, J. L. Stein et al., "Acidic fibroblast growth factor inhibits osteoblast differentiation in vitro: altered expression of collagenase, cell growth-related, and mineralization-associated genes", Journal of Cellular Biochemistry, vol. 61, no. 1, pp. 152-166, 1996.
31. D. L. Miller, S. Ortega, O. Bashayan, R. Basch, and C. Basilico, "Compensation by fbroblast growth factor 1 (FGF1) does not account for the mild phenotypic deffects observed in FGF2 null mice", Molecular and Cellular Biology, vol. 20, no. 6, pp. 2260-2268, 2000.
32. S. Kuroda, S. Kasugai, S. Oida, T. Iimura, K. Ohya, and T. Ohyama, "Anabolic effect of aminoterminally truncated fibroblast growth factor 4 (FGF4) on bone", Bone, vol. 25, no. 4, pp. 431-437, 1999.
33. M. Bosetti, M. Leigheb, R. A. Brooks, F. Boccafoschi, and M. F. Cannas, "Regulation of osteoblast and osteoclast functions by FGF-6", Journal of Cellular Physiology, vol. 225, no. 2, pp. 466-471, 2010.
34. Y.-M. Jeon, S.-H. Kook, S.-J. Rho et al., "Fibroblast growth factor-7 facilitates osteogenic differentiation of embryonic stem cells through the activation of ERK/Runx2 signaling", Molecular and Cellular Biochemistry, vol. 382, no. 1-2, pp. 37-45, 2013.
35. K. Omoteyama and M. Takagi, "FGF8 regulates myogenesis and induces Runx2 expression and osteoblast differentiation in cultured cells", Journal of Cellular Biochemistry, vol. 106, no. 4, pp. 546-552, 2009.
36. V. Govindarajan and P. A. Overbeek, "FGF9 can induce endochondral ossification in cranial mesenchyme", BMC Developmental Biology, vol. 6, article 7, 2006.
37. T. Kizhner, D. Ben-David, E. Rom, A. Yayon, and E. Livne, "Effects of FGF2 and FGF9 on osteogenic differentiation of bone marrow-derived progenitors", In Vitro Cellular and Developmental Biology-Animal, vol. 47, no. 4, pp. 294-301, 2011.
38. M. K. Hajihosseini, R. Duarte, J. Pegrum et al., "Evidence that Fgf10 contributes to the skeletal and visceral deffects of an apert syndrome mouse model", Developmental Dynamics, vol. 238, no. 2, pp. 376-385, 2009.
39. T. Shimoaka, T. Ogasawara, A. Yonamine et al., "Regulation of osteoblast, chondrocyte, and osteoclast functions by fbroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10", The Journal of Biological Chemistry, vol. 277, no. 9, pp. 7493-7500, 2002.
40. N. Ohbayashi, M. Shibayama, Y. Kurotaki et al., "FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis", Genes and Development, vol. 16, no. 7, pp. 870-879, 2002.
41. L. Chen and C.-X. Deng, "Roles of FGF signaling in skeletal development and human genetic diseases", Frontiers in Bioscience, vol. 10, no. 2, pp. 1961-1976, 2005.
42. G. M. Morriss-Kay and A. O. M. Wilkie, "Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies", Journal of Anatomy, vol. 207, no. 5, pp. 637-653, 2005.
43. D. M. Ornitz and P. J. Marie, "FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease", Genes & Development, vol. 16, no. 12, pp. 1446-1465, 2002.
44. D. M. Ornitz, "FGF signaling in the developing endochondral skeleton", Cytokine and Growth Factor Reviews, vol. 16, no. 2, pp. 205-213, 2005.
45. T. P. Yamaguchi, K. Harpal, M. Henkemeyer, and J. Rossant, "fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation", Genes and Development, vol. 8, no. 24, pp. 3032-3044, 1994.
46. A. L. Jacob, C. Smith, J. Partanen, and D. M. Ornitz, "Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation", Developmental Biology, vol. 296, no. 2, pp. 315-328, 2006.
47. E. W. Jabs, X. Li, A. F. Scott et al., "Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2", Nature Genetics, vol. 8, no. 3, pp. 275-279, 1994.
48. A. O. M. Wilkie, S. F. Slaney, M. Oldridge et al., "Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome", Nature Genetics, vol. 9, no. 2, pp. 165-172, 1995.
49. +/S252W mouse", Development, vol. 132, no. 5, pp. 3537-3548, 2005.
50. H. Miraoui, K. Oudina, H. Petite, Y. Tanimoto, K. Moriyama, and P. J. Marie, "Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling", The Journal of Biological Chemistry, vol. 284, no. 8, pp. 4897-4904, 2009.
51. F. Rousseau, J. Bonaventure, L. Legeai-Mallet et al., "Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia", Nature, vol. 371, no. 6494, pp. 252-254, 1994.
52. M. Muenke, K. W. Gripp, D. M. McDonald-McGinn et al., "A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome", The American Journal of Human Genetics, vol. 60, no. 3, pp. 555-564, 1997.
53. G. A. Meyers, S. J. Orlow, I. R. Munro, K. A. Przylepa, and E. W. Jabs, "Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans", Nature Genetics, vol. 11, no. 4, pp. 462-464, 1995.
54. C. Deng, A. Wynshaw-Boris, F. Zhou, A. Kuo, and P. Leder, "Fibroblast growth factor receptor 3 is a negative regulator of bone growth", Cell, vol. 84, no. 6, pp. 911-921, 1996.
55. S. Weizmann, A. Tong, A. Reich, O. Genina, A. Yayon, and E. Monsonego-Ornan, "FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: implications for endochondral ossification", Matrix Biology, vol. 24, no. 8, pp. 520-529, 2005.
56. S. Cool, R. Jackson, P. Pincus, I. Dickinson, and V. Nurcombe, "Fibroblast growth factor receptor 4 (FGFR4) expression in newborn murine calvaria and primary osteoblast cultures", International Journal of Developmental Biology, vol. 46, no. 4, pp. 519-523, 2002.
57. X. Bai, D. Miao, J. Li, D. Goltzman, and A. C. Karaplis, "Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders", Endocrinology, vol. 145, no. 11, pp. 5269-5279, 2004.
58. T. Larsson, R. Marsell, E. Schipani et al., "Transgenic mice expressing fibroblast growth factor 23 under the control of the α1 (I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis", Endocrinology, vol. 145, no. 7, pp. 3087-3094, 2004.
59. T. Shimada, M. Kakitani, Y. Yamazaki et al., "Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism", The Journal of Clinical Investigation, vol. 113, no. 4, pp. 561-568, 2004.
60. L. D. Quarles, "Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism", Nature Reviews Endocrinology, vol. 8, no. 5, pp. 276-286, 2012.
61. K. E. White, W. E. Evans, J. L. H. O'Riordan et al., "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23", Nature Genetics, vol. 26, no. 3, pp. 345-348, 2000.
62. T. Shimada, S. Mizutani, T. Muto et al., "Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia", Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 11, pp. 6500-6505, 2001.
63. Y. Yoshiko, H. Wang, T. Minamizaki et al., "Mineralized tissue cells are a principal source of FGF23", Bone, vol. 40, no. 6, pp. 1565-1573, 2007.
64. M. Mirams, B. G. Robinson, R. S. Mason, and A. E. Nelson, "Bone as a source of FGF23: regulation by phosphate?" Bone, vol. 35, no. 5, pp. 1192-1199, 2004.
65. R. Masuyama, I. Stockmans, S. Torrekens et al., "Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts", The Journal of Clinical Investigation, vol. 116, no. 12, pp. 3150-3159, 2006.
66. S. Liu, W. Tang, J. Zhou, L. Vierthaler, and L. D. Quarles, "Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice", The American Journal of Physiology-Endocrinology and Metabolism, vol. 293, no. 6, pp. E1636-E1644, 2007.
67. I. Urakawa, Y. Yamazaki, T. Shimada et al., "Klotho converts canonical FGF receptor into a specific receptor for FGF23", Nature, vol. 444, no. 7120, pp. 770-774, 2006.
68. H. Kurosu, Y. Ogawa, M. Miyoshi et al., "Regulation of fibroblast growth factor-23 signaling by Klotho", Journal of Biological Chemistry, vol. 281, no. 10, pp. 6120-6123, 2006.
69. A. Imura, Y. Tsuji, M. Murata et al., "α-klotho as a regulator of calcium homeostasis", Science, vol. 316, no. 5831, pp. 1615-1618, 2007.
70. J. Gattineni, C. Bates, K. Twombley et al., "FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1", The American Journal of Physiology-Renal Physiology, vol. 297, no. 2, pp. F282-F291, 2009.
71. 3 production", The Journal of Biological Chemistry, vol. 278, no. 4, pp. 2206-2211, 2003.
72. S. Liu, W. Tang, J. Zhou et al., "Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D", Journal of the American Society of Nephrology, vol. 17, no. 5, pp. 1305-1315, 2006.
73. 3 acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro", Journal of Endocrinology, vol. 206, no. 3, pp. 279-286, 2010.
74. I. Z. Ben-Dov, H. Galitzer, V. Lavi-Moshayof et al., "The parathyroid is a target organ for FGF23 in rats", The Journal of Clinical Investigation, vol. 117, no. 12, pp. 4003-4008, 2007.
75. H. Olauson, K. Lindberg, R. Amin et al., "Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion", PLoS Genetics, vol. 9, no. 12, Article ID e1003975, 2013.
76. Y. Rhee, N. Bivi, E. Farrow et al., "Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo", Bone, vol. 49, no. 4, pp. 636-643, 2011.
77. 3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4", The American Journal of Physiology-Renal Physiology, vol. 301, no. 2, pp. F371-F377, 2011.
78. N. Arai-Nunota, M. Mizobuchi, H. Ogata et al., "Intravenous phosphate loading increases fibroblast growth factor 23 in uremic rats", PLoS ONE, vol. 9, no. 3, Article ID e91096, 2014.
79. M. Kawai, S. Kinoshita, S. Shimba, K. Ozono, and T. Michigami, "Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm-dependent manner", The Journal of Biological Chemistry, vol. 289, no. 3, pp. 1457-1466, 2014.
80. R. C. Smith, L. M. O'Bryan, E. G. Farrow et al., "Circulating αKlotho influences phosphate handling by controlling FGF23 production", Journal of Clinical Investigation, vol. 122, no. 12, pp. 4710-4715, 2012.
81. M. Kuro-O, Y. Matsumura, H. Aizawa et al., "Mutation of the mouse klotho gene leads to a syndrome resembling ageing", Nature, vol. 390, no. 6655, pp. 45-51, 1997.
82. Y. Takei, H. Yamamoto, T. Sato et al., "Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells", Bone, vol. 50, no. 4, pp. 998-1005, 2012.
83. Q. Yuan, Y. Jiang, X. Zhao et al., "Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice", Journal of Bone and Mineral Research, vol. 29, no. 3, pp. 693-704, 2014.
84. D. Sitara, S. Kim, M. S. Razzaque et al., "Genetic evidence of serum phosphate-independent functions of FGF-23 on bone", PLoS Genetics, vol. 4, no. 8, Article ID e1000154, 2008.
85. Y. Matsumura, H. Aizawa, T. Shiraki-Iida, R. Nagai, M. Kuro-O, and Y.-I. Nabeshima, "Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein", Biochemical and Biophysical Research Communications, vol. 242, no. 3, pp. 626-630, 1998.
86. T. Shiraki-Iida, H. Aizawa, Y. Matsumura et al., "Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein", FEBS Letters, vol. 424, no. 1-2, pp. 6-10, 1998.
87. V. Shalhoub, S. C. Ward, B. Sun et al., "Fibroblast growth factor 23 (FGF23) and α-klotho stimulate osteoblastic MC3T3. E1 cell proliferation and inhibit mineralization", Calcified Tissue International, vol. 89, no. 2, pp. 140-150, 2011.
88. M. Kawai, S. Kinoshita, A. Kimoto et al., "FGF23 suppresses chondrocyte proliferation in the presence of solubleα-klotho both in vitro and in vivo", Journal of Biological Chemistry, vol. 288, no. 4, pp. 2414-2427, 2013.
89. C. Faul, A. P. Amaral, B. Oskouei et al., "FGF23 induces lef ventricular hypertrophy", Journal of Clinical Investigation, vol. 121, no. 11, pp. 4393-4408, 2011.
90. B. Angelin, T. E. Larsson, and M. Rudling, "Circulating fibroblast growth factors as metabolic regulators-a critical appraisal", Cell Metabolism, vol. 16, no. 6, pp. 693-705, 2012.
91. P. Krejci, D. Krakow, P. B. Mekikian, and W. R. Wilcox, "Fibroblast growth factors 1, 2, 17, and 19 are the predominant FGF ligands expressed in human fetal growth plate cartilage", Pediatric Research, vol. 61, no. 3, pp. 267-272, 2007.
92. W. Wei, P. A. Dutchak, X. Wang et al., "Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ", Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 8, pp. 3143-3148, 2012.
93. I. Delrieu, "The high molecular weight isoforms of basic fibroblast growth factor (FGF-2): an insight into an intracrine mechanism", FEBS Letters, vol. 468, no. 1, pp. 6-10, 2000.
94. P. Claus, F. Döring, S. Gringel et al., "Diferential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein", Journal of Biological Chemistry, vol. 278, no. 1, pp. 479-485, 2003.
95. L. Xiao, T. Naganawa, J. Lorenzo, T. O. Carpenter, J. D. Coffin, and M. M. Hurley, "Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO", The Journal of Biological Chemistry, vol. 285, no. 4, pp. 2834-2846, 2010.
96. M. Wolf, "Update on fibroblast growth factor 23 in chronic kidney disease", Kidney International, vol. 82, no. 7, pp. 737-747, 2012.
97. Z. Chen, X. Chen, J. Xie et al., "Fibroblast growth factor 23 is a predictor of aortic artery calcification in maintenance hemodialysis patients", Renal Failure, vol. 35, no. 5, pp. 660-666, 2013.
98. J. R. Montford, M. Chonchol, A. K. Cheung et al., "Low body mass index and dyslipidemia in dialysis patients linked to elevated plasma fibroblast growth factor 23", American Journal of Nephrology, vol. 37, no. 3, pp. 183-190, 2013.