A general computational approach for repeat protein design

Journal of Molecular Biology

Volumn 427, Issue 2, 2015, Pages 563-575

  Parmeggiani, Fabio ^a,e   Huang, Po Ssu ^a,e   Vorobiev, Sergey ^b   Xiao, Rong ^c,d   Park, Keunwan ^a,e   Caprari, Silvia ^a,f   Su, Min ^b   Seetharaman, Jayaraman ^b   Mao, Lei ^c,d   Janjua, Haleema ^c,d   Montelione, Gaetano T ^c,d   Hunt, John ^b   Baker, David ^a,e  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f MAX PLANCK INSTITUTE FOR INFORMATICS   (Germany)

Author keywords

Computational design; De novo design; Idealized proteins; Repeat proteins; Thermodynamic stability

Indexed keywords

ANKYRIN; ARMADILLO DOMAIN PROTEIN; HEAT REPEAT PROTEIN; LEUCINE RICH PROTEIN; PROTEIN; REPEAT PROTEIN; TETRATRICOPEPTIDE REPEAT PROTEIN; UNCLASSIFIED DRUG; WD40 PROTEIN; ACTIN BINDING PROTEIN; BIOMATERIAL; LEUCINE-RICH REPEAT PROTEINS;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; THERMOSTABILITY; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; MOLECULAR GENETICS; PROCEDURES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANKYRINS; ARMADILLO DOMAIN PROTEINS; BIOCOMPATIBLE MATERIALS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MICROFILAMENT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

EID: 84920768290     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.11.005     Document Type: Article

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