메뉴 건너뛰기




Volumn 94, Issue 1, 2015, Pages 18-30

The role of the PI3K pathway in colorectal cancer

Author keywords

Biomarkers; Colorectal; PI3K; PIK3CA; Predictive

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ACETYLSALICYLIC ACID; ALPELISIB; ANTINEOPLASTIC AGENT; B RAF KINASE INHIBITOR; BEVACIZUMAB; BUPARLISIB; CETUXIMAB; DACTOLISIB; ENCORAFENIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LINSITINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PICTILISIB; PILARALISIB; PIMASERTIB; PROTEIN KINASE B INHIBITOR; SELUMETINIB; SONOLISIB; TEMSIROLIMUS; TIVOZANIB; UNINDEXED DRUG; VOXTALISIB; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

EID: 84926116641     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2014.12.006     Document Type: Review
Times cited : (97)

References (94)
  • 2
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics 2011 the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R., Ward E., Brawley O., et al. Cancer statistics 2011 the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011, 61:212-236.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3
  • 3
    • 0031019918 scopus 로고    scopus 로고
    • Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study
    • de Gramont A., Bosset J.F., Milan C., et al. Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study. J Clin Oncol 1997, 15:808-815.
    • (1997) J Clin Oncol , vol.15 , pp. 808-815
    • de Gramont, A.1    Bosset, J.F.2    Milan, C.3
  • 4
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz L.B., Cox J.V., Blanke C., et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 2000, 343:905-914.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 5
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A., Figer A., Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000, 18:2938-2947.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 6
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285(November):1182-1186.
    • (1971) N Engl J Med , vol.285 , Issue.NOVEMBER , pp. 1182-1186
    • Folkman, J.1
  • 7
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 8
    • 0343819997 scopus 로고    scopus 로고
    • Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2 ERB B3) in colorectal adenocarcinomas and adenomas
    • Porebska I., Harlozińska A., Bojarowski T. Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2 ERB B3) in colorectal adenocarcinomas and adenomas. Tumour Biol 2000, 21:105-115.
    • (2000) Tumour Biol , vol.21 , pp. 105-115
    • Porebska, I.1    Harlozińska, A.2    Bojarowski, T.3
  • 9
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E., Köhne C.H., Hitre E., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009, 360:1408-1417.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3
  • 10
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:1626-1634.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 11
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Grothey A., Van Cutsem E., Sobrero A., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013, 381:303-312.
    • (2013) Lancet , vol.381 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 12
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E., Tabernero J., Lakomy R., et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012, 30:3499-3506.
    • (2012) J Clin Oncol , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 13
    • 0021828496 scopus 로고
    • Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
    • Whitman M., Kaplan D.R., Schaffhausen B., et al. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 1985, 315:239-242.
    • (1985) Nature , vol.315 , pp. 239-242
    • Whitman, M.1    Kaplan, D.R.2    Schaffhausen, B.3
  • 14
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006, 7:606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 15
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y., Wang Z., Bardelli A., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304:554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 16
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: variations on a theme
    • Yuan T.L., Cantley L.C. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008, 27:5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 18
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer
    • Katso R., Okkenhaug K., Ahmadi K., et al. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001, 17:615-675.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 615-675
    • Katso, R.1    Okkenhaug, K.2    Ahmadi, K.3
  • 19
    • 13944284494 scopus 로고    scopus 로고
    • Oncogenic mutations of PIK3CA in human cancers
    • Samuels Y., Velculescu V.E. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004, 3:1221-1224.
    • (2004) Cell Cycle , vol.3 , pp. 1221-1224
    • Samuels, Y.1    Velculescu, V.E.2
  • 20
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 21
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi D.R., James S.R., Downes C.P., et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997, 7:261-269.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3
  • 22
    • 58149175555 scopus 로고    scopus 로고
    • The life of a cell: apoptosis regulation by the PI3K/PKB pathway
    • Duronio V. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 2008, 415:333-344.
    • (2008) Biochem J , vol.415 , pp. 333-344
    • Duronio, V.1
  • 24
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 25
    • 34248592612 scopus 로고    scopus 로고
    • Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans
    • Rosenberg D.W., Yang S., Pleau D.C., et al. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Res 2007, 67:3551-3554.
    • (2007) Cancer Res , vol.67 , pp. 3551-3554
    • Rosenberg, D.W.1    Yang, S.2    Pleau, D.C.3
  • 26
    • 0033563165 scopus 로고    scopus 로고
    • Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
    • Toyota M., Ho C., Ahuja N., Jair K.W., et al. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res 1999, 59:2307-2312.
    • (1999) Cancer Res , vol.59 , pp. 2307-2312
    • Toyota, M.1    Ho, C.2    Ahuja, N.3    Jair, K.W.4
  • 27
    • 53149097362 scopus 로고    scopus 로고
    • BRAF KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
    • Velho S., Moutinho C., Cirnes L., et al. BRAF KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?. BMC Cancer 2008, 8:255.
    • (2008) BMC Cancer , vol.8 , pp. 255
    • Velho, S.1    Moutinho, C.2    Cirnes, L.3
  • 28
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • Kang S., Denley A., Vanhaesebroeck B., et al. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2006, 103:1289-1294.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3
  • 29
    • 0036195196 scopus 로고    scopus 로고
    • AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
    • Roy H.K., Olusola B.F., Clemens D.L., et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002, 23:201-205.
    • (2002) Carcinogenesis , vol.23 , pp. 201-205
    • Roy, H.K.1    Olusola, B.F.2    Clemens, D.L.3
  • 30
    • 84876954020 scopus 로고    scopus 로고
    • PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions
    • Waniczek D., Śnietura M., Młynarczyk-Liszka J., et al. PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions. Pol J Pathol 2013, 64:15-20.
    • (2013) Pol J Pathol , vol.64 , pp. 15-20
    • Waniczek, D.1    Śnietura, M.2    Młynarczyk-Liszka, J.3
  • 31
    • 44349111717 scopus 로고    scopus 로고
    • Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?
    • Colakoglu T., Yildirim S., Kayaselcuk F., et al. Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?. Am J Surg 2008, 195:719-725.
    • (2008) Am J Surg , vol.195 , pp. 719-725
    • Colakoglu, T.1    Yildirim, S.2    Kayaselcuk, F.3
  • 32
    • 0031883606 scopus 로고    scopus 로고
    • Genetics of Cowden syndrome: through the looking glass of oncology
    • Eng C. Genetics of Cowden syndrome: through the looking glass of oncology. Int J Oncol 1998, 12:701-710.
    • (1998) Int J Oncol , vol.12 , pp. 701-710
    • Eng, C.1
  • 33
    • 51649126752 scopus 로고    scopus 로고
    • Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice
    • Fujishita T., Aoki K., Lane H.A., et al. Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci U S A 2008, 105:13544-13549.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13544-13549
    • Fujishita, T.1    Aoki, K.2    Lane, H.A.3
  • 34
    • 84877358772 scopus 로고    scopus 로고
    • Stage at diagnosis and colorectal cancer survival in six high-income countries: a population-based study of patients diagnosed during 2000-2007
    • Maringe C., Walters S., Rachet B., et al. Stage at diagnosis and colorectal cancer survival in six high-income countries: a population-based study of patients diagnosed during 2000-2007. Acta Oncol 2013, 52:919-932.
    • (2013) Acta Oncol , vol.52 , pp. 919-932
    • Maringe, C.1    Walters, S.2    Rachet, B.3
  • 35
    • 77954320936 scopus 로고    scopus 로고
    • Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up
    • Labianca R., Nordlinger B., Beretta G.D., et al. Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up. Ann Oncol 2010, 21(Suppl. 5):v70-v77.
    • (2010) Ann Oncol , vol.21 , pp. v70-v77
    • Labianca, R.1    Nordlinger, B.2    Beretta, G.D.3
  • 36
    • 84866745407 scopus 로고    scopus 로고
    • Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial
    • Tournigand C., André T., Bonnetain F., et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial. J Clin Oncol 2012, 30:3353-3360.
    • (2012) J Clin Oncol , vol.30 , pp. 3353-3360
    • Tournigand, C.1    André, T.2    Bonnetain, F.3
  • 37
    • 34548676803 scopus 로고    scopus 로고
    • PIK3CA mutation is predictive of poor survival in patients with colorectal cancer
    • Kato S., Iida S., Higuchi T., et al. PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer 2007, 121:1771-1778.
    • (2007) Int J Cancer , vol.121 , pp. 1771-1778
    • Kato, S.1    Iida, S.2    Higuchi, T.3
  • 38
    • 63049111794 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    • Ogino S., Nosho K., Kirkner G.J., et al. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 2009, 27:1477-1484.
    • (2009) J Clin Oncol , vol.27 , pp. 1477-1484
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 39
    • 84890448787 scopus 로고    scopus 로고
    • Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial
    • [Epub ahead of print]
    • Ogino S., Liao X., Imamura Y., et al. Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial. J Natl Cancer Inst 2013, (November). [Epub ahead of print].
    • (2013) J Natl Cancer Inst , Issue.NOVEMBER
    • Ogino, S.1    Liao, X.2    Imamura, Y.3
  • 40
    • 78449241791 scopus 로고    scopus 로고
    • PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac
    • Kaur J., Sanyal S.N. PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. Tumour Biol 2010, 31:623-631.
    • (2010) Tumour Biol , vol.31 , pp. 623-631
    • Kaur, J.1    Sanyal, S.N.2
  • 41
    • 34248157118 scopus 로고    scopus 로고
    • British Doctors Aspirin Trial and the UK-TIA Aspirin Trial. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    • Flossmann E., Rothwell P.M. British Doctors Aspirin Trial and the GBR-TIA Aspirin Trial. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 2007, 369:1603-1613.
    • (2007) Lancet , vol.369 , pp. 1603-1613
    • Flossmann, E.1    Rothwell, P.M.2
  • 42
    • 84867817838 scopus 로고    scopus 로고
    • Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    • Liao X., Lochhead P., Nishihara R., et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012, 367:1596-1606.
    • (2012) N Engl J Med , vol.367 , pp. 1596-1606
    • Liao, X.1    Lochhead, P.2    Nishihara, R.3
  • 43
    • 84892843686 scopus 로고    scopus 로고
    • Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer
    • Domingo E., Church D.N., Sieber O., et al. Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. J Clin Oncol 2013, 31:4297-4305.
    • (2013) J Clin Oncol , vol.31 , pp. 4297-4305
    • Domingo, E.1    Church, D.N.2    Sieber, O.3
  • 44
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis C.S., Khambata-Ford S., Jonker D.J., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359:1757-1765.
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 45
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E., Köhne C.H., Láng I., et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011, 29:2011-2019.
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Köhne, C.H.2    Láng, I.3
  • 46
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi A., Martini M., Molinari F., et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009, 69:1851-1857.
    • (2009) Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3
  • 47
    • 40649096375 scopus 로고    scopus 로고
    • Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
    • Zhao L., Vogt P.K. Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci U S A 2008, 105:2652-2657.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2652-2657
    • Zhao, L.1    Vogt, P.K.2
  • 48
    • 84860634396 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
    • Mao C., Yang Z.Y., Hu X.F., et al. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol 2012, 23:1518-1525.
    • (2012) Ann Oncol , vol.23 , pp. 1518-1525
    • Mao, C.1    Yang, Z.Y.2    Hu, X.F.3
  • 49
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • Perrone F., Lampis A., Orsenigo M., et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol 2009, 20:84-90.
    • (2009) Ann Oncol , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3
  • 50
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman J.A., Chen L., Tan X., et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008, 14:1351-1356.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3
  • 51
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman P.B., Hauschild A., Robert C., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011, 364:2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 52
    • 84873360893 scopus 로고    scopus 로고
    • Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
    • Mao M., Tian F., Mariadason J.M., et al. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res 2013, 19:657-667.
    • (2013) Clin Cancer Res , vol.19 , pp. 657-667
    • Mao, M.1    Tian, F.2    Mariadason, J.M.3
  • 53
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M., You H., Levine A.J., et al. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006, 6:184-192.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3
  • 54
    • 84864441197 scopus 로고    scopus 로고
    • PI3K expression and PIK3CA mutations are related to colorectal cancer metastases
    • Yu-Fen Zhu, Bao-Hua Yu, Da-Li Li, et al. PI3K expression and PIK3CA mutations are related to colorectal cancer metastases. World J Gastroenterol 2012, 18:3745-3751.
    • (2012) World J Gastroenterol , vol.18 , pp. 3745-3751
    • Zhu, Y.-F.1    Yu, B.-H.2    Li, D.-L.3
  • 55
    • 67649386846 scopus 로고    scopus 로고
    • The antiproliferative cytostatic effects of a self-activating viridin prodrug
    • Smith A., Blois J., Yuan H., et al. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther 2009, 8:1666-1675.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1666-1675
    • Smith, A.1    Blois, J.2    Yuan, H.3
  • 56
    • 84856071447 scopus 로고    scopus 로고
    • Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
    • Bendell J.C., Rodon J., Burris H.A., et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol 2012, 30:282-290.
    • (2012) J Clin Oncol , vol.30 , pp. 282-290
    • Bendell, J.C.1    Rodon, J.2    Burris, H.A.3
  • 57
    • 84983585189 scopus 로고    scopus 로고
    • A Trial of Irinotecan and BKM120 in Previously Treated Advanced Colorectal Cancer [].
    • ctgov:NCT01304602
    • A Trial of Irinotecan and BKM120 in Previously Treated Advanced Colorectal Cancer []. ctgov:NCT01304602.
  • 58
    • 84983585186 scopus 로고    scopus 로고
    • P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Patients With Metastatic or Advanced RAS-Wild Type Colorectal Cancer [].
    • ctgov:NCT01591421
    • P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Patients With Metastatic or Advanced RAS-Wild Type Colorectal Cancer []. ctgov:NCT01591421.
  • 59
    • 84864493357 scopus 로고    scopus 로고
    • A multicenter phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors
    • Hong D.S., Bowles D.W., Falchook G.S., et al. A multicenter phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors. Clin Cancer Res 2012, 18(82):4173.
    • (2012) Clin Cancer Res , vol.18 , Issue.82 , pp. 4173
    • Hong, D.S.1    Bowles, D.W.2    Falchook, G.S.3
  • 60
    • 77956566979 scopus 로고    scopus 로고
    • A phase I dose-escalation study of XL147 (SAR245408), a PI3K inhibitor administered orally to patients (pts) with advanced malignancies
    • (suppl; abstr 3004)
    • Edelman G., Bedell C., Shapiro G., et al. A phase I dose-escalation study of XL147 (SAR245408), a PI3K inhibitor administered orally to patients (pts) with advanced malignancies. J Clin Oncol 2010, 28(15s). (suppl; abstr 3004).
    • (2010) J Clin Oncol , vol.28 , Issue.15 S
    • Edelman, G.1    Bedell, C.2    Shapiro, G.3
  • 61
    • 84926105922 scopus 로고    scopus 로고
    • First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors
    • Nov 4, [Epub ahead of print]
    • Sarker D., Ang J.E., Baird R., et al. First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2014, (Nov 4). [Epub ahead of print].
    • (2014) Clin Cancer Res.
    • Sarker, D.1    Ang, J.E.2    Baird, R.3
  • 62
    • 84883559711 scopus 로고    scopus 로고
    • Phase I study of BYL719, an alpha-specific PI3K inhibitor, in patients with PIK3CA mutant advanced solid tumors: preliminary efficacy and safety in patients with PIK3CA mutant ER-positive (ER+) metastatic breast cancer (MBC)
    • Juric D., Argiles G., Burris H.A., et al. Phase I study of BYL719, an alpha-specific PI3K inhibitor, in patients with PIK3CA mutant advanced solid tumors: preliminary efficacy and safety in patients with PIK3CA mutant ER-positive (ER+) metastatic breast cancer (MBC). Cancer Res. 2012, 72(24 (Suppl. 3)).
    • (2012) Cancer Res. , vol.72 , Issue.24
    • Juric, D.1    Argiles, G.2    Burris, H.A.3
  • 63
    • 84983578838 scopus 로고    scopus 로고
    • Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer [].
    • ctgov:NCT01719380
    • Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer []. ctgov:NCT01719380.
  • 64
    • 84875143933 scopus 로고    scopus 로고
    • Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Kα) for the treatment of PTEN deficient tumors
    • Rivero R.A., Hardwicke M.A. Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Kα) for the treatment of PTEN deficient tumors. Cancer Res 2012, 72(8 (Suppl. 1)).
    • (2012) Cancer Res , vol.72 , Issue.8
    • Rivero, R.A.1    Hardwicke, M.A.2
  • 65
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly K.E., Rojo F., She Q.B., et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006, 66:1500-1508.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 66
    • 84983579261 scopus 로고    scopus 로고
    • Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients [].
    • ctgov:NCT01337765
    • Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients []. ctgov:NCT01337765.
  • 67
    • 80053169195 scopus 로고    scopus 로고
    • The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer
    • Roper J., Richardson M.P., Wang W.V., et al. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PLoS ONE 2011, 6(9):e25132.
    • (2011) PLoS ONE , vol.6 , Issue.9 , pp. e25132
    • Roper, J.1    Richardson, M.P.2    Wang, W.V.3
  • 68
    • 84860540538 scopus 로고    scopus 로고
    • Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas
    • Migliardi G., Sassi F., Torti D., et al. Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas. Clin Cancer Res 2012, 18:2515-2525.
    • (2012) Clin Cancer Res , vol.18 , pp. 2515-2525
    • Migliardi, G.1    Sassi, F.2    Torti, D.3
  • 69
    • 84899750348 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors
    • Papadopoulos KP1, Tabernero J., Markman B., et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors. Clin Cancer Res 2014, 20:2445-2456.
    • (2014) Clin Cancer Res , vol.20 , pp. 2445-2456
    • Papadopoulos, K.P.1    Tabernero, J.2    Markman, B.3
  • 70
    • 77949881462 scopus 로고    scopus 로고
    • The PI3K pathway as drug target in human cancer
    • Courtney K.D., Corcoran R.B., Engelman J.A. The PI3K pathway as drug target in human cancer. J Clin Oncol 2010, 28:1075-1083.
    • (2010) J Clin Oncol , vol.28 , pp. 1075-1083
    • Courtney, K.D.1    Corcoran, R.B.2    Engelman, J.A.3
  • 71
    • 67649382929 scopus 로고    scopus 로고
    • AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
    • Vasudevan K.M., Barbie D.A., Davies M.A., et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009, 16:21-32.
    • (2009) Cancer Cell , vol.16 , pp. 21-32
    • Vasudevan, K.M.1    Barbie, D.A.2    Davies, M.A.3
  • 72
    • 83255162603 scopus 로고    scopus 로고
    • First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors
    • Yap T.A., Yan L., Patnaik A., et al. First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol 2011, 29:4688-4695.
    • (2011) J Clin Oncol , vol.29 , pp. 4688-4695
    • Yap, T.A.1    Yan, L.2    Patnaik, A.3
  • 73
    • 84983579251 scopus 로고    scopus 로고
    • MK-2206 and AZD6244 in Patients With Advanced Colorectal Carcinoma [].
    • ctgov:NCT01333475
    • MK-2206 and AZD6244 in Patients With Advanced Colorectal Carcinoma []. ctgov:NCT01333475.
  • 74
    • 84983579253 scopus 로고    scopus 로고
    • Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Cannot Removed by Surgery [].
    • ctgov:NCT01802320
    • Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Cannot Removed by Surgery []. ctgov:NCT01802320.
  • 75
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin D.A., Sabatini D.M. The pharmacology of mTOR inhibition. Sci Signal 2009, 2(67):pe24.
    • (2009) Sci Signal , vol.2 , Issue.67 , pp. pe24
    • Guertin, D.A.1    Sabatini, D.M.2
  • 76
    • 84881137155 scopus 로고    scopus 로고
    • Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens
    • Ng K., Tabernero J., Hwang J., et al. Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens. Clin Cancer Res 2013, 19:3987-3995.
    • (2013) Clin Cancer Res , vol.19 , pp. 3987-3995
    • Ng, K.1    Tabernero, J.2    Hwang, J.3
  • 77
    • 84877064638 scopus 로고    scopus 로고
    • Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer
    • Wolpin B.M., Ng K., Zhu A.X., et al. Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer. Oncologist 2013, 18:377-378.
    • (2013) Oncologist , vol.18 , pp. 377-378
    • Wolpin, B.M.1    Ng, K.2    Zhu, A.X.3
  • 78
    • 70949095836 scopus 로고    scopus 로고
    • Bevacizumab (B) plus everolimus (E) in refractory metastatic colorectal cancer (mCRC)
    • [abstract]
    • Bullock K.E., Hurwitz H.I., Uronis H.E., et al. Bevacizumab (B) plus everolimus (E) in refractory metastatic colorectal cancer (mCRC). J Clin Oncol 2009, 27:4080. [abstract].
    • (2009) J Clin Oncol , vol.27 , pp. 4080
    • Bullock, K.E.1    Hurwitz, H.I.2    Uronis, H.E.3
  • 79
    • 80052197143 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus everolimus for refractory metastatic colorectal cancer
    • Altomare I., Bendell J.C., Bullock K.E., et al. Phase II trial of bevacizumab plus everolimus for refractory metastatic colorectal cancer. Oncologist 2011, 16:1131-1137.
    • (2011) Oncologist , vol.16 , pp. 1131-1137
    • Altomare, I.1    Bendell, J.C.2    Bullock, K.E.3
  • 80
    • 84877350259 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma
    • Spindler K.L., Sorensen M.M., Pallisgaard N., et al. Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma. Acta Oncol 2013, 52:963-970.
    • (2013) Acta Oncol , vol.52 , pp. 963-970
    • Spindler, K.L.1    Sorensen, M.M.2    Pallisgaard, N.3
  • 81
    • 84877007803 scopus 로고    scopus 로고
    • Phase I study of everolimus (RAD001) with irinotecan (Iri) and cetuximab (C) in second-line metastatic colorectal cancer (mCRC): Hoosier Oncology Group. GI05-102 - final report
    • [abstract]
    • Shahda S., Yu M., Picus J., et al. Phase I study of everolimus (RAD001) with irinotecan (Iri) and cetuximab (C) in second-line metastatic colorectal cancer (mCRC): Hoosier Oncology Group. GI05-102 - final report. J Clin Oncol 2011, 29:3587. [abstract].
    • (2011) J Clin Oncol , vol.29 , pp. 3587
    • Shahda, S.1    Yu, M.2    Picus, J.3
  • 82
    • 84877009420 scopus 로고    scopus 로고
    • Phase I study of RAD001 (everolimus), cetuximab, and irinotecan as second-line therapy in metastatic colorectal cancer (mCRC)
    • [abstract]
    • Sharma S., Reid T., Hoosen S., et al. Phase I study of RAD001 (everolimus), cetuximab, and irinotecan as second-line therapy in metastatic colorectal cancer (mCRC). J Clin Oncol 2009, 27:e15115. [abstract].
    • (2009) J Clin Oncol , vol.27 , pp. e15115
    • Sharma, S.1    Reid, T.2    Hoosen, S.3
  • 83
    • 84983589390 scopus 로고    scopus 로고
    • MTOR inhibitor everolimus (Ev) and IGFR inhibitor OSI-906 (OSI) for the treatment of patients (pts) with refractory metastatic colorectal cancer (mCRC): a Sarah Cannon Research Institute phase I trial
    • [abstract]
    • Hart L., Burris H.A., Infante J.R., et al. mTOR inhibitor everolimus (Ev) and IGFR inhibitor OSI-906 (OSI) for the treatment of patients (pts) with refractory metastatic colorectal cancer (mCRC): a Sarah Cannon Research Institute phase I trial. J Clin Oncol 2011, 29:e14054. [abstract].
    • (2011) J Clin Oncol , vol.29 , pp. e14054
    • Hart, L.1    Burris, H.A.2    Infante, J.R.3
  • 84
    • 84877008587 scopus 로고    scopus 로고
    • Phase I study of mFOLFOX-6, bevacizumab, and mTOR inhibitor RAD001 as first-line treatment of metastatic colorectal cancer
    • [abstract]
    • Glynn W.G., John R.W., Kimberly J., et al. Phase I study of mFOLFOX-6, bevacizumab, and mTOR inhibitor RAD001 as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2012, 30:600. [abstract].
    • (2012) J Clin Oncol , vol.30 , pp. 600
    • Glynn, W.G.1    John, R.W.2    Kimberly, J.3
  • 86
    • 50949104555 scopus 로고    scopus 로고
    • Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy
    • Yu K., Toral-Barza L., Shi C., et al. Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy. Cancer Biol Ther 2008, 7:307-315.
    • (2008) Cancer Biol Ther , vol.7 , pp. 307-315
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3
  • 87
    • 73349129405 scopus 로고    scopus 로고
    • Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
    • Faber A.C., Li D., Song Y., Liang M.C., et al. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci U S A 2009, 106:19503-19508.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 19503-19508
    • Faber, A.C.1    Li, D.2    Song, Y.3    Liang, M.C.4
  • 88
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: of feedbacks and cross-talks
    • Carracedo A., Pandolfi P.P. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 2008, 27:5527-5541.
    • (2008) Oncogene , vol.27 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 89
    • 84859874162 scopus 로고    scopus 로고
    • The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer
    • Shimizu T., Tolcher A.W., Papadopoulos K.P., et al. The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer. Clin Cancer Res 2012, 18:2316-2325.
    • (2012) Clin Cancer Res , vol.18 , pp. 2316-2325
    • Shimizu, T.1    Tolcher, A.W.2    Papadopoulos, K.P.3
  • 90
    • 84874650275 scopus 로고    scopus 로고
    • Development of PI3K inhibitors: lessons learned from early clinical trials
    • Rodon J., Dienstmann R., Serra V., et al. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol 2013, 10:143-153.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 143-153
    • Rodon, J.1    Dienstmann, R.2    Serra, V.3
  • 91
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G., Hirth P., Tsai J., et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467:596-599.
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1    Hirth, P.2    Tsai, J.3
  • 92
    • 84865758081 scopus 로고    scopus 로고
    • Genomic complexity and AKT dependence in serous ovarian cancer
    • Hanrahan A.J., Schultz N., Westfal M.L., et al. Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Discov 2012, 2:56-67.
    • (2012) Cancer Discov , vol.2 , pp. 56-67
    • Hanrahan, A.J.1    Schultz, N.2    Westfal, M.L.3
  • 93
    • 84894477310 scopus 로고    scopus 로고
    • Evaluating many treatments and biomarkers in oncology: a new design
    • Kaplan R., Maughan T., Crook A., et al. Evaluating many treatments and biomarkers in oncology: a new design. J Clin Oncol 2013, 31:4562-4570.
    • (2013) J Clin Oncol , vol.31 , pp. 4562-4570
    • Kaplan, R.1    Maughan, T.2    Crook, A.3
  • 94
    • 84878066430 scopus 로고    scopus 로고
    • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer
    • Coffee E.M., Faber A.C., Roper J., et al. Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. Clin Cancer Res 2013, 19:2688-2698.
    • (2013) Clin Cancer Res , vol.19 , pp. 2688-2698
    • Coffee, E.M.1    Faber, A.C.2    Roper, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.