-
2
-
-
80051580618
-
Cancer statistics 2011 the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
-
Siegel R., Ward E., Brawley O., et al. Cancer statistics 2011 the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011, 61:212-236.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 212-236
-
-
Siegel, R.1
Ward, E.2
Brawley, O.3
-
3
-
-
0031019918
-
Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study
-
de Gramont A., Bosset J.F., Milan C., et al. Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study. J Clin Oncol 1997, 15:808-815.
-
(1997)
J Clin Oncol
, vol.15
, pp. 808-815
-
-
de Gramont, A.1
Bosset, J.F.2
Milan, C.3
-
4
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
-
Saltz L.B., Cox J.V., Blanke C., et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 2000, 343:905-914.
-
(2000)
N Engl J Med
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
-
5
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
de Gramont A., Figer A., Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000, 18:2938-2947.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2938-2947
-
-
de Gramont, A.1
Figer, A.2
Seymour, M.3
-
6
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285(November):1182-1186.
-
(1971)
N Engl J Med
, vol.285
, Issue.NOVEMBER
, pp. 1182-1186
-
-
Folkman, J.1
-
7
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350:2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
8
-
-
0343819997
-
Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2 ERB B3) in colorectal adenocarcinomas and adenomas
-
Porebska I., Harlozińska A., Bojarowski T. Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2 ERB B3) in colorectal adenocarcinomas and adenomas. Tumour Biol 2000, 21:105-115.
-
(2000)
Tumour Biol
, vol.21
, pp. 105-115
-
-
Porebska, I.1
Harlozińska, A.2
Bojarowski, T.3
-
9
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E., Köhne C.H., Hitre E., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009, 360:1408-1417.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
-
10
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
11
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Grothey A., Van Cutsem E., Sobrero A., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013, 381:303-312.
-
(2013)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
-
12
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E., Tabernero J., Lakomy R., et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012, 30:3499-3506.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
13
-
-
0021828496
-
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
-
Whitman M., Kaplan D.R., Schaffhausen B., et al. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 1985, 315:239-242.
-
(1985)
Nature
, vol.315
, pp. 239-242
-
-
Whitman, M.1
Kaplan, D.R.2
Schaffhausen, B.3
-
14
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006, 7:606-619.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
15
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y., Wang Z., Bardelli A., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304:554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
16
-
-
51849111556
-
PI3K pathway alterations in cancer: variations on a theme
-
Yuan T.L., Cantley L.C. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008, 27:5497-5510.
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
18
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer
-
Katso R., Okkenhaug K., Ahmadi K., et al. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001, 17:615-675.
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
-
19
-
-
13944284494
-
Oncogenic mutations of PIK3CA in human cancers
-
Samuels Y., Velculescu V.E. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004, 3:1221-1224.
-
(2004)
Cell Cycle
, vol.3
, pp. 1221-1224
-
-
Samuels, Y.1
Velculescu, V.E.2
-
20
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
21
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi D.R., James S.R., Downes C.P., et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997, 7:261-269.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
-
22
-
-
58149175555
-
The life of a cell: apoptosis regulation by the PI3K/PKB pathway
-
Duronio V. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 2008, 415:333-344.
-
(2008)
Biochem J
, vol.415
, pp. 333-344
-
-
Duronio, V.1
-
24
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
25
-
-
34248592612
-
Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans
-
Rosenberg D.W., Yang S., Pleau D.C., et al. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Res 2007, 67:3551-3554.
-
(2007)
Cancer Res
, vol.67
, pp. 3551-3554
-
-
Rosenberg, D.W.1
Yang, S.2
Pleau, D.C.3
-
26
-
-
0033563165
-
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
-
Toyota M., Ho C., Ahuja N., Jair K.W., et al. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res 1999, 59:2307-2312.
-
(1999)
Cancer Res
, vol.59
, pp. 2307-2312
-
-
Toyota, M.1
Ho, C.2
Ahuja, N.3
Jair, K.W.4
-
27
-
-
53149097362
-
BRAF KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
-
Velho S., Moutinho C., Cirnes L., et al. BRAF KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?. BMC Cancer 2008, 8:255.
-
(2008)
BMC Cancer
, vol.8
, pp. 255
-
-
Velho, S.1
Moutinho, C.2
Cirnes, L.3
-
28
-
-
31944448780
-
Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
-
Kang S., Denley A., Vanhaesebroeck B., et al. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2006, 103:1289-1294.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1289-1294
-
-
Kang, S.1
Denley, A.2
Vanhaesebroeck, B.3
-
29
-
-
0036195196
-
AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
-
Roy H.K., Olusola B.F., Clemens D.L., et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002, 23:201-205.
-
(2002)
Carcinogenesis
, vol.23
, pp. 201-205
-
-
Roy, H.K.1
Olusola, B.F.2
Clemens, D.L.3
-
30
-
-
84876954020
-
PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions
-
Waniczek D., Śnietura M., Młynarczyk-Liszka J., et al. PTEN expression profiles in colorectal adenocarcinoma and its precancerous lesions. Pol J Pathol 2013, 64:15-20.
-
(2013)
Pol J Pathol
, vol.64
, pp. 15-20
-
-
Waniczek, D.1
Śnietura, M.2
Młynarczyk-Liszka, J.3
-
31
-
-
44349111717
-
Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?
-
Colakoglu T., Yildirim S., Kayaselcuk F., et al. Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?. Am J Surg 2008, 195:719-725.
-
(2008)
Am J Surg
, vol.195
, pp. 719-725
-
-
Colakoglu, T.1
Yildirim, S.2
Kayaselcuk, F.3
-
32
-
-
0031883606
-
Genetics of Cowden syndrome: through the looking glass of oncology
-
Eng C. Genetics of Cowden syndrome: through the looking glass of oncology. Int J Oncol 1998, 12:701-710.
-
(1998)
Int J Oncol
, vol.12
, pp. 701-710
-
-
Eng, C.1
-
33
-
-
51649126752
-
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice
-
Fujishita T., Aoki K., Lane H.A., et al. Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci U S A 2008, 105:13544-13549.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13544-13549
-
-
Fujishita, T.1
Aoki, K.2
Lane, H.A.3
-
34
-
-
84877358772
-
Stage at diagnosis and colorectal cancer survival in six high-income countries: a population-based study of patients diagnosed during 2000-2007
-
Maringe C., Walters S., Rachet B., et al. Stage at diagnosis and colorectal cancer survival in six high-income countries: a population-based study of patients diagnosed during 2000-2007. Acta Oncol 2013, 52:919-932.
-
(2013)
Acta Oncol
, vol.52
, pp. 919-932
-
-
Maringe, C.1
Walters, S.2
Rachet, B.3
-
35
-
-
77954320936
-
Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up
-
Labianca R., Nordlinger B., Beretta G.D., et al. Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up. Ann Oncol 2010, 21(Suppl. 5):v70-v77.
-
(2010)
Ann Oncol
, vol.21
, pp. v70-v77
-
-
Labianca, R.1
Nordlinger, B.2
Beretta, G.D.3
-
36
-
-
84866745407
-
Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial
-
Tournigand C., André T., Bonnetain F., et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial. J Clin Oncol 2012, 30:3353-3360.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3353-3360
-
-
Tournigand, C.1
André, T.2
Bonnetain, F.3
-
37
-
-
34548676803
-
PIK3CA mutation is predictive of poor survival in patients with colorectal cancer
-
Kato S., Iida S., Higuchi T., et al. PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer 2007, 121:1771-1778.
-
(2007)
Int J Cancer
, vol.121
, pp. 1771-1778
-
-
Kato, S.1
Iida, S.2
Higuchi, T.3
-
38
-
-
63049111794
-
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
-
Ogino S., Nosho K., Kirkner G.J., et al. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 2009, 27:1477-1484.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1477-1484
-
-
Ogino, S.1
Nosho, K.2
Kirkner, G.J.3
-
39
-
-
84890448787
-
Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial
-
[Epub ahead of print]
-
Ogino S., Liao X., Imamura Y., et al. Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial. J Natl Cancer Inst 2013, (November). [Epub ahead of print].
-
(2013)
J Natl Cancer Inst
, Issue.NOVEMBER
-
-
Ogino, S.1
Liao, X.2
Imamura, Y.3
-
40
-
-
78449241791
-
PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac
-
Kaur J., Sanyal S.N. PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. Tumour Biol 2010, 31:623-631.
-
(2010)
Tumour Biol
, vol.31
, pp. 623-631
-
-
Kaur, J.1
Sanyal, S.N.2
-
41
-
-
34248157118
-
British Doctors Aspirin Trial and the UK-TIA Aspirin Trial. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
-
Flossmann E., Rothwell P.M. British Doctors Aspirin Trial and the GBR-TIA Aspirin Trial. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 2007, 369:1603-1613.
-
(2007)
Lancet
, vol.369
, pp. 1603-1613
-
-
Flossmann, E.1
Rothwell, P.M.2
-
42
-
-
84867817838
-
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
-
Liao X., Lochhead P., Nishihara R., et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012, 367:1596-1606.
-
(2012)
N Engl J Med
, vol.367
, pp. 1596-1606
-
-
Liao, X.1
Lochhead, P.2
Nishihara, R.3
-
43
-
-
84892843686
-
Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer
-
Domingo E., Church D.N., Sieber O., et al. Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. J Clin Oncol 2013, 31:4297-4305.
-
(2013)
J Clin Oncol
, vol.31
, pp. 4297-4305
-
-
Domingo, E.1
Church, D.N.2
Sieber, O.3
-
44
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis C.S., Khambata-Ford S., Jonker D.J., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359:1757-1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
45
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E., Köhne C.H., Láng I., et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011, 29:2011-2019.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2011-2019
-
-
Van Cutsem, E.1
Köhne, C.H.2
Láng, I.3
-
46
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
-
Sartore-Bianchi A., Martini M., Molinari F., et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009, 69:1851-1857.
-
(2009)
Cancer Res
, vol.69
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
-
47
-
-
40649096375
-
Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
-
Zhao L., Vogt P.K. Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci U S A 2008, 105:2652-2657.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2652-2657
-
-
Zhao, L.1
Vogt, P.K.2
-
48
-
-
84860634396
-
PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
-
Mao C., Yang Z.Y., Hu X.F., et al. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol 2012, 23:1518-1525.
-
(2012)
Ann Oncol
, vol.23
, pp. 1518-1525
-
-
Mao, C.1
Yang, Z.Y.2
Hu, X.F.3
-
49
-
-
59049089201
-
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
-
Perrone F., Lampis A., Orsenigo M., et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol 2009, 20:84-90.
-
(2009)
Ann Oncol
, vol.20
, pp. 84-90
-
-
Perrone, F.1
Lampis, A.2
Orsenigo, M.3
-
50
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman J.A., Chen L., Tan X., et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008, 14:1351-1356.
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
-
51
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman P.B., Hauschild A., Robert C., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011, 364:2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
52
-
-
84873360893
-
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
-
Mao M., Tian F., Mariadason J.M., et al. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res 2013, 19:657-667.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 657-667
-
-
Mao, M.1
Tian, F.2
Mariadason, J.M.3
-
53
-
-
33644513730
-
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M., You H., Levine A.J., et al. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006, 6:184-192.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
-
54
-
-
84864441197
-
PI3K expression and PIK3CA mutations are related to colorectal cancer metastases
-
Yu-Fen Zhu, Bao-Hua Yu, Da-Li Li, et al. PI3K expression and PIK3CA mutations are related to colorectal cancer metastases. World J Gastroenterol 2012, 18:3745-3751.
-
(2012)
World J Gastroenterol
, vol.18
, pp. 3745-3751
-
-
Zhu, Y.-F.1
Yu, B.-H.2
Li, D.-L.3
-
55
-
-
67649386846
-
The antiproliferative cytostatic effects of a self-activating viridin prodrug
-
Smith A., Blois J., Yuan H., et al. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther 2009, 8:1666-1675.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1666-1675
-
-
Smith, A.1
Blois, J.2
Yuan, H.3
-
56
-
-
84856071447
-
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
-
Bendell J.C., Rodon J., Burris H.A., et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol 2012, 30:282-290.
-
(2012)
J Clin Oncol
, vol.30
, pp. 282-290
-
-
Bendell, J.C.1
Rodon, J.2
Burris, H.A.3
-
57
-
-
84983585189
-
A Trial of Irinotecan and BKM120 in Previously Treated Advanced Colorectal Cancer [].
-
ctgov:NCT01304602
-
A Trial of Irinotecan and BKM120 in Previously Treated Advanced Colorectal Cancer []. ctgov:NCT01304602.
-
-
-
-
58
-
-
84983585186
-
P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Patients With Metastatic or Advanced RAS-Wild Type Colorectal Cancer [].
-
ctgov:NCT01591421
-
P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Patients With Metastatic or Advanced RAS-Wild Type Colorectal Cancer []. ctgov:NCT01591421.
-
-
-
-
59
-
-
84864493357
-
A multicenter phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors
-
Hong D.S., Bowles D.W., Falchook G.S., et al. A multicenter phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors. Clin Cancer Res 2012, 18(82):4173.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.82
, pp. 4173
-
-
Hong, D.S.1
Bowles, D.W.2
Falchook, G.S.3
-
60
-
-
77956566979
-
A phase I dose-escalation study of XL147 (SAR245408), a PI3K inhibitor administered orally to patients (pts) with advanced malignancies
-
(suppl; abstr 3004)
-
Edelman G., Bedell C., Shapiro G., et al. A phase I dose-escalation study of XL147 (SAR245408), a PI3K inhibitor administered orally to patients (pts) with advanced malignancies. J Clin Oncol 2010, 28(15s). (suppl; abstr 3004).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Edelman, G.1
Bedell, C.2
Shapiro, G.3
-
61
-
-
84926105922
-
First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors
-
Nov 4, [Epub ahead of print]
-
Sarker D., Ang J.E., Baird R., et al. First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2014, (Nov 4). [Epub ahead of print].
-
(2014)
Clin Cancer Res.
-
-
Sarker, D.1
Ang, J.E.2
Baird, R.3
-
62
-
-
84883559711
-
Phase I study of BYL719, an alpha-specific PI3K inhibitor, in patients with PIK3CA mutant advanced solid tumors: preliminary efficacy and safety in patients with PIK3CA mutant ER-positive (ER+) metastatic breast cancer (MBC)
-
Juric D., Argiles G., Burris H.A., et al. Phase I study of BYL719, an alpha-specific PI3K inhibitor, in patients with PIK3CA mutant advanced solid tumors: preliminary efficacy and safety in patients with PIK3CA mutant ER-positive (ER+) metastatic breast cancer (MBC). Cancer Res. 2012, 72(24 (Suppl. 3)).
-
(2012)
Cancer Res.
, vol.72
, Issue.24
-
-
Juric, D.1
Argiles, G.2
Burris, H.A.3
-
63
-
-
84983578838
-
Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer [].
-
ctgov:NCT01719380
-
Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer []. ctgov:NCT01719380.
-
-
-
-
64
-
-
84875143933
-
Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Kα) for the treatment of PTEN deficient tumors
-
Rivero R.A., Hardwicke M.A. Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Kα) for the treatment of PTEN deficient tumors. Cancer Res 2012, 72(8 (Suppl. 1)).
-
(2012)
Cancer Res
, vol.72
, Issue.8
-
-
Rivero, R.A.1
Hardwicke, M.A.2
-
65
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly K.E., Rojo F., She Q.B., et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006, 66:1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
66
-
-
84983579261
-
Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients [].
-
ctgov:NCT01337765
-
Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients []. ctgov:NCT01337765.
-
-
-
-
67
-
-
80053169195
-
The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer
-
Roper J., Richardson M.P., Wang W.V., et al. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PLoS ONE 2011, 6(9):e25132.
-
(2011)
PLoS ONE
, vol.6
, Issue.9
, pp. e25132
-
-
Roper, J.1
Richardson, M.P.2
Wang, W.V.3
-
68
-
-
84860540538
-
Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas
-
Migliardi G., Sassi F., Torti D., et al. Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas. Clin Cancer Res 2012, 18:2515-2525.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2515-2525
-
-
Migliardi, G.1
Sassi, F.2
Torti, D.3
-
69
-
-
84899750348
-
Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors
-
Papadopoulos KP1, Tabernero J., Markman B., et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors. Clin Cancer Res 2014, 20:2445-2456.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 2445-2456
-
-
Papadopoulos, K.P.1
Tabernero, J.2
Markman, B.3
-
71
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
Vasudevan K.M., Barbie D.A., Davies M.A., et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009, 16:21-32.
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
-
72
-
-
83255162603
-
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors
-
Yap T.A., Yan L., Patnaik A., et al. First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol 2011, 29:4688-4695.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4688-4695
-
-
Yap, T.A.1
Yan, L.2
Patnaik, A.3
-
73
-
-
84983579251
-
MK-2206 and AZD6244 in Patients With Advanced Colorectal Carcinoma [].
-
ctgov:NCT01333475
-
MK-2206 and AZD6244 in Patients With Advanced Colorectal Carcinoma []. ctgov:NCT01333475.
-
-
-
-
74
-
-
84983579253
-
Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Cannot Removed by Surgery [].
-
ctgov:NCT01802320
-
Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Cannot Removed by Surgery []. ctgov:NCT01802320.
-
-
-
-
75
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
Guertin D.A., Sabatini D.M. The pharmacology of mTOR inhibition. Sci Signal 2009, 2(67):pe24.
-
(2009)
Sci Signal
, vol.2
, Issue.67
, pp. pe24
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
76
-
-
84881137155
-
Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens
-
Ng K., Tabernero J., Hwang J., et al. Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens. Clin Cancer Res 2013, 19:3987-3995.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3987-3995
-
-
Ng, K.1
Tabernero, J.2
Hwang, J.3
-
77
-
-
84877064638
-
Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer
-
Wolpin B.M., Ng K., Zhu A.X., et al. Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer. Oncologist 2013, 18:377-378.
-
(2013)
Oncologist
, vol.18
, pp. 377-378
-
-
Wolpin, B.M.1
Ng, K.2
Zhu, A.X.3
-
78
-
-
70949095836
-
Bevacizumab (B) plus everolimus (E) in refractory metastatic colorectal cancer (mCRC)
-
[abstract]
-
Bullock K.E., Hurwitz H.I., Uronis H.E., et al. Bevacizumab (B) plus everolimus (E) in refractory metastatic colorectal cancer (mCRC). J Clin Oncol 2009, 27:4080. [abstract].
-
(2009)
J Clin Oncol
, vol.27
, pp. 4080
-
-
Bullock, K.E.1
Hurwitz, H.I.2
Uronis, H.E.3
-
79
-
-
80052197143
-
Phase II trial of bevacizumab plus everolimus for refractory metastatic colorectal cancer
-
Altomare I., Bendell J.C., Bullock K.E., et al. Phase II trial of bevacizumab plus everolimus for refractory metastatic colorectal cancer. Oncologist 2011, 16:1131-1137.
-
(2011)
Oncologist
, vol.16
, pp. 1131-1137
-
-
Altomare, I.1
Bendell, J.C.2
Bullock, K.E.3
-
80
-
-
84877350259
-
Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma
-
Spindler K.L., Sorensen M.M., Pallisgaard N., et al. Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma. Acta Oncol 2013, 52:963-970.
-
(2013)
Acta Oncol
, vol.52
, pp. 963-970
-
-
Spindler, K.L.1
Sorensen, M.M.2
Pallisgaard, N.3
-
81
-
-
84877007803
-
Phase I study of everolimus (RAD001) with irinotecan (Iri) and cetuximab (C) in second-line metastatic colorectal cancer (mCRC): Hoosier Oncology Group. GI05-102 - final report
-
[abstract]
-
Shahda S., Yu M., Picus J., et al. Phase I study of everolimus (RAD001) with irinotecan (Iri) and cetuximab (C) in second-line metastatic colorectal cancer (mCRC): Hoosier Oncology Group. GI05-102 - final report. J Clin Oncol 2011, 29:3587. [abstract].
-
(2011)
J Clin Oncol
, vol.29
, pp. 3587
-
-
Shahda, S.1
Yu, M.2
Picus, J.3
-
82
-
-
84877009420
-
Phase I study of RAD001 (everolimus), cetuximab, and irinotecan as second-line therapy in metastatic colorectal cancer (mCRC)
-
[abstract]
-
Sharma S., Reid T., Hoosen S., et al. Phase I study of RAD001 (everolimus), cetuximab, and irinotecan as second-line therapy in metastatic colorectal cancer (mCRC). J Clin Oncol 2009, 27:e15115. [abstract].
-
(2009)
J Clin Oncol
, vol.27
, pp. e15115
-
-
Sharma, S.1
Reid, T.2
Hoosen, S.3
-
83
-
-
84983589390
-
MTOR inhibitor everolimus (Ev) and IGFR inhibitor OSI-906 (OSI) for the treatment of patients (pts) with refractory metastatic colorectal cancer (mCRC): a Sarah Cannon Research Institute phase I trial
-
[abstract]
-
Hart L., Burris H.A., Infante J.R., et al. mTOR inhibitor everolimus (Ev) and IGFR inhibitor OSI-906 (OSI) for the treatment of patients (pts) with refractory metastatic colorectal cancer (mCRC): a Sarah Cannon Research Institute phase I trial. J Clin Oncol 2011, 29:e14054. [abstract].
-
(2011)
J Clin Oncol
, vol.29
, pp. e14054
-
-
Hart, L.1
Burris, H.A.2
Infante, J.R.3
-
84
-
-
84877008587
-
Phase I study of mFOLFOX-6, bevacizumab, and mTOR inhibitor RAD001 as first-line treatment of metastatic colorectal cancer
-
[abstract]
-
Glynn W.G., John R.W., Kimberly J., et al. Phase I study of mFOLFOX-6, bevacizumab, and mTOR inhibitor RAD001 as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2012, 30:600. [abstract].
-
(2012)
J Clin Oncol
, vol.30
, pp. 600
-
-
Glynn, W.G.1
John, R.W.2
Kimberly, J.3
-
86
-
-
50949104555
-
Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy
-
Yu K., Toral-Barza L., Shi C., et al. Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy. Cancer Biol Ther 2008, 7:307-315.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 307-315
-
-
Yu, K.1
Toral-Barza, L.2
Shi, C.3
-
87
-
-
73349129405
-
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
-
Faber A.C., Li D., Song Y., Liang M.C., et al. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci U S A 2009, 106:19503-19508.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 19503-19508
-
-
Faber, A.C.1
Li, D.2
Song, Y.3
Liang, M.C.4
-
88
-
-
51849084360
-
The PTEN-PI3K pathway: of feedbacks and cross-talks
-
Carracedo A., Pandolfi P.P. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 2008, 27:5527-5541.
-
(2008)
Oncogene
, vol.27
, pp. 5527-5541
-
-
Carracedo, A.1
Pandolfi, P.P.2
-
89
-
-
84859874162
-
The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer
-
Shimizu T., Tolcher A.W., Papadopoulos K.P., et al. The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer. Clin Cancer Res 2012, 18:2316-2325.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2316-2325
-
-
Shimizu, T.1
Tolcher, A.W.2
Papadopoulos, K.P.3
-
90
-
-
84874650275
-
Development of PI3K inhibitors: lessons learned from early clinical trials
-
Rodon J., Dienstmann R., Serra V., et al. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol 2013, 10:143-153.
-
(2013)
Nat Rev Clin Oncol
, vol.10
, pp. 143-153
-
-
Rodon, J.1
Dienstmann, R.2
Serra, V.3
-
91
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G., Hirth P., Tsai J., et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467:596-599.
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
-
92
-
-
84865758081
-
Genomic complexity and AKT dependence in serous ovarian cancer
-
Hanrahan A.J., Schultz N., Westfal M.L., et al. Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Discov 2012, 2:56-67.
-
(2012)
Cancer Discov
, vol.2
, pp. 56-67
-
-
Hanrahan, A.J.1
Schultz, N.2
Westfal, M.L.3
-
93
-
-
84894477310
-
Evaluating many treatments and biomarkers in oncology: a new design
-
Kaplan R., Maughan T., Crook A., et al. Evaluating many treatments and biomarkers in oncology: a new design. J Clin Oncol 2013, 31:4562-4570.
-
(2013)
J Clin Oncol
, vol.31
, pp. 4562-4570
-
-
Kaplan, R.1
Maughan, T.2
Crook, A.3
-
94
-
-
84878066430
-
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer
-
Coffee E.M., Faber A.C., Roper J., et al. Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. Clin Cancer Res 2013, 19:2688-2698.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2688-2698
-
-
Coffee, E.M.1
Faber, A.C.2
Roper, J.3
|