-
1
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
2
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004;4:335-48
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
3
-
-
79951627404
-
Current and future directions in mammalian target of rapamycin inhibitors development
-
Fasolo A, Sessa C. Current and future directions in mammalian target of rapamycin inhibitors development. Expert Opin Investig Drugs 2011;20:381-94
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 381-394
-
-
Fasolo, A.1
Sessa, C.2
-
4
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271-81
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
5
-
-
68949102180
-
Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
-
Hess G, Herbrecht R, Romaguera J, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol 2009;27:3822-9
-
(2009)
J Clin Oncol
, vol.27
, pp. 3822-3829
-
-
Hess, G.1
Herbrecht, R.2
Romaguera, J.3
-
6
-
-
84855556875
-
Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
-
Chawla SP, Staddon AP, Baker LH, et al. Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. J Clin Oncol 2012;30:78-84
-
(2012)
J Clin Oncol
, vol.30
, pp. 78-84
-
-
Chawla, S.P.1
Staddon, A.P.2
Baker, L.H.3
-
7
-
-
5444267283
-
Tolerability and steady-state pharmacokinetics of everolimus in maintenance renal transplant patients
-
Budde K, Neumayer HH, Lehne G, et al. Tolerability and steady-state pharmacokinetics of everolimus in maintenance renal transplant patients. Nephrol Dial Transplant 2004;19:2606-14
-
(2004)
Nephrol Dial Transplant
, vol.19
, pp. 2606-2614
-
-
Budde, K.1
Neumayer, H.H.2
Lehne, G.3
-
8
-
-
0141433268
-
Everolimus in de novo cardiac transplantation: Pharmacokinetics therapeutic range and influence on cyclosporine exposure
-
Kovarik JM, Eisen H, Dorent R, et al. Everolimus in de novo cardiac transplantation: pharmacokinetics, therapeutic range, and influence on cyclosporine exposure. J Heart Lung Transplant 2003;22:1117-25
-
(2003)
J Heart Lung Transplant
, vol.22
, pp. 1117-1125
-
-
Kovarik, J.M.1
Eisen, H.2
Dorent, R.3
-
9
-
-
0037570816
-
Pharmacokinetics of an everolimus-cyclosporine immunosuppressive regimen over the first 6 months after kidney transplantation
-
Kovarik JM, Kaplan B, Silva HT, et al. Pharmacokinetics of an everolimus-cyclosporine immunosuppressive regimen over the first 6 months after kidney transplantation. Am J Transplant 2003;3:606-13
-
(2003)
Am J Transplant
, vol.3
, pp. 606-613
-
-
Kovarik, J.M.1
Kaplan, B.2
Silva, H.T.3
-
10
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012;366:520-9
-
(2012)
N Engl J Med
, vol.366
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
11
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-56
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
12
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
Yao JC, Shah MH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 2011;364:514-23
-
(2011)
N Engl J Med
, vol.364
, pp. 514-523
-
-
Yao, J.C.1
Shah, M.H.2
Ito, T.3
-
13
-
-
78049510428
-
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
-
Krueger DA, Care MM, Holland K, et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 2010;363:1801-11
-
(2010)
N Engl J Med
, vol.363
, pp. 1801-1811
-
-
Krueger, D.A.1
Care, M.M.2
Holland, K.3
-
14
-
-
54949144410
-
MTOR inhibitors in the treatment of cancer
-
Fasolo A, Sessa C. mTOR inhibitors in the treatment of cancer. Expert Opin Investig Drugs 2008;17:1717-34
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1717-1734
-
-
Fasolo, A.1
Sessa, C.2
-
15
-
-
84862528335
-
Targeting mTOR pathways in human malignancies
-
Fasolo A, Sessa C. Targeting mTOR pathways in human malignancies. Curr Pharm Des 2012;18:2766-77
-
(2012)
Curr Pharm des
, vol.18
, pp. 2766-2777
-
-
Fasolo, A.1
Sessa, C.2
-
16
-
-
43249131245
-
Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase i tumor pharmacodynamic study in patients with advanced solid tumors
-
Tabernero J, Rojo F, Calvo E, et al. Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 2008;26:1603-10
-
(2008)
J Clin Oncol
, vol.26
, pp. 1603-1610
-
-
Tabernero, J.1
Rojo, F.2
Calvo, E.3
-
17
-
-
34247127783
-
Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
-
Nozawa H, Watanabe T, Nagawa H. Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. Cancer Lett 2007;251:105-13
-
(2007)
Cancer Lett
, vol.251
, pp. 105-113
-
-
Nozawa, H.1
Watanabe, T.2
Nagawa, H.3
-
18
-
-
34548178582
-
The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells
-
Dormond O, Madsen JC, Briscoe DM. The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. J Biol Chem 2007;282:23679-86
-
(2007)
J Biol Chem
, vol.282
, pp. 23679-23686
-
-
Dormond, O.1
Madsen, J.C.2
Briscoe, D.M.3
-
19
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
20
-
-
1842852634
-
Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors
-
Xu G, Zhang W, Bertram P, et al. Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors. Int J Oncol 2004;24:893-900
-
(2004)
Int J Oncol
, vol.24
, pp. 893-900
-
-
Xu, G.1
Zhang, W.2
Bertram, P.3
-
21
-
-
0344826531
-
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/-compound mutant mice
-
Aoki K, Tamai Y, Horiike S, et al. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/-compound mutant mice. Nat Genet 35:323-30.2003
-
(2003)
Nat Genet
, vol.35
, pp. 323-330
-
-
Aoki, K.1
Tamai, Y.2
Horiike, S.3
-
23
-
-
2942518250
-
Lost in translation: Dysregulation of cap-dependent translation and cancer
-
Bjornsti MA, Houghton PJ. Lost in translation: dysregulation of cap-dependent translation and cancer. Cancer Cell 2004;5:519-23
-
(2004)
Cancer Cell
, vol.5
, pp. 519-523
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
24
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002;22:7004-14
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
-
25
-
-
84863971730
-
A multicenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma
-
Renner C, Zinzani PL, Gressin R, et al. A multicenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma. Haematologica 2012;97:1085-91
-
(2012)
Haematologica
, vol.97
, pp. 1085-1091
-
-
Renner, C.1
Zinzani, P.L.2
Gressin, R.3
-
26
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006;5:671-88
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
27
-
-
0034904742
-
Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon
-
Berkel HJ, Turbat-Herrera EA, Shi R, et al. Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon. Cancer Epidemiol Biomarkers Prev 2001;10:663-6
-
(2001)
Cancer Epidemiol Biomarkers Prev
, vol.10
, pp. 663-666
-
-
Berkel, H.J.1
Turbat-Herrera, E.A.2
Shi, R.3
-
28
-
-
0039656540
-
Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis
-
Rosenwald IB, Chen JJ, Wang S, et al. Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis. Oncogene 1999;18:2507-17
-
(1999)
Oncogene
, vol.18
, pp. 2507-2517
-
-
Rosenwald, I.B.1
Chen, J.J.2
Wang, S.3
-
29
-
-
70449907014
-
The role of mTORC1 pathway in intestinal tumorigenesis
-
Fujishita T, Aoki M, Taketo MM. The role of mTORC1 pathway in intestinal tumorigenesis. Cell Cycle 2009;8:3684-7
-
(2009)
Cell Cycle
, vol.8
, pp. 3684-3687
-
-
Fujishita, T.1
Aoki, M.2
Taketo, M.M.3
-
30
-
-
84868691651
-
The promise of mTOR inhibitors in the treatment of colorectal cancer
-
Kim DD, Eng C. The promise of mTOR inhibitors in the treatment of colorectal cancer. Expert Opin Investig Drugs 2012
-
(2012)
Expert Opin Investig Drugs
-
-
Kim, D.D.1
Eng, C.2
-
31
-
-
43249086546
-
Phase i pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
-
O'Donnell A, Faivre S, Burris HA III, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol 2008;26:1588-95
-
(2008)
J Clin Oncol
, vol.26
, pp. 1588-1595
-
-
O'Donnell, A.1
Faivre, S.2
Burris III, H.A.3
-
32
-
-
84868704043
-
Phase II trial of RAD001 in patients with refractory metastatic colorectal cancer
-
abstract 513]
-
Gold PJ, Iriarte D, Arthur J, et al. Phase II trial of RAD001 in patients with refractory metastatic colorectal cancer. JCO 2008;27(15s):[abstract 513]
-
(2008)
JCO
, vol.27
, Issue.15 S
-
-
Gold, P.J.1
Iriarte, D.2
Arthur, J.3
-
33
-
-
84877009790
-
Multicenter phase II study of RAD001 in patients with chemotherapy-refractory metastatic colorectal cancer
-
abstract 446]
-
Fuchs CS, Tabernero JM, Hwang J, et al. Multicenter phase II study of RAD001 in patients with chemotherapy-refractory metastatic colorectal cancer. JCO 2009;17(15s):[abstract 446]
-
(2009)
JCO
, vol.17
, Issue.15 S
-
-
Fuchs, C.S.1
Tabernero, J.M.2
Hwang, J.3
-
34
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-8
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
35
-
-
18144399578
-
MTOR-targeted therapy of cancer with rapamycin derivatives
-
Vignot S, Faivre S, Aguirre D, et al. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 2005;16:525-37
-
(2005)
Ann Oncol
, vol.16
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
-
36
-
-
78650511420
-
Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo
-
O'Reilly T, McSheehy PM, Wartmann M, et al. Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo. Anticancer Drugs 2011;22:58-78
-
(2011)
Anticancer Drugs
, vol.22
, pp. 58-78
-
-
O'Reilly, T.1
McSheehy, P.M.2
Wartmann, M.3
-
37
-
-
77950541904
-
Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: A review
-
Agarwala SS, Case S. Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: a review. Oncologist 2010;15:236-45
-
(2010)
Oncologist
, vol.15
, pp. 236-245
-
-
Agarwala, S.S.1
Case, S.2
-
38
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
39
-
-
63449098382
-
MTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor
-
Lane HA, Wood JM, McSheehy PM, et al. mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin Cancer Res 2009;15:1612-22
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1612-1622
-
-
Lane, H.A.1
Wood, J.M.2
McSheehy, P.M.3
-
40
-
-
43249095919
-
Tumor angiogenesis
-
Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-49
-
(2008)
N Engl J Med
, vol.358
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
41
-
-
77549088772
-
Pathways mediating VEGF-independent tumor angiogenesis
-
Ferrara N. Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev 2010;21:21-6
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 21-26
-
-
Ferrara, N.1
-
42
-
-
0036275356
-
Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling
-
Humar R, Kiefer FN, Berns H, et al. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 2002;16:771-80
-
(2002)
FASEB J
, vol.16
, pp. 771-780
-
-
Humar, R.1
Kiefer, F.N.2
Berns, H.3
-
43
-
-
0042342564
-
The von Hippel-Lindau protein vascular endothelial growth factor and kidney cancer
-
George DJ, Kaelin WG Jr. The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. N Engl J Med 2003;349:419-21
-
(2003)
N Engl J Med
, vol.349
, pp. 419-421
-
-
George, D.J.1
Kaelin, Jr.W.G.2
-
44
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-5
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
45
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25:1539-44
-
(2007)
J Clin Oncol
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
46
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
47
-
-
84866152751
-
Bevacizumab plus chemotherapy continued beyone first progression in patients with metastatic colorectal cancer previously treated with BEV plus CT. results of a randomized phase III intergroup study (TML study)
-
abstract 3503]
-
Arnold D, Andre T, Bennouna J, et al. Bevacizumab plus chemotherapy continued beyone first progression in patients with metastatic colorectal cancer previously treated with BEV plus CT. results of a randomized phase III intergroup study (TML study). JCO 2012;30s:[abstract 3503]
-
(2012)
JCO
, vol.30 S
-
-
Arnold, D.1
Andre, T.2
Bennouna, J.3
-
48
-
-
84867047384
-
Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients with Metastatic Colorectal Cancer Previously Treated with an Oxaliplatin-Based Regimen
-
Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen. J Clin Oncol 2012;30:3499-506
-
(2012)
J Clin Oncol
, vol.30
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
49
-
-
84867621414
-
Phase III CORRECT trial of regorafenib in metastatic colorectal cancer
-
abstract 3502]
-
Van Cutsem E, Sobrero AF, Siena S, et al. Phase III CORRECT trial of regorafenib in metastatic colorectal cancer. JCO 2012;30s:[abstract 3502]
-
(2012)
JCO
, vol.30 S
-
-
Van Cutsem, E.1
Sobrero, A.F.2
Siena, S.3
-
50
-
-
61449124545
-
Results of a phase i study of bevacizumab (BV), everolimus (EV), and erlotinib (E) in patients with advanced solid tumors
-
Bendell JC, George D, Nixon A, et al. Results of a phase I study of bevacizumab (BV), everolimus (EV), and erlotinib (E) in patients with advanced solid tumors. J Clinl Oncol ASCO Ann Meet Proc Part I 2007;25:3548
-
(2007)
J Clinl Oncol ASCO Ann Meet Proc Part i
, vol.25
, pp. 3548
-
-
Bendell, J.C.1
George, D.2
Nixon, A.3
-
51
-
-
70949095836
-
Bevacizumab plus everolimus in refractory metastatic colorectal cancer
-
abstract 4080]
-
Bullock KE, Hurwitz H, Uronis HE, et al. Bevacizumab plus everolimus in refractory metastatic colorectal cancer. JCO 2009;27(15s):[abstract 4080]
-
(2009)
JCO
, vol.27
, Issue.15 S
-
-
Bullock, K.E.1
Hurwitz, H.2
Uronis, H.E.3
-
52
-
-
80052197143
-
A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer
-
Altomare I, Bendell JC, Bullock KE, et al. A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer. Oncologist 2011;16:1131-7
-
(2011)
Oncologist
, vol.16
, pp. 1131-1137
-
-
Altomare, I.1
Bendell, J.C.2
Bullock, K.E.3
-
53
-
-
84871430564
-
Multicenter phase IB/II study of everolimus (RAD001) and tivozanib (AV-951) in patients with refractory, metastatic colorectal cancer
-
abstract 560]
-
Wolpin BM, Ng K, Zhu AX, et al. Multicenter phase IB/II study of everolimus (RAD001) and tivozanib (AV-951) in patients with refractory, metastatic colorectal cancer. JCO 2012;30(4s):[abstract 560]
-
(2012)
JCO
, vol.30
, Issue.4 S
-
-
Wolpin, B.M.1
Ng, K.2
Zhu, A.X.3
-
54
-
-
84874458619
-
Phase i study of mFOLFOX-6 bevacizumab and mTOR inhibitor RAD001 as first-line treatment of metastatic colorectal cancer
-
abstract 600]
-
Gilcrease GW, Weis JR, Jones K, et al. Phase I study of mFOLFOX-6, bevacizumab, and mTOR inhibitor RAD001 as first-line treatment of metastatic colorectal cancer. JCO 2012;30s:[abstract 600]
-
(2012)
JCO
, vol.30 S
-
-
Gilcrease, G.W.1
Weis, J.R.2
Jones, K.3
-
55
-
-
84874505798
-
Phase i study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors
-
abstract 490]
-
Rangwala RA, Bendell J, Kozloff M, et al. Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors. JCO 2012;30(4s):[abstract 490]
-
(2012)
JCO
, vol.30
, Issue.4 S
-
-
Rangwala, R.A.1
Bendell, J.2
Kozloff, M.3
-
56
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004;351:337-45
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
57
-
-
84867117207
-
Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
-
Tejpar S, Celik I, Schlichting M, et al. Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J Clin Oncol 2012;30:3570-7
-
(2012)
J Clin Oncol
, vol.30
, pp. 3570-3577
-
-
Tejpar, S.1
Celik, I.2
Schlichting, M.3
-
58
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011;29:2011-19
-
(2011)
J Clin Oncol
, vol.29
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
-
59
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007;25:1658-64
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
60
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
-
Sartore-Bianchi A, Martini M, Molinari F, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009;69:1851-7
-
(2009)
Cancer Res
, vol.69
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
-
61
-
-
40349108627
-
Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs
-
Bianco R, Garofalo S, Rosa R, et al. Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer 2008;98:923-30
-
(2008)
Br J Cancer
, vol.98
, pp. 923-930
-
-
Bianco, R.1
Garofalo, S.2
Rosa, R.3
-
62
-
-
84877007803
-
Phase i study of everolimus (RAD001) with irinotecan and cetuximab in second-line metastatic colorectal cancer: Hoosier Oncology Group GI05-102-Final report
-
abstract 3587]
-
Shahda S, Yu M, Picus J, et al. Phase I study of everolimus (RAD001) with irinotecan and cetuximab in second-line metastatic colorectal cancer: Hoosier Oncology Group GI05-102-Final report. JCO 2011;29s:[abstract 3587]
-
(2011)
JCO
, vol.29 S
-
-
Shahda, S.1
Yu, M.2
Picus, J.3
-
63
-
-
84874478393
-
A phase Ib/II study of second-line therapy with panitumumab irinotecan and everolimus in metastatic colorectal cancer with KRAS wild type
-
abstract TPS162]
-
Townsend AR, Pirc L, Hardingham J, et al. A phase Ib/II study of second-line therapy with panitumumab, irinotecan, and everolimus in metastatic colorectal cancer with KRAS wild type. JCO 2011;29s:[abstract TPS162]
-
(2011)
JCO
, vol.29 S
-
-
Townsend, A.R.1
Pirc, L.2
Hardingham, J.3
-
64
-
-
79960597638
-
Phase i study of the combination of everolimus (RAD001) with panitumumab in patients with refractory solid malignancies
-
abstract e13085]
-
Davies JM, Raftery LL, Sanoff KH, et al. Phase I study of the combination of everolimus (RAD001) with panitumumab in patients with refractory solid malignancies. JCO 2011;28s:[abstract e13085]
-
(2011)
JCO
, vol.28 S
-
-
Davies, J.M.1
Raftery, L.L.2
Sanoff, K.H.3
-
65
-
-
84863472663
-
A phase i study of bevacizumab, everolimus and panitumumab in advanced solid tumors
-
Vlahovic G, Meadows KL, Uronis HE, et al. A phase I study of bevacizumab, everolimus and panitumumab in advanced solid tumors. Cancer Chemother Pharmacol 2012;70:95-102
-
(2012)
Cancer Chemother Pharmacol
, vol.70
, pp. 95-102
-
-
Vlahovic, G.1
Meadows, K.L.2
Uronis, H.E.3
-
66
-
-
84866554939
-
Phase i study of bevacizumab, everolimus, and panobinostat (LBH-589) in advanced solid tumors
-
Strickler JH, Starodub AN, Jia J, et al. Phase I study of bevacizumab, everolimus, and panobinostat (LBH-589) in advanced solid tumors. Cancer Chemother Pharmacol 2012;70:251-8
-
(2012)
Cancer Chemother Pharmacol
, vol.70
, pp. 251-258
-
-
Strickler, J.H.1
Starodub, A.N.2
Jia, J.3
-
67
-
-
84877008465
-
MTOR inhibitor everolimus and IGFR inhibitor OSI-906 for the treatment of patients with refractory metastatic colorectal cancer: A Sarah Cannon Research Institute phase i trial
-
abstract e14054]
-
Hart L, Burris HA, Infante JR, et al. mTOR inhibitor everolimus and IGFR inhibitor OSI-906 for the treatment of patients with refractory metastatic colorectal cancer: A Sarah Cannon Research Institute phase I trial. JCO 2011;29s:[abstract e14054]
-
(2011)
JCO
, vol.29 S
-
-
Hart, L.1
Burris, H.A.2
Infante, J.R.3
-
68
-
-
84877302015
-
Phase i study of everolimus (RAD001) and AMG479 in patients with advanced solid tumors and colorectal cancer
-
abstract TPS157]
-
Khawaja MR, Younger A, Funke JM, et al. Phase I study of everolimus (RAD001) and AMG479 in patients with advanced solid tumors and colorectal cancer. JCO 2011;29s:[abstract TPS157]
-
(2011)
JCO
, vol.29 S
-
-
Khawaja, M.R.1
Younger, A.2
Funke, J.M.3
-
69
-
-
84868687031
-
Phase i study of the combination of everolimus (RAD001) with 5FU/LV in patients with refractory solid malignancies
-
abstract 512]
-
Davies JM, McRee AJ, Sanoff HK, et al. Phase I study of the combination of everolimus (RAD001) with 5FU/LV in patients with refractory solid malignancies. JCO 2011;29(4s):[abstract 512]
-
(2011)
JCO
, vol.29
, Issue.4 S
-
-
Davies, J.M.1
McRee, A.J.2
Sanoff, H.K.3
-
70
-
-
33845701788
-
Everolimus interferes with healing of experimental intestinal anastomoses
-
van der Vliet JA, Willems MC, de Man BM, et al. Everolimus interferes with healing of experimental intestinal anastomoses. Transplantation 2006;82:1477-83
-
(2006)
Transplantation
, vol.82
, pp. 1477-1483
-
-
Van Der Vliet, J.A.1
Willems, M.C.2
De Man, B.M.3
-
71
-
-
74549154398
-
Persistent effects of everolimus on strength of experimental wounds in intestine and fascia
-
Willems MC, van der Vliet JA, de Man BM, et al. Persistent effects of everolimus on strength of experimental wounds in intestine and fascia. Wound Repair Regen 2010;18:98-104
-
(2010)
Wound Repair Regen
, vol.18
, pp. 98-104
-
-
Willems, M.C.1
Van Der Vliet, J.A.2
De Man, B.M.3
-
72
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington LS, Findlay GM, Gray A, et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 2004;166:213-23
-
(2004)
J Cell Biol
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
-
73
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004;14:1650-6
-
(2004)
Curr Biol
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
74
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
-
Zhang H, Cicchetti G, Onda H, et al. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 2003;112:1223-33
-
(2003)
J Clin Invest
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
Cicchetti, G.2
Onda, H.3
-
75
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo A, Ma L, Teruya-Feldstein J, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008;118:3065-74
-
(2008)
J Clin Invest
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
-
76
-
-
58049200573
-
Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors
-
Carracedo A, Baselga J, Pandolfi PP. Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors. Cell Cycle 2008;7:3805-9
-
(2008)
Cell Cycle
, vol.7
, pp. 3805-3809
-
-
Carracedo, A.1
Baselga, J.2
Pandolfi, P.P.3
-
77
-
-
63349097231
-
Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer
-
Zhang YJ, Tian XQ, Sun DF, et al. Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer. Cancer Invest 2009;27:273-85
-
(2009)
Cancer Invest
, vol.27
, pp. 273-285
-
-
Zhang, Y.J.1
Tian, X.Q.2
Sun, D.F.3
-
78
-
-
14844318528
-
Pathology of the future: Molecular profiling for targeted therapy
-
Espina V, Geho D, Mehta AI, et al. Pathology of the future: molecular profiling for targeted therapy. Cancer Invest 2005;23:36-46
-
(2005)
Cancer Invest
, vol.23
, pp. 36-46
-
-
Espina, V.1
Geho, D.2
Mehta, A.I.3
-
79
-
-
33746544343
-
New paradigms in anticancer therapy: Targeting multiple signaling pathways with kinase inhibitors
-
Faivre S, Djelloul S, Raymond E. New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors. Semin Oncol 2006;33:407-20
-
(2006)
Semin Oncol
, vol.33
, pp. 407-420
-
-
Faivre, S.1
Djelloul, S.2
Raymond, E.3
-
80
-
-
34248576166
-
Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells
-
Wang LH, Chan JL, Li W. Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells. Int J Cancer 2007;121:157-64
-
(2007)
Int J Cancer
, vol.121
, pp. 157-164
-
-
Wang, L.H.1
Chan, J.L.2
Li, W.3
-
81
-
-
66449106340
-
Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
-
Breuleux M, Klopfenstein M, Stephan C, et al. Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition. Mol Cancer Ther 2009;8:742-53
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 742-753
-
-
Breuleux, M.1
Klopfenstein, M.2
Stephan, C.3
-
82
-
-
2942724235
-
MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004;10:594-601
-
(2004)
Nat Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
-
83
-
-
4544314561
-
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
-
Torres-Arzayus MI, Font de Mora J, Yuan J, et al. High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell 2004;6:263-74
-
(2004)
Cancer Cell
, vol.6
, pp. 263-274
-
-
Torres-Arzayus, M.I.1
Font De Mora, J.2
Yuan, J.3
-
84
-
-
77955288855
-
Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
-
Di Nicolantonio F, Arena S, Tabernero J, et al. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J Clin Invest 2010;120:2858-66
-
(2010)
J Clin Invest
, vol.120
, pp. 2858-2866
-
-
Di Nicolantonio, F.1
Arena, S.2
Tabernero, J.3
-
85
-
-
84863258395
-
PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors
-
Meric-Bernstam F, Akcakanat A, Chen H, et al. PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors. Clin Cancer Res 2012;18:1777-89
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1777-1789
-
-
Meric-Bernstam, F.1
Akcakanat, A.2
Chen, H.3
|