메뉴 건너뛰기




Volumn 17, Issue 5, 2015, Pages

Nutri(meta)genetics and Cardiovascular Disease: Novel Concepts in the Interaction of Diet and Genomic Variation

Author keywords

Atherosclerosis; B vitamins; Betaine; Cardiovascular risk; Choline; Diabetes; Flavin monooxygenase; Genetic variation; Genome; Homocysteine; Metagenome; Microbiome; Nutrition; Obesity; Phosphatidyl choline; Trimethylamine oxide

Indexed keywords

BETAINE; CARNITINE; CHOLINE; DIMETHYLANILINE MONOOXYGENASE; HOMOCYSTEINE; METHIONINE; PROBIOTIC AGENT; SIMVASTATIN; TRIMETHYLAMINE; TRIMETHYLAMINE OXIDE;

EID: 84925957068     PISSN: 15233804     EISSN: 15346242     Source Type: Journal    
DOI: 10.1007/s11883-015-0505-x     Document Type: Review
Times cited : (15)

References (59)
  • 1
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • COI: 1:CAS:528:DC%2BC38Xhtleru7jO, PID: 22972295
    • Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489:220–30.
    • (2012) Nature , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3    Jansson, J.K.4    Knight, R.5
  • 3
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • COI: 1:CAS:528:DC%2BC3cXislahsLc%3D, PID: 20203603
    • Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3    Arumugam, M.4    Burgdorf, K.S.5    Manichanh, C.6
  • 4
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012; 486:207–14.
    • (2012) Nature , vol.486 , pp. 207-214
  • 5
    • 72949091232 scopus 로고    scopus 로고
    • Bacterial community variation in human body habitats across space and time
    • COI: 1:CAS:528:DC%2BD1MXhsFGmsL7K, PID: 19892944
    • Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326:1694–7.
    • (2009) Science , vol.326 , pp. 1694-1697
    • Costello, E.K.1    Lauber, C.L.2    Hamady, M.3    Fierer, N.4    Gordon, J.I.5    Knight, R.6
  • 6
    • 79952763661 scopus 로고    scopus 로고
    • Succession of microbial consortia in the developing infant gut microbiome
    • COI: 1:CAS:528:DC%2BC3MXjvVCkurs%3D, PID: 20668239
    • Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, et al. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4578–85.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4578-4585
    • Koenig, J.E.1    Spor, A.2    Scalfone, N.3    Fricker, A.D.4    Stombaugh, J.5    Knight, R.6
  • 7
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • COI: 1:CAS:528:DC%2BC3MXjvVCktbo%3D, PID: 20847294
    • Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4554–61.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 9
    • 77950847866 scopus 로고    scopus 로고
    • Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota
    • COI: 1:CAS:528:DC%2BC3cXktlynsbw%3D, PID: 20376150
    • Hehemann JH, Correc G, Barbeyron T, Helbert W, Czjzek M, Michel G. Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature. 2010;464:908–12.
    • (2010) Nature , vol.464 , pp. 908-912
    • Hehemann, J.H.1    Correc, G.2    Barbeyron, T.3    Helbert, W.4    Czjzek, M.5    Michel, G.6
  • 10
    • 34249036137 scopus 로고    scopus 로고
    • A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model
    • PID: 17515922
    • Martin FP, Dumas ME, Wang Y, Legido-Quigley C, Yap IK, Tang H, et al. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Mol Syst Biol. 2007;3:112.
    • (2007) Mol Syst Biol , vol.3 , pp. 112
    • Martin, F.P.1    Dumas, M.E.2    Wang, Y.3    Legido-Quigley, C.4    Yap, I.K.5    Tang, H.6
  • 11
    • 80054059835 scopus 로고    scopus 로고
    • Enteric microbiome metabolites correlate with response to simvastatin treatment
    • COI: 1:CAS:528:DC%2BC3MXhsVSgtr%2FL, PID: 22022402
    • Kaddurah-Daouk R, Baillie RA, Zhu H, Zeng ZB, Wiest MM, Nguyen UT, et al. Enteric microbiome metabolites correlate with response to simvastatin treatment. PLoS One. 2011;6:e25482.
    • (2011) PLoS One , vol.6 , pp. 25482
    • Kaddurah-Daouk, R.1    Baillie, R.A.2    Zhu, H.3    Zeng, Z.B.4    Wiest, M.M.5    Nguyen, U.T.6
  • 12
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • COI: 1:CAS:528:DC%2BC3MXmtFSgurY%3D, PID: 21512004
    • Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011;332:974–7.
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3    Tran, G.4    Jabri, B.5    Chatila, T.A.6
  • 13
    • 78650647326 scopus 로고    scopus 로고
    • Has the microbiota played a critical role in the evolution of the adaptive immune system?
    • COI: 1:CAS:528:DC%2BC3cXhsF2jtbjI, PID: 21205662
    • Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science. 2010;330:1768–73.
    • (2010) Science , vol.330 , pp. 1768-1773
    • Lee, Y.K.1    Mazmanian, S.K.2
  • 14
    • 68149091349 scopus 로고    scopus 로고
    • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    • COI: 1:CAS:528:DC%2BD1MXptFOjtrY%3D, PID: 19644121
    • Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science. 2009;325:617–20.
    • (2009) Science , vol.325 , pp. 617-620
    • Slack, E.1    Hapfelmeier, S.2    Stecher, B.3    Velykoredko, Y.4    Stoel, M.5    Lawson, M.A.6
  • 16
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3MXnsFOqs7g%3D, PID: 21677746
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 2011;474:298–306.
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 17
    • 79953748870 scopus 로고    scopus 로고
    • Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
    • PID: 21209126
    • Joossens M, Huys G, Cnockaert M, De Preter V, Verbeke K, Rutgeerts P, et al. Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives. Gut. 2011;60:631–7.
    • (2011) Gut , vol.60 , pp. 631-637
    • Joossens, M.1    Huys, G.2    Cnockaert, M.3    De Preter, V.4    Verbeke, K.5    Rutgeerts, P.6
  • 18
    • 84860436361 scopus 로고    scopus 로고
    • Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma
    • COI: 1:CAS:528:DC%2BC38Xjs1GrtLo%3D, PID: 22422004
    • Russell SL, Gold MJ, Hartmann M, Willing BP, Thorson L, Wlodarska M, et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep. 2012;13:440–7.
    • (2012) EMBO Rep , vol.13 , pp. 440-447
    • Russell, S.L.1    Gold, M.J.2    Hartmann, M.3    Willing, B.P.4    Thorson, L.5    Wlodarska, M.6
  • 19
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
    • COI: 1:CAS:528:DC%2BC3MXht1ekt7nF, PID: 21876150
    • Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108:16050–5.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16050-16055
    • Bravo, J.A.1    Forsythe, P.2    Chew, M.V.3    Escaravage, E.4    Savignac, H.M.5    Dinan, T.G.6
  • 20
    • 0014286347 scopus 로고
    • Cecal enlargement, cardiac output, and O2 consumption in germfree rats
    • COI: 1:STN:280:DyaF1c3osVOgtg%3D%3D, PID: 5656680
    • Wostmann BS, Bruckner-Kardoss E, Knight Jr PL. Cecal enlargement, cardiac output, and O2 consumption in germfree rats. Proc Soc Exp Biol Med. 1968;128:137–41.
    • (1968) Proc Soc Exp Biol Med , vol.128 , pp. 137-141
    • Wostmann, B.S.1    Bruckner-Kardoss, E.2    Knight, P.L.3
  • 21
    • 0017887048 scopus 로고
    • Oxygen consumption of germfree and conventional mice
    • COI: 1:STN:280:DyaE1c3ksFejsQ%3D%3D, PID: 682576
    • Bruckner-Kardoss E, Wostmann BS. Oxygen consumption of germfree and conventional mice. Lab Anim Sci. 1978;28:282–6.
    • (1978) Lab Anim Sci , vol.28 , pp. 282-286
    • Bruckner-Kardoss, E.1    Wostmann, B.S.2
  • 22
    • 0020068173 scopus 로고
    • Oxygen consumption and thyroid hormones in germfree mice fed glucose-amino acid liquid diet
    • COI: 1:CAS:528:DyaL38Xhs1Wgt7c%3D, PID: 7062149
    • Wostmann BS, Bruckner-Kardoss E, Pleasants JR. Oxygen consumption and thyroid hormones in germfree mice fed glucose-amino acid liquid diet. J Nutr. 1982;112:552–9.
    • (1982) J Nutr , vol.112 , pp. 552-559
    • Wostmann, B.S.1    Bruckner-Kardoss, E.2    Pleasants, J.R.3
  • 23
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • PID: 23985870
    • Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541–6.
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1    Nielsen, T.2    Qin, J.3    Prifti, E.4    Hildebrand, F.5    Falony, G.6
  • 24
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • PID: 15505215
    • Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101:15718–23.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15718-15723
    • Backhed, F.1    Ding, H.2    Wang, T.3    Hooper, L.V.4    Koh, G.Y.5    Nagy, A.6
  • 26
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • PID: 17183312
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027–31.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 27
    • 78650616947 scopus 로고    scopus 로고
    • Toward defining the autoimmune microbiome for type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3cXhsFylur3P, PID: 20613793
    • Giongo A, Gano KA, Crabb DB, Mukherjee N, Novelo LL, Casella G, et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J. 2011;5:82–91.
    • (2011) ISME J , vol.5 , pp. 82-91
    • Giongo, A.1    Gano, K.A.2    Crabb, D.B.3    Mukherjee, N.4    Novelo, L.L.5    Casella, G.6
  • 28
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of Type 1 diabetes
    • COI: 1:CAS:528:DC%2BD1cXht1yju7%2FK, PID: 18806780
    • Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature. 2008;455:1109–13.
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1    Ley, R.E.2    Volchkov, P.Y.3    Stranges, P.B.4    Avanesyan, L.5    Stonebraker, A.C.6
  • 29
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • COI: 1:CAS:528:DC%2BC3sXotlGls7k%3D, PID: 23719380
    • Karlsson FH, Tremaroli V, Nookaew I, Bergstrom G, Behre CJ, Fagerberg B, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498:99–103.
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1    Tremaroli, V.2    Nookaew, I.3    Bergstrom, G.4    Behre, C.J.5    Fagerberg, B.6
  • 30
    • 77749292085 scopus 로고    scopus 로고
    • Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
    • COI: 1:CAS:528:DC%2BC3cXisFyntLk%3D, PID: 20071648
    • Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010;91:535–46.
    • (2010) Am J Clin Nutr , vol.91 , pp. 535-546
    • Siri-Tarino, P.W.1    Sun, Q.2    Hu, F.B.3    Krauss, R.M.4
  • 31
    • 77958198870 scopus 로고    scopus 로고
    • Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients
    • COI: 1:CAS:528:DC%2BC3cXhtlyqu77I, PID: 20711693
    • Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep. 2010;12:384–90.
    • (2010) Curr Atheroscler Rep , vol.12 , pp. 384-390
    • Siri-Tarino, P.W.1    Sun, Q.2    Hu, F.B.3    Krauss, R.M.4
  • 33
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • COI: 1:CAS:528:DC%2BC3MXksVCrsrw%3D, PID: 21475195, This “bedside to bench” study utilized metabolomics approaches to identify a plasma metabolite associated with increased cardiovascular risk, and, subsequently, using germ-free mice, demonstrated that the metabolite trimethylamine oxide was derived from metabolism of phosphatidyl choline, a common dietary component, by gut microbiota, and promoted atherosclerosis
    • Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472:57–63. This “bedside to bench” study utilized metabolomics approaches to identify a plasma metabolite associated with increased cardiovascular risk, and, subsequently, using germ-free mice, demonstrated that the metabolite trimethylamine oxide was derived from metabolism of phosphatidyl choline, a common dietary component, by gut microbiota, and promoted atherosclerosis.
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3    Koeth, R.4    Levison, B.S.5    Dugar, B.6
  • 34
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • COI: 1:CAS:528:DC%2BC3sXntVCmsrc%3D, PID: 23614584, This seminal human study demonstrated that human gut microbiota were crucial in generating trimethylamine oxide from dietary phosphatidylcholine. This report also showed the association of elevated plasma levels of trimethylamine oxide with the risk of cardiovascular events
    • Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368:1575–84. This seminal human study demonstrated that human gut microbiota were crucial in generating trimethylamine oxide from dietary phosphatidylcholine. This report also showed the association of elevated plasma levels of trimethylamine oxide with the risk of cardiovascular events.
    • (2013) N Engl J Med , vol.368 , pp. 1575-1584
    • Tang, W.H.1    Wang, Z.2    Levison, B.S.3    Koeth, R.A.4    Britt, E.B.5    Fu, X.6
  • 35
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • COI: 1:CAS:528:DC%2BC3sXlsVCqu7w%3D, PID: 23563705, This original report demonstrated that omnivorous humans generated more trimethylamine from dietary carnitine compared to vegans and that gut microbiota were crucial to this effect. Using a mouse model, the investigators also showed the interaction of dietary carnitine and gut microbiota in promoting atherosclerosis. This study demonstrated the role of microbiota in the link between consumption of red meat and the risk of atherosclerosis
    • Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19:576–85. This original report demonstrated that omnivorous humans generated more trimethylamine from dietary carnitine compared to vegans and that gut microbiota were crucial to this effect. Using a mouse model, the investigators also showed the interaction of dietary carnitine and gut microbiota in promoting atherosclerosis. This study demonstrated the role of microbiota in the link between consumption of red meat and the risk of atherosclerosis.
    • (2013) Nat Med , vol.19 , pp. 576-585
    • Koeth, R.A.1    Wang, Z.2    Levison, B.S.3    Buffa, J.A.4    Org, E.5    Sheehy, B.T.6
  • 36
    • 84896537331 scopus 로고    scopus 로고
    • Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
    • COI: 1:CAS:528:DC%2BC2cXjtl2kt74%3D, PID: 24591617
    • Zhu Y, Jameson E, Crosatti M, Schafer H, Rajakumar K, Bugg TD, et al. Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proc Natl Acad Sci U S A. 2014;111:4268–73.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 4268-4273
    • Zhu, Y.1    Jameson, E.2    Crosatti, M.3    Schafer, H.4    Rajakumar, K.5    Bugg, T.D.6
  • 37
    • 7144253814 scopus 로고    scopus 로고
    • Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication
    • COI: 1:CAS:528:DyaK1cXjsVars74%3D, PID: 9536088
    • Treacy EP, Akerman BR, Chow LM, Youil R, Bibeau C, Lin J, et al. Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication. Hum Mol Genet. 1998;7:839–45.
    • (1998) Hum Mol Genet , vol.7 , pp. 839-845
    • Treacy, E.P.1    Akerman, B.R.2    Chow, L.M.3    Youil, R.4    Bibeau, C.5    Lin, J.6
  • 38
    • 84872139636 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
    • COI: 1:CAS:528:DC%2BC3sXmvVKnsg%3D%3D, PID: 23312283
    • Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013;17:49–60.
    • (2013) Cell Metab , vol.17 , pp. 49-60
    • Bennett, B.J.1    de Aguiar Vallim, T.Q.2    Wang, Z.3    Shih, D.M.4    Meng, Y.5    Gregory, J.6
  • 39
    • 0034905367 scopus 로고    scopus 로고
    • In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 gene
    • COI: 1:CAS:528:DC%2BD3MXlt1Cmu78%3D, PID: 11461189
    • Lambert DM, Mamer OA, Akerman BR, Choiniere L, Gaudet D, Hamet P, et al. In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 gene. Mol Genet Metab. 2001;73:224–9.
    • (2001) Mol Genet Metab , vol.73 , pp. 224-229
    • Lambert, D.M.1    Mamer, O.A.2    Akerman, B.R.3    Choiniere, L.4    Gaudet, D.5    Hamet, P.6
  • 40
    • 79960365932 scopus 로고    scopus 로고
    • Lipid metabolism by gut microbes and atherosclerosis
    • COI: 1:CAS:528:DC%2BC3MXosFaisro%3D, PID: 21737814
    • Loscalzo J. Lipid metabolism by gut microbes and atherosclerosis. Circ Res. 2011;109:127–9.
    • (2011) Circ Res , vol.109 , pp. 127-129
    • Loscalzo, J.1
  • 41
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56:111–28.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 42
    • 77449125765 scopus 로고    scopus 로고
    • Quo vadis: whither homocysteine research?
    • COI: 1:CAS:528:DC%2BD1MXns1Chu7Y%3D, PID: 19484390
    • Joseph J, Handy DE, Loscalzo J. Quo vadis: whither homocysteine research? Cardiovasc Toxicol. 2009;9:53–63.
    • (2009) Cardiovasc Toxicol , vol.9 , pp. 53-63
    • Joseph, J.1    Handy, D.E.2    Loscalzo, J.3
  • 43
    • 84882730688 scopus 로고    scopus 로고
    • Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology
    • COI: 1:CAS:528:DC%2BC3sXhtlaqtrjM, PID: 23955381
    • Joseph J, Loscalzo J. Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Nutrients. 2013;5:3235–56.
    • (2013) Nutrients , vol.5 , pp. 3235-3256
    • Joseph, J.1    Loscalzo, J.2
  • 45
    • 84898859680 scopus 로고    scopus 로고
    • Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
    • COI: 1:CAS:528:DC%2BC2cXmsFertbg%3D, PID: 24497336
    • Wang Z, Tang WH, Buffa JA, Fu X, Britt EB, Koeth RA, et al. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Heart J. 2014;35:904–10.
    • (2014) Eur Heart J , vol.35 , pp. 904-910
    • Wang, Z.1    Tang, W.H.2    Buffa, J.A.3    Fu, X.4    Britt, E.B.5    Koeth, R.A.6
  • 46
    • 84978350638 scopus 로고    scopus 로고
    • A Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota—the “RISTOMED project”: randomized controlled trial in healthy older people
    • Valentini L, Pinto A, Bourdel-Marchasson I, Ostan R, Brigidi P, Turroni S, A et al. Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota—the “RISTOMED project”: randomized controlled trial in healthy older people. Clin Nutr. 2014.
    • (2014) Clin Nutr
    • Valentini, L.1    Pinto, A.2    Bourdel-Marchasson, I.3    Ostan, R.4    Brigidi, P.5    Turroni, S.6
  • 47
    • 77957075815 scopus 로고    scopus 로고
    • Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    • PID: 20679230
    • De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010;107:14691–6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14691-14696
    • De Filippo, C.1    Cavalieri, D.2    Di Paola, M.3    Ramazzotti, M.4    Poullet, J.B.5    Massart, S.6
  • 48
    • 84883057637 scopus 로고    scopus 로고
    • Dietary intervention impact on gut microbial gene richness
    • COI: 1:CAS:528:DC%2BC3sXhtlCntrnM, PID: 23985875
    • Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013;500:585–8.
    • (2013) Nature , vol.500 , pp. 585-588
    • Cotillard, A.1    Kennedy, S.P.2    Kong, L.C.3    Prifti, E.4    Pons, N.5    Le Chatelier, E.6
  • 49
    • 33846542071 scopus 로고    scopus 로고
    • Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    • COI: 1:CAS:528:DC%2BD2sXhtVSitbo%3D, PID: 17210919
    • Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007;104:979–84.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 979-984
    • Backhed, F.1    Manchester, J.K.2    Semenkovich, C.F.3    Gordon, J.I.4
  • 50
    • 84866973849 scopus 로고    scopus 로고
    • Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b
    • COI: 1:CAS:528:DC%2BC38XhsVWmt77M, PID: 22821931
    • Wang D, Xia M, Yan X, Li D, Wang L, Xu Y, et al. Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b. Circ Res. 2012;111:967–81.
    • (2012) Circ Res , vol.111 , pp. 967-981
    • Wang, D.1    Xia, M.2    Yan, X.3    Li, D.4    Wang, L.5    Xu, Y.6
  • 51
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • COI: 1:CAS:528:DC%2BC3cXkt1Cgt7o%3D, PID: 20203013
    • Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science. 2010;328:228–31.
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1    Aitken, J.D.2    Carvalho, F.A.3    Cullender, T.C.4    Mwangi, S.5    Srinivasan, S.6
  • 52
    • 84901335706 scopus 로고    scopus 로고
    • Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine
    • COI: 1:CAS:528:DC%2BC2cXnvV2isb8%3D, PID: 24675659
    • Hartiala J, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, et al. Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscl Thromb Vasc Biol. 2014;34:1307–13.
    • (2014) Arterioscl Thromb Vasc Biol , vol.34 , pp. 1307-1313
    • Hartiala, J.1    Bennett, B.J.2    Tang, W.H.3    Wang, Z.4    Stewart, A.F.5    Roberts, R.6
  • 54
    • 84883478660 scopus 로고    scopus 로고
    • Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013; 341:1241214-1-10
    • Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013; 341:1241214-1-10.
  • 55
    • 78650037263 scopus 로고    scopus 로고
    • Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    • COI: 1:CAS:528:DC%2BC3MXlsVamtg%3D%3D, PID: 20876719
    • Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes. 2010;59:3049–57.
    • (2010) Diabetes , vol.59 , pp. 3049-3057
    • Furet, J.P.1    Kong, L.C.2    Tap, J.3    Poitou, C.4    Basdevant, A.5    Bouillot, J.L.6
  • 56
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhsVaqt7fJ, PID: 23023125
    • Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490:55–60.
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1    Li, Y.2    Cai, Z.3    Li, S.4    Zhu, J.5    Zhang, F.6
  • 57
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: a network-based approach to human disease
    • COI: 1:CAS:528:DC%2BC3cXhsFOiu7vM, PID: 21164525
    • Barabasi AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011;12:56–68.
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 58
    • 84866986817 scopus 로고    scopus 로고
    • Computational systems biology and in silico modeling of the human microbiome
    • Borenstein E. Computational systems biology and in silico modeling of the human microbiome. Brief Bionform. 2012;13:769–80.
    • (2012) Brief Bionform , vol.13 , pp. 769-780
    • Borenstein, E.1
  • 59
    • 84856011484 scopus 로고    scopus 로고
    • Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC38Xht1ensbc%3D, PID: 22184244
    • Greenblum S, Turnbaugh PJ, Borenstein E. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proc Natl Acad Sci U S A. 2012;109:594–9.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 594-599
    • Greenblum, S.1    Turnbaugh, P.J.2    Borenstein, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.