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Volumn 5, Issue , 2014, Pages

Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; RAC1 PROTEIN; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; VAV2 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAC1 PROTEIN, HUMAN; TIAM1 PROTEIN, HUMAN; VAV PROTEIN; VAV2 PROTEIN, HUMAN;

EID: 84901020430     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4907     Document Type: Article
Times cited : (76)

References (70)
  • 1
    • 3142592401 scopus 로고    scopus 로고
    • Not just a sink: Endosomes in control of signal transduction
    • DOI 10.1016/j.ceb.2004.06.005, PII S0955067404000742
    • Miaczynska, M., Pelkmans, L. & Zerial, M. Not just a sink: endosomes in control of signal transduction. Curr. Opin. Cell Biol. 16, 400-406 (2004). (Pubitemid 38903146)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.4 , pp. 400-406
    • Miaczynska, M.1    Pelkmans, L.2    Zerial, M.3
  • 2
    • 25444461165 scopus 로고    scopus 로고
    • C-Met signalling: Spatio-temporal decisions
    • Kermorgant, S. & Parker, P. J. c-Met signalling: spatio-temporal decisions. Cell Cycle 4, 352-355 (2005). (Pubitemid 41359712)
    • (2005) Cell Cycle , vol.4 , Issue.3 , pp. 352-355
    • Kermorgant, S.1    Parker, P.J.2
  • 3
    • 62849097694 scopus 로고    scopus 로고
    • New roles for endosomes: From vesicular carriers to multi-purpose platforms
    • Gould, G. W. & Lippincott-Schwartz, J. New roles for endosomes: from vesicular carriers to multi-purpose platforms. Nat. Rev. Mol. Cell Biol. 10, 287-292 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 287-292
    • Gould, G.W.1    Lippincott-Schwartz, J.2
  • 4
    • 69249137477 scopus 로고    scopus 로고
    • Endocytosis and signalling: Intertwining molecular networks
    • Sorkin, A. & von Zastrow, M. Endocytosis and signalling: intertwining molecular networks. Nat. Rev. Mol. Cell Biol. 10, 609-622 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 609-622
    • Sorkin, A.1    Von Zastrow, M.2
  • 5
    • 75749096347 scopus 로고    scopus 로고
    • The endocytic matrix
    • Scita, G. & Di Fiore, P. P. The endocytic matrix. Nature 463, 464-473 (2010).
    • (2010) Nature , vol.463 , pp. 464-473
    • Scita, G.1    Di Fiore, P.P.2
  • 7
    • 0036899420 scopus 로고    scopus 로고
    • Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    • DOI 10.1016/S1534-5807(02)00364-7
    • Teis, D., Wunderlich, W. & Huber, L. A. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 3, 803-814 (2002). (Pubitemid 35460781)
    • (2002) Developmental Cell , vol.3 , Issue.6 , pp. 803-814
    • Teis, D.1    Wunderlich, W.2    Huber, L.A.3
  • 8
    • 42949092018 scopus 로고    scopus 로고
    • The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development
    • DOI 10.1016/j.cell.2008.02.044, PII S0092867408003942
    • Schenck, A. et al. The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133, 486-497 (2008). (Pubitemid 351608689)
    • (2008) Cell , vol.133 , Issue.3 , pp. 486-497
    • Schenck, A.1    Goto-Silva, L.2    Collinet, C.3    Rhinn, M.4    Giner, A.5    Habermann, B.6    Brand, M.7    Zerial, M.8
  • 10
    • 79959999334 scopus 로고    scopus 로고
    • A direct role for Met endocytosis in tumorigenesis
    • Joffre, C. et al. A direct role for Met endocytosis in tumorigenesis. Nat. Cell Biol. 13, 827-837 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 827-837
    • Joffre, C.1
  • 11
    • 0035901973 scopus 로고    scopus 로고
    • Down-regulation of MET, the receptor for hepatocyte growth factor
    • DOI 10.1038/sj.onc.1204475
    • Hammond, D. E., Urbe, S., Vande Woude, G. F. & Clague, M. J. Down-regulation of MET, the receptor for hepatocyte growth factor. Oncogene 20, 2761-2770 (2001). (Pubitemid 32549833)
    • (2001) Oncogene , vol.20 , Issue.22 , pp. 2761-2770
    • Hammond, D.E.1    Urbe, S.2    Vande Woude, G.F.3    Clague, M.J.4
  • 12
    • 0033581834 scopus 로고    scopus 로고
    • Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells-regulation by Rho, Rac and Rab small G proteins
    • Kamei, T. et al. Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells-regulation by Rho, Rac and Rab small G proteins. Oncogene 18, 6776-6784 (1999).
    • (1999) Oncogene , vol.18 , pp. 6776-6784
    • Kamei, T.1
  • 13
    • 77955293901 scopus 로고    scopus 로고
    • Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation
    • Abella, J. V., Parachoniak, C. A., Sangwan, V. & Park, M. Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation. J. Biol. Chem. 285, 24956-24967 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 24956-24967
    • Abella, J.V.1    Parachoniak, C.A.2    Sangwan, V.3    Park, M.4
  • 14
    • 0043208954 scopus 로고    scopus 로고
    • Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met
    • DOI 10.1074/jbc.M302116200
    • Kermorgant, S., Zicha, D. & Parker, P. J. Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met. J. Biol. Chem. 278, 28921-28929 (2003). (Pubitemid 36935802)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.31 , pp. 28921-28929
    • Kermorgant, S.1    Zicha, D.2    Parker, P.J.3
  • 15
    • 6344248651 scopus 로고    scopus 로고
    • PKC controls HGF-dependent c-Met traffic, signalling and cell migration
    • DOI 10.1038/sj.emboj.7600396
    • Kermorgant, S., Zicha, D. & Parker, P. J. PKC controls HGF-dependent c-Met traffic, signalling and cell migration. EMBO J. 23, 3721-3734 (2004). (Pubitemid 39389704)
    • (2004) EMBO Journal , vol.23 , Issue.19 , pp. 3721-3734
    • Kermorgant, S.1    Zicha, D.2    Parker, P.J.3
  • 16
    • 51649130231 scopus 로고    scopus 로고
    • Receptor trafficking controls weak signal delivery: A strategy used by c-Met for STAT3 nuclear accumulation
    • Kermorgant, S. & Parker, P. J. Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation. J. Cell Biol. 182, 855-863 (2008).
    • (2008) J. Cell Biol. , vol.182 , pp. 855-863
    • Kermorgant, S.1    Parker, P.J.2
  • 17
    • 77952117888 scopus 로고    scopus 로고
    • Direct detection of guidance receptor activity during border cell migration
    • Janssens, K., Sung, H. H. & Rorth, P. Direct detection of guidance receptor activity during border cell migration. Proc. Natl Acad. Sci. USA 107, 7323-7328 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 7323-7328
    • Janssens, K.1    Sung, H.H.2    Rorth, P.3
  • 18
    • 54549102284 scopus 로고    scopus 로고
    • Derailed endocytosis: An emerging feature of cancer
    • Mosesson, Y., Mills, G. B. & Yarden, Y. Derailed endocytosis: an emerging feature of cancer. Nat. Rev. Cancer 8, 835-850 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 835-850
    • Mosesson, Y.1    Mills, G.B.2    Yarden, Y.3
  • 19
    • 0028894787 scopus 로고
    • Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells
    • Ridley, A. J., Comoglio, P. M. & Hall, A. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol. Cell Biol. 15, 1110-1122 (1995).
    • (1995) Mol. Cell Biol. , vol.15 , pp. 1110-1122
    • Ridley, A.J.1    Comoglio, P.M.2    Hall, A.3
  • 20
    • 6344255031 scopus 로고    scopus 로고
    • Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
    • DOI 10.1016/j.molcel.2004.10.006, PII S109727650400615X
    • Ishibe, S., Joly, D., Liu, Z. X. & Cantley, L. G. Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Mol. Cell 16, 257-267 (2004). (Pubitemid 39388840)
    • (2004) Molecular Cell , vol.16 , Issue.2 , pp. 257-267
    • Ishibe, S.1    Joly, D.2    Liu, Z.-X.3    Cantley, L.G.4
  • 21
    • 77749251988 scopus 로고    scopus 로고
    • Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI
    • Chianale, F. et al. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proc. Natl Acad. Sci. USA 107, 4182-4187 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 4182-4187
    • Chianale, F.1
  • 22
    • 45049085512 scopus 로고    scopus 로고
    • Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor
    • Takahashi, K. & Suzuki, K. Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor. Exp. Cell Res. 314, 2313-2322 (2008).
    • (2008) Exp. Cell Res. , vol.314 , pp. 2313-2322
    • Takahashi, K.1    Suzuki, K.2
  • 23
    • 21744432683 scopus 로고    scopus 로고
    • GDIs: Central regulatory molecules in Rho GTPase activation
    • DOI 10.1016/j.tcb.2005.05.001, PII S0962892405001273
    • DerMardirossian, C. & Bokoch, G. M. GDIs: central regulatory molecules in Rho GTPase activation. Trends. Cell Biol. 15, 356-363 (2005). (Pubitemid 40943524)
    • (2005) Trends in Cell Biology , vol.15 , Issue.7 , pp. 356-363
    • DerMardirossian, C.1    Bokoch, G.M.2
  • 24
    • 41149162021 scopus 로고    scopus 로고
    • Regulation of actin cytoskeleton dynamics by Arf-family GTPases
    • Myers, K. R. & Casanova, J. E. Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends. Cell Biol. 18, 184-192 (2008).
    • (2008) Trends. Cell Biol. , vol.18 , pp. 184-192
    • Myers, K.R.1    Casanova, J.E.2
  • 25
    • 34547697832 scopus 로고    scopus 로고
    • Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells
    • Koga, F., Tsutsumi, S. & Neckers, L. M. Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells. Cell Cycle 6, 1393-1402 (2007). (Pubitemid 47327975)
    • (2007) Cell Cycle , vol.6 , Issue.11 , pp. 1393-1402
    • Koga, F.1    Tsutsumi, S.2    Neckers, L.M.3
  • 27
    • 0036551486 scopus 로고    scopus 로고
    • Scatter-factor and semaphorin receptors: Cell signalling for invasive growth
    • Trusolino, L. & Comoglio, P. M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat. Rev. Cancer 2, 289-300 (2002). (Pubitemid 37328782)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.4 , pp. 289-300
    • Trusolino, L.1    Comoglio, P.M.2
  • 28
    • 0037302117 scopus 로고    scopus 로고
    • HGF/SF-Met signaling in the control of branching morphogenesis and invasion
    • DOI 10.1002/jcb.10358
    • Zhang, Y. W. & Vande Woude, G. F. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J. Cell. Biochem. 88, 408-417 (2003). (Pubitemid 36119916)
    • (2003) Journal of Cellular Biochemistry , vol.88 , Issue.2 , pp. 408-417
    • Zhang, Y.-W.1    Vande Woude, G.F.2
  • 29
    • 38549115197 scopus 로고    scopus 로고
    • The Met tyrosine kinase receptor in development and cancer
    • Gentile, A., Trusolino, L. & Comoglio, P. M. The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev. 27, 85-94 (2008).
    • (2008) Cancer Metastasis Rev. , vol.27 , pp. 85-94
    • Gentile, A.1    Trusolino, L.2    Comoglio, P.M.3
  • 32
    • 0030791855 scopus 로고    scopus 로고
    • Expression of the c-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression
    • DOI 10.1002/(SICI)1097-0215(19970620) 74:3<301::AID-IJC12>3.0.CO;2- E
    • Beviglia, L., Matsumoto, K., Lin, C. S., Ziober, B. L. & Kramer, R. H. Expression of the c-Met/HGF receptor in human breast carcinoma: correlation with tumor progression. Int. J. Cancer 74, 301-309 (1997). (Pubitemid 27321800)
    • (1997) International Journal of Cancer , vol.74 , Issue.3 , pp. 301-309
    • Beviglia, L.1    Matsumoto, K.2    Lin, C.-S.3    Ziober, B.L.4    Kramer, R.H.5
  • 33
    • 0032523074 scopus 로고    scopus 로고
    • Expression of c-met is a strong independent prognostic factor in breast carcinoma
    • DOI 10.1002/(SICI)1097-0142(19980415) 82:8<1513::AID-CNCR13>3.0. CO;2-7
    • Ghoussoub, R. A. et al. Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer 82, 1513-1520 (1998). (Pubitemid 28164998)
    • (1998) Cancer , vol.82 , Issue.8 , pp. 1513-1520
    • Ghoussoub, R.A.D.1    Dillon, D.A.2    D'Aquila, T.3    Rimm, E.B.4    Fearon, E.R.5    Rimm, D.L.6
  • 34
    • 0033404948 scopus 로고    scopus 로고
    • Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma
    • DOI 10.1002/(SICI)1097-0142(19991201) 86:11<2259::AID-CNCR13>3.0. CO;2-2
    • Camp, R. L., Rimm, E. B. & Rimm, D. L. Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma. Cancer 86, 2259-2265 (1999). (Pubitemid 30010366)
    • (1999) Cancer , vol.86 , Issue.11 , pp. 2259-2265
    • Camp, R.L.1    Rimm, E.B.2    Rimm, D.L.3
  • 35
    • 0037446118 scopus 로고    scopus 로고
    • Tissue microarray-based studies of patients with lymph node negative breast carcinoma show that Met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors
    • DOI 10.1002/cncr.11335
    • Tolgay Ocal, I., Dolled-Filhart, M., D'Aquila, T. G., Camp, R. L. & Rimm, D. L. Tissue microarray-based studies of patients with lymph node negative breast carcinoma show that met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors. Cancer 97, 1841-1848 (2003). (Pubitemid 36397257)
    • (2003) Cancer , vol.97 , Issue.8 , pp. 1841-1848
    • Ocal, I.T.1    Dolled-Filhart, M.2    D'Aquila, T.G.3    Camp, R.L.4    Rimm, D.L.5
  • 37
    • 69149108735 scopus 로고    scopus 로고
    • Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer
    • Ponzo, M. G. et al. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proc. Natl Acad. Sci. USA 106, 12903-12908 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 12903-12908
    • Ponzo, M.G.1
  • 38
    • 69149089019 scopus 로고    scopus 로고
    • Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
    • Graveel, C. R. et al. Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer. Proc. Natl Acad. Sci. USA 106, 12909-12914 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 12909-12914
    • Graveel, C.R.1
  • 39
    • 84891845042 scopus 로고    scopus 로고
    • C-Met in invasive breast cancer: Is there a relationship with the basal-like subtype?
    • Ho-Yen, C. M. et al. C-Met in invasive breast cancer: is there a relationship with the basal-like subtype? Cancer 120, 163-171 (2013).
    • (2013) Cancer , vol.120 , pp. 163-171
    • Ho-Yen, C.M.1
  • 40
    • 40449113978 scopus 로고    scopus 로고
    • Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
    • DOI 10.1158/0008-5472.CAN-07-5962
    • Shattuck, D. L., Miller, J. K., Carraway, 3rd K. L. & Sweeney, C. Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res. 68, 1471-1477 (2008). (Pubitemid 351346855)
    • (2008) Cancer Research , vol.68 , Issue.5 , pp. 1471-1477
    • Shattuck, D.L.1    Miller, J.K.2    Carraway III, K.L.3    Sweeney, C.4
  • 41
    • 44849139232 scopus 로고    scopus 로고
    • Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells
    • Mueller, K. L., Hunter, L. A., Ethier, S. P. & Boerner, J. L. Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Cancer Res. 68, 3314-3322 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 3314-3322
    • Mueller, K.L.1    Hunter, L.A.2    Ethier, S.P.3    Boerner, J.L.4
  • 42
    • 16844363750 scopus 로고    scopus 로고
    • Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients
    • Lee, W. Y. et al. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. Clin. Cancer Res. 11, 2222-2228 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2222-2228
    • Lee, W.Y.1
  • 43
    • 33646892646 scopus 로고    scopus 로고
    • Dynasore, a cell-permeable inhibitor of dynamin
    • Macia, E. et al. Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10, 839-850 (2006).
    • (2006) Dev. Cell , vol.10 , pp. 839-850
    • MacIa, E.1
  • 44
    • 0029585762 scopus 로고
    • Rab 7: An important regulator of late endocytic membrane traffic
    • DOI 10.1083/jcb.131.6.1435
    • Feng, Y., Press, B. & Wandinger-Ness, A. Rab 7: an important regulator of late endocytic membrane traffic. J. Cell Biol. 131, 1435-1452 (1995). (Pubitemid 26001749)
    • (1995) Journal of Cell Biology , vol.131 , Issue.6 , pp. 1435-1452
    • Feng, Y.1    Press, B.2    Wandinger-Ness, A.3
  • 46
    • 79958214335 scopus 로고    scopus 로고
    • GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration
    • Parachoniak, C. A., Luo, Y., Abella, J. V., Keen, J. H. & Park, M. GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Dev. Cell 20, 751-763 (2011).
    • (2011) Dev. Cell , vol.20 , pp. 751-763
    • Parachoniak, C.A.1    Luo, Y.2    Abella, J.V.3    Keen, J.H.4    Park, M.5
  • 48
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker, M., Gherardi, E., Perryman, M. & Gray, J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327, 239-242 (1987). (Pubitemid 17071053)
    • (1987) Nature , vol.326 , Issue.6119 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 49
    • 0036714174 scopus 로고    scopus 로고
    • Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo
    • DOI 10.1042/BJ20020844
    • Gampel, A. & Mellor, H. Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo. Biochem. J. 366, 393-398 (2002). (Pubitemid 35001683)
    • (2002) Biochemical Journal , vol.366 , Issue.2 , pp. 393-398
    • Gampel, A.1    Mellor, H.2
  • 50
    • 77951877243 scopus 로고    scopus 로고
    • VAV2 regulates epidermal growth factor receptor endocytosis and degradation
    • Thalappilly, S., Soubeyran, P., Iovanna, J. L. & Dusetti, N. J. VAV2 regulates epidermal growth factor receptor endocytosis and degradation. Oncogene 29, 2528-2539 (2010).
    • (2010) Oncogene , vol.29 , pp. 2528-2539
    • Thalappilly, S.1    Soubeyran, P.2    Iovanna, J.L.3    Dusetti, N.J.4
  • 51
    • 33745308103 scopus 로고    scopus 로고
    • PI3K and RAC signalling in leukocyte and cancer cell migration
    • Barber, M. A. & Welch, H. C. PI3K and RAC signalling in leukocyte and cancer cell migration. Bull. Cancer 93, E44-E52 (2006).
    • (2006) Bull. Cancer , vol.93
    • Barber, M.A.1    Welch, H.C.2
  • 52
    • 0032428684 scopus 로고    scopus 로고
    • SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
    • DOI 10.1016/S0092-8674(00)81701-8
    • Tsukazaki, T., Chiang, T. A., Davison, A. F., Attisano, L. & Wrana, J. L. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95, 779-791 (1998). (Pubitemid 29014458)
    • (1998) Cell , vol.95 , Issue.6 , pp. 779-791
    • Tsukazaki, T.1    Chiang, T.A.2    Davison, A.F.3    Attisano, L.4    Wrana, J.L.5
  • 53
    • 0037144841 scopus 로고    scopus 로고
    • TGF beta receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2
    • Hayes, S., Chawla, A. & Corvera, S. TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J. Cell Biol. 158, 1239-1249 (2002).
    • (2002) J. Cell Biol. , vol.158 , pp. 1239-1249
    • Hayes, S.1    Chawla, A.2    Corvera, S.3
  • 55
    • 33751294581 scopus 로고    scopus 로고
    • The role of scaffold proteins in MEK/ERK signalling
    • DOI 10.1042/BST0340833
    • Sacks, D. B. The role of scaffold proteins in MEK/ERK signalling. Biochem. Soc. Trans. 34, 833-836 (2006). (Pubitemid 44796432)
    • (2006) Biochemical Society Transactions , vol.34 , Issue.5 , pp. 833-836
    • Sacks, D.B.1
  • 56
    • 0032538792 scopus 로고    scopus 로고
    • Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2
    • Schuebel, K. E., Movilla, N., Rosa, J. L. & Bustelo, X. R. Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J. 17, 6608-6621 (1998). (Pubitemid 28521795)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6608-6621
    • Schuebel, K.E.1    Movilla, N.2    Rosa, J.L.3    Bustelo, X.R.4
  • 57
    • 0033826334 scopus 로고    scopus 로고
    • Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins
    • Liu, B. P. & Burridge, K. Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol. Cell Biol. 20, 7160-7169 (2000).
    • (2000) Mol. Cell Biol. , vol.20 , pp. 7160-7169
    • Liu, B.P.1    Burridge, K.2
  • 58
    • 84879561364 scopus 로고    scopus 로고
    • Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration
    • Jones, M. C., Machida, K., Mayer, B. J. & Turner, C. E. Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol. Biol. Cell 24, 1882-1894 (2013).
    • (2013) Mol. Biol. Cell , vol.24 , pp. 1882-1894
    • Jones, M.C.1    Machida, K.2    Mayer, B.J.3    Turner, C.E.4
  • 60
    • 18244392909 scopus 로고    scopus 로고
    • Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells
    • DOI 10.1091/mbc.E04-10-0904
    • Aoki, K., Nakamura, T., Fujikawa, K. & Matsuda, M. Local phosphatidylinositol 3, 4, 5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol. Biol. Cell 16, 2207-2217 (2005). (Pubitemid 40632206)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.5 , pp. 2207-2217
    • Aoki, K.1    Nakamura, T.2    Fujikawa, K.3    Matsuda, M.4
  • 61
    • 33750337537 scopus 로고    scopus 로고
    • Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo 180 to promote adhesion disassembly
    • DOI 10.1083/jcb.200602125
    • Sturge, J., Wienke, D. & Isacke, C. M. Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J. Cell Biol. 175, 337-347 (2006). (Pubitemid 44631427)
    • (2006) Journal of Cell Biology , vol.175 , Issue.2 , pp. 337-347
    • Sturge, J.1    Wienke, D.2    Isacke, C.M.3
  • 62
    • 53749092962 scopus 로고    scopus 로고
    • Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments
    • Caswell, P. T. et al. Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J. Cell Biol. 183, 143-155 (2008).
    • (2008) J. Cell Biol. , vol.183 , pp. 143-155
    • Caswell, P.T.1
  • 66
    • 25144439353 scopus 로고    scopus 로고
    • A mouse model of activating met mutations
    • Graveel, C. R., London, C. A. & Vande Woude, G. F. A mouse model of activating Met mutations. Cell Cycle 4, 518-520 (2005). (Pubitemid 41359769)
    • (2005) Cell Cycle , vol.4 , Issue.4 , pp. 518-520
    • Graveel, C.R.1    London, C.A.2    Vande Woude, G.F.3
  • 67
    • 84874786083 scopus 로고    scopus 로고
    • Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
    • Muller, P. A. et al. Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene 32, 1252-1265 (2013).
    • (2013) Oncogene , vol.32 , pp. 1252-1265
    • Muller, P.A.1
  • 68
    • 84867131849 scopus 로고    scopus 로고
    • Rho GEFs and cancer: Linking gene expression and metastatic dissemination
    • Barrio-Real, L. & Kazanietz, M. G. Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci. Signal. 5, pe43 (2012).
    • (2012) Sci. Signal. , vol.5
    • Barrio-Real, L.1    Kazanietz, G.M.2
  • 69
    • 84867136829 scopus 로고    scopus 로고
    • The Rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells
    • Citterio, C. et al. The Rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Sci. Signal. 5, ra71 (2012).
    • (2012) Sci. Signal. , vol.5
    • Citterio, C.1
  • 70
    • 2542450910 scopus 로고    scopus 로고
    • PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49
    • DOI 10.1091/mbc.E03-10-0732
    • Jeffries, T. R., Dove, S. K., Michell, R. H. & Parker, P. J. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol. Biol. Cell 15, 2652-2663 (2004). (Pubitemid 38691855)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.6 , pp. 2652-2663
    • Jeffries, T.R.1    Dove, S.K.2    Michell, R.H.3    Parker, P.J.4


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